刘建文 收藏
( 任职于 药学院)
刘建文，1994年毕业于上海中医药大学获得医学博士学位；1995年应日本国科学技术厅邀请，作为STA Fellow在大阪生物科学研究所(Osaka Bioscience Institute)和日本理化学研究所(Institute of Physical and Chemical Research)进行客座研究。研究天然药物对血管内皮细胞纤溶活性因子的基因调空作用。2001年毕业于日本广岛大学(省立)遗传子制御工学研究室，研究自由基与癌转移的过程及实验药物干预的分子机理，获得应用生物科学博士学位。现主要研究方向：细胞周期阻滞及凋亡诱导剂的发现与作用机理研究；肿瘤细胞凋亡小分子RNA表达、调控... 详细>>
- Oxidative stress contributes to silica nanoparticle-induced cytotoxicity in human embryonic kidney cells被引量：262收藏
- 作者：Wang, Fen Gao, Feng Lan, Minbo Yuan, Huihui Huang, Yongping Liu, Jianwen
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：TOXICOLOGY IN VITRO 2009
- 关键词：Silica nanoparticles Cytotoxicity Oxidative stress
- 质疑
- Nano-SiO2 induces apoptosis via activation of p53 and Bax mediated by oxidative stress in human hepatic cell line被引量：170收藏
- 作者：Ye, Yiyi Liu, Jianwen Xu, Jianhe Sun, Lijuan Chen, Mingcang Lan, Minbo
- 机构：E China Univ Sci & Technol
- 来源：TOXICOLOGY IN VITRO 2010
- 关键词：Nano-SiO2 Oxidative stress Apoptosis p53 Bax Human hepatic cells
- 质疑
- A New Class of Naphthalimide-Based Antitumor Agents That Inhibit Topoisomerase II and Induce Lysosomal Membrane Permeabilization and Apoptosis被引量：153收藏
- 作者：Chen, Zhuo Liang, Xin Zhang, Huanying Xie, Hua Liu, Jianwen Xu, Yufang Zhu, Weiping Wang, Yi Wang, Xin Tan, Shaoying Kuang, Dong Qian, Xuhong
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2010
- 质疑
- MiR-139 inhibits invasion and metastasis of colorectal cancer by targeting the type I insulin-like growth factor receptor被引量：137收藏
- 作者：Shen, Ke Liang, Qiannan Xu, Ke Cui, Daling Jiang, Lin Yin, Peihao Lu, Yanhua Li, Qi Liu, Jianwen
- 机构：Putuo Hosp Shanghai Univ Tradit Chinese Med;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOCHEMICAL PHARMACOLOGY 2012
- 关键词：miR-139 CRC Metastasis Invasion IGF-IR
- 质疑
- MiR-27a-3p functions as an oncogene in gastric cancer by targeting BTG2被引量：124收藏
- 作者：Zhou, Lin Liang, Xin Zhang, Lingling Yang, Liyan Nagao, Norio Wu, Hongkun Liu, Chang Lin, Shengchao Cai, Guoxiang Liu, Jianwen
- 机构：Second Mil Med Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;Prefectural Univ Hiroshima;Fudan Univ
- 来源：ONCOTARGET 2016
- 关键词：miR-27a-3p apoptosis BTG2 gastric cancer cell proliferation
- 质疑
- Hesperidin Upregulates Heme Oxygenase-1 To Attenuate Hydrogen Peroxide-Induced Cell Damage in Hepatic L02 Cells被引量：110收藏
- 作者：Chen, Ming-cang Ye, Yi-yi Ji, Guang Liu, Jian-wen
- 机构：Shanghai Univ Tradit Chinese Med;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2010
- 关键词：Hesperidin heme oxygenase-1 (HO-1) mitogen-activated protein kinases (MAPK) nuclear factor erythroid 2 related factor (Nrf2) hydrogen peroxide (H2O2)
- 质疑
- miR-139-5p Inhibits the Epithelial-Mesenchymal Transition and Enhances the Chemotherapeutic Sensitivity of Colorectal Cancer Cells by Downregulating BCL2被引量：104收藏
- 作者：Li, Qingguo Liang, Xin Wang, Yuwei Meng, Xianke Xu, Ye Cai, Sanjun Wang, Zhimin Liu, Jianwen Cai, Guoxiang
- 机构：Fudan Univ;Fudan Univ;E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Natl Human Genome Ctr
- 来源：SCIENTIFIC REPORTS 2016
- 质疑
- Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression被引量：99收藏
- 作者：Chen, Nian-Hong Liu, Jian-Wen Zhong, Jian-Jiang
- 机构：Shanghai Jiao Tong Univ;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：PHARMACOLOGICAL REPORTS 2010
- 关键词：ganoderic acid T metastasis invasion MMP-9 uPA
