成果/Result
- Two-Dimensional Design Strategy to Construct Smart Fluorescent Probes for the Precise Tracking of Senescence被引量：109收藏
- 作者：Gao, Ying Hu, Yulu Liu, Qimeng Li, Xiaokang Li, Xinming Kim, Chu-Young James, Tony D. Li, Jian Chen, Xi Guo, Yuan
- 机构：Northwest Univ;East China Univ Sci & Technol;Univ Texas El Paso;Univ Bath;Tongji Univ
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2021
- 关键词：bioimaging fluorescent probes lysosomal pH senescence β -galactosidase
- Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents被引量：83收藏
- 作者：Li, Xiaokang Wang, Huan Lu, Zhengyu Zheng, Xinyu Ni, Wei Zhu, Jin Fu, Yan Lian, Fulin Zhang, Naixia Li, Jian Zhang, Haiyan Mao, Fei
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2016
- Photoactivatable senolysis with single-cell resolution delays aging被引量：78收藏
- 作者：Shi, Donglei Liu, Wenwen Gao, Ying Li, Xinming Huang, Yunyuan Li, Xiaokang James, Tony D. Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;Hainan Univ;Univ Bath;Dali Univ
- 来源：NATURE AGING 2023
- First-generation species-selective chemical probes for fluorescence imaging of human senescence-associated β-galactosidase被引量：76收藏
- 作者：Li, Xiaokang Qiu, Wenjing Li, Jinwen Chen, Xi Hu, Yulu Gao, Ying Shi, Donglei Li, Xinming Lin, Huiling Hu, Zelan Dong, Guoqiang Sheng, Chunquan Jiang, Bei Xia, Conglong Kim, Chu-Young Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;Second Mil Med Univ;Dali Univ;Univ Texas El Paso
- 来源：CHEMICAL SCIENCE 2020
- 关键词：Probes - Fluorescence imaging - Enzymes - Fluorescence spectroscopy - Mammals
- Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease被引量：75收藏
- 作者：Xu, Yi-xiang Wang, Huan Li, Xiao-kang Dong, Sheng-nan Liu, Wen-wen Gong, Qi Wang, Tian-duan-yi Tang, Yun Zhu, Jin Li, Jian Zhang, Hai-yan Mao, Fei
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2018
- 关键词：Multifunctional agents AChE inhibitors MAO-B inhibitors Metal chelating agents Alzheimer's disease
- Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease被引量：57收藏
- 作者：Mao, Fei Wang, Huan Ni, Wei Zheng, Xinyu Wang, Manjiong Bao, Keting Ling, Dazheng Li, Xiaokang Xu, Yixiang Zhang, Haiyan Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：ACS CHEMICAL NEUROSCIENCE 2018
- 关键词：Alzheimer's disease drug repositioning dual-target inhibitor AChE inhibition PDE5 inhibition
- A novel colorimetric and ratiometric fluorescent probe for selective detection of bisulfite in real samples and living cells被引量：52收藏
- 作者：Li, Jin Gao, Ying Guo, Haoran Li, Xiaokang Tang, Haoyang Li, Jian Guo, Yuan
- 机构：Northwest Univ;East China Univ Sci & Technol;Xian Univ Posts & Telecommun
- 来源：DYES AND PIGMENTS 2019
- 关键词：Colorimetric and ratiometric Fluorescent probe Bisulfite Real samples Live-cell imaging
- A ratiometric near-infrared fluorescence strategy based on spiropyran in situ switching for tracking dynamic changes of live-cell lysosomal pH被引量：49收藏
- 作者：Li, Jin Li, Xiaokang Jia, Jianbo Chen, Xi Lv, Yinjuan Guo, Yuan Li, Jian
- 机构：Northwest Univ;East China Univ Sci & Technol
- 来源：DYES AND PIGMENTS 2019
- 关键词：Ratiometric sensing NIR fluorescent probe Spiropyran Fluorescence imaging Lysosomal pH
