周勉 收藏
( 任职于 生物工程学院)
生物工程专业：硕士生导师 生物化学与分子生物学专业：硕士生导师 生物工程领域：工程硕士导师 周勉，博士，副教授，硕士生导师。2009年毕业于南京大学生命科学院生物技术专业，获理学学士学位。同年赴美国德克萨斯大学西南医学中心（UT Southwestern Medical Center at Dallas）生理学系攻读博士学位，从事密码子使用偏好对蛋白质表达、折叠、和功能影响的研究。2014年取得博士学位，研究成果发表在Nature，Molecular M... 详细>>
- Codon usage is an important determinant of gene expression levels largely through its effects on transcription被引量：333收藏
- 作者：Zhou, Zhipeng Dang, Yunkun Zhou, Mian Li, Lin Yu, Chien-hung Fu, Jingjing Chen, She Liu, Yi
- 机构：Univ Texas Southwestern Med Ctr Dallas;East China Univ Sci & Technol;Natl Inst Biol Sci
- 来源：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2016
- 关键词：Neurospora codon usage transcription
- 质疑
- Addressing MRSA infection and antibacterial resistance with peptoid polymers被引量：236收藏
- 作者：Xie, Jiayang Zhou, Min Qian, Yuxin Cong, Zihao Chen, Sheng Zhang, Wenjing Jiang, Weinan Dai, Chengzhi Shao, Ning Ji, Zhemin Zou, Jingcheng Xiao, Ximian Liu, Longqiang Chen, Minzhang Li, Jin Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：NATURE COMMUNICATIONS 2021
- 质疑
- Poly(2-Oxazoline)-Based Functional Peptide Mimics: Eradicating MRSA Infections and Persisters while Alleviating Antimicrobial Resistance被引量：229收藏
- 作者：Zhou, Min Qian, Yuxin Xie, Jiayang Zhang, Wenjing Jiang, Weinan Xiao, Ximian Chen, Sheng Dai, Chengzhi Cong, Zihao Ji, Zhemin Shao, Ning Liu, Longqiang Wu, Yuequn Liu, Runhui
- 机构：East China Univ Sci & Technol
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2020
- 关键词：antibiotics antimicrobials drug design peptides polymers
- 质疑
- Ectopic Osteogenesis of Macroscopic Tissue Constructs Assembled from Human Mesenchymal Stem Cell-Laden Microcarriers through In Vitro Perfusion Culture被引量：148收藏
- 作者：Chen, Maiqin Zhou, Min Ye, Zhaoyang Zhou, Yan Tan, Wen-Song
- 机构：E China Univ Sci & Technol
- 来源：PLOS ONE 2014
- 质疑
- Mit1 Transcription Factor Mediates Methanol Signaling and Regulates the Alcohol Oxidase 1 (AOX1) Promoter in Pichia pastoris被引量：95收藏
- 作者：Wang, Xiaolong Wang, Qi Wang, Jinjia Bai, Peng Shi, Lei Shen, Wei Zhou, Mian Zhou, Xiangshan Zhang, Yuanxing Cai, Menghao
- 机构：E China Univ Sci & Technol;SCICB
- 来源：JOURNAL OF BIOLOGICAL CHEMISTRY 2016
- 关键词：DNA-protein interaction protein domain signal transduction transcription coactivator transcription regulation AOX1 promoter Mit1 Pichia pastoris glycerol repression methanol induction
- 质疑
- Host defense peptide mimicking poly--peptides with fast, potent and broad spectrum antibacterial activities被引量：94收藏
- 作者：Zhang, Qiang Ma, Pengcheng Xie, Jiayang Zhang, Si Xiao, Ximian Qiao, Zhongqian Shao, Ning Zhou, Min Zhang, Wenjing Dai, Chengzhi Qian, Yuxin Qi, Fan Liu, Runhui
- 机构：East China Univ Sci & Technol
- 来源：BIOMATERIALS SCIENCE 2019
- 关键词：Antibiotics - Bacteria - Mammals - Antimicrobial agents - Network security
- 质疑
- Short Guanidinium-Functionalized Poly(2-oxazoline)s Displaying Potent Therapeutic Efficacy on Drug-Resistant Fungal Infections被引量：84收藏
- 作者：Jiang, Weinan Zhou, Min Cong, Zihao Xie, Jiayang Zhang, Wenjing Chen, Sheng Zou, Jingcheng Ji, Zhemin Shao, Ning Chen, Xin Li, Maoquan Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Tongji Univ
