成果/Result
- Impact of Antifouling PEG Layer on the Performance of Functional Peptides in Regulating Cell Behaviors被引量：190收藏
- 作者：Chen, Qj Yu, Shan Zhang, Donghui Zhang, Wenjing Zhang, Haodong Zou, Jingcheng Mao, Zhengwei Yuan, Yuan Gao, Changyou Liu, Runhui
- 机构：East China Univ Sci & Technol;Zhejiang Univ
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2019
- 关键词：Peptides - Chain length - Adhesives - Cells - Scaffolds (biology) - Cell engineering
- Surface Modified with a Host Defense Peptide-Mimicking β-Peptide Polymer Kills Bacteria on Contact with High Efficacy被引量：118收藏
- 作者：Qian, Yuxin Qi, Fan Chen, Qi Zhang, Qiang Qiao, Zhongqian Zhang, Si Wei, Ting Yu, Qian Yu, Shan Mao, Zhengwei Gao, Changyou Ding, Yiru Cheng, Yanyong Jin, Chenyu Xie, Hexin Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACS APPLIED MATERIALS & INTERFACES 2018
- 关键词：beta-peptide polymer graft to antimicrobial surface divalent ion membrane destabilization biocompatible surface antimicrobial resistance MRSA
- Reshaping the Active Pocket of Amine Dehydrogenases for Asymmetric Synthesis of Bulky Aliphatic Amines被引量：102收藏
- 作者：Chen, Fei-Fei Zheng, Gao-Wei Liu, Lei Li, Hao Chen, Qi Li, Fu-Long Li, Chun-Xiu Xu, Jian-He
- 机构：East China Univ Sci & Technol
- 来源：ACS CATALYSIS 2018
- 关键词：amine dehydrogenase reductive amination chiral amine protEIn engineering biocatalysis substrate scope
- Silk-Inspired β-Peptide Materials Resist Fouling and the ForEIgn-Body Response被引量：82收藏
- 作者：Zhang, Donghui Chen, Qi Zhang, Wenjing Liu, Hengjiang Wan, Jianglin Qian, Yuxin Li, Bing Tang, Songchao Liu, Yu Chen, Shengfu Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Zhejiang Univ
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2020
- 关键词：materials science peptides polymers self-assembly surface chemistry
- Preparation of Structurally Diverse Chiral Alcohols by Engineering Ketoreductase CgKR1被引量：82收藏
- 作者：Zheng, Gao-Wei Liu, Yuan-Yang Chen, Qi Huang, Lei Yu, Hui-Lei Lou, Wen-Yong Li, Chun-Xiu Bai, Yun-Peng Li, Ai-Tao Xu, Jian-He
- 机构：East China Univ Sci & Technol;South China Univ Technol;Max Planck Inst Kohlenforsch
- 来源：ACS CATALYSIS 2017
- 关键词：asymmetric reduction ketoreductase chiral alcohol protEIn engineering substrate specificity biocatalysis
- A Motif-Based Deep Learning Tool for the Identification of Unusual NADH-Dependent Imine Reductases被引量：73收藏
- 作者：Shen, Xin-Yuan Wu, Yu-Xuan Ma, Zhi-Feng Yi, Xiao Shi, Min Zhu, Zhen-Yu Jin, Tian Hu, Xiao-Yu Huang, Zi-Yi Gao, Yun-Fei Chen, Qi Yu, Hui-Qun Xu, Jian-He Fan, Gui-Sheng Zheng, Gao-Wei
- 机构： State Key Laboratory of Bioreactor Engineering; School of Information Science and Engineering
- 来源：SSRN 2025
- 关键词：Amination - Enzyme immobilization - Enzyme inhibition - Enzyme kinetics - Hydrolases - Lipases
- Switching Cofactor Dependence of 7β-Hydroxysteroid Dehydrogenase for Cost-Effective Production of Ursodeoxycholic Acid被引量：66收藏
- 作者：You, Zhi-Neng Chen, Qi Shi, Shou-Cheng Zheng, Ming-Min Pan, Jiang Qian, Xiao-Long Li, Chun-Xiu Xu, Jian-He
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Suzhou Bioforany EnzyTech Co Ltd
- 来源：ACS CATALYSIS 2019
