成果/Result
- Bioactive Indole Diketopiperazine Alkaloids from the Marine Endophytic Fungus Aspergillus sp. YJ191021被引量：29收藏
- 作者：Yang, Jin Gong, Lizhi Guo, Miaomiao Jiang, Yu Ding, Yi Wang, Zhijie Xin, Xiujuan An, Faliang
- 机构：East China Univ Sci & Technol;Beijing Technol & Business Univ
- 来源：MARINE DRUGS 2021
- 关键词：indole diketopiperazine alkaloids endophytic fungus Aspergillus sp antimicrobial
- Cloning of thermostable cellulase genes of Clostridium thermocellum and their secretive expression in Bacillus subtilis被引量：24收藏
- 作者：Liu, Jian-Ming Xin, Xiu-Juan Li, Chun-Xiu Xu, Jian-He Bao, Jie
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Applied Biochemistry and Biotechnology 2012
- 关键词：Bacteriology - Clostridium - Strain - Cellulose - Gene expression
- Cloning of Thermostable Cellulase Genes of Clostridium thermocellum and Their Secretive Expression in Bacillus subtilis被引量：24收藏
- 作者：Liu, Jian-Ming Xin, Xiu-Juan Li, Chun-Xiu Xu, Jian-He Bao, Jie
- 机构：E China Univ Sci & Technol
- 来源：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 2012
- 关键词：Clostridium thermocellum Bacillus subtilis pP43JM2 Cellulase genes Synergy
- Perpyrrospirone A, an unprece dente d hirsutellone peroxide from the marine-derived Penicillium citrinum被引量：19收藏
- 作者：Ding, Yi Jiang, Yu Xu, Sunjie Xin, Xiujuan An, Faliang
- 机构：East China Univ Sci & Technol
- 来源：CHINESE CHEMICAL LETTERS 2023
- 关键词：Penicillium citrinum Hirsutellone Peroxide X-ray Cytotoxicity
- β-葡萄糖苷酶基因和内切葡聚糖酶基因在枯草芽孢杆菌中的表达被引量：14收藏
- 作者：王远 高秋强 辛秀娟 鲍杰
- 机构：华东理工大学生物反应器工程国家重点实验室
- 来源：《应用与环境生物学报》 2013
- 关键词：枯草芽孢杆菌 β-葡萄糖苷酶 内切葡聚糖酶 胞外分泌 共表达
- 摘要：为了实现多种纤维素酶基因的分泌型共表达,利用含有枯草芽孢杆菌中性蛋白酶NprB信号肽的穿梭质粒pP43JM2作为表达载体,将来源于热纤梭菌的内切葡聚糖酶基因celA与来源于多粘芽孢杆菌的β-葡萄糖苷酶基因bglA和bgl...
- 下载全文在线阅读
- Association study of four activity SNPs of CYP3A4 with the precocious puberty in Chinese girls被引量：13收藏
- 作者：Xin, XJ Luan, XH Xiao, JH Wei, DZ Wang, JH Lu, DR Yang, SL
- 机构：E China Univ Sci & Technol;Fudan Univ;Shanghai Bioengn Res Ctr
- 来源：NEUROSCIENCE LETTERS 2005
- 关键词：precocious puberty CYP3A4 genetic variation
- Hypericin Enhances Paclitaxel-Induced B16-F10 Cell Apoptosis by Activating a Cytochrome c Release-Dependent Pathway被引量：11收藏
- 作者：Sun, Liyun Li, Zixuan Shang, Huoli Xin, Xiujuan
- 机构：East China Univ Sci & Technol
- 来源：FRONTIERS IN PHARMACOLOGY 2021
- 关键词：hypericin paclitaxel apoptosis B16-F10 cells mitochondrial dysfunction cytochrome c release
- Enhancement of Emodin Production by Medium Optimization and KH2PO4 Supplementation in Submerged Fermentation of Marine-Derived Aspergillus favipes HN4-13被引量：11收藏
- 作者：Qiu, Xiaohan Gong, Lizhi Xin, Xiujuan An, Faliang
- 机构：East China Univ Sci & Technol
- 来源：MARINE DRUGS 2021
