张元兴 收藏
( 任职于 生物工程学院)
生物工程专业：博士生导师/硕士生导师 生物化工专业：博士生导师/硕士生导师 生物工程领域：工程硕士生导师 1982年1月毕业于华东化工学院化学工程系，获学士学位。1984年7月毕业于华东化工学院生物化工系，获硕士学位，1995年9月评为华东理工大学教授。1997年担任博士生导师。1998年享受国务院政府特殊津贴。 曾任国家863高技术计划海洋技术领域专家组副组长，国务院学位委员会生物工程临时学科评议组专家，华东理工大学生物工程学院院长。受聘为国家海洋食品工程技术研究中心专家指导委员会副主... 详细>>
被引量：9,079H指数：48SCI-EXPANDED： 308 EI： 138 北大核心： 110 CSCD： 142
- Genome Sequence of the Versatile Fish Pathogen Edwardsiella tarda Provides Insights into its Adaptation to Broad Host Ranges and Intracellular Niches被引量：208收藏
- 作者：Wang, Qiyao Yang, Minjun Xiao, Jingfan Wu, Haizhen Wang, Xin Lv, Yuanzhi Xu, Lili Zheng, Huajun Wang, Shengyue Zhao, Guoping Liu, Qin Zhang, Yuanxing
- 机构：
- 来源：PLOS ONE 2009
- 质疑
- The Bacterial T6SS Effector EvpP Prevents NLRP3 Inflammasome Activation by Inhibiting the Ca2+-Dependent MAPK-Jnk Pathway被引量：140收藏
- 作者：Chen, Hao Yang, Dahai Han, Fajun Tan, Jinchao Zhang, Lingzhi Xiao, Jingfan Zhang, Yuanxing Liu, Qin
- 机构：East China Univ Sci & Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：CELL HOST & MICROBE 2017
- 质疑
- Methanol-Independent Protein Expression by AOX1 Promoter with trans-Acting Elements Engineering and Glucose-Glycerol-Shift Induction in Pichia pastoris被引量：136收藏
- 作者：Wang, Jinjia Wang, Xiaolong Shi, Lei Qi, Fei Zhang, Ping Zhang, Yuanxing Zhou, Xiangshan Song, Zhiwei Cai, Menghao
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg;Bioproc Technol Inst;Natl Univ Singapore
- 来源：SCIENTIFIC REPORTS 2017
- 质疑
- Phylogenomics characterization of a highly virulent Edwardsiella strain ET080813T encoding two distinct T3SS and three T6SS gene clusters: Propose a novel species as Edwardsiella anguillarum sp nov.被引量：126收藏
- 作者：Shao, Shuai Lai, Qiliang Liu, Qin Wu, Haizhen Xiao, Jingfan Shao, Zongze Wang, Qiyao Zhang, Yuanxing
- 机构：E China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol;State Key Lab Breeding Base Marine Genet Resource;SOA;Key Lab Marine Genet Resources Fujian Prov
- 来源：SYSTEMATIC AND APPLIED MICROBIOLOGY 2015
- 关键词：Edwardsiella anguillarum sp nov. Taxonomy MLST DOH Phylogenomics
- 质疑
- Engineered monoculture and co-culture of methylotrophic yeast for de novo production of monacolin J and lovastatin from methanol被引量：123收藏
- 作者：Liu, Yiqi Tu, Xiaohu Xu, Qin Bai, Chenxiao Kong, Chuixing Liu, Qi Yu, Jiahui Peng, Qiangqiang Zhou, Xiangshan Zhang, Yuanxing Cai, Menghao
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：METABOLIC ENGINEERING 2018
- 关键词：Methanol Methylotrophic yeast Co-culture Heterologous biosynthesis Monacolin J Lovastatin
- 质疑
- Isolation and identification of fish pathogen Edwardsiella tarda from mariculture in China被引量：119收藏
- 作者：Xiao, Jingfan Wang, Qiyao Liu, Qin Wang, Xin Liu, Huan Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：AQUACULTURE RESEARCH 2008