- A novel multistage antiplasmodial inhibitor targeting Plasmodium falciparum histone deacetylase 1被引量：44收藏
- 作者：Huang, Zhenghui Li, Ruoxi Tang, Tongke Ling, Dazheng Wang, Manjiong Xu, Dandan Sun, Maoxin Zheng, Lulu Zhu, Feng Min, Hui Boonhok, Rachasak Ding, Yan Wen, Yuhao Chen, Yicong Li, Xiaokang Chen, Yuxi Liu, Taiping Han, Jiping Miao, Jun Fang, Qiang Cao, Yaming Tang, Yun Cui, Jie Xu, Wenyue Cui, Liwang Zhu, Jin Wong, Gary Li, Jian Jiang, Lubin
- 机构：Univ Chinese Acad Sci;East China Univ Sci & Technol;East China Univ Sci & Technol;ShanghaiTech Univ;Bengbu Med Coll
- 来源：CELL DISCOVERY 2020
- Curcumin-based polarity fluorescent probes: Design strategy and biological applications被引量：41收藏
- 作者：Hu, Linghao Shi, Donglei Li, Xinming Zhu, Jin Mao, Fei Li, Xiaokang Xia, Conglong Jiang, Bei Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;Dali Univ
- 来源：DYES AND PIGMENTS 2020
- 关键词：Curcumin Polarity-specificity Polarity fluorescent probe Lysosome Live-cell imaging Design strategy
- Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease Agents被引量：41收藏
- 作者：Xu, Yixiang Zhang, Jian Wang, Huan Mao, Fei Bao, Keting Liu, Wenwen Zhu, Jin Li, Xiaokang Zhang, Haiyan Li, Jian
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Sci
- 来源：ACS CHEMICAL NEUROSCIENCE 2019
- 关键词：Alzheimer's disease multifunctional agents AChE inhibitors MAO-B inhibitors metal chelating agents
- Novel Vilazodone Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation被引量：39收藏
- 作者：Li, Xiaokang Wang, Huan Xu, Yixiang Liu, Wenwen Gong, Qi Wang, Wei Qiu, Xiaoxia Zhu, Jin Mao, Fei Zhang, Haiyan Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：ACS CHEMICAL NEUROSCIENCE 2017
- 关键词：Alzheimer's disease depression multitarget-directed ligand ChE inhibition 5-HT1A agonist 5-HT reuptake inhibition
- Discovery of Novel Plasmodium falciparum HDAC1 Inhibitors with Dual-Stage Antimalarial Potency and Improved Safety Based on the Clinical Anticancer Drug Candidate Quisinostat被引量：38收藏
- 作者：Li, Ruoxi Ling, Dazheng Tang, Tongke Huang, Zhenghui Wang, Manjiong Ding, Yan Liu, Taiping Wei, Hanwen Xu, Wenyue Mao, Fei Zhu, Jin Li, Xiaokang Jiang, Lubin Li, Jian
- 机构：East China Univ Sci & Technol;Univ Chinese Acad Sci;ShanghaiTech Univ;Army Med Univ;Dali Univ
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2021
- Spiropyran in Situ Switching: A Real-Time Fluorescence Strategy for Tracking DNA G-Quadruplexes in Live Cells被引量：37收藏
- 作者：Li, Jin Yin, Xinchi Li, Bin Li, Xiaokang Pan, Yuanjiang Li, Jian Guo, Yuan
- 机构：Northwest Univ;Zhejiang Univ;East China Univ Sci & Technol
- 来源：ANALYTICAL CHEMISTRY 2019
- 关键词：Cytology - Fluorescence imaging - Cells - Diagnosis - Red Shift
- A senolysis-based theragnostic prodrug strategy towards chronic renal failure被引量：35收藏
- 作者：Song, Yihe Li, Xinming Shi, Donglei Sun, Tianyue Liu, Wenwen Li, Xiaokang Qiao, Sicong Chen, Xin Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;Hainan Univ;Tongji Univ;Dali Univ
- 来源：CHEMICAL SCIENCE 2022
- 关键词：Mammals
- Stress response decay with aging visualized using a dual-channel logic-based fluorescent probe被引量：34收藏