- 质疑
- Protective effects of hesperidin against oxidative stress of tert-butyl hydroperoxide in human hepatocytes被引量：93收藏
- 作者：Chen, Mingcang Gu, Honggang Ye, Yiyi Lin, Bing Sun, Lijuan Deng, Weiping Zhang, Jingzhe Liu, Jianwen
- 机构：E China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med
- 来源：FOOD AND CHEMICAL TOXICOLOGY 2010
- 关键词：Hesperidin, Oxidative stress, tert-butyl hydroperoxide (t-BuOOH), heme oxygenase-1 (HO-1) Extracellular signal-regulated protein kinase 1/2 (ERK 1/2) Nuclear factor erythroid 2 related factor (Nrf2)
- 质疑
- Antimetastatic effect of prodigiosin through inhibition of tumor invasion被引量：90收藏
- 作者：Zhang, J Shen, YL Liu, JW Wei, DZ
- 机构：E China Univ Sci & Technol
- 来源：BIOCHEMICAL PHARMACOLOGY 2005
- 关键词：prodigiosin metastasis invasion MMPs RhoA
- 质疑
- In vitro toxicity of silica nanoparticles in myocardial cells被引量：90收藏
- 作者：Ye, Yiyi Liu, Jianwen Chen, Mingcang Sun, Lijuan Lan, Minbo
- 机构：E China Univ Sci & Technol; E China Univ Sci & Technol
- 来源：ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 2010
- 关键词：Silica nanoparticle Oxidative stress Cytotoxicity Myocardial cell
- 质疑
- Astragaloside IV inhibits progression of lung cancer by mediating immune function of Tregs and CTLs by interfering with IDO被引量：88收藏
- 作者：Zhang, Anle Zheng, Yuanhong Que, Zujun Zhang, Lingling Lin, Shengchao Vanminh Le Liu, Jianwen Tian, Jianhui
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med
- 来源：JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 2014
- 关键词：IDO AS-IV Immunotherapy Regulatory T cells Cytotoxic T lymphocytes
- 质疑
- Highly selective fluorescent chemosensor with red shift for cysteine in buffer solution and its bioimage: symmetrical naphthalimide aldehyde被引量：87收藏
- 作者：Duan, Liping Xu, Yufang Qian, Xuhong Wang, Fang Liu, Jianwen Cheng, Tanyu
- 机构：E China Univ Sci & Technol
- 来源：TETRAHEDRON LETTERS 2008
- 质疑
- miR-1915 inhibits Bcl-2 to modulate multidrug resistance by increasing drug-sensitivity in human colorectal carcinoma cells被引量：85收藏
- 作者：Xu, Ke Liang, Xin Cui, Daling Wu, Yixin Shi, Weibin Liu, Jianwen
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Hamamatsu Univ Sch Med;Shanghai Jiao Tong Univ
- 来源：MOLECULAR CARCINOGENESIS 2013
- 关键词：colorectal carcinoma multidrug-resistance microRNA Bcl-2 microRNA array
- 质疑
- Photodynamic-therapy Activates Immune Response by disrupting Immunity Homeostasis of Tumor Cells, which Generates Vaccine for Cancer Therapy被引量：83收藏
- 作者：Zheng, Yuanhong Yin, Guifang Le, Vanminh Zhang, Anle Chen, Siyu Liang, Xin Liu, Jianwen
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 2016
- 关键词：DAMPs Immunogenic apoptosis Antitumor vaccination Hypericin CD47
- 质疑
- Lnc-ATB contributes to gastric cancer growth through a MiR-141-3p/TGFβ2 feedback loop被引量：79收藏
- 作者：Lei, Kecheng Liang, Xin Gao, Yuwei Xu, Baixue Xu, Yichun Li, Yueqi Tao, Yiwen Shi, Weibin Liu, Jianwen
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Guangzhou Med Univ;Shanghai Jiao Tong Univ
- 来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2017
- 关键词：Gastric cancer lnc-ATB miR-141-3p TGF-beta
- 质疑
- Sulfur-substituted naphthalimides as photoactivatable anticancer agents: DNA interaction, fluorescence imaging, and phototoxic effects in cultured tumor cells被引量：76收藏
