成果/Result
- A modular approach to the engineering of a centimeter-sized bone tissue construct with human amniotic mesenchymal stem cells-laden microcarriers被引量：94收藏
- 作者：Chen, Maiqin Wang, Xiu Ye, Zhaoyang Zhang, Yan Zhou, Yan Tan, Wen-Song
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOMATERIALS 2011
- 关键词：Tissue engineering Modular approach Microcarriers Macrotissue Mesenchymal stem cells Osteogenic differentiation
- Effect of porosity on long-term degradation of poly (ε-caprolactone) scaffolds and thEIr cellular response被引量：80收藏
- 作者：Zhang, Qingchun Jiang, Yun Zhang, Yan Ye, Zhaoyang Tan, Wensong Lang, Meidong
- 机构：E China Univ Sci & Technol;Lib Zhejiang Univ Technol;E China Univ Sci & Technol
- 来源：POLYMER DEGRADATION AND STABILITY 2013
- 关键词：Poly (epsilon-caprolactone) Scaffold Degradation Porosity Cell culture
- Bioleaching of copper from waste printed circuit boards by bacteria-free cultural supernatant of iron-sulfur-oxidizing bacteria被引量：78收藏
- 作者：Wu, Weijin Liu, Xiaocui Zhang, Xu Zhu, Minglong Tan, Wensong
- 机构：East China Univ Sci & Technol
- 来源：BIORESOURCES AND BIOPROCESSING 2018
- 关键词：Wasted printed circuit boards Bioleaching Leptospirillum ferriphilum and Sulfobacillus thermosulfidooxidans Biooxidation-leaching-separation cycle
- Myocardial regeneration: Roles of stem cells and hydrogels被引量：75收藏
- 作者：Ye, Zhaoyang Zhou, Yan Cai, Haibo Tan, Wensong
- 机构：E China Univ Sci & Technol
- 来源：ADVANCED DRUG DELIVERY REVIEWS 2011
- 关键词：Myocardial regeneration Cell therapy Tissue engineering Stem cells Hydrogels
- Mechanism underlying the bioleaching process of LiCoO2 by sulfur-oxidizing and iron-oxidizing bacteria被引量：66收藏
- 作者：Wu, Weijin Liu, Xiaocui Zhang, Xu Li, Xiyan Qiu, Yongqiu Zhu, Minglong Tan, Wensong
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF BIOSCIENCE AND BIOENGINEERING 2019
- 关键词：Bioleaching LiCoO2 Pyrite Sulfur-oxidizing and iron-oxidizing bacteria Extracellular polymeric substances
- Effect of the culture media optimization, pH and temperature on the biohydrogen production and the hydrogenase activities by Klebsiella pneumoniae ECU-15被引量：63收藏
- 作者：Xiao, Yan Zhang, Xu Zhu, Minglong Tan, Wensong
- 机构：E China Univ Sci & Technol
- 来源：BIORESOURCE TECHNOLOGY 2013
- 关键词：Biohydrogen production Response surface methodology (RSM) Hydrogenase Medium compositions Klebsiella pneumoniae
- A combinatorial variation in surface chemistry and pore size of three-dimensional porous poly(ε-caprolactone) scaffolds modulates the behaviors of mesenchymal stem cells被引量：62收藏
- 作者：Zhao, Yingdi Tan, Ke Zhou, Yan Ye, Zhaoyang Tan, Wen-Song
- 机构：E China Univ Sci & Technol
- 来源：MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 2016
- 关键词：Tissue engineering Mesenchymal stem cells Three-dimensional porous scaffolds Surface chemistry Pore size
- Multi-Scale Analysis of Nickel Tolerance Mechanism for Thermophilic Sulfobacillus Thermosulfidooxidans in Bioleaching被引量：61收藏
- 作者：Chen, Guanglin Shi, Hongjie Ding, Huili Zhang, Xu Gu, Tingyue Zhu, Minglong Tan, Wensong
- 机构： State Key Laboratory of Bioreactor Engineering; Department of Chemical and Biomolecular Engineering
- 来源：SSRN 2022
- 关键词：Adenosinetriphosphate - Cell proliferation - Energy utilization - Genes - Metabolism - Metal ions - Nickel
- Synthesis, characterization, fluorescence labeling and cellular internalization of novel amine-functionalized poly(ethylene glycol)-block- poly(Ε-caprolactone) amphiphilic block copolymers被引量：54收藏