- 关键词：emodin Aspergillus favipes HN4-13 KH2PO4 submerged fermentation
- Adsorption Characteristics and Enrichment of Emodin from Marine-Derived Aspergillus flavipes HN4-13 Extract by Macroporous Resin XAD-16被引量：11收藏
- 作者：Gong, Lizhi Wu, Yuzhen Qiu, Xiaohan Xin, Xiujuan An, Faliang Guo, Miaomiao
- 机构：Beijing Technol & Business Univ;East China Univ Sci & Technol
- 来源：MARINE DRUGS 2022
- 关键词：Aspergillus flavipes HN4-13 emodin macroporous resin XAD-16 adsorption kinetics and isotherms enrichment
- DMC triggers MDA-MB-231 cells apoptosis via inhibiting protective autophagy and PI3K/AKT/mTOR pathway by enhancing ROS level被引量：10收藏
- 作者：Jiang, Yu Xu, Sunjie Guo, Miaomiao Lu, Zhi Wei, Xing An, Faliang Xin, Xiujuan
- 机构：East China Univ Sci & Technol;Beijing Technol & Business Univ;Shanghai Inoherb Cosmet Co Ltd;Marine Biomed Sci & Technol Innovat Platform Linga
- 来源：TOXICOLOGY IN VITRO 2024
- 关键词：DMC MDA-MB-231 cells Apoptosis PI3K-AKT-mTOR pathway
- 壳聚糖修饰L-天门冬酰胺酶对酶活及抗原的影响被引量：10收藏
- 作者：辛秀娟 魏东芝 董常松 周文瑜 刘建文
- 机构：华东理工大学生物反应器工程国家重点实验室
- 来源：《华东理工大学学报（自然科学版）》 2002
- 关键词：酶活 抗原 N,0-羧甲基壳聚糖 L-天门冬酰胺酶 化学修饰 癌细胞 免疫沉淀 生物药品
- 摘要：采用水溶性壳聚糖对 L-天门冬酰胺酶进行化学修饰 ,修饰后的酶活回收率高达 70 % ,修饰酶的比活为每毫克蛋白质 1 2 1 .79U,p H值为 7.4,更接近于人体血浆 p H值 (7.2～ 7.4) ,对底物的亲...
- 下载全文在线阅读
- Four previously undescribed diketopiperazines from marine fungus Aspergillus puniceus FAHY0085 and their effects on liver X receptor a被引量：9收藏
- 作者：Hong, Qi Guo, Miao-Miao Yang, Jin Wei, Xing Liao, Li Xin, Xiu-Juan Zhang, Di An, Fa-Liang
- 机构：East China Univ Sci & Technol;Jiangsu Ocean Univ;Beijing Technol & Business Univ;Minist Nat Resources;Shanghai Jiao Tong Univ
- 来源：PHYTOCHEMISTRY 2023
- 关键词：Marine -derived fungus Diketopiperazines LXR & alpha
- Hypericin-mediated photodynamic therapy enhances gemcitabine induced Capan-2 cell apoptosis via inhibiting NADPH level被引量：9收藏
- 作者：Sun, Liyun Shang, Huoli Wu, Yuzhen Xin, Xiujuan
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF PHARMACY AND PHARMACOLOGY 2022
- 关键词：hypericin gemcitabine Capan-2 apoptosis reactive oxygen species
- Protection effect of 20(S)-ginsenoside Rg2 extracted from cultured Panax notoginseng cells on hydrogen peroxide-induced cytotoxity of human umbilical cord vein endothelial cells in vitro被引量：9收藏
- 作者：Xin, XJ Zhong, JJ Wei, DZ Liu, JW
- 机构：E China Univ Sci & Technol
- 来源：PROCESS BIOCHEMISTRY 2005
- 关键词：20(S)-ginsenoside Rg(2) VEC-304 plasmonigen activator (PA) reactive oxygen species (ROS)
- 性早熟相关基因的研究进展被引量：9收藏
- 作者：郭正霞 辛秀娟 肖君华
- 机构：华东理工大学生物反应器工程国家重点实验室生物化学研究所
- 来源：《国外医学（儿科学分册）》 2004
- 关键词：青春期 早熟 下丘脑一垂体系统 促性腺激素释放激素
- 摘要：人类青春期发育是一个极其复杂的过程,涉及到下丘脑-垂体-性腺轴的活动,该轴的提前发动将会导致性早熟,其中下丘脑促性腺激素释放激素神经元的活动起了关键性的作用。性早熟在很大程度上与遗传密切相关,是一由多基因决定的复杂的遗传...
