成果/Result
- A modular approach to the engineering of a centimeter-sized bone tissue construct with human amniotic mesenchymal stem cells-laden microcarriers被引量：94收藏
- 作者：Chen, Maiqin Wang, Xiu Ye, Zhaoyang Zhang, Yan Zhou, Yan Tan, Wen-Song
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOMATERIALS 2011
- 关键词：Tissue engineering Modular approach Microcarriers Macrotissue Mesenchymal stem cells Osteogenic differentiation
- Antihypertensive Effects, Molecular Docking Study, and Isothermal Titration Calorimetry Assay of Angiotensin I-Converting Enzyme Inhibitory Peptides from Chlorella vulgaris被引量：87收藏
- 作者：Xie, Jingli Chen, Xujun Wu, Junjie Zhang, Yanyan Zhou, Yan Zhang, Lujia Tang, Ya-Jie Wei, Dongzhi
- 机构：East China Univ Sci & Technol;Hubei Univ Technol;Shanghai Business Sch;SCICB
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2018
- 关键词：Chlorella vulgaris ACE inhibitory peptides anti hypertensive activity molecular docking isothermal titration calorimetry
- Myocardial regeneration: Roles of stem cells and hydrogels被引量：75收藏
- 作者：Ye, Zhaoyang Zhou, Yan Cai, Haibo Tan, Wensong
- 机构：E China Univ Sci & Technol
- 来源：ADVANCED DRUG DELIVERY REVIEWS 2011
- 关键词：Myocardial regeneration Cell therapy Tissue engineering Stem cells Hydrogels
- A combinatorial variation in surface chemistry and pore size of three-dimensional porous poly(ε-caprolactone) scaffolds modulates the behaviors of mesenchymal stem cells被引量：62收藏
- 作者：Zhao, Yingdi Tan, Ke Zhou, Yan Ye, Zhaoyang Tan, Wen-Song
- 机构：E China Univ Sci & Technol
- 来源：MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 2016
- 关键词：Tissue engineering Mesenchymal stem cells Three-dimensional porous scaffolds Surface chemistry Pore size
- In Situ Forming and Reversibly Cross-Linkable Hydrogels Based on Copolypept(o)ides and Polysaccharides被引量：58收藏
- 作者：Tong, Yanping Wang, Zhaochuang Xiao, Yan Liu, Wei Pan, Jinghao Zhou, Yan Lang, Meidong
- 机构： Key Laboratory for Ultrafine Materials of Ministry of Education; State Key Laboratory of Bioreactor Engineering
- 来源：ACS Applied Bio Materials 2019
- 关键词：Amides - Amino acids - Drug delivery - Cell culture - Scaffolds (biology) - Ring opening polymerization - Biocompatibility - Biomechanics - Esters - Cell engineering - Gelation - Sodium alginate
- Synthesis, characterization, fluorescence labeling and cellular internalization of novel amine-functionalized poly(ethylene glycol)-block- poly(Ε-caprolactone) amphiphilic block copolymers被引量：54收藏
- 作者：Yan, Jinliang Ye, Zhaoyang Luo, Houyong Chen, Min Zhou, Yan Tan, Wensong Xiao, Yan Zhang, Yan Lang, Meidong
- 机构： State Key Laboratory of Bioreactor Engineering; Key Laboratory for Ultrafine Materials of Ministry of Education
- 来源：Polymer Chemistry 2011
- 关键词：Drug delivery - Medical applications - ProtEIns - Fluorophores - Particle size - Ring opening polymerization - Critical micelle concentration - Hyaluronic acid - Polyols - Esters - Ethylene glycol - Organic acids - Block copolymers - Cell culture - Solutions - Ethylene - Fluorescence microscopy - Polyethylene glycols - Polyethylene oxides
- Three-Dimensional and Serum-Free Culture in Fixed-Bed Bioreactor Enhance Exosome Production by Affecting the Cytoskeleton被引量：52收藏
- 作者：Zhou, Yan Huo, Chuanfu Zhao, Yuanyuan Song, Meng Guo, Yuzhe Li, Shihao Tan, Wensong
