王启要 收藏
( 任职于 生物工程学院)
生物工程专业：博士生导师/硕士生导师 生物化学与分子生物学：博士生导师/硕士生导师 微生物学：硕士生导师 生物工程领域：工程硕士生导师 王启要，博士，生物反应器工程国家重点实验室教授，博士生导师。现任华东理工大学生物工程学院副院长。青岛海洋科学与技术国家实验室兼职研究员。国家现代农业产业技术体系病害防控岗位科学家和功能室主任，第二届农业部水产养殖病害防治专家委员会委员。2013.12-2014.12，美国哈佛医学院/霍华德·休斯医学研究院Matthew K. Waldor教授实验室访问学者。Microbiological R... 详细>>
被引量：4,745H指数：38SCI-EXPANDED： 188 EI： 52 北大核心： 14 CSSCI： 2 CSCD： 8
- Genome Sequence of the Versatile Fish Pathogen Edwardsiella tarda Provides Insights into its Adaptation to Broad Host Ranges and Intracellular Niches被引量：208收藏
- 作者：Wang, Qiyao Yang, Minjun Xiao, Jingfan Wu, Haizhen Wang, Xin Lv, Yuanzhi Xu, Lili Zheng, Huajun Wang, Shengyue Zhao, Guoping Liu, Qin Zhang, Yuanxing
- 机构：
- 来源：PLOS ONE 2009
- 质疑
- Edwardsiella piscicida: A versatile emerging pathogen of fish被引量：148收藏
- 作者：Leung, Ka Yin Wang, Qiyao Yang, Zhiyun Siame, Bupe A.
- 机构：Guangdong Technion Israel Inst Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Trinity Western Univ
- 来源：VIRULENCE 2019
- 关键词：Edwardsiella piscicida T3SS/T6SS and effectors intracellular and systemic infection resistome virulence mechanisms
- 质疑
- Phylogenomics characterization of a highly virulent Edwardsiella strain ET080813T encoding two distinct T3SS and three T6SS gene clusters: Propose a novel species as Edwardsiella anguillarum sp nov.被引量：126收藏
- 作者：Shao, Shuai Lai, Qiliang Liu, Qin Wu, Haizhen Xiao, Jingfan Shao, Zongze Wang, Qiyao Zhang, Yuanxing
- 机构：E China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol;State Key Lab Breeding Base Marine Genet Resource;SOA;Key Lab Marine Genet Resources Fujian Prov
- 来源：SYSTEMATIC AND APPLIED MICROBIOLOGY 2015
- 关键词：Edwardsiella anguillarum sp nov. Taxonomy MLST DOH Phylogenomics
- 质疑
- Isolation and identification of fish pathogen Edwardsiella tarda from mariculture in China被引量：119收藏
- 作者：Xiao, Jingfan Wang, Qiyao Liu, Qin Wang, Xin Liu, Huan Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：AQUACULTURE RESEARCH 2008
- 关键词：antibiotics susceptibility aquaculture chloramphenicol resistance Edwardsiella tarda pathogenicity
- 质疑
- Edwardsiella tarda T6SS component evpP is regulated by esrB and iron, and plays essential roles in the invasion of fish被引量：89收藏
- 作者：Wang, Xin Wang, Qiyao Xiao, Jingfan Liu, Qin Wu, Haizhen Xu, Lili Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：FISH & SHELLFISH IMMUNOLOGY 2009
- 关键词：Edwardsiella tarda evpP esrB Iron Invasion
- 质疑
- CRISPR-Cas9-mediated genomic multiloci integration in Pichia pastoris被引量：89收藏
- 作者：Liu, Qi Shi, Xiaona Song, Lili Liu, Haifeng Zhou, Xiangshan Wang, Qiyao Zhang, Yuanxing Cai, Menghao
- 机构：East China Univ Sci & Technol;Chinare Resources Angde Biotech Pharmaceut Co Ltd;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：MICROBIAL CELL FACTORIES 2019
- 关键词：Pichia pastoris CRISPR-Cas9 Homology directed repair Multiloci integration Multistep enzymatic pathway
- 质疑
- Edwardsiella Comparative Phylogenomics Reveal the New Intra/Inter-Species Taxonomic Relationships, Virulence Evolution and Niche Adaptation Mechanisms被引量：86收藏
- 作者：Yang, Minjun Lv, Yuanzhi Xiao, Jingfan Wu, Haizhen Zheng, Huajun Liu, Qin Zhang, Yuanxing Wang, Qiyao
- 机构：E China Univ Sci & Technol;Chinese Natl Human Genome Ctr Shanghai