- 作者：Yan, Jinliang Ye, Zhaoyang Luo, Houyong Chen, Min Zhou, Yan Tan, Wensong Xiao, Yan Zhang, Yan Lang, Meidong
- 机构： State Key Laboratory of Bioreactor Engineering; Key Laboratory for Ultrafine Materials of Ministry of Education
- 来源：Polymer Chemistry 2011
- 关键词：Drug delivery - Medical applications - ProtEIns - Fluorophores - Particle size - Ring opening polymerization - Critical micelle concentration - Hyaluronic acid - Polyols - Esters - Ethylene glycol - Organic acids - Block copolymers - Cell culture - Solutions - Ethylene - Fluorescence microscopy - Polyethylene glycols - Polyethylene oxides
- Three-Dimensional and Serum-Free Culture in Fixed-bed Bioreactor Enhance Exosome Production by Affecting the Cytoskeleton被引量：52收藏
- 作者：Zhou, Yan Huo, Chuanfu Zhao, Yuanyuan Song, Meng Guo, Yuzhe Li, Shihao Tan, Wensong
- 机构： State Key Laboratory of Bioreactor Engineering; Shanghai Key Laboratory of Multiphase Materials Chemical Engineering
- 来源：SSRN 2024
- 关键词：Bioconversion - Cell culture - Microfiltration - Plastic bottles - ProtEIns - Stem cells
- Fine tuning micellar core-forming block of poly(ethylene glycol)- block -poly(Ε-caprolactone) amphiphilic copolymers based on chemical modification for the solubilization and delivery of doxorubicin被引量：50收藏
- 作者：Yan, Jinliang Ye, Zhaoyang Chen, Min Liu, Zhanzhan Xiao, Yan Zhang, Yan Zhou, Yan Tan, Wensong Lang, Meidong
- 机构： Key Laboratory for Ultrafine Materials of Ministry of Education; State Key Laboratory of Bioreactor Engineering
- 来源：Biomacromolecules 2011
- 关键词：Chemical modification - Esterification - Polyethylene glycols - Solutions - Controlled drug delivery - Critical micelle concentration - Motion Picture Experts Group standards - Esters - Ethylene glycol - Polyethylene oxides - Polyols - Lactic acid - Ring opening polymerization - Solubility - Targeted drug delivery - Block copolymers - Fluorescence spectroscopy
- Advances in bioleaching of waste lithium batteries under metal ion stress被引量：50收藏
- 作者：Zhang, Xu Shi, Hongjie Tan, Ningjie Zhu, Minglong Tan, Wensong Daramola, Damilola Gu, Tingyue
- 机构：East China Univ Sci & Technol;Ohio Univ
- 来源：BIORESOURCES AND BIOPROCESSING 2023
- 关键词：Bioleaching Metal ion stress Biofilm Waste lithium battery Electrochemistry
- Characteristics of fermentative hydrogen production with Klebsiella pneumoniae ECU-15 isolated from anaerobic sewage sludge被引量：46收藏
- 作者：Niu, Kun Zhang, Xu Tan, Wen-Song Zhu, Ming-Long
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：International Journal of Hydrogen Energy 2010
- 关键词：Sewage sludge - Bacteria - Hydrogen production
- Pendant small functional groups on poly(Ε-caprolactone) substrate modulate adhesion, proliferation and differentiation of human mesenchymal stem cells被引量：45收藏
- 作者：Chen, Min Zhang, Yi Zhou, Yan Zhang, Yan Lang, Meidong Ye, Zhaoyang Tan, Wen-Song
- 机构： State Key Laboratory of Bioreactor Engineering; Key Laboratory for Ultrafine Materials of Ministry of Education
- 来源：Colloids and Surfaces B: Biointerfaces 2015
- 关键词：Tissue regeneration - Tissue - Adhesion - Scaffolds (biology) - Biomaterials - Cell culture - Cell engineering - Surface chemistry
- Porous chitosan derivative scaffolds affect proliferation and osteogenesis of mesenchymal stem cell via reducing intracellular ROS被引量：44收藏