- 机构： State Key Laboratory of Bioreactor Engineering; Shanghai Key Laboratory of Multiphase Materials Chemical Engineering
- 来源：SSRN 2024
- 关键词：Bioconversion - Cell culture - Microfiltration - Plastic bottles - ProtEIns - Stem cells
- Preparation and characterization of antibacterial polyvinyl alcohol/chitosan sponge and potential applied for wound dressing被引量：51收藏
- 作者：Fan, Yao Lu, Qiaohui Liang, Wencheng Wang, Youchang Zhou, Yan Lang, Meidong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：EUROPEAN POLYMER JOURNAL 2021
- 关键词：PVA DMAEMA Chitosan Wound dressing Antibacterial
- Fine tuning micellar core-forming block of poly(ethylene glycol)- block -poly(Ε-caprolactone) amphiphilic copolymers based on chemical modification for the solubilization and delivery of doxorubicin被引量：50收藏
- 作者：Yan, Jinliang Ye, Zhaoyang Chen, Min Liu, Zhanzhan Xiao, Yan Zhang, Yan Zhou, Yan Tan, Wensong Lang, Meidong
- 机构： Key Laboratory for Ultrafine Materials of Ministry of Education; State Key Laboratory of Bioreactor Engineering
- 来源：Biomacromolecules 2011
- 关键词：Chemical modification - Esterification - Polyethylene glycols - Solutions - Controlled drug delivery - Critical micelle concentration - Motion Picture Experts Group standards - Esters - Ethylene glycol - Polyethylene oxides - Polyols - Lactic acid - Ring opening polymerization - Solubility - Targeted drug delivery - Block copolymers - Fluorescence spectroscopy
- Pendant small functional groups on poly(Ε-caprolactone) substrate modulate adhesion, proliferation and differentiation of human mesenchymal stem cells被引量：45收藏
- 作者：Chen, Min Zhang, Yi Zhou, Yan Zhang, Yan Lang, Meidong Ye, Zhaoyang Tan, Wen-Song
- 机构： State Key Laboratory of Bioreactor Engineering; Key Laboratory for Ultrafine Materials of Ministry of Education
- 来源：Colloids and Surfaces B: Biointerfaces 2015
- 关键词：Tissue regeneration - Tissue - Adhesion - Scaffolds (biology) - Biomaterials - Cell culture - Cell engineering - Surface chemistry
- Microfluidic Regulation of Porous Poly(L-Lactide-Co-Ε-Caprolactone) Microcarrier to Refine Myoblast Differentiation Potential被引量：42收藏
- 作者：Wang, Zining Wang, Lu Song, Meng An, Chenjing Li, Yijing Zhou, Yan Cen, Lian
- 机构： Shanghai Key Laboratory of Multiphase Materials Chemical Engineering; State Key Laboratory of Bioreactor Engineering
- 来源：SSRN 2024
- 关键词：Cytology - Gene expression - Macrophages - Microspheres - Muscle
- A multifunctional green antibacterial rapid hemostasis composite wound dressing for wound healing被引量：42收藏
- 作者：Liang, Wencheng Lu, Qiaohui Yu, Fan Zhang, Junyong Xiao, Chuang Dou, Xiaoming Zhou, Yan Mo, Xiumei Li, Jun Lang, Meidong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Donghua Univ;Tongji Univ
- 来源：BIOMATERIALS SCIENCE 2021
- Lycopene production in recombinant strains of Escherichia coli is improved by knockout of the central carbon metabolism gene coding for glucose-6-phosphate dehydrogenase被引量：41收藏
- 作者：Zhou, Yan Nambou, Komi Wei, Liujing Cao, Jingjing Imanaka, Tadayuki Hua, Qiang
- 机构：E China Univ Sci & Technol
- 来源：BIOTECHNOLOGY LETTERS 2013
- 关键词：Escherichia coli Glucose-6-phosphate dehydrogenase Lycopene MEP pathway
- Fabrication of three-dimensional poly(ε-caprolactone) scaffolds with hierarchical pore structures for tissue engineering被引量：36收藏
- 作者：Zhang, Qingchun Luo, Houyong Zhang, Yan Zhou, Yan Ye, Zhaoyang Tan, Wensong Lang, Meidong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 2013
