蔡孟浩 收藏
( 任职于 生物工程学院)
男，博士，副教授，华东理工大学生物工程学院。2006年毕业于华东理工大学理工优秀生部，获工学学士学位；2009年-2010年英国布里斯托大学化学院联合培养博士生；2011年获得华东理工大学生物化工博士学位。2011年-2014年，华东理工大学师资博士后、助理研究员，2014年任职副教授。 获得上海市青年科技启明星计划，生物工程学院青年英才培养计划，上海市研究生创新计划资助。担任中国微生物学会海洋微生物学专业委员会委员（2016-2021年），第四届中国生物化学与分子生物学学会海洋生物化学与分子生物学分会理事（2016-2020年），上海市生物工程学会合成生物学专业委员会委员... 详细>>
- Methanol-Independent Protein Expression by AOX1 Promoter with trans-Acting Elements Engineering and Glucose-Glycerol-Shift Induction in Pichia pastoris被引量：136收藏
- 作者：Wang, Jinjia Wang, Xiaolong Shi, Lei Qi, Fei Zhang, Ping Zhang, Yuanxing Zhou, Xiangshan Song, Zhiwei Cai, Menghao
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg;Bioproc Technol Inst;Natl Univ Singapore
- 来源：SCIENTIFIC REPORTS 2017
- 质疑
- Genetic, molecular, and biochemical basis of fungal tropolone biosynthesis被引量：133收藏
- 作者：Davison, Jack al Fahad, Ahmed Cai, Menghao Song, Zhongshu Yehia, Samar Y. Lazarus, Colin M. Bailey, Andrew M. Simpson, Thomas J. Cox, Russell J.
- 机构：Univ Bristol;E China Univ Sci & Technol;Future Univ Egypt;Univ Bristol
- 来源：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2012
- 关键词：oxidative rearrangement azaphilone colchicine
- 质疑
- Engineered monoculture and co-culture of methylotrophic yeast for de novo production of monacolin J and lovastatin from methanol被引量：123收藏
- 作者：Liu, Yiqi Tu, Xiaohu Xu, Qin Bai, Chenxiao Kong, Chuixing Liu, Qi Yu, Jiahui Peng, Qiangqiang Zhou, Xiangshan Zhang, Yuanxing Cai, Menghao
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：METABOLIC ENGINEERING 2018
- 关键词：Methanol Methylotrophic yeast Co-culture Heterologous biosynthesis Monacolin J Lovastatin
- 质疑
- Mit1 Transcription Factor Mediates Methanol Signaling and Regulates the Alcohol Oxidase 1 (AOX1) Promoter in Pichia pastoris被引量：95收藏
- 作者：Wang, Xiaolong Wang, Qi Wang, Jinjia Bai, Peng Shi, Lei Shen, Wei Zhou, Mian Zhou, Xiangshan Zhang, Yuanxing Cai, Menghao
- 机构：E China Univ Sci & Technol;SCICB
- 来源：JOURNAL OF BIOLOGICAL CHEMISTRY 2016
- 关键词：DNA-protein interaction protein domain signal transduction transcription coactivator transcription regulation AOX1 promoter Mit1 Pichia pastoris glycerol repression methanol induction
- 质疑
- CRISPR-Cas9-mediated genomic multiloci integration in Pichia pastoris被引量：89收藏
- 作者：Liu, Qi Shi, Xiaona Song, Lili Liu, Haifeng Zhou, Xiangshan Wang, Qiyao Zhang, Yuanxing Cai, Menghao
- 机构：East China Univ Sci & Technol;Chinare Resources Angde Biotech Pharmaceut Co Ltd;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：MICROBIAL CELL FACTORIES 2019
- 关键词：Pichia pastoris CRISPR-Cas9 Homology directed repair Multiloci integration Multistep enzymatic pathway
- 质疑
- A novel methanol-free Pichia pastoris system for recombinant protein expression被引量：60收藏
- 作者：Shen, Wei Xue, Ying Liu, Yiqi Kong, Chuixing Wang, Xiaolong Huang, Mengmeng Cai, Menghao Zhou, Xiangshan Zhang, Yuanxing Zhou, Mian
- 机构：East China Univ Sci & Technol;SCICB
- 来源：MICROBIAL CELL FACTORIES 2016
- 关键词：Recombination protein expression AOX1 promoter Dihydroxyacetone GUT1 DAK Pichia pastoris
- 质疑
- Structure and physicochemical properties of amphiphilic agar modified with octenyl succinic anhydride被引量：56收藏
- 作者：Chen, Huijing Chen, Fuquan Xiao, Qiong Cai, Menghao Yang, Qiuming Weng, Huifen Xiao, Anfeng