- 关键词：biocatalysis cofactor dependence small-and-smart library 7 beta-hydroxysteroid dehydrogenase molecular dynamics simulation ursodeoxycholic acid
- The impact of antifouling layers in fabricating bioactive surfaces被引量：61收藏
- 作者：Chen, Qi Zhang, Donghui Gu, Jiawei Zhang, Haodong Wu, Xue Cao, Chuntao Zhang, Xinyue Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACTA BIOMATERIALIA 2021
- 关键词：Fouling Antifouling PEG Bioactive surface Cell adhesion Functional peptides
- Discovery of an Imine Reductase for Reductive Amination of Carbonyl Compounds with Sterically Challenging Amines被引量：54收藏
- 作者：Chen, Fei-Fei He, Xue-Feng Zhu, Xin-Xin Zhang, Zhi Shen, Xin-Yuan Chen, Qi Xu, Jian-He Turner, Nicholas J. Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol;Univ Manchester
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2023
- 关键词：Carbonyl compounds - Nucleophiles - Substrates - Synthesis (chemical)
- Rational Engineering of Formate Dehydrogenase Substrate/Cofactor Affinity for Better Performance in NADPH Regeneration被引量：46收藏
- 作者：Jiang, He-Wen Chen, Qi Pan, Jiang Zheng, Gao-Wei Xu, Jian-He
- 机构：East China Univ Sci & Technol
- 来源：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 2020
- 关键词：Binding affinity Burkholderia stabilis Formate dehydrogenase NADPH regeneration Rational engineering
- Development of an engineered thermostable amine dehydrogenase for the synthesis of structurally diverse chiral amines被引量：44收藏
- 作者：Liu, Lei Wang, Dong-Hao Chen, Fei-Fei Zhang, Zhi-Jun Chen, Qi Xu, Jian-He Wang, Zhi-Long Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：CATALYSIS SCIENCE & TECHNOLOGY 2020
- 关键词：Ammonia - Amino acids - Amines
- Asymmetric Reductive Amination of Structurally Diverse Ketones with Ammonia Using a Spectrum-Extended Amine Dehydrogenase被引量：41收藏
- 作者：Wang, Dong-Hao Chen, Qi Yin, Sai-Nan Ding, Xu-Wei Zheng, Yu-Cong Zhang, Zhi Zhang, Yu-Hui Chen, Fei-Fei Xu, Jian-He Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACS CATALYSIS 2021
- 关键词：< em > reductive amination < em > < em > amine dehydrogenase < em > < em > protEIn engineering < em > < em > substrate scope < em > < em > chiral amine < em >
- Regioselectivity Engineering of Epoxide Hydrolase: Near-Perfect Enantioconvergence through a Single Site Mutation被引量：41收藏
- 作者：Li, Fu-Long Kong, Xu-Dong Chen, Qi Zheng, Yu-Cong Xu, Qin Chen, Fei-Fei Fan, Li-Qiang Lin, Guo-Qiang Zhou, Jiahai Yu, Hui-Lei Xu, Jian-He
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ
- 来源：ACS CATALYSIS 2018
- 关键词：biocatalysis epoxide hydrolase crystal structure regioselectivity enantioconvergence protEIn engineering
- De Novo Multienzyme Synthetic Pathways for Lactic Acid Production被引量：31收藏
- 作者：Ding, Xu-Wei Rong, Jing Pan, Ze-Peng Zhu, Xin-Xin Zhu, Zhen-Yu Chen, Qi Zhang, Zhi-Jun Xu, Jian-He Li, Chun-Xiu Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol
- 来源：ACS CATALYSIS 2024
- 关键词：biocatalysis C1 compound lacticacid multienzyme cascade protEIn engineering
- Efficient synthesis of a statin precursor in high space-time yield by a new aldehyde-tolerant aldolase identified from Lactobacillus brevis被引量：30收藏
- 作者：Jiao, Xue-Cheng Pan, Jiang Xu, Guo-Chao Kong, Xu-Dong Chen, Qi Zhang, Zhi-Jun Xu, Jian-He
