成果/Result
- Euler-Lagrange computational fluid dynamics for (bio)reactor scale down: An analysis of organism lifelines被引量：104收藏
- 作者：Haringa, Cees Tang, Wenjun Deshmukh, Amit T. Xia, Jianye Reuss, Matthias Heijnen, Joseph J. Mudde, Robert F. Noorman, Henk J.
- 机构：Delft Univ Technol;ECUST;DSM Biotechnol Ctr;Univ Stuttgart;Delft Univ Technol
- 来源：ENGINEERING IN LIFE SCIENCES 2016
- 关键词：CFD Euler-Lagrange Fermentation Industrial scale Scale down
- Integration of microbial kinetics and fluid dynamics toward model-driven scale-up of industrial bioprocesses被引量：74收藏
- 作者：Wang, Guan Tang, Wenjun Xia, Jianye Chu, Ju Noorman, Henk van Gulik, Walter M.
- 机构：E China Univ Sci & Technol;DSM Biotechnol Ctr;Delft Univ Technol
- 来源：ENGINEERING IN LIFE SCIENCES 2015
- 关键词：Computational fluid dynamics Heterogeneity Mathematical model Scale down Scale up
- Fluid dynamics investigation of variant impeller combinations by simulation and fermentation experiment被引量：61收藏
- 作者：Xia, Jian-Ye Wang, Yong-Hong Zhang, Si-Liang Chen, Ning Yin, Peng Zhuang, Ying-Ping Chu, Ju
- 机构：E China Univ Chem Technol
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2009
- 关键词：Dissolved oxygen Fluid mechanics Gas-liquid mass transfer Mixing Mycelia fermentation Shear environment
- The Impact of Systems Biology on Bioprocessing被引量：60收藏
- 作者：Campbell, Kate Xia, Jianye Nielsen, Jens
- 机构：Chalmers Univ Technol;East China Univ Sci & Technol;Tech Univ Denmark
- 来源：TRENDS IN BIOTECHNOLOGY 2017
- 关键词：Creep - Plant shutdowns - Computational methods - Fossil fuels - Data handling - Genes - Learning systems - Information analysis - Digital storage - Physiology
- Flow Pattern, Mixing, Gas Hold-Up and Mass Transfer Coefficient of Triple-Impeller Configurations in Stirred Tank Bioreactors被引量：60收藏
- 作者：Xie, Minghui Xia, Jianye Zhou, Zhen Chu, Ju Zhuang, Yingping Zhang, Siliang
- 机构：E China Univ Sci & Technol
- 来源：INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 2014
- 关键词：Gases - Liquids - Mixing - Pumps - Turbine components - Flow patterns - Mass transfer - Turbomachine blades - Velocity
- Proteome allocations change linearly with the specific growth rate of Saccharomyces cerevisiae under glucose limitation被引量：51收藏
- 作者：Xia, Jianye Sanchez, Benjamin J. Chen, Yu Campbell, Kate Kasvandik, Sergo Nielsen, Jens
- 机构：East China Univ Sci & Technol;Chalmers Univ Technol;Chinese Acad Sci;Univ Tartu;BioInnovat Inst
- 来源：NATURE COMMUNICATIONS 2022
- CFD analysis of the turbulent flow in baffled shake flasks被引量：49收藏
- 作者：Li, Chao Xia, Jian-Ye Chu, Ju Wang, Yong-Hong Zhuang, Ying-Ping Zhang, Si-Liang
- 机构：E China Univ Sci & Technol
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2013
- 关键词：Shake flask Hydrodynamics Mass transfer Mixing Shear force Power consumption
- Application of Euler-Lagrange CFD for quantitative evaluating the effect of shear force on Carthamus tinctorius L. cell in a stirred tank bioreactor被引量：49收藏
- 作者：Liu, Yu Wang, Ze-Jian Xia, Jian-Ye Haringa, Cees Liu, Ya-Ping Chu, Ju Zhuang, Ying-Ping Zhang, Si-Liang
- 机构：East China Univ Sci & Technol;Dalian Pract Biotechnol Co Ltd;Delft Univ Technol
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2016