- 下载全文在线阅读
- Association study of TAC3 and TACR3 gene polymorphisms with idiopathic precocious puberty in Chinese girls被引量：8收藏
- 作者：Xin, Xiujuan Zhang, Jing Chang, Yaning Wu, Yixin
- 机构：E China Univ Sci & Technol;Hamamatsu Univ Sch Med
- 来源：JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM 2015
- 关键词：association study genotyping idiopathic puberty TAC3 TACR3
- A Newly Authenticated Compound from Traditional Chinese Medicine Decoction Induces Melanogenesis in B16-F10 Cells by Increasing Tyrosinase Activity被引量：8收藏
- 作者：Xin, Xiu Juan Zou, Jiahong Zou, Tao Shang, Huoli Sun, Li Yun
- 机构：East China Univ Sci & Technol
- 来源：EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2018
- Bioactive indole alkaloids from insect derived endophytic Aspergillus lentulus被引量：8收藏
- 作者：Wang, Zhijie Jiang, Yu Xin, Xiujuan An, Faliang
- 机构：East China Univ Sci & Technol
- 来源：FITOTERAPIA 2021
- 关键词：Endophytic fungus Aspergillus lentulus Indole alkaloids
- Substrate promiscuity of pyruvate kinase on various deoxynucleoside diphosphates for synthesis of deoxynucleoside triphosphates被引量：7收藏
- 作者：Gao, Shuhong Bao, Jie Gu, Xiaoming Xin, Xiujuan Chen, Changhua Ryu, Dewey D. Y.
- 机构：E China Univ Sci & Technol;Univ Calif Davis
- 来源：ENZYME AND MICROBIAL TECHNOLOGY 2008
- 关键词：Promiscuity Pyruvate kinase (PK) Deoxynucleoside triphosphate (dNTP) Bacillus sp PK Zymomonas mobilis PK
- Curdepsidone A Induces Intrinsic Apoptosis and Inhibits Protective Autophagy via the ROS/PI3K/AKT Signaling Pathway in HeLa Cells被引量：7收藏
- 作者：Xu, Sunjie Li, Zhimin Xin, Xiujuan An, Faliang
- 机构：East China Univ Sci & Technol;Marine Biomed Sci & Technol Innovat Platform Lin G
- 来源：MARINE DRUGS 2024
- 关键词：curdepsidone A HeLa cells anti-tumor activity ROS PI3K/AKT signaling pathway
- Regulation of the HMOX1 gene by the transcription factor AP-2δ with unique DNA binding site被引量：6收藏
- 作者：Sun, Liyun Zhao, Yuxia Gu, Shaohua Mao, Yumin Ji, Chaoneng Xin, Xiujuan
- 机构：E China Univ Sci & Technol;Fudan Univ
- 来源：MOLECULAR MEDICINE REPORTS 2014
- 关键词：AP-2 delta heme oxygenase-1 luciferase assay electromobility shift assays
- Development of a High-Titer Culture Medium for the Production of Cholesterol by Engineered Saccharomyces cerevisiae and Its Fed-Batch Cultivation Strategy被引量：6收藏
- 作者：Wang, Ling-Xu Zheng, Gao-Fan Xin, Xiu-Juan An, Fa-Liang
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY 2022
- 关键词：Cholesterol S cerevisiae fermentation optimization fed -batch culture citric acid
- 问题教学法在植物生理学实验教学中的应用被引量：6收藏
- 作者：辛秀娟 张惠展
- 机构：华东理工大学生物工程学院
- 来源：《高校生物学教学研究（电子版）》 2013
- 关键词：植物生理学实验教学 问题教学法 传统教学法 学习兴趣 教学效率
- 摘要：植物生理学实验是构架理论和实践的纽带,教学法的恰当运用能起到事半功倍的教学效果,对学生学习兴趣的培养和知识结构的理解等方面都能起到积极的作用。本文对植物生理实验教学中使用问题教学法(PBL)和传统教学法后,学生学习的效果...