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2022
- 关键词：Antifungal Polymers Drug-Resistant Fungi Guanidinium-Pendent Peptidomimetics Poly(2-oxazoline)s
- 质疑
- Practical Preparation of Infection-Resistant Biomedical Surfaces from Antimicrobial β-Peptide Polymers被引量：83收藏
- 作者：Qi, Fan Qian, Yuxin Shao, Ning Zhou, Ruiyi Zhang, Si Lu, Ziyi Zhou, Min Xie, Jiayang Wei, Ting Yu, Qian Liu, Runhui
- 机构：East China Univ Sci & Technol;Soochow Univ
- 来源：ACS APPLIED MATERIALS & INTERFACES 2019
- 关键词：beta-peptide polymer host defense peptide antimicrobial surface MRSA subcutaneous infection
- 质疑
- Nonoptimal codon usage influences protein structure in intrinsically disordered regions被引量：77收藏
- 作者：Zhou, Mian Wang, Tao Fu, Jingjing Xiao, Guanghua Liu, Yi
- 机构：Univ Texas SW Med Ctr Dallas;Univ Texas SW Med Ctr Dallas;E China Univ Sci & Technol
- 来源：MOLECULAR MICROBIOLOGY 2015
- 质疑
- Heterochiral β-Peptide Polymers Combating Multidrug-Resistant Cancers Effectively without Inducing Drug Resistance被引量：67收藏
- 作者：Shao, Ning Yuan, Ling Ma, Pengcheng Zhou, Min Xiao, Ximian Cong, Zihao Wu, Yueming Xiao, Guohui Fei, Jian Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2022
- 关键词：Diseases - Biocompatibility - Cancer cells - Tumors
- 质疑
- Water-Insensitive Synthesis of Poly-β-Peptides with Defined Architecture被引量：66收藏
- 作者：Zhou, Min Xiao, Ximian Cong, Zihao Wu, Yueming Zhang, Wenjing Ma, Pengcheng Chen, Sheng Zhang, Haodong Zhang, Danfeng Zhang, Donghui Luan, Xiangfeng Mai, Yiyong Liu, Runhui
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2020
- 关键词：polymerization poly-beta-peptides secondary structure water-insensitive polymerization beta-NTA
- 质疑
- A dual-targeting antifungal is effective against multidrug-resistant human fungal pathogens被引量：61收藏
- 作者：Zhou, Min Liu, Longqiang Cong, Zihao Jiang, Weinan Xiao, Ximian Xie, Jiayang Luo, Zhengjie Chen, Sheng Wu, Yueming Xue, Xinying Shao, Ning Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Capital Med Univ;Shandong Second Med Univ
- 来源：NATURE MICROBIOLOGY 2024
- 质疑
- A novel methanol-free Pichia pastoris system for recombinant protein expression被引量：60收藏
- 作者：Shen, Wei Xue, Ying Liu, Yiqi Kong, Chuixing Wang, Xiaolong Huang, Mengmeng Cai, Menghao Zhou, Xiangshan Zhang, Yuanxing Zhou, Mian
- 机构：East China Univ Sci & Technol;SCICB
- 来源：MICROBIAL CELL FACTORIES 2016
- 关键词：Recombination protein expression AOX1 promoter Dihydroxyacetone GUT1 DAK Pichia pastoris
- 质疑
- Codon usage affects the structure and function of the Drosophila circadian clock protein PERIOD被引量：51收藏
- 作者：Fu, Jingjing Murphy, Katherine A. Zhou, Mian Li, Ying H. Lam, Vu H. Tabuloc, Christine A. Chiu, Joanna C. Liu, Yi
- 机构：Univ Texas Southwestern Med Ctr Dallas;Univ Calif Davis;East China Univ Sci & Technol
- 来源：GENES & DEVELOPMENT 2016
- 关键词：circadian clock codon usage Drosophila period protein structure
- 质疑
- Codon usage biases co-evolve with transcription termination machinery to suppress premature cleavage and polyadenylation被引量：47收藏
- 作者：Zhou, Zhipeng Dang, Yunkun Zhou, Mian Yuan, Haiyan Liu, Yi
- 机构：Univ Texas Southwestern Med Ctr Dallas;Yunnan Univ;Yunnan Univ;East China Univ Sci & Technol