- 机构：E China Univ Sci & Technol; E China Univ Sci & Technol
- 来源：CATALYSIS SCIENCE & TECHNOLOGY 2015
- 关键词：Crystal structure - Stereochemistry - Acetaldehyde - Hydrogen bonds - Ketones - Stability - Substrates
- Facile Synthesis of High Molecular WEIght Polypeptides via Fast and Moisture Insensitive Polymerization of α-Amino Acid N-Carboxyanhydrides被引量：28收藏
- 作者：Wu, Yue-Ming Zhang, Wei-Wei Zhou, Rui-Yi Chen, Qi Xie, Chen-Yu Xiang, Heng-Xue Sun, Bin Zhu, Mei-Fang Liu, Run-Hui
- 机构：East China Univ Sci & Technol;Donghua Univ;East China Univ Sci & Technol
- 来源：CHINESE JOURNAL OF POLYMER SCIENCE 2020
- 关键词：NCA polymerization Polypeptide Open vessel Fast polymerization HighM(w)
- Engineered Imine Reductase for Larotrectinib Intermediate Manufacture被引量：28收藏
- 作者：Chen, Qi Li, Bo-Bo Zhang, Lilan Chen, Xin-Ru Zhu, Xin-Xin Chen, Fei-Fei Shi, Min Chen, Chun-Chi Yang, Yu Guo, Rey-Ting Liu, Weidong Xu, Jian-He Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol;Hubei Univ;Chinese Acad Sci
- 来源：ACS CATALYSIS 2022
- 关键词：asymmetric reduction biocatalysis directed evolution imine reductase larotrectinib
- Switching a Newly Discovered Lactonase into an Efficient and Thermostable Phosphotriesterase by Simple Double Mutations His250Ile/Ile263Trp被引量：28收藏
- 作者：Luo, Xiao-Jing Kong, Xu-Dong Zhao, Jian Chen, Qi Zhou, Jiahai Xu, Jian-He
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2014
- 关键词：organophosphate phosphotriesterase lactonase site-directed mutagenesis functional switch X-ray crystallography
- Marked enhancement of Acinetobacter sp. Organophosphorus hydrolase activity by a single residue substitution Ile211Ala被引量：27收藏
- 作者：Chen, Jie Luo, Xiao-Jing Chen, Qi Pan, Jiang Zhou, Jiahai Xu, Jian-He
- 机构： State Key Laboratory of Bioreactor Engineering; Shanghai Institute of Organic Chemistry
- 来源：Bioresources and Bioprocessing 2015
- 关键词：Hydrolases
- Universal and One-Step Modification to Render Diverse Materials Bioactivation被引量：27收藏
- 作者：Chen, Qi Zhang, Xinyue Zhang, Donghui Liu, Guojian Ma, Ke Liu, Jingjing Ma, Kaiqian Chen, Minzhang Li, Yongsheng Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Soochow Univ
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2023
- 关键词：Adhesives - Amino acids - Molecules - Peptides - Tissue regeneration
- Identification two key residues at the intersection of domains of a thioether monooxygenase for improving its sulfoxidation performance被引量：22收藏
- 作者：Ren, Shi-Miao Liu, Feng Wu, Yin-Qi Chen, Qi Zhang, Zhi-jun Yu, Hui-Lei Xu, Jian-He
- 机构：East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2021
- 关键词：biocatalysis protEIn engineering (S)‐ omeprazole thioether monooxygenases
- Engineering carbonyl reductase for one-pot chemobiocatalytic enantioselective synthesis of a value-added N-containing chiral alcohol from N-acetyl-d-glucosamine被引量：19收藏
- 作者：Hao, Ya-Cheng Zong, Min-Hua Chen, Qi Li, Ning
- 机构：South China Univ Technol;East China Univ Sci & Technol
- 来源：GREEN CHEMISTRY 2023
- 关键词：Amino acids - Chemical stability - Enzyme activity - Glucosamine - Ketones - Molecular dynamics - Stereochemistry
- Engineering P450LaMO stereospecificity and product selectivity for selective C-H oxidation of tetralin-like alkylbenzenes被引量：18收藏