- 来源：PLOS ONE 2012
- 质疑
- QseBC controls flagellar motility, fimbrial hemagglutination and intracellular virulence in fish pathogen Edwardsiella tarda被引量：78收藏
- 作者：Wang, Xin Wang, Qiyao Yang, Minjun Xiao, Jingfan Liu, Qin Wu, Haizhen Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：FISH & SHELLFISH IMMUNOLOGY 2011
- 关键词：Edwardsiella tarda QesBC Motililty Hemagglutination Virulence
- 质疑
- Gene Silencing Through CRISPR Interference in Bacteria: Current Advances and Future Prospects被引量：75收藏
- 作者：Zhang, Riyu Xu, Wensheng Shao, Shuai Wang, Qiyao
- 机构：East China Univ Sci & Technol;Beijing Agr Univ;Shanghai Collaborat Innovat Ctr Biomfg;Shanghai Engn Res Ctr Maricultured Anim Vaccines
- 来源：FRONTIERS IN MICROBIOLOGY 2021
- 关键词：CRISPR Cas gene silencing essential genes Tn-seq CRISPRi screen
- 质疑
- Gene expression profiling in live attenuated Edwardsiella tarda vaccine immunized and challenged zebrafish: Insights into the basic mechanisms of protection seen in immunized fish被引量：71收藏
- 作者：Yang, Dahai Liu, Qin Ni, Chunshan Li, Shuai Wu, Haizhen Wang, Qiyao Xiao, Jinfan Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 2013
- 关键词：Zebrafish Edwardsiella tarda Live attenuated vaccine Immune responses CTLs
- 质疑
- A σE-Mediated Temperature Gauge Controls a Switch from LuxR-Mediated Virulence Gene Expression to Thermal Stress Adaptation in Vibrio alginolyticus被引量：68收藏
- 作者：Gu, Dan Guo, Min Yang, Minjun Zhang, Yuanxing Zhou, Xiaohui Wang, Qiyao
- 机构：East China Univ Sci & Technol;Chinese Natl Human Genome Ctr Shanghai;Shanghai Collaborat Innovat Ctr Biomfg Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines;Univ Connecticut
- 来源：PLOS PATHOGENS 2016
- 质疑
- Immune responses of zebrafish (Danio rerio) induced by bath-vaccination with a live attenuated Vibrio anguillarum vaccine candidate被引量：65收藏
- 作者：Zhang, Zhihui Wu, Haizhen Xiao, Jingfan Wang, Qiyao Liu, Qin Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：FISH & SHELLFISH IMMUNOLOGY 2012
- 关键词：Bath-vaccination Danio rerio Immunoprotection Live attenuated vaccine Vibrio anguillarum
- 质疑
- Roles of LuxR in regulating extracellular alkaline serine protease A, extracellular polysaccharide and mobility of Vibrio alginolyticus被引量：63收藏
- 作者：Rui, Haopeng Liu, Qin Ma, Yue Wang, Qiyao Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：FEMS MICROBIOLOGY LETTERS 2008
- 关键词：Vibrio alginolyticus quorum sensing LuxR(val) ProA collagenase extracellular protease
- 质疑
- Characterization of Edwardsiella tarda rpoS: effect on serum resistance, chondroitinase activity, biofilm formation, and autoinducer synthetases expression被引量：62收藏
- 作者：Xiao, Jingfan Wang, Qiyao Liu, Qin Xu, Lili Wang, Xin Wu, Haizhen Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2009
- 关键词：Edwardsiella tarda Chondroitinase rpoS Virulence Quorum sensing
- 质疑
- leSensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zbrafish被引量：61收藏
- 作者：Yang, Dahai Zheng, Xin Chen, Shouwen Wang, Zhuang Xu, Wenting Tan, Jinchao Hu, Tianjian Hou, Mingyu Wang, Wenhui Gu, Zhaoyan Wang, Qiyao Zhang, Ruilin Zhang, Yuanxing Liu, Qin
- 机构：East China Univ Sci & Technol;Qingdao Natl Lab Marine Sci & Technol;Shanghai Engn Res Ctr Marine Cultured Anim Vaccin;Shanghai Collaborat Innovat Ctr Biomfg;Fudan Univ