- 下载全文在线阅读
- 泡菜中亚硝酸盐降解乳酸菌的筛选与鉴定被引量：5收藏
- 作者：王颉 李标 李彦涛 辛秀娟
- 机构：华东理工大学生物反应器工程国家重点实验室
- 来源：《食品与药品》 2014
- 关键词：乳酸菌 泡菜 耐盐 亚硝酸盐 降解
- 摘要：目的从泡菜中筛选亚硝酸盐降解能力强的乳酸菌。方法采用平板涂布法和平板划线法从泡菜中分离若干株产酸菌株,从中筛选出产酸能力强、生长速度快、亚硝酸盐降解性能高的菌株。对优选菌株进行了形态学、生理学鉴定,测定其16S rRNA...
- 下载全文在线阅读
- Octahydroindolizine alkaloid Homocrepidine A from Dendrobium crepidatum attenuate P. acnes-induced inflammatory in vitro and in vivo被引量：5收藏
- 作者：Gong, Lizhi Xu, Jiayao Guo, Miaomiao Zhao, Jian Xin, Xiujuan Zhang, Chaofeng Ni, Xiaoming Hu, Yang An, Faliang
- 机构：East China Univ Sci & Technol;Nanjing Univ Chinese Med;Marine Biomed Sci & Technol Innovat Platform Lin g;Beijing Technol & Business Univ;China Pharmaceut Univ
- 来源：JOURNAL OF ETHNOPHARMACOLOGY 2024
- 关键词：Dendrobium crepidatum Anti-inflammatory TLR2 NLRP3 P. acnes
- Efficient ilamycins production utilizing Enteromorpha prolifera by metabolically engineered Streptomyces atratus被引量：5收藏
- 作者：Jiang, Yu-Xi Zheng, Gao-Fan Chen, Long-Chao Yang, Na Xin, Xiu-Juan Ma, Jun-Ying Ju, Jian-Hua Wu, Hui Zhao, Ming Wang, Ruida An, Fa-Liang
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Marine Biomed Sci & Technol Innovat Platform Lin;Anhui Polytech Univ
- 来源：BIOTECHNOLOGY FOR BIOFUELS AND BIOPRODUCTS 2023
- 关键词：Ilamycins Anti-tuberculosis Streptomyces atratus SCSIO ZH16 Entromorpha prolifera BldD
- Combinatorial strategies for production improvement of anti-tuberculosis antibiotics ilamycins E1/E2 from deep sea-derived Streptomyces atratus SCSIO ZH16 ΔilaR被引量：4收藏
- 作者：Zhu, Yunfei Zheng, Gaofan Xin, Xiujuan Ma, Junying Ju, Jianhua An, Faliang
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：BIORESOURCES AND BIOPROCESSING 2022
- 关键词：Ilamycins Streptomyces atratus Fermentation optimization Exogenous adding strategy
- 丝状真菌Amorphotheca resinae ZN1的糠醛降解代谢分析被引量：4收藏
- 作者：王晓凤 张建 辛秀娟 鲍杰
- 机构：华东理工大学生物工程学院生物反应器工程国家重点实验室
- 来源：《生物工程学报》 2012
- 关键词：降解途径 生物脱毒 糠醛 木质纤维素
- 摘要：木质纤维素在预处理过程产生的降解产物对后续的酶水解和微生物发酵过程产生了强烈的抑制。因此,这些抑制物的脱除即所谓的"脱毒"步骤是正常进行后续酶解和发酵的前提条件。我们对本实验室筛选的丝状真菌Amorphotheca re...
- 下载全文在线阅读
- Improving the bioactivity of rHirudin with boronophenylalanine site-specific modification被引量：3收藏
- 作者：Xin, Xiujuan Liu, Wenshe Sun, Liyun
- 机构：E China Univ Sci & Technol;Texas A&M Univ
- 来源：MOLECULAR MEDICINE REPORTS 2015
- 关键词：antithrombin activity boronophenylalanine proliferation inhibition recombinant Hirudin site-specific modification
- Palmitoyl copper peptide and acetyl tyrosine complex enhances melanin production in both A375 and B16 cell lines被引量：3收藏
- 作者：Hong, Minhua Gui, Yingyue Xu, Jiayao Zhao, Xianglong Jiang, Chunyang Zhao, Jian Xin, Xiujuan Liu, Dan Tang, Xiaolin Tang, Rong An, Faliang
- 机构：East China Univ Sci & Technol;Shanghai Peptide Biotechnol Co Ltd;Marine Biomed Sci & Technol Innovat Platform Lin G
- 来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2025
- 关键词：Tyrosinase enzyme activity Melanin Copper peptide Melanogenic agent