- 作者：Tian, Jingye Shi, Donglei Zhang, Yanhui Li, Xiaokang Li, Xinming Teng, Hao James, Tony D. Li, Jian Guo, Yuan
- 机构：Northwest Univ;East China Univ Sci & Technol;Univ Bath
- 来源：CHEMICAL SCIENCE 2021
- 关键词：Chlorine compounds - Computer circuits - Probes
- Lysosomal polarity increases with aging as revealed by a lysosome- targetable near -infrared fluorescent probe被引量：34收藏
- 作者：Shi, Donglei Hu, Linghao Li, Xinming Liu, Wenwen Gao, Ying Li, Xiaokang Jiang, Bei Xia, Conglong Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;Dali Univ
- 来源：SENSORS AND ACTUATORS B-CHEMICAL 2020
- 关键词：Fluorescence spectroscopy - Cytology - Infrared devices - Probes - Fluorescence
- Selective visualization of live-cell mitochondria' thiophenols and their induced oxidative stress process by a rationally designed rhodol-based fluorescent probe被引量：33收藏
- 作者：Liu, Qimeng Li, Anyang Li, Xiaokang Li, Bin Zhang, Yanhui Li, Jian Guo, Yuan
- 机构：Northwest Univ;East China Univ Sci & Technol;Northwest Univ
- 来源：SENSORS AND ACTUATORS B-CHEMICAL 2019
- 关键词：Mitochondria-targeted Fluorescent Probe Thiophenol Oxidative stress Damage Live-cell Imaging
- Drug Repurposing of Quisinostat to Discover Novel Plasmodium falciparum HDAC1 Inhibitors with Enhanced Triple-Stage Antimalarial Activity and Improved Safety被引量：28收藏
- 作者：Wang, Manjiong Tang, Tongke Li, Ruoxi Huang, Zhenghui Ling, Dazheng Zheng, Lulu Ding, Yan Liu, Taiping Xu, Wenyue Zhu, Feng Min, Hui Boonhok, Rachasak Mao, Fei Zhu, Jin Li, Xiaokang Jiang, Lubin Li, Jian
- 机构：East China Univ Sci & Technol;Univ Chinese Acad Sci;ShanghaiTech Univ;Army Med Univ;Univ S Florida
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2022
- Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment被引量：25收藏
- 作者：Liu, Wenwen Wang, Huan Li, Xiaokang Xu, Yixiang Zhang, Jian Wang, Wei Gong, Qi Qiu, Xiaoxia Zhu, Jin Mao, Fei Zhang, Haiyan Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY 2018
- 关键词：Depression Cognitive impairment Multitarget-directed ligand 5-HT1A agonist 5-HT reuptake inhibition ChE inhibition
- Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetyicholinesterase (AChE) and Phosphodiesterase 5 (PDE5)被引量：24收藏
- 作者：Ni, Wei Wang, Huan Li, Xiaokang Zheng, Xinyu Wang, Manjiong Zhang, Jian Gong, Qi Ling, Dazheng Mao, Fei Zhang, Haiyan Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：ACS CHEMICAL NEUROSCIENCE 2018
- 关键词：Multifunctional agents AChE inhibitors PDE5 inhibitors Alzheimer's disease
- Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer's disease被引量：24收藏
- 作者：Li, Xiaokang Lu, Jian Xu, Yixiang Wang, Jiaying Qiu, Xiaoxia Fan, Lei Li, Baoli Liu, Wenwen Mao, Fei Zhu, Jin Shen, Xu Li, Jian
- 机构：East China Univ Sci & Technol;Nanjing Univ Chinese Med;Chinese Acad Sci
- 来源：ACTA PHARMACEUTICA SINICA B 2020
- 关键词：Alzheimer's disease Autophagy Nitazoxanide beta-amyloid Tau protein
- Development of Novel N-hydroxypyridone Derivatives as Potential Anti-Ischemic Stroke Agents被引量：21收藏
- 作者：Hu, Linghao Feng, Hongxuan Zhang, Hongguang Yu, Songda Zhao, Qinyuan Wang, Wei Bao, Fengxia Ding, Xun Hu, Jiajing Wang, Manjiong Xu, Yixiang Wu, Zengrui Li, Xiaokang Tang, Yun Mao, Fei Chen, Xiaoyan Zhang, Haiyan Li, Jian