- 关键词：Poly(epsilon-caprolactone) Scaffolds Pore size Fibroblasts
- Identification of multiple sources of the acidic charge variants in an IgG1 monoclonal antibody被引量：35收藏
- 作者：Miao, Shiwei Xie, Panpan Zou, Mao Fan, Li Liu, Xuping Zhou, Yan Zhao, Liang Ding, Ding Wang, Haibin Tan, Wen-Song
- 机构：East China Univ Sci & Technol;Hisun Pharmaceut Hangzhou Co Ltd
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2017
- 关键词：mAb IgG1 Acidic charge heterogenEIty Deamidation Galactosylation Disulfide bond reduction
- The combined effect of sodium butyrate and low culture temperature on the production, sialylation, and biological activity of an antibody produced in CHO cells被引量：33收藏
- 作者：Chen, Fei Kou, Tianci Fan, Li Zhou, Yan Ye, Zhaoyang Zhao, Liang Tan, Wen-Song
- 机构：E China Univ Sci & Technol
- 来源：BIOTECHNOLOGY AND BIOPROCESS ENGINEERING 2011
- 关键词：CHO cells sodium butyrate low culture temperature sialylation N-glycolylneuraminic acid
- Elucidating the effects of pH shift on IgG1 monoclonal antibody acidic charge variant levels in Chinese hamster ovary cell cultures被引量：33收藏
- 作者：Xie, Panpan Niu, Huijie Chen, Xinning Zhang, Xintao Miao, Shiwei Deng, Xiancun Liu, Xuping Tan, Wen-Song Zhou, Yan Fan, Li
- 机构：East China Univ Sci & Technol;Hisun Pharmaceut Hangzhou Co Ltd
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2016
- 关键词：Acidic charge variants IgG1 monoclonal antibody Disulfide bond reduction Galactosylation Deamination Liquid chromatography mass spectrometry
- AICAR, a small chemical molecule, primes osteogenic differentiation of adult mesenchymal stem cells被引量：32收藏
- 作者：Wu, Wei Ye, Zhaoyang Zhou, Yan Tan, Wen-Song
- 机构：E China Univ Sci & Technol
- 来源：INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS 2011
- 关键词：AICAR Mesenchymal stem cells Differentiation Osteogenesis Small molecule
- Perfusion seeding of collagen-chitosan sponges for dermal tissue engineering被引量：31收藏
- 作者：Ding, Chun-Mei Zhou, Yan He, Yan-Na Tan, Wen-Song
- 机构：E China Univ Sci & Technol
- 来源：PROCESS BIOCHEMISTRY 2008
- 关键词：tissue engineering fibroblast collagen-chitosan sponge cell seeding perfusion cell distribution
- Novel antibacterial cellulose diacetate-based composite 3D scaffold as potential wound dressing被引量：31收藏
- 作者：Liang, Wencheng Jiang, Mingli Zhang, Junyong Dou, Xiaoming Zhou, Yan Jiang, Yun Zhao, Li Lang, Meidong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Zhejiang Univ Technol
- 来源：JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 2021
- 关键词：Cellulose diacetate Electrospinning 3D scaffold Wound dressing
- Dipeptidyl peptidase IV inhibitory peptides from Chlorella vulgaris: in silico gastrointestinal hydrolysis and molecular mechanism被引量：31收藏
- 作者：Zhu, Qiaosha Chen, Xujun Wu, Junjie Zhou, Yan Qian, Yang Fang, Ming Xie, Jingli Wei, Dongzhi
- 机构：East China Univ Sci & Technol;Fudan Univ;SCICB
- 来源：EUROPEAN FOOD RESEARCH AND TECHNOLOGY 2017
- 关键词：Chlorella vulgaris DPP-IV inhibitory peptides In silico hydrolysis Molecular docking
- Fabrication of viable and functional pre-vascularized modular bone tissues by coculturing MSCs and HUVECs on microcarriers in spinner flasks被引量：30收藏
- 作者：Zhang, Songjie Zhou, Min Ye, Zhaoyang Zhou, Yan Tan, Wen-Song
- 机构：East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY JOURNAL 2017
