成果/Result
- Two-Dimensional Design Strategy to Construct Smart Fluorescent Probes for the Precise Tracking of Senescence被引量：109收藏
- 作者：Gao, Ying Hu, Yulu Liu, Qimeng Li, Xiaokang Li, Xinming Kim, Chu-Young James, Tony D. Li, Jian Chen, Xi Guo, Yuan
- 机构：Northwest Univ;East China Univ Sci & Technol;Univ Texas El Paso;Univ Bath;Tongji Univ
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2021
- 关键词：bioimaging fluorescent probes lysosomal pH senescence β -galactosidase
- First-generation species-selective chemical probes for fluorescence imaging of human senescence-associated β-galactosidase被引量：76收藏
- 作者：Li, Xiaokang Qiu, Wenjing Li, Jinwen Chen, Xi Hu, Yulu Gao, Ying Shi, Donglei Li, Xinming Lin, Huiling Hu, Zelan Dong, Guoqiang Sheng, Chunquan Jiang, Bei Xia, Conglong Kim, Chu-Young Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;Second Mil Med Univ;Dali Univ;Univ Texas El Paso
- 来源：CHEMICAL SCIENCE 2020
- 关键词：Probes - Fluorescence imaging - Enzymes - Fluorescence spectroscopy - Mammals
- Selective visualization of live-cell mitochondrial thiophenols and thEIr induced oxidative stress process by a rationally designed rhodol-based fluorescent probe被引量：52收藏
- 作者：Liu, Qimeng Li, Anyang Li, Xiaokang Li, Bin Zhang, Yanhui Li, Jian Guo, Yuan
- 机构： Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education; State Key Laboratory of Bioreactor Engineering; Key Laboratory of Resource Biology and Biotechnology in Western China of the Ministry of Education
- 来源：Sensors and Actuators, B: Chemical 2019
- 关键词：Fluorescence imaging - Oxidative stress - Lanthanum compounds - Oxygen - Fluorescence spectroscopy - Cytology - Mitochondria
- A novel colorimetric and ratiometric fluorescent probe for selective detection of bisulfite in real samples and living cells被引量：52收藏
- 作者：Li, Jin Gao, Ying Guo, Haoran Li, Xiaokang Tang, Haoyang Li, Jian Guo, Yuan
- 机构：Northwest Univ;East China Univ Sci & Technol;Xian Univ Posts & Telecommun
- 来源：DYES AND PIGMENTS 2019
- 关键词：Colorimetric and ratiometric Fluorescent probe Bisulfite Real samples Live-cell imaging
- A ratiometric near-infrared fluorescence strategy based on spiropyran in situ switching for tracking dynamic changes of live-cell lysosomal pH被引量：49收藏
- 作者：Li, Jin Li, Xiaokang Jia, Jianbo Chen, Xi Lv, Yinjuan Guo, Yuan Li, Jian
- 机构：Northwest Univ;East China Univ Sci & Technol
- 来源：DYES AND PIGMENTS 2019
- 关键词：Ratiometric sensing NIR fluorescent probe Spiropyran Fluorescence imaging Lysosomal pH
- Curcumin-based polarity fluorescent probes: Design strategy and biological applications被引量：41收藏
- 作者：Hu, Linghao Shi, Donglei Li, Xinming Zhu, Jin Mao, Fei Li, Xiaokang Xia, Conglong Jiang, Bei Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;Dali Univ
- 来源：DYES AND PIGMENTS 2020
- 关键词：Curcumin Polarity-specificity Polarity fluorescent probe Lysosome Live-cell imaging Design strategy
- Spiropyran in Situ Switching: A Real-Time Fluorescence Strategy for Tracking DNA G-Quadruplexes in Live Cells被引量：37收藏
- 作者：Li, Jin Yin, Xinchi Li, Bin Li, Xiaokang Pan, Yuanjiang Li, Jian Guo, Yuan
- 机构：Northwest Univ;Zhejiang Univ;East China Univ Sci & Technol
- 来源：ANALYTICAL CHEMISTRY 2019
- 关键词：Cytology - Fluorescence imaging - Cells - Diagnosis - Red Shift
- A senolysis-based theragnostic prodrug strategy towards chronic renal failure被引量：35收藏
- 作者：Song, Yihe Li, Xinming Shi, Donglei Sun, Tianyue Liu, Wenwen Li, Xiaokang Qiao, Sicong Chen, Xin Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;Hainan Univ;Tongji Univ;Dali Univ