- 来源：ELIFE 2018
- 质疑
- Microbial Metabolite Inspired β-Peptide Polymers Displaying Potent and Selective Antifungal Activity被引量：41收藏
- 作者：Zhang, Donghui Shi, Chao Cong, Zihao Chen, Qi Bi, Yufang Zhang, Junyu Ma, Kaiqian Liu, Shiqi Gu, Jiawei Chen, Minzhang Lu, Ziyi Zhang, Haodong Xie, Jiayang Xiao, Ximian Liu, Longqiang Jiang, Weinan Shao, Ning Chen, Sheng Zhou, Min Shao, Xiaoyan Dai, Yidong Li, Maoquan Zhang, Lixin Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Ruijin Rehabil Hosp;Tongji Univ
- 来源：ADVANCED SCIENCE 2022
- 关键词：antifungal agents fungal keratitis host defense peptide mimicking poly(DL-diaminopropionic acid) beta-peptide polymers
- 质疑
- Codon usage bias regulates gene expression and protein conformation in yeast expression system P. pastoris被引量：40收藏
- 作者：Xu, Yichun Liu, Kunshan Han, Yu Xing, Yanzi Zhang, Yuanxing Yang, Qiuying Zhou, Mian
- 机构：East China Univ Sci & Technol;Hubei Univ
- 来源：MICROBIAL CELL FACTORIES 2021
- 关键词：Codon bias P pastoris Protein expression Conformation
- 质疑
- PpNrg1 is a transcriptional repressor for glucose and glycerol repression of AOX1 promoter in methylotrophic yeast Pichia pastoris被引量：38收藏
- 作者：Wang, Xiaolong Cai, Menghao Shi, Lei Wang, Qi Zhu, Jinxiang Wang, Jinjia Zhou, Mian Zhou, Xiangshan Zhang, Yuanxing
- 机构：E China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：BIOTECHNOLOGY LETTERS 2016
- 关键词：AOX1 promoter Catabolite repression Glucose Glycerol PpNrg1 Pichia pastoris Transcriptional regulation
- 质疑
- Identification and characterization of novel promoters for recombinant protein production in yeast Pichia pastoris被引量：37收藏
- 作者：Xu, Ning Zhu, Jinxiang Zhu, Qiaoyun Xing, Yanzi Cai, Menghao Jiang, Tianyi Zhou, Mian Zhang, Yuanxing
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg;Roche R&D Ctr China Ltd
- 来源：YEAST 2018
- 关键词：carbon source Pichia pastoris promoter recombinant protein expression
- 质疑
- Breaking or following the membrane-targeting mechanism: Exploring the antibacterial mechanism of host defense peptide mimicking poly(2-oxazoline)s被引量：36收藏
- 作者：Dai, Chengzhi Zhou, Min Jiang, Weinan Xiao, Ximian Zou, Jingcheng Qian, Yuxin Cong, Zihao Ji, Zhemin Liu, Longqiang Xie, Jiayang Qiao, Zhongqian Liu, Runhui
- 机构：East China Univ Sci & Technol;Fudan Univ
- 来源：JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 2020
- 关键词：Poly(2-oxazoline) Host defense peptide Antibacterial mechanism Membrane-targeting Antimicrobial resistance
- 质疑
- Peptide-Mimicking Poly(2-oxazoline)s Displaying Potent Antimicrobial Properties被引量：34收藏
- 作者：Zhou, Min Jiang, Weinan Xie, Jiayang Zhang, Wenjing Ji, Zhemin Zou, Jingcheng Cong, Zihao Xiao, Ximian Gu, Jiawei Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CHEMMEDCHEM 2021
- 关键词：poly(2-oxazoline) peptide mimicking host defense peptide antimicrobial resistance antibacterial mechanism
- 质疑
- Fabrication of viable and functional pre-vascularized modular bone tissues by coculturing MSCs and HUVECs on microcarriers in spinner flasks被引量：30收藏
- 作者：Zhang, Songjie Zhou, Min Ye, Zhaoyang Zhou, Yan Tan, Wen-Song
- 机构：East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY JOURNAL 2017
