成果/Result
- The yeast peroxisome: A dynamic storage depot and subcellular factory for squalene overproduction被引量：194收藏
- 作者：Liu, Guo-Song Li, Tian Zhou, Wei Jiang, Min Tao, Xin-Yi Liu, Min Zhao, Ming Ren, Yu-Hong Gao, Bei Wang, Feng-Qing Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol
- 来源：METABOLIC ENGINEERING 2020
- 关键词：Synthetic biology Saccharomyces cerevisiae Peroxisome Storage depot Subcellular factory Terpene
- Long-circulating polymeric nanoparticles bearing a combinatorial coating of PEG and water-soluble chitosan被引量：191收藏
- 作者：Sheng, Yan Liu, Changsheng Yuan, Yuan Tao, Xinyi Yang, Fan Shan, Xiaoqian Zhou, Huanjun Xu, Feng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOMATERIALS 2009
- 关键词：Polymeric nanoparticles Polyethylene glycol Water-soluble chitosan Long-circulating Biodistribution
- In vitro macrophage uptake and in vivo biodistribution of PLA-PEG nanoparticles loaded with hemoglobin as blood substitutes: effect of PEG content被引量：123收藏
- 作者：Sheng, Yan Yuan, Yuan Liu, Changsheng Tao, Xinyi Shan, Xiaoqian Xu, Feng
- 机构：E China Univ Sci & Technol; E China Univ Sci & Technol
- 来源：JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 2009
- 关键词：Polyethylene oxides - Hydrophilicity - Nanoparticles - Encapsulation - Macrophages - Blood - Drug delivery - Efficiency - Pharmacokinetics - Biocompatibility
- Metabolic compartmentalization in yeast mitochondria: Burden and solution for squalene overproduction被引量：115收藏
- 作者：Zhu, Zhan-Tao Du, Meng-Meng Gao, Bei Tao, Xin-Yi Zhao, Ming Ren, Yu-Hong Wang, Feng-Qing Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol
- 来源：METABOLIC ENGINEERING 2021
- 关键词：Saccharomyces cerevisiae Mitochondrial engineering Metabolic burden Squalene Dual engineering
- Protective effects of hyperoside (quercetin-3-o-galactoside) to PC12 cells against cytotoxicity induced by hydrogen peroxide and tert-butyl hydroperoxide被引量：99收藏
- 作者：Liu, ZY Tao, XY Zhang, CW Lu, YH Wei, DZ
- 机构：E China Univ Sci & Technol
- 来源：BIOMEDICINE & PHARMACOTHERAPY 2005
- 关键词：hyperoside hydrogen peroxide tert-butyl hydroperoxide PC12 cells
- Preparation of hemoglobin-loaded nano-sized particles with porous structure as oxygen carriers被引量：89收藏
- 作者：Zhao, Jian Liu, Chang-Sheng Yuan, Yuan Tao, Xin-Yi Shan, Xiao-Qian Sheng, Yan Wu, Fan
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOMATERIALS 2007
- 关键词：nanoparticles hemoglobin encapsulation efficiency pore-connecting efficiency oxygen-carrying capacity circulation time
- Unraveling and engineering the production of 23,24-bisnorcholenic steroids in sterol metabolism被引量：80收藏
- 作者：Xu, Li-Qin Liu, Yong-Jun Yao, Kang Liu, Hao-Hao Tao, Xin-Yi Wang, Feng-Qing Wei, Dong-Zhi
- 机构：E China Univ Sci & Technol
- 来源：SCIENTIFIC REPORTS 2016
- Epidermal Growth Factor-Ferritin H-Chain Protein Nanoparticles for Tumor Active Targeting被引量：79收藏
- 作者：Li, Xu Qiu, Lihui Zhu, Pei Tao, Xinyi Imanaka, Tadayuki Zhao, Jing Huang, Youguo Tu, Yaping Cao, Xuni
- 机构：Creighton Univ;E China Univ Sci & Technol;Chinese Acad Sci
- 来源：SMALL 2012