- 关键词：Plant cell culture Fluid mechanics Agitation Power consumption C tinctorius L. cell Stress thresholds
- Power consumption, local and average volumetric mass transfer coefficient in multiple-impeller stirred bioreactors for xanthan gum solutions被引量：48收藏
- 作者：Xie, Ming-hui Xia, Jian-ye Zhou, Zhen Zhou, Guo-zhong Chu, Ju Zhuang, Ying-ping Zhang, Si-liang Noorman, Henk
- 机构：E China Univ Sci & Technol;Wenzhou Great Wall Mixer Design Inst;DSM Biotechnol Ctr
- 来源：CHEMICAL ENGINEERING SCIENCE 2014
- 关键词：Power Mass transfer Xanthan gum Non-Newtonian fluid Impeller combination
- Enzymatic Preparation of the Chiral (S)-Sulfoxide Drug Esomeprazole at Pilot-Scale Levels被引量：45收藏
- 作者：Xu, Na Zhu, Jun Wu, Yin-Qi Zhang, Yan Xia, Jian-Ye Zhao, Qian Lin, Guo-Qiang Yu, Hui-Lei Xu, Jian-He
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Jiangsu Aosaikang Pharmaceut Co Ltd
- 来源：ORGANIC PROCESS RESEARCH & DEVELOPMENT 2020
- 关键词：prazole sulfide monooxygenase esomeprazole asymmetric oxidation oxygen mass transfer reaction regulation
- A 9-pool metabolic structured kinetic model describing days to seconds dynamics of growth and product formation by Penicillium chrysogenum被引量：45收藏
- 作者：Tang, Wenjun Deshmukh, Amit T. Haringa, Cees Wang, Guan van Gulik, Walter van Winden, Wouter Reuss, Matthias Heijnen, Joseph J. Xia, Jianye Chu, Ju Noorman, Henk J.
- 机构：East China Univ Sci & Technol;DSM Biotechnol Ctr;Delft Univ Technol;Univ Stuttgart
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2017
- 关键词：structured model black box model feast-famine kinetics Penicillium chrysogenum
- Real-time and on-line monitoring of ethanol fermentation process by viable cell sensor and electronic nose被引量：42收藏
- 作者：Feng, Yao Tian, Xiwei Chen, Yang Wang, Zeyu Xia, Jianye Qian, Jiangchao Zhuang, Yingping Chu, Ju
- 机构：East China Univ Sci & Technol
- 来源：BIORESOURCES AND BIOPROCESSING 2021
- 关键词：Ethanol On-line Viable cell sensor Electronic nose
- Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains被引量：40收藏
- 作者：Xia, Jianye Wang, Guan Fan, Meng Chen, Min Wang, Zeyu Zhuang, Yingping
- 机构：East China Univ Sci & Technol
- 来源：CHINESE JOURNAL OF CHEMICAL ENGINEERING 2021
- 关键词：Fermentation Scale-up Bioreactors Gas-liquid flow Kinetics
- Industrial bioprocess control and optimization in the context of systems biotechnology被引量：38收藏
- 作者：Wang, Yong Chu, Ju Zhuang, Yingping Wang, Yonghong Xia, Jianye Zhang, Siliang
- 机构：E China Univ Sci & Technol
- 来源：BIOTECHNOLOGY ADVANCES 2009
- 关键词：Industrial bioprocess Systems biotechnology Bioprocess control and optimization
- Advances and Practices of Bioprocess Scale-up被引量：36收藏
- 作者：Xia, Jianye Wang, Guan Lin, Jihan Wang, Yonghong Chu, Ju Zhuang, Yingping Zhang, Siliang
- 机构：East China Univ Sci & Technol
- 来源：BIOREACTOR ENGINEERING RESEARCH AND INDUSTRIAL APPLICATIONS II 2016
- 关键词：Bioprocess engineering Scale-up Bioprocess monitoring Fluid dynamics Microbial kinetics Mathematical model
- Multi-omics integrative analysis with genome-scale metabolic model simulation reveals global cellular adaptation of Aspergillus niger under industrial enzyme production condition被引量：36收藏