- 来源：CHEMICAL SCIENCE 2022
- 关键词：Mammals
- Stress response decay with aging visualized using a dual-channel logic-based fluorescent probe被引量：34收藏
- 作者：Tian, Jingye Shi, Donglei Zhang, Yanhui Li, Xiaokang Li, Xinming Teng, Hao James, Tony D. Li, Jian Guo, Yuan
- 机构：Northwest Univ;East China Univ Sci & Technol;Univ Bath
- 来源：CHEMICAL SCIENCE 2021
- 关键词：Chlorine compounds - Computer circuits - Probes
- Lysosomal polarity increases with aging as revealed by a lysosome- targetable near -infrared fluorescent probe被引量：34收藏
- 作者：Shi, Donglei Hu, Linghao Li, Xinming Liu, Wenwen Gao, Ying Li, Xiaokang Jiang, Bei Xia, Conglong Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;Dali Univ
- 来源：SENSORS AND ACTUATORS B-CHEMICAL 2020
- 关键词：Fluorescence spectroscopy - Cytology - Infrared devices - Probes - Fluorescence
- Design, Synthesis and Therapeutic Evaluation of Novel Antimalarial Derivatives Based on the Clinical Antitumor Candidate Drug Quisinostat被引量：32收藏
- 作者：Li, Jian Song, Jiamei Li, Ruoxi Huang, Zhenghui Qian, Yunan Wang, Xicheng Shao, Qiqi Mao, Fei Wang, Manjiong Jiang, Lubin Li, Xiaokang
- 机构： State Key Laboratory of Bioreactor Engineering; Key Laboratory of Molecular Virology and Immunology; Key Laboratory of Xinjiang Phytomedicine Resource and Utilization; Key Laboratory of Tropical Biological Resources of Ministry of Education; Nanjing Advanced Academy of Life and Health
- 来源：SSRN 2024
- 关键词：Acetylation - Diseases - Electrophoresis - Structural optimization
- A rapid-response near-infrared fluorescent probe with a large Stokes shift for senescence-associated β-galactosidase activity detection and imaging of senescent cells被引量：19收藏
- 作者：Qiu, Wenjing Li, Xiaokang Shi, Donglei Li, Xinming Gao, Ying Li, Jinwen Mao, Fei Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;Dali Univ;East China Univ Sci & Technol
- 来源：DYES AND PIGMENTS 2020
- 关键词：Senescence-associated beta-galactosidase NIR fluorescent probe Aging Senescent cells Living-cell imaging
- A Metal-free Approach to 3-Aryl-3-hydroxy-2-oxindoles by Treatment of 3-Acyloxy-2-oxindoles with Diaryliodonium Salts被引量：9收藏
- 作者：Li, Xiaokang Ni, Wei Mao, Fei Wang, Wei Li, Jian
- 机构：E China Univ Sci & Technol;Univ New Mexico
- 来源：CHEMISTRY-AN ASIAN JOURNAL 2016
- 关键词：3-acyloxy-2-oxindoles 3-aryl-3-hydroxy-2-oxindole arylation diaryliodonium salt metal-free
- Molecular engineering development of β-galactosidase-activatable fluorogenic probes for precise senescence tracking in cells, tissues and a mouse model of psoriasis被引量：2收藏
- 作者：Lv, Xinhang Yu, Yangxin Chen, Zhuowei Wang, Guangwei Li, Xiaokang Sun, Ling Wu, Lingyu Wu, Jiale Li, Jian Guo, Yuan Shi, Donglei
- 机构：Hainan Univ;Hainan Univ;Northwest Univ;East China Univ Sci & Technol;Shihezi Univ
- 来源：SENSORS AND ACTUATORS B-CHEMICAL 2025
- 关键词：SA-beta-gal Senescent cells Psoriasis Fluorescent probe Anti-aging drugs High-throughput evaluation
- Novel Combination Therapy for Heart Failure: Trimebutine-Methoxsalen Identified through Synergistic Network Virtual Screening and Experimental Validation被引量：1收藏
- 作者：Huang, Yunyuan Chen, Xin Yang, Jin Yao, Yue Wang, Manjiong Lu, Taotao Li, Xiao Wang, Jiqun Qiao, Sicong Shi, Donglei Li, Xiaokang Li, Jian Xu, Yixiang
- 机构：Cent China Normal Univ;Jinan Univ;East China Univ Sci & Technol;Hainan Univ
- 来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING 2024
- 关键词：Cardiology - Diagnosis - Disease control - Drug therapy