- 作者：Wang, Jin Zhou, Lehao Sun, Qihao Cai, Haibo Tan, Wen-Song
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Carbohydrate Polymers 2020
- 关键词：Biocompatibility - Bone - Cell culture - Defects - Flowcharting - Physicochemical properties - Scaffolds (biology) - Stem cells
- Enhanced enzymatic hydrolysis of rice straw pretreated by alkali assisted with photocatalysis technology被引量：44收藏
- 作者：Niu, Kun Chen, Peng Zhang, Xu Tan, Wen-Song
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY 2009
- 关键词：straw pretreatment alkali photocatalysis nano-TiO2
- The effects of ROS-mediating oxygen tension on human CD34+CD38- cells induced into mature dendritic cells被引量：44收藏
- 作者：Fan, Jinli Cai, Haibo Li, Qunliang Du, Zheng Tan, Wensong
- 机构： State Key Laboratory of Bioreactor Engineering; School of Chemistry and Chemical Engineering; Shanghai Clinical Research Center
- 来源：Journal of Biotechnology 2012
- 关键词：Amino acids - Cytology - Stem cells - Cell membranes - Oxygen - Gene expression
- Polyvinyl alcohol, N-acetylcystEIne, and methyl-β-cyclodextrin exhibit albumin functions in natural killer cell culture被引量：40收藏
- 作者：Xu, Ruisheng Zhang, Guofeng Huang, Huimin Zhao, Yuanyuan Tan, Wen-Song Cai, Haibo
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Journal of Bioscience and Bioengineering 2025
- 关键词：Animal cell culture - Body fluids - Fatty acid methyl ester - Mitochondria - Plant cell culture - Reactive oxygen species
- Enhancement of recombinant human EPO production and sialylation in Chinese hamster ovary cells through Bombyx mori 30Kc19 gene expression被引量：39收藏
- 作者：Wang, Zesong Park, Ju Hyun Park, Hee Ho Tan, Wensong Park, Tai Hyun
- 机构： School of Chemical and Biological Engineering; The State Key Laboratory of Bioreactor Engineering
- 来源：Biotechnology and Bioengineering 2011
- 关键词：Recombinant protEIns - Gene expression - Phosphatases - Cell membranes - Mitochondria - GlycoprotEIns - Mammals - Glycosylation - Cell culture
- In Situ Controlled Release of rhBMP-2 in Gelatin-Coated 3D Porous Poly(ε-caprolactone) Scaffolds for Homogeneous Bone Tissue Formation被引量：38收藏
- 作者：Zhang, Qingchun Tan, Ke Zhang, Yan Ye, Zhaoyang Tan, Wen-Song Lang, Meidong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOMACROMOLECULES 2014
- 关键词：Scaffolds (biology) - Cell culture - Bone - Coatings
- Understanding the mechanistic roles of 30Kc6 gene in apoptosis and specific productivity in antibody-producing Chinese hamster ovary cells被引量：36收藏
- 作者：Wang, Zesong Ma, Xuhui Fan, Li Rhee, Won Jong Park, Tai Hyun Zhao, Liang Tan, Wen-Song
- 机构： State Key Laboratory of Bioreactor Engineering; Biopharmaceutical R and D; School of Chemical and Biological Engineering
- 来源：Applied Microbiology and Biotechnology 2012
- 关键词：Antibiotics - Productivity - Amino acids - Cell membranes - Mammals - Recombinant protEIns - Mitochondria - Monoclonal antibodies - Transcription - Cell culture - Chemical activation
- Fabrication of three-dimensional poly(ε-caprolactone) scaffolds with hierarchical pore structures for tissue engineering被引量：36收藏
- 作者：Zhang, Qingchun Luo, Houyong Zhang, Yan Zhou, Yan Ye, Zhaoyang Tan, Wensong Lang, Meidong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 2013
- 关键词：Poly(epsilon-caprolactone) Scaffolds Pore size Fibroblasts
- High cell density perfusion process for high yield of influenza A virus production using MDCK suspension cells被引量：36收藏