- 作者：Lu, Hongzhong Cao, Weiqiang Liu, Xiaoyun Sui, Yufei Ouyang, Liming Xia, Jianye Huang, Mingzhi Zhuang, Yingping Zhang, Siliang Noorman, Henk Chu, Ju
- 机构：East China Univ Sci & Technol;DSM Biotechnol Ctr
- 来源：SCIENTIFIC REPORTS 2018
- Integrated isotope-assisted metabolomics and 13C metabolic flux analysis reveals metabolic flux redistribution for high glucoamylase production by Aspergillus niger被引量：35收藏
- 作者：Lu, Hongzhong Liu, Xiaoyun Huang, Mingzhi Xia, Jianye Chu, Ju Zhuang, Yingping Zhang, Siliang Noorman, Henk
- 机构：E China Univ Sci & Technol;DSM Biotechnol Ctr
- 来源：MICROBIAL CELL FACTORIES 2015
- 关键词：Aspergillus niger Glucoamylase C-13 metabolic flux analysis Metabolomics Cofactor metabolism
- Comparative performance of different scale-down simulators of substrate gradients in Penicillium chrysogenum cultures: the need of a biological systems response analysis被引量：31收藏
- 作者：Wang, Guan Zhao, Junfei Haringa, Cees Tang, Wenjun Xia, Jianye Chu, Ju Zhuang, Yingping Zhang, Siliang Deshmukh, Amit T. van Gulik, Walter Heijnen, Joseph J. Noorman, Henk J.
- 机构：ECUST;Delft Univ Technol;DSM Biotechnol Ctr;Delft Univ Technol;Delft Univ Technol
- 来源：MICROBIAL BIOTECHNOLOGY 2018
- Computational investigation of fluid dynamics in a recently developed centrifugal impeller bioreactor被引量：30收藏
- 作者：Xia, Jian-Ye Wang, Si-Jing Zhang, Si-Liang Zhong, Jian-Jiang
- 机构：E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2008
- 关键词：CFD centrifugal impeller velocity profile shear force fluid circulation circulation time distribution
- Comprehensive reconstruction and in silico analysis of Aspergillus niger genome-scale metabolic network model that accounts for 1210 ORFs被引量：28收藏
- 作者：Lu, Hongzhong Cao, Weiqiang Ouyang, Liming Xia, Jianye Huang, Mingzhi Chu, Ju Zhuang, Yingping Zhang, Siliang Noorman, Henk
- 机构：East China Univ Sci & Technol;DSM Biotechnol Ctr
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2017
- 关键词：Aspergillus niger genome-scale metabolic model multi-omics glucoamylase
- Prelude to rational scale-up of penicillin production: a scale-down study被引量：28收藏
- 作者：Wang, Guan Chu, Ju Noorman, Henk Xia, Jianye Tang, Wenjun Zhuang, Yingping Zhang, Siliang
- 机构：E China Univ Sci & Technol;DSM Biotechnol Ctr
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2014
- 关键词：Scale-down Scale-up Gradients Model Computational Penicillin P. chrysogenum
- Integration of enzyme constraints in a genome-scale metabolic model of Aspergillus niger improves phenotype predictions被引量：27收藏
- 作者：Zhou, Jingru Zhuang, Yingping Xia, Jianye
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：MICROBIAL CELL FACTORIES 2021
- 关键词：Genome-scale metabolic model Proteome constraint GSMM Aspergillus niger Differential expression of enzymes
- Quantitative evaluation of the shear threshold on Carthamus tinctorius L. cell growth with computational fluid dynamics in shaken flask bioreactors被引量：26收藏
- 作者：Liu, Yu Wang, Ze-Jian Zhang, JianWen Xia, Jian-ye Chu, Ju Zhang, Si-Liang Zhuang, Ying-Ping
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Delft Univ Technol
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2016