- 来源：NATURE COMMUNICATIONS 2018
- 质疑
- Sensor histidine kinase is a β-lactam receptor and induces resistance to β-lactam antibiotics被引量：61收藏
- 作者：Li, Lu Wang, Qiyao Zhang, Hui Yang, Minjun Khan, Mazhar I. Zhou, Xiaohui
- 机构：Univ Connecticut;E China Univ Sci & Technol;Jiangsu Acad Agr Sci;Chinese Natl Human Genome Ctr Shanghai
- 来源：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2016
- 关键词：Vibrio histidine kinase beta-lactam receptor beta-lactamase
- 质疑
- Role of Alkaline Serine Protease, Asp, in Vibrio alginolyticus Virulence and Regulation of Its Expression by LuxO-LuxR Regulatory System被引量：60收藏
- 作者：Rui Haopeng Liu, Qin Wang, Qiyao Ma, Yue Liu, Huan Shi, Cunbin Zhang, Yuanxing
- 机构：E China Univ Sci & Technol;Chinese Acad Fishery Sci
- 来源：JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY 2009
- 关键词：Alkaline serine protease asp quorum sensing Vibrio alginolyticus
- 质疑
- Regulation of Vibrio alginolyticus virulence by the LuxS quorum-sensing system被引量：59收藏
- 作者：Ye, J. Ma, Y. Liu, Q. Zhao, D. L. Wang, Q. Y. Zhang, Y. X.
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF FISH DISEASES 2008
- 关键词：autoinducer AI-2 luxS quorum sensing Vibrio alginolyticus virulence
- 质疑
- RNA-seq liver transcriptome analysis reveals an activated MHC-I pathway and an inhibited MHC-II pathway at the early stage of vaccine immunization in zebrafish被引量：58收藏
- 作者：Yang, Dahai Liu, Qin Yang, Minjun Wu, Haizhen Wang, Qiyao Xiao, Jingfan Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：BMC GENOMICS 2012
- 质疑
- Characterization of two TonB systems in marine fish pathogen Vibrio alginolyticus:: their roles in iron utilization and virulence被引量：56收藏
- 作者：Wang, Qiyao Liu, Qin Cao, Xiaodan Yang, Minjun Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：ARCHIVES OF MICROBIOLOGY 2008
- 关键词：iron transportation TonB system Vibrio alginolyticus virulence
- 质疑
- Hemolysin EthA in Edwardsiella tarda is essential for fish invasion in vivo and in vitro and regulated by two-component system EsrA-EsrB and nucleoid protein HhaEt被引量：56收藏
- 作者：Wang, Xin Wang, Qiyao Xiao, Jingfan Liu, Qin Wu, Haizhen Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：FISH & SHELLFISH IMMUNOLOGY 2010
- 关键词：Edwardsiella tarda Hemolysin EthA esrB hha(Et)
- 质疑
- Transcriptomic dissection of the horizontally acquired response regulator EsrB reveals its global regulatory roles in the physiological adaptation and activation of T3SS and the cognate effector repertoire in Edwardsiella piscicida during infection toward turbot被引量：56收藏
- 作者：Liu, Yang Zhao, Luyao Yang, Minjun Yin, Kaiyu Zhou, Xiaohui Leung, Ka Yin Liu, Qin Zhang, Yuanxing Wang, Qiyao
- 机构：East China Univ Sci & Technol;Chinese Natl Human Genome Ctr Shanghai;Univ Connecticut;Trinity Western Univ;Shanghai Engn Res Ctr Maricultured Anim Vaccines
- 来源：VIRULENCE 2017
- 关键词：Edwardsiella piscicida effectors EsrB RNA-seq T3SS T6SS
- 质疑
- Transcriptome Profiling Reveals Th17-Like Immune Responses Induced in Zebrafish Bath-Vaccinated with a Live Attenuated Vibrio anguillarum被引量：54收藏
- 作者：Zhang, Hua Fei, Chao Wu, Haizhen Yang, Minjun Liu, Qin Wang, Qiyao Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：PLOS ONE 2013