- 关键词：antibiotics susceptibility aquaculture chloramphenicol resistance Edwardsiella tarda pathogenicity
- 质疑
- Mit1 Transcription Factor Mediates Methanol Signaling and Regulates the Alcohol Oxidase 1 (AOX1) Promoter in Pichia pastoris被引量：95收藏
- 作者：Wang, Xiaolong Wang, Qi Wang, Jinjia Bai, Peng Shi, Lei Shen, Wei Zhou, Mian Zhou, Xiangshan Zhang, Yuanxing Cai, Menghao
- 机构：E China Univ Sci & Technol;SCICB
- 来源：JOURNAL OF BIOLOGICAL CHEMISTRY 2016
- 关键词：DNA-protein interaction protein domain signal transduction transcription coactivator transcription regulation AOX1 promoter Mit1 Pichia pastoris glycerol repression methanol induction
- 质疑
- CRISPR-Cas9-mediated genomic multiloci integration in Pichia pastoris被引量：89收藏
- 作者：Liu, Qi Shi, Xiaona Song, Lili Liu, Haifeng Zhou, Xiangshan Wang, Qiyao Zhang, Yuanxing Cai, Menghao
- 机构：East China Univ Sci & Technol;Chinare Resources Angde Biotech Pharmaceut Co Ltd;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：MICROBIAL CELL FACTORIES 2019
- 关键词：Pichia pastoris CRISPR-Cas9 Homology directed repair Multiloci integration Multistep enzymatic pathway
- 质疑
- Edwardsiella tarda T6SS component evpP is regulated by esrB and iron, and plays essential roles in the invasion of fish被引量：89收藏
- 作者：Wang, Xin Wang, Qiyao Xiao, Jingfan Liu, Qin Wu, Haizhen Xu, Lili Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：FISH & SHELLFISH IMMUNOLOGY 2009
- 关键词：Edwardsiella tarda evpP esrB Iron Invasion
- 质疑
- Zebrafish GSDMEb Cleavage-Gated Pyroptosis Drives Septic Acute Kidney Injury In Vivo被引量：88收藏
- 作者：Wang, Zhuang Gu, Zhaoyan Hou, Qing Chen, Weijie Mu, Di Zhang, Yuanxing Liu, Qin Liu, Zhihong Yang, Dahai
- 机构：East China Univ Sci & Technol;Nanjing Univ;Shanghai Engn Res Ctr Maricultured Anim Vaccines;Qingdao Natl Lab Marine Sci & Technol
- 来源：JOURNAL OF IMMUNOLOGY 2020
- 质疑
- Edwardsiella Comparative Phylogenomics Reveal the New Intra/Inter-Species Taxonomic Relationships, Virulence Evolution and Niche Adaptation Mechanisms被引量：86收藏
- 作者：Yang, Minjun Lv, Yuanzhi Xiao, Jingfan Wu, Haizhen Zheng, Huajun Liu, Qin Zhang, Yuanxing Wang, Qiyao
- 机构：E China Univ Sci & Technol;Chinese Natl Human Genome Ctr Shanghai
- 来源：PLOS ONE 2012
- 质疑
- Upconversion fluorescent strip sensor for rapid determination of Vibrio anguillarum被引量：85收藏
- 作者：Zhao, Peng Wu, Yuanyuan Zhu, Yihua Yang, Xiaoling Jiang, Xin Xiao, Jingfan Zhang, Yuanxing Li, Chunzhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：NANOSCALE 2014
- 关键词：Assays - Monoclonal antibodies
- 质疑
- QseBC controls flagellar motility, fimbrial hemagglutination and intracellular virulence in fish pathogen Edwardsiella tarda被引量：78收藏
- 作者：Wang, Xin Wang, Qiyao Yang, Minjun Xiao, Jingfan Liu, Qin Wu, Haizhen Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：FISH & SHELLFISH IMMUNOLOGY 2011
- 关键词：Edwardsiella tarda QesBC Motililty Hemagglutination Virulence