- 关键词：Diseases - Tumors - Cytology - Controlled drug delivery - Proteins - Cells - Mammals - Safety factor - Targeted drug delivery - Cancer cells - Chains
- Metabolic Engineering of Saccharomyces cerevisiae To Overproduce Squalene被引量：71收藏
- 作者：Li, Tian Liu, Guo-Song Zhou, Wei Jiang, Min Ren, Yu-Hong Tao, Xin-Yi Liu, Min Zhao, Ming Wang, Feng-Qing Gao, Bei Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2020
- 关键词：Saccharomyces cerevisiae metabolic engineering squalene overproduction ethanol carbon source utilization
- Simple and Cheap CRISPR/Cas12a Biosensor Based on Plug-and-Play of DNA Aptamers for the Detection of Endocrine-Disrupting Compounds被引量：65收藏
- 作者：Wang, Feng-Qing Zhao, Yunqiu Zhu, Lin Ding, Yaxue Ji, Weiting Liu, Kun Liu, Ke Gao, Bei Tao, Xinyi Dong, Yu-Guo Wei, Dongzhi
- 机构： State Key Laboratory of Bioreactor Engineering; Key Laboratory of Biocatalysis and Intelligent Manufacturing
- 来源：SSRN 2023
- 关键词：DNA - Endocrine disrupters - Phenols
- High-Level Production of Sesquiterpene Patchoulol in Saccharomyces cerevisiae被引量：57收藏
- 作者：Liu, Min Lin, Yang-Chen Guo, Jiao-Jiao Du, Meng-Meng Tao, Xinyi Gao, Bei Zhao, Ming Ma, Yushu Wang, Feng-Qing Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol
- 来源：ACS SYNTHETIC BIOLOGY 2021
- 关键词：patchoulol physiological status metabolic engineering Saccharomyces cerevisiae sesquiterpene cell factories
- In vitro macrophage uptake and in vivo biodistribution of long-circulation nanoparticles with poly(ethylene-glycol)-modified PLA (BAB type) triblock copolymer被引量：56收藏
- 作者：Shan, Xiaoqian Liu, Changsheng Yuan, Yuan Xu, Feng Tao, Xinyi Sheng, Yan Zhou, Huanjun
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：COLLOIDS AND SURFACES B-BIOINTERFACES 2009
- 关键词：Nanoparticles BAB type copolymers PEGylation degree Uptake by macrophages Plasma clearance Biodistribution
- Long-circulation of hemoglobin-loaded polymeric nanoparticles as oxygen carriers with modulated surface charges被引量：55收藏
- 作者：Xu, Feng Yuan, Yuan Shan, Xiaoqian Liu, Changsheng Tao, Xinyi Sheng, Yan Zhou, Huanjun
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：INTERNATIONAL JOURNAL OF PHARMACEUTICS 2009
- 关键词：Hb-loaded polymeric nanoparticles Blood long-circulation zeta-Potential Biodistribution
- Significantly Enhanced Production of Patchoulol in Metabolically Engineered Saccharomyces cerevisiae被引量：53收藏
- 作者：Ma, Bin Liu, Min Li, Zhen-Hai Tao, Xinyi Wei, Dong-Zhi Wang, Feng-Qing
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2019
- 关键词：patchoulol sesquiterpene metabolic engineering Saccharomyces cerevisiae terpenoids
- Reversion of multidrug resistance by tumor targeted delivery of antisense oligodeoxynucleotides in hydroxypropyl-chitosan nanoparticles被引量：52收藏
- 作者：Wang, Jiaqi Tao, Xinyi Zhang, Yufei Wei, Dongzhi Ren, Yuhong
- 机构：E China Univ Sci & Technol
- 来源：BIOMATERIALS 2010
- 关键词：Hydroxypropyl-chitosan nanoparticles Tumor-targeted Antisense oligodeoxynucleotides Multidrug resistance