- 关键词：Fluid mechanics Power consumption Aggregation Plant cell bioreactors C. tinctorius L. cell Stress thresholds
- A novel impeller configuration to improve fungal physiology performance and energy conservation for cephalosporin C production被引量：25收藏
- 作者：Yang, Yiming Xia, Jianye Li, Jianhua Chu, Ju Li, Liang Wang, Yonghong Zhuang, Yingping Zhang, Siliang
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2012
- 关键词：Impeller configuration Cephalosporin C Morphology Computational fluid dynamics
- Real-time fluid dynamics investigation and physiological response for erythromycin fermentation scale-up from 50 L to 132 m3 fermenter被引量：24收藏
- 作者：Zou, Xiang Xia, Jian-ye Chu, Ju Zhuang, Ying-ping Zhang, Si-liang
- 机构：E China Univ Sci & Technol;Southwest Univ
- 来源：BIOPROCESS AND BIOSYSTEMS ENGINEERING 2012
- 关键词：Erythromycin biosynthesis Fermentation Fluid mechanics Non-Newtonian fluids Physiological response Scale-up
- Novel scale-up strategy based on three-dimensional shear space for animal cell culture被引量：22收藏
- 作者：Li, Chao Teng, Xiaonuo Peng, Huadong Yi, Xiaoping Zhuang, Yingping Zhang, Siliang Xia, Jianye
- 机构：East China Univ Sci & Technol;Imperial Coll London;Imperial Coll London
- 来源：CHEMICAL ENGINEERING SCIENCE 2020
- 关键词：Shear rate Animal cell culture Scale-up Computational fluid dynamics Stirred tank bioreactor
- Improvement of glucoamylase production using axial impellers with low power consumption and homogeneous mass transfer被引量：22收藏
- 作者：Tang, Wenjun Pan, Ao Lu, Hongzhong Xia, Jianye Zhuang, Yingping Zhang, Siliang Chu, Ju Noorman, Henk
- 机构：E China Univ Sci & Technol;DSM Biotechnol Ctr
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2015
- 关键词：Glucoamylase Impeller type Aspergillus niger Morphology analysis CFD
- Power input effects on degeneration in prolonged penicillin chemostat cultures: A systems analysis at flux, residual glucose, metabolite, and transcript levels被引量：18收藏
- 作者：Wang, Guan Wu, Baofeng Zhao, Junfei Haringa, Cees Xia, Jianye Chu, Ju Zhuang, Yingping Zhang, Siliang Heijnen, Joseph J. van Gulik, Walter Deshmukh, Amit T. Noorman, Henk J.
- 机构：ECUST;Delft Univ Technol;Delft Univ Technol;DSM Biotechnol Ctr;Delft Univ Technol
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2018
- 关键词：degeneration glucose transport power input redox energy metabolism scale down
- Dependence of fungal characteristics on seed morphology and shear stress in bioreactors被引量：18收藏
- 作者：Lu, Hongzhong Li, Chao Tang, Wenjun Wang, Zejian Xia, Jianye Zhang, Siliang Zhuang, Yingping Chu, Ju Noorman, Henk
- 机构：E China Univ Sci & Technol;DSM Biotechnol Ctr
- 来源：BIOPROCESS AND BIOSYSTEMS ENGINEERING 2015
- 关键词：Aspergillus niger Morphological control Stirred tank Mass transfer Rheology Hydrodynamics
- Dynamic response of Aspergillus niger to single pulses of glucose with high and low concentrations被引量：16收藏
- 作者：Wang, Shuai Liu, Peng Shu, Wei Li, Chao Li, Huan Liu, Shanshan Xia, Jianye Noorman, Henk
- 机构：East China Univ Sci & Technol;DSM Biotechnol Ctr
- 来源：BIORESOURCES AND BIOPROCESSING 2019
- 关键词：Aspergillus niger Substrate pulse Glucose excess Rapid sampling Dynamic responses Intracellular metabolites