- 质疑
- Systematic mutation analysis of two-component signal transduction systems reveals EsrA-EsrB and PhoP-PhoQ as the major virulence regulators in Edwardsiella tarda被引量：53收藏
- 作者：Lv, Yuanzhi Xiao, Jingfan Liu, Qin Wu, Haizhen Zhang, Yuanxing Wang, Qiyao
- 机构：E China Univ Sci & Technol
- 来源：VETERINARY MICROBIOLOGY 2012
- 关键词：Edwardsiella tarda Two-component system Virulence EsrB PhoP Antimicrobial peptide
- 质疑
- Dysregulated hemolysin liberates bacteria outer membrane vesicles for cytosolic lipopolysaccharide sensing被引量：52收藏
- 作者：Chen, Shouwen Yang, Dahai Wen, Ying Jiang, Zhiwei Zhang, Lingzhi Jiang, Jiatiao Chen, Yaozhen Hu, Tianjian Wang, Qiyao Zhang, Yuanxing Liu, Qin
- 机构：East China Univ Sci & Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines;Univ Michigan;Univ Michigan;Xijing Hosp
- 来源：PLOS PATHOGENS 2018
- 质疑
- Critical role for a promoter discriminator in RpoS control of virulence in Edwardsiella piscicida被引量：51收藏
- 作者：Yin, Kaiyu Guan, Yunpeng Ma, Ruiqing Wei, Lifan Liu, Bing Liu, Xiaohong Zhou, Xiangshan Ma, Yue Zhang, Yuanxing Waldor, Matthew K. Wang, Qiyao
- 机构：East China Univ Sci & Technol;Qingdao Natl Lab Marine Sci & Technol;East China Univ Sci & Technol;Univ Autonoma Barcelona;Brigham & Womens Hosp
- 来源：PLOS PATHOGENS 2018
- 质疑
- Involvement of LuxS in the regulation of motility and flagella biogenesis in Vibrio alginolyticus被引量：51收藏
- 作者：Tian, Yang Wang, Qiyao Liu, Qin Ma, Yue Cao, Xiaodan Guan, Lingyu Zhang, Yuanxing
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Bioscience, Biotechnology and Biochemistry 2008
- 关键词：Bacteria - Bioassay - Gene expression - Real time control
- 质疑
- Roles of Hfq in the stress adaptation and virulence in fish pathogen Vibrio alginolyticus and its potential application as a target for live attenuated vaccine被引量：49收藏
- 作者：Liu, Huan Wang, Qiyao Liu, Qin Cao, Xiaodan Shi, Cunbin Zhang, Yuanxing
- 机构：E China Univ Sci & Technol;Chinese Acad Fishery Sci
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2011
- 关键词：Hfq Quorum sensing Stress resistance Extracellular protease Vibrio alginolyticus
- 质疑
- An invasive and low virulent Edwardsiella tarda esrB mutant promising as live attenuated vaccine in aquaculture被引量：49收藏
- 作者：Yang, Weizheng Wang, Lixia Zhang, Lingzhi Qu, Jiangbo Wang, Qiyao Zhang, Yuanxing
- 机构：E China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol;TianYuan Aquat Prod Co Ltd
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2015
- 关键词：Edwardsiella tarda T3SS T6SS esrB Invasive phenotype Vaccine
- 质疑
- Time-Resolved Transposon Insertion Sequencing Reveals Genome-Wide Fitness Dynamics during Infection被引量：48收藏
- 作者：Yang, Guanhua Billings, Gabriel Hubbard, Troy P. Park, Joseph S. Leung, Ka Yin Liu, Qin Davis, Brigid M. Zhang, Yuanxing Wang, Qiyao Waldor, Matthew K.
- 机构：East China Univ Sci & Technol;Qingdao Natl Lab Marine Sci & Technol;Dept Microbiol & Immunobiol;Harvard Med Sch;Howard Hughes Med Inst
- 来源：MBIO 2017
- 关键词：Edwardsiella piscicida live attenuated vaccine pattern analysis of conditional essentiality (PACE) transposon insertion sequencing fitness dynamics and profiles
- 质疑