- 机构：Jimei Univ;East China Univ Sci & Technol;Natl R&D Ctr Red Alga Proc Technol;Fujian Prov Engn Technol Res Ctr Marine Funct Foo
- 来源：CARBOHYDRATE POLYMERS 2021
- 关键词：Agar Octenyl succinic anhydride Characterization Rheology
- 质疑
- Engineered fungal polyketide biosynthesis in Pichia pastoris: a potential excellent host for polyketide production被引量：52收藏
- 作者：Gao, Limei Cai, Menghao Shen, Wei Xiao, Siwei Zhou, Xiangshan Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：MICROBIAL CELL FACTORIES 2013
- 关键词：Polyketide Pichia pastoris 6-MSA 6-MSAS Heterologous expression Fermentation
- 质疑
- Engineered ethanol-driven biosynthetic system for improving production of acetyl-CoA derived drugs in Crabtree-negative yeast被引量：45收藏
- 作者：Liu, Yiqi Bai, Chenxiao Liu, Qi Xu, Qin Qian, Zhilan Peng, Qiangqiang Yu, Jiahui Xu, Mingqiang Zhou, Xiangshan Zhang, Yuanxing Cai, Menghao
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：METABOLIC ENGINEERING 2019
- 关键词：Ethanol Crabtree-negative yeast Acetyl-CoA Monacolin J Metabolic engineering Coculture
- 质疑
- Characterization of a thermostable raw-starch hydrolyzing α-amylase from deep-sea thermophile Geobacillus sp.被引量：43收藏
- 作者：Jiang, Tao Cai, Menghao Huang, Mengmeng He, Hao Lu, Jian Zhou, Xiangshan Zhang, Yuanxing
- 机构：E China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：PROTEIN EXPRESSION AND PURIFICATION 2015
- 关键词：alpha-Amylase Geobacillus sp. Heterologous expression Thermophile
- 质疑
- Regulating unfolded protein response activator HAC1p for production of thermostable raw-starch hydrolyzing α-amylase in Pichia pastoris被引量：39收藏
- 作者：Huang, Mengmeng Gao, Yanyun Zhou, Xiangshan Zhang, Yuanxing Cai, Menghao
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：BIOPROCESS AND BIOSYSTEMS ENGINEERING 2017
- 关键词：Unfolded protein response HAC1p Heterologous expression P. pastoris Raw-starch hydrolyzing alpha-amylase
- 质疑
- PpNrg1 is a transcriptional repressor for glucose and glycerol repression of AOX1 promoter in methylotrophic yeast Pichia pastoris被引量：38收藏
- 作者：Wang, Xiaolong Cai, Menghao Shi, Lei Wang, Qi Zhu, Jinxiang Wang, Jinjia Zhou, Mian Zhou, Xiangshan Zhang, Yuanxing
- 机构：E China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：BIOTECHNOLOGY LETTERS 2016
- 关键词：AOX1 promoter Catabolite repression Glucose Glycerol PpNrg1 Pichia pastoris Transcriptional regulation
- 质疑
- Identification and characterization of novel promoters for recombinant protein production in yeast Pichia pastoris被引量：37收藏
- 作者：Xu, Ning Zhu, Jinxiang Zhu, Qiaoyun Xing, Yanzi Cai, Menghao Jiang, Tianyi Zhou, Mian Zhang, Yuanxing
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg;Roche R&D Ctr China Ltd
- 来源：YEAST 2018
- 关键词：carbon source Pichia pastoris promoter recombinant protein expression
- 质疑
- Genetically shaping morphology of the filamentous fungus Aspergillus glaucus for production of antitumor polyketide aspergiolide A被引量：37收藏
- 作者：Cai, Menghao Zhang, Ying Hu, Wei Shen, Wei Yu, Zhenzhong Zhou, Weiqiang Jiang, Tao Zhou, Xiangshan Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：MICROBIAL CELL FACTORIES 2014
- 关键词：Filamentous fungi Aspergillus glaucus Genetically morphology shaping Shear stress Aspergiolide A
- 质疑