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2020
- Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo被引量：20收藏
- 作者：Ni, Shuaishuai Wei, Hanwen Li, Baoli Chen, Feifei Liu, Yifu Chen, Wenhua Xu, Yixiang Qiu, Xiaoxia Li, Xiaokang Lu, Yanli Liu, Wenwen Hu, Linhao Lin, Dazheng Wang, Manjiong Zheng, Xinyu Mao, Fei Zhu, Jin Lan, Lefu. Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2017
- Specific tracking of monoamine oxidase A in heart failure models by a far-red fluorescent probe with an ultra large Stokes shift被引量：20收藏
- 作者：Li, Xinming Shi, Donglei Song, Yihe Xu, Yixiang Gao, Ying Qiu, Wenjing Chen, Xin Li, Xiaokang Huang, Yunyuan Feng, Yanjun Li, Baoli Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;East China Univ Sci & Technol;Dali Univ;Tongji Univ
- 来源：CHINESE CHEMICAL LETTERS 2022
- 关键词：Heart failure Monoamine oxidase A Oxidative stress Fluorescent probe Far-red emission Diagnosis
- A rapid-response near-infrared fluorescent probe with a large Stokes shift for senescence-associated β-galactosidase activity detection and imaging of senescent cells被引量：19收藏
- 作者：Qiu, Wenjing Li, Xiaokang Shi, Donglei Li, Xinming Gao, Ying Li, Jinwen Mao, Fei Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;Dali Univ;East China Univ Sci & Technol
- 来源：DYES AND PIGMENTS 2020
- 关键词：Senescence-associated beta-galactosidase NIR fluorescent probe Aging Senescent cells Living-cell imaging
- Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes被引量：18收藏
- 作者：Xu, Yi-xiang Huang, Yun-yuan Song, Rong-rong Ren, Yan-liang Chen, Xin Zhang, Chao Mao, Fei Li, Xiao-kang Zhu, Jin Ni, Shuai-shuai Wan, Jian Li, Jian
- 机构：East China Univ Sci & Technol;Cent China Normal Univ;Shanghai Univ Tradit Chinese Med
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2020
- 关键词：Diabetes FBPase Disulfiram Covalent inhibitors Drug repurposing
- Discovery of Potent, Selective Stem Cell Factor Receptor/Platelet Derived Growth Factor Receptor Alpha (c-KIT/PDGFRα) Dual Inhibitor for the Treatment of Imatinib-Resistant Gastrointestinal Stromal Tumors (GISTs)被引量：17收藏
- 作者：Lu, Yanli Mao, Fei Li, Xiaokang Zheng, Xinyu Wang, Manjiong Xu, Cling Zhu, Jin Li, Jian
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2017
- Repurposing of antipsychotics perphenazine for the treatment of endometrial cancer被引量：16收藏
- 作者：Chen, Yang Cui, Yunxia Sun, Xiao Wu, Huiwen Ou, Manjiao Tang, Yunzhe Ni, Shuaishuai Li, Xiaokang Zhu, Jin Mao, Fei Wang, Yudong Li, Jian
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Univ Tradit Chinese Med
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2020
- Discovery of synergistic activity of fluoroquinolones in combination with antimicrobial peptides against clinical polymyxin-resistant Pseudomonas aeruginosa DK2被引量：16收藏
- 作者：Zheng, Xinyu Cao, Qiao Cao, Qin Mao, Fei Li, Xiaokang Zhu, Jin Lan, Lefu Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：CHINESE CHEMICAL LETTERS 2020
- 关键词：Polymyxin B Pseudomonas aeruginosa Fluoroquinolones Synergy Cystic fibrosis Antimicrobial peptides