- 关键词：Bone tissue engineering Endothelial cells Mesenchymal stem cells Microcarriers Vascularization
- 质疑
- Serine/threonine kinase PpkA coordinates the interplay between T6SS2 activation and quorum sensing in the marine pathogen Vibrio alginolyticus被引量：28收藏
- 作者：Yang, Zhen Zhou, Xiaohui Ma, Yue Zhou, Mian Waldor, Matthew K. Zhang, Yuanxing Wang, Qiyao
- 机构：East China Univ Sci & Technol;Qingdao Natl Lab Marine Sci & Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines;Univ Connecticut;Harvard Med Sch
- 来源：ENVIRONMENTAL MICROBIOLOGY 2018
- 质疑
- Synthesis of poly-α/β-peptides with tunable sequence via the copolymerization on N-carboxyanhydride and N-thiocarboxyanhydride被引量：27收藏
- 作者：Zhou, Min Zou, Jingcheng Liu, Longqiang Xiao, Ximian Deng, Shuai Wu, Yueming Xie, Jiayang Cong, Zihao Ji, Zhemin Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ISCIENCE 2021
- 质疑
- Genome-Wide Determination of Gene Essentiality by Transposon Insertion Sequencing in Yeast Pichia pastoris被引量：23收藏
- 作者：Zhu, Jinxiang Gong, Ruiqing Zhu, Qiaoyun He, Qiulin Xu, Ning Xu, Yichun Cai, Menghao Zhou, Xiangshan Zhang, Yuanxing Zhou, Mian
- 机构：East China Univ Sci & Technol;SCICB
- 来源：SCIENTIFIC REPORTS 2018
- 质疑
- Statistic Copolymers Working as Growth Factor-Binding Mimics of Fibronectin被引量：23收藏
- 作者：Zhang, Wenjing Wu, Yueming Chen, Qi Zhang, Haodong Zhou, Min Chen, Kang Cao, Chuntao Guo, Han Xu, Jianrong Liu, Honglai Lin, Haodong Liu, Changsheng Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Shanghai Univ Tradit Chinese Med;East China Univ Sci & Technol
- 来源：ADVANCED SCIENCE 2022
- 关键词：fibronectin mimicking growth factor binding statistic copolymers
- 质疑
- Kinase Screening in Pichia pastoris Identified Promising Targets Involved in Cell Growth and Alcohol Oxidase 1 Promoter (PAOX1) Regulation被引量：22收藏
- 作者：Shen, Wei Kong, Chuixing Xue, Ying Liu, Yiqi Cai, Menghao Zhang, Yuanxing Jiang, Tianyi Zhou, Xiangshan Zhou, Mian
- 机构：East China Univ Sci & Technol;SCICB;Roche R&D Ctr China Ltd
- 来源：PLOS ONE 2016
- 质疑
- AI-guided few-shot inverse design of HDP-mimicking polymers against drug-resistant bacteria被引量：22收藏
- 作者：Wu, Tianyu Zhou, Min Zou, Jingcheng Chen, Qi Qian, Feng Kurths, Juergen Liu, Runhui Tang, Yang
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Potsdam Inst Climate Impact Res PIK;Humboldt Univ
- 来源：NATURE COMMUNICATIONS 2024
- 质疑
- Biodegradable peptide polymers as alternatives to antibiotics used in aquaculture被引量：19收藏
- 作者：Ma, Pengcheng Wu, Yueming Jiang, Weinan Shao, Ning Zhou, Min Chen, Yuan Xie, Jiayang Qiao, Zhongqian Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOMATERIALS SCIENCE 2022
- 关键词：Antibiotics - Aquaculture - Bacteria - Biodegradable polymers - Disease control
- 质疑
- De novo biosynthesis of 2′-fucosyllactose in engineered Pichia pastoris被引量：18收藏
- 作者：Qian, Difan Zhang, Chunyue Deng, Chen Zhou, Mian Fan, Liqiang Zhao, Liming
- 机构：East China Univ Sci & Technol;Shanghai Changzheng Hosp;Shanghai Collaborat Innovat Ctr Biomfg Technol SCI
- 来源：BIOTECHNOLOGY LETTERS 2023
- 关键词：Biosynthesis 2 '-Fucosyllactose Human milk oligosaccharides Pichia pastoris
- 质疑