- Methylotrophic yeast Pichia pastoris as a chassis organism for polyketide synthesis via the full citrinin biosynthetic pathway被引量：36收藏
- 作者：Xue, Ying Kong, Chuixing Shen, Wei Bai, Chenxiao Ren, Yanna Zhou, Xiangshan Zhang, Yuanxing Cai, Menghao
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：JOURNAL OF BIOTECHNOLOGY 2017
- 关键词：Polyketides Pichia pastoris Heterologous biosynthesis Citrinin Biosynthetic pathway
- 质疑
- A programmable high-expression yeast platform responsive to user-defined signals被引量：35收藏
- 作者：Liu, Qi Song, Lili Peng, Qiangqiang Zhu, Qiaoyun Shi, Xiaona Xu, Mingqiang Wang, Qiyao Zhang, Yuanxing Cai, Menghao
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：SCIENCE ADVANCES 2022
- 关键词：Recombinant proteins - Transcription
- 质疑
- Identified biosynthetic pathway of aspergiolide A and a novel strategy to increase its production in a marine-derived fungus Aspergillus glaucus by feeding of biosynthetic precursors and inhibitors simultaneously被引量：35收藏
- 作者：Sun, Xueqian Zhou, Xiangshan Cai, Menghao Tao, Kejing Zhang, Yuanxing
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Bioresource Technology 2009
- 关键词：Ketones - Biosynthesis - Metabolites
- 质疑
- Preparation, characterization, and application of high-whiteness agar bleached with hydrogen peroxide被引量：35收藏
- 作者：An, Ding Xiao, Qiong Zhang, Cong Cai, Menghao Zhang, Yonghui Weng, Huifen Chen, Fuquan Xiao, Anfeng
- 机构：Jimei Univ;East China Univ Sci & Technol;Natl R&D Ctr Red Alga Proc Technol;Fujian Prov Engn Technol Res Ctr Marine Funct Foo
- 来源：FOOD HYDROCOLLOIDS 2021
- 关键词：High-whiteness agar Hydrogen peroxide Bleaching Quality promotion Diversified application
- 质疑
- Significant stimulation of o-phthalic acid in biosynthesis of aspergiolide A by a marine fungus Aspergillus glaucus被引量：34收藏
- 作者：Sun, Xueqian Zhou, Xiangshan Cai, Menghao Zhou, Jiushun Zhang, Yuanxing
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Bioresource Technology 2010
- 关键词：Carboxylic acids - Biosynthesis - Ketones - Biochemistry
- 质疑
- Significance of seed culture methods on mycelial morphology and production of a novel anti-cancer anthraquinone by marine mangrove endophytic fungus Halorosellinia sp. (No. 1403)被引量：34收藏
- 作者：Yu, Chao Cai, Menghao Kang, Li Zhang, Yuanxing Zhou, Xiangshan
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Process Biochemistry 2012
- 关键词：Mycelium - Aromatic compounds - Biomass - Bottles - Diseases - Ketones
- 质疑
- Statistical optimization of medium composition for aspergiolide A production by marine-derived fungus Aspergillus glaucus被引量：32收藏
- 作者：Cai, Meng-Hao Zhou, Xiang-Shan Sun, Xue-Qian Tao, Ke-Jing Zhang, Yuan-Xing
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY 2009
- 关键词：Aspergillus glaucus Aspergiolide A Statistical methodologies Medium optimization Carbon-nitrogen ratio
- 质疑
- De Novo Production of Plant 4′-Deoxyflavones Baicalein and Oroxylin A from Ethanol in Crabtree-Negative Yeast被引量：32收藏
- 作者：Qian, Zhilan Yu, Jiahui Chen, Xinjie Kang, Yijia Ren, Yanna Liu, Qi Lu, Jian Zhao, Qing Cai, Menghao
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Sci;East China Univ Sci & Technol
- 来源：ACS SYNTHETIC BIOLOGY 2022
- 关键词：plant 4 '-deoxyflavones Scutellaria baicalensis Georgi Pichia pastoris transcriptional regulation device fine-tuning pathway control