- 作者：Wu, Yixiao Bissinger, Thomas Genzel, Yvonne Liu, Xuping Reichl, Udo Tan, Wen-Song
- 机构：East China Univ Sci & Technol;Max Planck Inst Dynam Complex Tech Syst;Shanghai BioEngine Sci Tech Co Ltd;Otto von Guericke Univ
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2021
- 关键词：MDCK cells Influenza A virus ATF-based perfusion Process optimization Lab-scale bioreactors
- Analysis of cell lysis for improved understanding between the shake tube and stirred tank reactor perfusion CHO cell cultures被引量：35收藏
- 作者：Zhang, Weijian Ran, Qingyuan Zhou, Yang Zhao, Liang Ye, Qian Tan, Wen-Song
- 机构： The State Key Laboratory of Bioreactor Engineering
- 来源：Cytotechnology 2025
- 关键词：Cell culture - Reactor refueling - Tanks (containers)
- Role of the plasma membrane ROS-generating NADPH oxidase in CD34+ progenitor cells preservation by hypoxia被引量：35收藏
- 作者：Fan, Jinli Cai, Haibo Tan, Wen-Song
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Journal of Biotechnology 2007
- 关键词：Blood - Cell culture - Cell membranes - Phosphates - RNA - Scavenging
- Identification of multiple sources of the acidic charge variants in an IgG1 monoclonal antibody被引量：35收藏
- 作者：Miao, Shiwei Xie, Panpan Zou, Mao Fan, Li Liu, Xuping Zhou, Yan Zhao, Liang Ding, Ding Wang, Haibin Tan, Wen-Song
- 机构：East China Univ Sci & Technol;Hisun Pharmaceut Hangzhou Co Ltd
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2017
- 关键词：mAb IgG1 Acidic charge heterogenEIty Deamidation Galactosylation Disulfide bond reduction
- Enhancement of therapeutic monoclonal antibody production in CHO cells using 30Kc6 gene被引量：34收藏
- 作者：Wang, Zesong Park, Ju Hyun Park, Hee Ho Tan, Wensong Park, Tai Hyun
- 机构： School of Chemical and Biological Engineering; The State Key Laboratory of Bioreactor Engineering
- 来源：Process Biochemistry 2010
- 关键词：Mitochondria - Gene expression - Body fluids - Cell culture - Gene therapy - Mammals - Cell membranes - Cloning - Monoclonal antibodies - Recombinant protEIns
- Characteristics of bio-desilication and bio-flotation of Paenibacillus mucilaginosus BM-4 on aluminosilicate minerals被引量：34收藏
- 作者：Zhao, Jiangman Wu, Weijin Zhang, Xu Zhu, Minglong Tan, Wensong
- 机构：East China Univ Sci & Technol
- 来源：INTERNATIONAL JOURNAL OF MINERAL PROCESSING 2017
- 关键词：Bio-desilication Aluminosilicate minerals Paenibacillus mucilaginosus Bioflotation Bioadsorption
- Expression of anti-apoptotic 30Kc6 gene inhibiting hyperosmotic pressure-induced apoptosis in antibody-producing Chinese hamster ovary cells被引量：34收藏
- 作者：Wang, Zesong Ma, Xuhui Zhao, Liang Fan, Li Tan, Wen-Song
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Process Biochemistry 2012
- 关键词：Cell culture - Mitochondria - Cell membranes - Recombinant protEIns - Osmosis - Productivity - Antibodies - Gene expression - Mammals
- Responses of CHO-DHFR cells to ratio of asparagine to glutamine in feed media: cell growth, antibody production, metabolic waste, glutamate, and energy metabolism被引量：34收藏
- 作者：Zhang, Li-xiang Zhang, Wei-yan Wang, Chen Liu, Jin-tao Deng, Xian-cun Liu, Xu-ping Fan, Li Tan, Wen-song
- 机构： The State Key Laboratory of Bioreactor Engineering; Zhejiang Hisun Pharmaceutical Co. Ltd
- 来源：Bioresources and Bioprocessing 2016
- 关键词：Amino acids - Cell culture - Cell growth - Growth kinetics - Monoclonal antibodies - Physiology