- 质疑
- N-Fused quinoxalines and benzoquinoxalines as attractive emitters for organic light emitting diodes被引量：74收藏
- 作者：Lindner, Benjamin D. Zhang, Yexiang Hoefle, Stefan Berger, Nancy Teusch, Claudia Jesper, Malte Hardcastle, Kenneth I. Qian, Xuhong Lemmer, Uli Colsmann, Alexander Bunz, Uwe H. F. Hamburger, Manuel
- 机构：Heidelberg Univ;E China Univ Sci & Technol;KIT;Georgia Inst Technol;InnovationLab GmbH
- 来源：JOURNAL OF MATERIALS CHEMISTRY C 2013
- 关键词：Quantum theory - Organic light emitting diodes (OLED)
- 质疑
- Resveratrol inhibits hypoxia-induced metastasis potential enhancement by restricting hypoxia-induced factor-1α expression in colon carcinoma cells被引量：74收藏
- 作者：Wu, Hongzhong Liang, Xin Fang, Yishi Qin, Xiaoran Zhang, Yuanxing Liu, Jianwen
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Chempartner Co Ltd
- 来源：BIOMEDICINE & PHARMACOTHERAPY 2008
- 关键词：Resveratrol Metastasis potential Colon carcinoma cell Hypoxia Hypoxia-induced factor-1 alpha
- 质疑
- Gene expression profiling in live attenuated Edwardsiella tarda vaccine immunized and challenged zebrafish: Insights into the basic mechanisms of protection seen in immunized fish被引量：71收藏
- 作者：Yang, Dahai Liu, Qin Ni, Chunshan Li, Shuai Wu, Haizhen Wang, Qiyao Xiao, Jinfan Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 2013
- 关键词：Zebrafish Edwardsiella tarda Live attenuated vaccine Immune responses CTLs
- 质疑
- A σE-Mediated Temperature Gauge Controls a Switch from LuxR-Mediated Virulence Gene Expression to Thermal Stress Adaptation in Vibrio alginolyticus被引量：68收藏
- 作者：Gu, Dan Guo, Min Yang, Minjun Zhang, Yuanxing Zhou, Xiaohui Wang, Qiyao
- 机构：East China Univ Sci & Technol;Chinese Natl Human Genome Ctr Shanghai;Shanghai Collaborat Innovat Ctr Biomfg Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines;Univ Connecticut
- 来源：PLOS PATHOGENS 2016
- 质疑
- 不同甲醇流加策略对重组毕赤酵母高密度发酵生产水蛭素的影响被引量：66收藏
- 作者：周祥山 范卫民 张元兴
- 机构：华东理工大学生物反应器工程国家重点实验室
- 来源：《生物工程学报》 2002
- 关键词：甲醇 流加策略 重组毕赤酵母 高密度发酵 水蛭素
- 摘要：考察了不同甲醇流加策略对毕赤酵母高密度发酵生产水蛭素的影响。溶氧控制法不能有效地防止甲醇的过量流加。气相色谱离线检测法虽然防止了甲醇流加过量 ,但甲醇浓度的波动较大。利用甲醇传感器在线检测控制甲醇的流加可维持较恒定的甲醇...
- 下载全文在线阅读质疑
- Immune responses of zebrafish (Danio rerio) induced by bath-vaccination with a live attenuated Vibrio anguillarum vaccine candidate被引量：65收藏
- 作者：Zhang, Zhihui Wu, Haizhen Xiao, Jingfan Wang, Qiyao Liu, Qin Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：FISH & SHELLFISH IMMUNOLOGY 2012
- 关键词：Bath-vaccination Danio rerio Immunoprotection Live attenuated vaccine Vibrio anguillarum
- 质疑
- Soluble Diazaiptycenes: Materials for Solution-Processed Organic Electronics被引量：64收藏
- 作者：Biegger, Philipp Stolz, Sebastian Intorp, Sebastian N. Zhang, Yexiang Engelhart, Jens U. Rominger, Frank Hardcastle, Kenneth I. Lemmer, Uli Qian, Xuhong Hamburger, Manuel Bunz, U. H. F.