- 质疑
- Statistical optimization of medium composition for aspergiolide A production by marine-derived fungus Aspergillus glaucus被引量：30收藏
- 作者：Cai, Meng-Hao Zhou, Xiang-Shan Sun, Xue-Qian Tao, Ke-Jing Zhang, Yuan-Xing
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Journal of Industrial Microbiology and Biotechnology 2009
- 关键词：Carbon - Nitrogen - Sodium - Statistical methods - Yeast
- 质疑
- Roles of cobalt in biosynthesis stimulation of a cytotoxic compound from marine-derived Aspergillus glaucus被引量：30收藏
- 作者：Cai, Menghao Sun, Xueqian Zhou, Xiangshan Zhang, Yuanxing
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Process Biochemistry 2012
- 关键词：Aspergillus - Biochemistry - Biosynthesis - Cobalt - Ketones - Trace elements
- 质疑
- Modulation of acetate utilization in Komagataella phaffii by metabolic engineering of tolerance and metabolism被引量：30收藏
- 作者：Xu, Qin Bai, Chenxiao Liu, Yiqi Song, Lili Tian, Lin Yan, Yunfeng Zhou, Jinfeng Zhou, Xiangshan Zhang, Yuanxing Cai, Menghao
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：BIOTECHNOLOGY FOR BIOFUELS 2019
- 关键词：Komagataella phaffii Acetate utilization Acetyl-CoA Kinase screening Metabolic engineering
- 质疑
- Polyketides in Aspergillus terreus: biosynthesis pathway discovery and application被引量：29收藏
- 作者：Yin, Ying Cai, Menghao Zhou, Xiangshan Li, Zhiyong Zhang, Yuanxing
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2016
- 关键词：Polyketide Aspergillus terreus Biosynthesis pathway Gene cluster Heterologous expression
- 质疑
- Efficient strategy for enhancing aspergiolide A production by citrate feedings and its effects on sexual development and growth of marine-derived fungus Aspergillus glaucus被引量：28收藏
- 作者：Cai, Menghao Zhou, Xiangshan Zhou, Jiushun Niu, Chuanpeng Kang, Li Sun, Xueqian Zhang, Yuanxing
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Bioresource Technology 2010
- 关键词：Biochemistry - Sodium compounds - pH effects - Citric acid
- 质疑
- Heterologous pathway assembly reveals molecular steps of fungal terreic acid biosynthesis被引量：26收藏
- 作者：Kong, Chuixing Huang, Hezhou Xue, Ying Liu, Yiqi Peng, Qiangqiang Liu, Qi Xu, Qin Zhu, Qiaoyun Yin, Ying Zhou, Xiangshan Zhang, Yuanxing Cai, Menghao
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：SCIENTIFIC REPORTS 2018
- 质疑
- A novel pH–precursor–glucose synergic control strategy for dinactin biosynthesis by an arctic actinomycete Streptomyces sp.被引量：25收藏
- 作者：He, Hao Xue, Ying Xu, Ning Yin, Ying Lu, Jian Cai, Menghao Zhang, Yuanxing
- 机构： State Key Laboratory of Bioreactor Engineering; Shanghai Collaborative Innovation Center for Biomanufacturing
- 来源：Process Biochemistry 2016
- 关键词：Bacteria - Gene encoding - Biochemistry - Glucose
- 质疑
- Identified biosynthetic pathway of aspergiolide A and a novel strategy to increase its production in a marine-derived fungus Aspergillus glaucus by feeding of biosynthetic precursors and inhibitors simultaneously被引量：24收藏
- 作者：Sun, Xueqian Zhou, Xiangshan Cai, Menghao Tao, Kejing Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：BIORESOURCE TECHNOLOGY 2009
- 关键词：Aspergillus glaucus Aspergiolide A Pathway specific inhibitor Polyketide pathway Precursor
- 质疑