- Ammonia-containing dimethyl sulfoxide: An improved solvent for the dissolution of formazan crystals in the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay被引量：51收藏
- 作者：Wang, Hengwei Wang, Fengqing Tao, Xinyi Cheng, Hairong
- 机构：Shanghai Jiao Tong Univ;E China Univ Sci & Technol
- 来源：ANALYTICAL BIOCHEMISTRY 2012
- 关键词：MTT assay Formazan Dimethyl sulfoxide Ammonia pH Viability
- Metabolic engineering of Pichia pastoris for the production of dammarenediol-II被引量：51收藏
- 作者：Liu, Xin-Bin Liu, Min Tao, Xin-Yi Zhang, Zhong-Xi Wang, Feng-Qing Wei, Dong-Zhi
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2015
- 关键词：Dammarenediol-II Metabolic engineering Pichia pastoris Ginsenosides 2,3-Oxidosqualene
- Effect of themicrobial lipopeptide on tumor cell lines: apoptosis induced by disturbing the fatty acid composition of cell membrane被引量：46收藏
- 作者：Liu, Xiangyang Tao, Xinyi Zou, Aihua Yang, Shizhong Zhang, Lixin Mu, Bozhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Acad Sci
- 来源：PROTEIN & CELL 2010
- 关键词：Bacillus subtilis lipopeptide antitumor activity membrane fatty acid apoptosis
- Pharmacological activity and hydrolysis behavior of novel ibuprofen glucopyranoside conjugates被引量：43收藏
- 作者：Zhao, Xiangguo Tao, Xinyi Wei, Dongzhi Song, Qingxun
- 机构：E China Univ Sci & Technol
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2006
- 关键词：ester glucopyranoside ibuprofen non-steroidal anti-inflammatory drugs (NSAIDs) prodrug ulceration
- Development of a fed-batch process for the production of anticancer drug TATm-survivin(T34A) in Escherichia coli被引量：40收藏
- 作者：Zhang, Haiyi Zheng, Yu Liu, Qinghai Tao, Xinyi Zheng, Wenyun Ma, Xingyuan Wei, Dongzhi
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Biochemical Engineering Journal 2009
- 关键词：Batch cell culture - Controlled drug delivery - Recombinant proteins - Batch data processing - Gene expression
- Influence of PEG chain on the complement activation suppression and longevity in vivo prolongation of the PCL biomedical nanoparticles被引量：40收藏
- 作者：Shan, Xiaoqian Yuan, Yuan Liu, Changsheng Tao, Xinyi Sheng, Yan Xu, Feng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOMEDICAL MICRODEVICES 2009
- 关键词：PEGylation NPs Prolong longevity in vivo Biodistribution Complement activation
- Engineered 3-Ketosteroid 9α-Hydroxylases in Mycobacterium neoaurum: an Efficient Platform for Production of Steroid Drugs被引量：36收藏
- 作者：Liu, Hao-Hao Xu, Li-Qin Yao, Kang Xiong, Liang-Bin Tao, Xin-Yi Liu, Min Wang, Feng-Qing Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol
- 来源：APPLIED AND ENVIRONMENTAL MICROBIOLOGY 2018
- 关键词：3-ketosteroid-9 alpha-hydroxylase androst-1,4-diene-3,17-dione (ADD) 9 alpha-hydroxy-4-androstene-3,17-dione (9-OHAD) mycobacterium Mn25795 sterols 9 alpha-hydroxy-4-androstene-3,17-dione androst-1,4-diene-3,17-dione sterol
- Engineering Saccharomyces cerevisiae for Hyperproduction of β-Amyrin by Mitigating the Inhibition Effect of Squalene on β-Amyrin Synthase被引量：35收藏
- 作者：Du, Meng-Meng Zhu, Zhan-Tao Zhang, Ge-Ge Zhao, Yun-Qiu Gao, Bei Tao, Xin-Yi Liu, Min Ren, Yu-Hong Wang, Feng-Qing Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2022