- 机构：Heidelberg Univ;InnovationLab GmbH;Karlsruher Inst Technol;Karlsruhe Inst Technol;Georgia Inst Technol
- 来源：JOURNAL OF ORGANIC CHEMISTRY 2015
- 关键词：Quantum chemistry - Crystallization - Organic light emitting diodes (OLED)
- 质疑
- Roles of LuxR in regulating extracellular alkaline serine protease A, extracellular polysaccharide and mobility of Vibrio alginolyticus被引量：63收藏
- 作者：Rui, Haopeng Liu, Qin Ma, Yue Wang, Qiyao Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：FEMS MICROBIOLOGY LETTERS 2008
- 关键词：Vibrio alginolyticus quorum sensing LuxR(val) ProA collagenase extracellular protease
- 质疑
- Characterization of Edwardsiella tarda rpoS: effect on serum resistance, chondroitinase activity, biofilm formation, and autoinducer synthetases expression被引量：62收藏
- 作者：Xiao, Jingfan Wang, Qiyao Liu, Qin Xu, Lili Wang, Xin Wu, Haizhen Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2009
- 关键词：Edwardsiella tarda Chondroitinase rpoS Virulence Quorum sensing
- 质疑
- leSensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zbrafish被引量：61收藏
- 作者：Yang, Dahai Zheng, Xin Chen, Shouwen Wang, Zhuang Xu, Wenting Tan, Jinchao Hu, Tianjian Hou, Mingyu Wang, Wenhui Gu, Zhaoyan Wang, Qiyao Zhang, Ruilin Zhang, Yuanxing Liu, Qin
- 机构：East China Univ Sci & Technol;Qingdao Natl Lab Marine Sci & Technol;Shanghai Engn Res Ctr Marine Cultured Anim Vaccin;Shanghai Collaborat Innovat Ctr Biomfg;Fudan Univ
- 来源：NATURE COMMUNICATIONS 2018
- 质疑
- A novel methanol-free Pichia pastoris system for recombinant protein expression被引量：60收藏
- 作者：Shen, Wei Xue, Ying Liu, Yiqi Kong, Chuixing Wang, Xiaolong Huang, Mengmeng Cai, Menghao Zhou, Xiangshan Zhang, Yuanxing Zhou, Mian
- 机构：East China Univ Sci & Technol;SCICB
- 来源：MICROBIAL CELL FACTORIES 2016
- 关键词：Recombination protein expression AOX1 promoter Dihydroxyacetone GUT1 DAK Pichia pastoris
- 质疑
- Role of Alkaline Serine Protease, Asp, in Vibrio alginolyticus Virulence and Regulation of Its Expression by LuxO-LuxR Regulatory System被引量：60收藏
- 作者：Rui Haopeng Liu, Qin Wang, Qiyao Ma, Yue Liu, Huan Shi, Cunbin Zhang, Yuanxing
- 机构：E China Univ Sci & Technol;Chinese Acad Fishery Sci
- 来源：JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY 2009
- 关键词：Alkaline serine protease asp quorum sensing Vibrio alginolyticus
- 质疑
- Notable mucosal immune responses induced in the intestine of zebrafish (Danio rerio) bath-vaccinated with a live attenuated Vibrio anguillarum vaccine被引量：60收藏
- 作者：Liu, Xiaohong Wu, Haizhen Chang, Xinyue Tang, Yufei Liu, Qin Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：FISH & SHELLFISH IMMUNOLOGY 2014
- 关键词：Live attenuated Vibrio anguillarum Zebrafish Bath-vaccination Mucosal immune responses
- 质疑
- Extraction and identification of collagen-derived peptides with hematopoietic activity from Colla Corii Asini被引量：59收藏
- 作者：Wu, Hongzhong Ren, Chunyan Yang, Fang Qin, Yufeng Zhang, Yuanxing Liu, Jianwen
- 机构：E China Univ Sci & Technol;HUYA Biosci Int;Icahn Sch Med Mt Sinai;E China Univ Sci & Technol;Shandong Dongeejiao Grp
- 来源：JOURNAL OF ETHNOPHARMACOLOGY 2016
- 关键词：Colla Corii Asini E-jiao Traditional Chinese medicine Anemia Hematopoiesis Cancer
- 质疑
- Regulation of Vibrio alginolyticus virulence by the LuxS quorum-sensing system被引量：59收藏
- 作者：Ye, J. Ma, Y. Liu, Q. Zhao, D. L. Wang, Q. Y. Zhang, Y. X.
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF FISH DISEASES 2008
- 关键词：autoinducer AI-2 luxS quorum sensing Vibrio alginolyticus virulence
- 质疑
- RNA-seq liver transcriptome analysis reveals an activated MHC-I pathway and an inhibited MHC-II pathway at the early stage of vaccine immunization in zebrafish被引量：58收藏
- 作者：Yang, Dahai Liu, Qin Yang, Minjun Wu, Haizhen Wang, Qiyao Xiao, Jingfan Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：BMC GENOMICS 2012
- 质疑
- Characterization of two TonB systems in marine fish pathogen Vibrio alginolyticus:: their roles in iron utilization and virulence被引量：56收藏
- 作者：Wang, Qiyao Liu, Qin Cao, Xiaodan Yang, Minjun Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：ARCHIVES OF MICROBIOLOGY 2008
- 关键词：iron transportation TonB system Vibrio alginolyticus virulence
- 质疑