- 关键词：Bone tissue engineering Endothelial cells Mesenchymal stem cells Microcarriers Vascularization
- Modeling and optimization of membrane preparation conditions of the alginate-based microcapsules with response surface methodology被引量：30收藏
- 作者：Ma, Ying Zhang, Ying Zhao, Shan Wang, Yu Wang, Siran Zhou, Yan Li, Na Xie, Hongguo Yu, Weiting Liu, Yang Wang, Wei Ma, Xiaojun
- 机构：Chinese Acad Sci;Chinese Acad Sci;E China Univ Sci & Technol
- 来源：JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 2012
- 关键词：microencapsulation membrane preparation optimization conditions response surface methodology modeling
- Hepatocyte culture on 3D porous scaffolds of PCL/PMCL被引量：27收藏
- 作者：Xiao, Yan Zhou, Miaomiao Zhang, Mi Liu, Wei Zhou, Yan Lang, Meidong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：COLLOIDS AND SURFACES B-BIOINTERFACES 2019
- 关键词：Poly(epsilon-caprolactone) Porous scaffold Crystalline degree Hepatocyte culture
- Detailed understanding of enhanced specific productivity in Chinese hamster ovary cells at low culture temperature被引量：26收藏
- 作者：Kou, Tian-Ci Fan, Li Zhou, Yan Ye, Zhao-Yang Liu, Xu-Ping Zhao, Liang Tan, Wen-Song
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF BIOSCIENCE AND BIOENGINEERING 2011
- 关键词：Chinese hamster ovary (CHO) cells TNFR-Fc mRNA stability Transcriptional rate Low temperature
- Modulating and modeling aggregation of cell-seeded microcarriers in stirred culture system for macrotissue engineering被引量：25收藏
- 作者：Mei, Yang Luo, Houyong Tang, Qiang Ye, Zhaoyang Zhou, Yan Tan, Wen-Song
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2010
- 关键词：Microcarriers Macrotissue engineering Aggregation behavior Bioreactor
- Regulation of mesenchymal stem cell osteogenic potential via microfluidic manipulation of microcarrier surface curvature被引量：24收藏
- 作者：Jin, Ziyang Zhai, Yishu Zhou, Yi Guo, Pan Chai, Miaomiao Tan, Wensong Zhou, Yan Cen, Lian
- 机构：East China Univ Sci & Technol
- 来源：CHEMICAL ENGINEERING JOURNAL 2022
- 关键词：Surface curvature Microspheres Microfluidics Cytoskeleton Osteogenic
- A Drug-Free Therapeutic System for Cancer Therapy by Diselenide-Based Polymers Themselves被引量：23收藏
- 作者：Wei, Chao Liang, Bingyu Li, Yongsheng Yan, Bingkun Zhou, Yan Liu, Yingbin Lang, Meidong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Res Ctr Biliary Tract Dis
- 来源：ADVANCED HEALTHCARE MATERIALS 2021
- 关键词：cancer therapy drug‐ free therapeutic systems poly(diselenide‐ carbonate) reactive oxygen species self‐ anticancer activity
- In situ ornamenting poly(ε-caprolactone) electrospun fibers with different fiber diameters using chondrocyte-derived extracellular matrix for chondrogenesis of mesenchymal stem cells被引量：19收藏
- 作者：Xu, Jiazhu Fang, Qi Liu, Yanli Zhou, Yan Ye, Zhaoyang Tan, Wen-Song
- 机构：East China Univ Sci & Technol
- 来源：COLLOIDS AND SURFACES B-BIOINTERFACES 2021
- 关键词：Electrospinning Articular chondrocytes Decellularization Chondrogenesis Mesenchymal stem cells
- Insight into the roles of hypoxanthine and thydimine on cultivating antibody-producing CHO cells: cell growth, antibody production and long-term stability被引量：18收藏
- 作者：Chen, Fei Fan, Li Wang, Jiaqi Zhou, Yan Ye, Zhaoyang Zhao, Liang Tan, Wen-Song
- 机构：E China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2012
- 关键词：Chinese hamster ovary cells Hypoxanthine Thymidine Methotrexate Long-term stability Monoclonal antibody