- 关键词：beta-amyrin squalene inhibition peroxisome compartmentalization competition pathway Saccharomyces cerevisiae
- In vitro macrophage uptake and in vivo biodistribution of long-circulation nanoparticles with poly(ethylene-glycol)-modified PLA (BAB type) triblock copolymer被引量：35收藏
- 作者：Shan, Xiaoqian Liu, Changsheng Yuan, Yuan Xu, Feng Tao, Xinyi Sheng, Yan Zhou, Huanjun
- 机构： The State Key Laboratory of Bioreactor Engineering; Key Laboratory for Ultrafine Materials; Engineering Research Center for Biomedical Materials
- 来源：Colloids and Surfaces B: Biointerfaces 2009
- 关键词：Polyethylene oxides - Biocompatibility - Macrophages - Ethylene glycol - Antigen-antibody reactions - Drug delivery - Nanoparticles - Polyvinyl alcohols - Hydrophilicity - Polyols
- New compounds from a hydrothermal vent crab-associated fungus Aspergillus versicolor XZ-4被引量：33收藏
- 作者：Pan, Chengqian Shi, Yutong Chen, Xuegang Chen, Chen-Tung Arthur Tao, Xinyi Wu, Bin
- 机构：Zhejiang Univ;Natl Sun Yat Sen Univ;East China Univ Sci & Technol
- 来源：ORGANIC & BIOMOLECULAR CHEMISTRY 2017
- 关键词：Amino acids - Quantum chemistry - Aspergillus - Molluscs - Nuclear magnetic resonance spectroscopy - Musculoskeletal system - Stereochemistry - Hot springs
- Tyrosinase inhibitory effects and inhibition mechanisms of nobiletin and hesperidin from citrus peel crude extracts被引量：32收藏
- 作者：Zhang, Chongwei Lu, Yanhua Tao, Lin Tao, Xinyi Su, Xiaochun Wei, Dongzhi
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2007
- 关键词：citrus unshiu Marc. nobiletin hesperidin B16 mouse melanoma crude extract tyrosinase inhibitor melanin Traditional Chinese Medicine SAR
- Efficient display of active lipase LipB52 with a Pichia pastoris cell surface display system and comparison with the LipB52 displayed on Saccharomyces cerevisiae cell surface被引量：32收藏
- 作者：Jiang, Zhengbing Gao, Bei Ren, Ren Tao, Xingyi Ma, Yushu Wei, Dongzhi
- 机构：E China Univ Sci & Technol;Hubei Univ
- 来源：BMC BIOTECHNOLOGY 2008
- Anti-inflammatory effects of active constituents extracted from Chinese medicinal herbs against Propionibacterium acnes被引量：31收藏
- 作者：Fu, Shiyu Sun, Changlei Tao, Xinyi Ren, Yuhong
- 机构：E China Univ Sci & Technol
- 来源：NATURAL PRODUCT RESEARCH 2012
- 关键词：anti-inflammatory activity acne cytokines Chinese medicinal herbs
- Engineered 3-ketosteroid 9a-hydroxylases in Mycobacterium neoaurum: An efficient platform for production of steroid drugs被引量：30收藏
- 作者：Liu, Hao-Hao Xu, Li-Qin Yao, Kang Xiong, Liang-Bin Tao, Xin-Yi Liu, Min Wang, Feng-Qing Wei, Dong-Zhi
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Applied and Environmental Microbiology 2018
- 关键词：Metabolic engineering - Lipids - Alcohols - Metabolism
- Cell-penetrating and endoplasmic reticulum-locating TAT-IL-24-KDEL fusion protein induces tumor apoptosis被引量：29收藏
- 作者：Zhang, Jian Sun, Aiyou Xu, Rui Tao, Xinyi Dong, Yuguo Lv, Xinxin Wei, Dongzhi
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF CELLULAR PHYSIOLOGY 2016