- 作者：Li, Ren-Jie Li, Aitao Zhao, Jing Chen, Qi Li, Ning Yu, Hui-Lei Xu, Jian-He
- 机构：East China Univ Sci & Technol;Hubei Univ;Chinese Acad Sci;South China Univ Technol
- 来源：CATALYSIS SCIENCE & TECHNOLOGY 2018
- 关键词：Ketones - Genetic engineering - Amino acids - Biochemical engineering - ProtEIns
- Design of a self-sufficient hydride-shuttling cascade for concurrent bioproduction of 7,12-dioxolithocholate and l-tert-leucine被引量：18收藏
- 作者：You, Zhi-Neng Zhou, Ke Han, Yu Yang, Bing-Yi Chen, Qi Pan, Jiang Qian, Xiao-Long Li, Chun-Xiu Xu, Jian-He
- 机构：East China Univ Sci & Technol;Suzhou Bioforany Enzynch Co Ltd
- 来源：GREEN CHEMISTRY 2021
- 关键词：Amines - Cost effectiveness - Hydrides
- Piezoelectric hydrogel with self-powered biomechanical stimulation enhances bone regeneration被引量：18收藏
- 作者：Zhang, Shuyan Huang, Lei Chen, Weisin Chen, Qi Liu, Xin Su, Dihan Xiao, Lan Zhou, Dong Zhang, Jian Jiang, Libo Li, Yulin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Fudan Univ;Griffith Univ;Shanghai Univ
- 来源：ACTA BIOMATERIALIA 2025
- 关键词：Regenerated silk fibroin Stable piezoelectricity Mechanical properties Osseointegration Angiogenesis
- Engineering of Halide Methyltransferase BxHMT through Dynamic Cross-Correlation Network Analysis被引量：18收藏
- 作者：Gao, Chun-Yu Yang, Gui-Ying Ding, Xu-Wei Xu, Jian-He Cheng, Xiaolin Zheng, Gao-Wei Chen, Qi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Ohio State Univ
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2024
- 关键词：biocatalysis halide methyltransferase protEIn engineering dynamic cross-correlation network analysis
- An Engineered Imine Reductase for Highly Diastereo- and Enantioselective Synthesis of β-Branched Amines with Contiguous Stereocenters被引量：17收藏
- 作者：Zhu, Zhen-Yu Shi, Min Li, Chen-Lin Gao, Yun-Fei Shen, Xin-Yuan Ding, Xu-Wei Chen, Fei-Fei Xu, Jian-He Chen, Qi Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2024
- 关键词：biocatalysis dynamic kinetic resolution imine reductase tofacitinib protEIn engineering
- Substrate channel evolution of an esterase for the synthesis of cilastatin被引量：15收藏
- 作者：Luan, Zheng-Jiao Li, Fu-Long Dou, Shuai Chen, Qi Kong, Xu-Dong Zhou, Jiahai Yu, Hui-Lei Xu, Jian-He
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Acad Sci
- 来源：CATALYSIS SCIENCE & TECHNOLOGY 2015
- 关键词：Carboxylation - Enzyme activity
- A green-by-design system for efficient bio-oxidation of an unnatural hexapyranose into chiral lactone for building statin side-chains被引量：15收藏
- 作者：Jiao, Xue-Cheng Zhang, Yu-Jun Chen, Qi Pan, Jiang Xu, Jian-He
- 机构：East China Univ Sci & Technol; East China Univ Sci & Technol
- 来源：CATALYSIS SCIENCE & TECHNOLOGY 2016
- 关键词：Product design - Chains - Oxidation - Catalyst activity - Reaction intermediates
- Engineering of halide methyltransferases for synthesis of SAE and its application in biosynthesis of ethyl vanillin被引量：15收藏
- 作者：Yang, Gui-Ying Zheng, Gao-Wei Zeng, Bu-Bing Xu, Jian-He Chen, Qi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：MOLECULAR CATALYSIS 2023
- 关键词：Halide methyltransferase Semi-rational design Molecular dynamics simulation Biocatalysis Ethyl vanillin