- 作者：Ott, Ingo Xu, Yufang Liu, Jianwen Kokoschka, Malte Harlos, Melanie Sheldrick, William S. Qian, Xuhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Free Univ Berlin;Ruhr Univ Bochum
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY 2008
- 关键词：antitumor drugs naphthalimides phototoxicity photodynamic therapy photoinduced electron transfer (PET)
- 质疑
- Resveratrol inhibits hypoxia-induced metastasis potential enhancement by restricting hypoxia-induced factor-1α expression in colon carcinoma cells被引量：74收藏
- 作者：Wu, Hongzhong Liang, Xin Fang, Yishi Qin, Xiaoran Zhang, Yuanxing Liu, Jianwen
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Chempartner Co Ltd
- 来源：BIOMEDICINE & PHARMACOTHERAPY 2008
- 关键词：Resveratrol Metastasis potential Colon carcinoma cell Hypoxia Hypoxia-induced factor-1 alpha
- 质疑
- Kaempferol-7-O-β-D-glucoside (KG) isolated from Smilax china L. rhizome induces G2/M phase arrest and apoptosis on HeLa cells in a p53-independent manner被引量：74收藏
- 作者：Xu, Wen Liu, Jianwen Li, Changlong Wu, He-Zhen Liu, Yan-Wen
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Hubei Coll Tradit Chinese Med
- 来源：CANCER LETTERS 2008
- 关键词：Smilux china L. Kaempferol-7-O-beta-D-glucoside G(2)/M phase arrest apoptosis HeLa human cervix carcinoma cells
- 质疑
- Network-based identification of microRNAs as potential pharmacogenomic biomarkers for anticancer drugs被引量：74收藏
- 作者：Li, Jie Lei, Kecheng Wu, Zengrui Li, Weihua Liu, Guixia Liu, Jianwen Cheng, Feixiong Tang, Yun
- 机构：East China Univ Sci & Technol;Sichuan Univ;Harvard Med Sch;Northeastern Univ
- 来源：ONCOTARGET 2016
- 关键词：pharmacogenomics miRNA network-based inference metformin breast cancer
- 质疑
- EpCAM Aptamer-Functionalized Cationic Liposome-Based Nanoparticles Loaded with miR-139-5p for Targeted Therapy in Colorectal Cancer被引量：74收藏
- 作者：Zhao, Yuyu Xu, Jiajun Van Minh Le Gong, Qianyi Li, Shaoyu Gao, Feng Ni, Lei Liu, Jianwen Liang, Xin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Natl Inst Med Mat;Xinjiang Med Univ
- 来源：MOLECULAR PHARMACEUTICS 2019
- 关键词：nanoparticle CRC targeted therapy miR-139-5p
- 质疑
- Preparation of polysaccharide derivates chitosan-graft-poly(ε-caprolactone) amphiphilic copolymer micelles for 5-fluorouracil drug delivery被引量：72收藏
- 作者：Gu, Chunhua Le, Vanminh Lang, Meidong Liu, Jianwen
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：COLLOIDS AND SURFACES B-BIOINTERFACES 2014
- 关键词：Chitosan Graft copolymer 5-Fluorouracil Drug delivery
- 质疑
- Self-assembly of mitochondria-specific peptide amphiphiles amplifying lung cancer cell death through targeting the VDAC1-hexokinase-II complex被引量：72收藏
- 作者：Liu, Dan Angelova, Angelina Liu, Jianwen Garamus, Vasil M. Angelov, Borislav Zhang, Xinlei Li, Yawen Feger, Guillaume Li, Na Zou, Aihua
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ Paris Saclay;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MATERIALS CHEMISTRY B 2019
- 关键词：Circular dichroism spectroscopy - Self assembly - Diseases - X ray scattering - Dichroism - Cell death - Peptides - Biological organs
- 质疑
- Downregulation of miR-155-5p enhances the anti-tumor effect of cetuximab on triple-negative breast cancer cells via inducing cell apoptosis and pyroptosis被引量：70收藏
- 作者：Xu, Wen Song, Changfeng Wang, Xiaotong Li, Yueqi Bai, Xue Liang, Xin Wu, Jingjing Liu, Jianwen
- 机构：East China Univ Sci & Technol;Shanghai Key Lab New Drug Design;Shanghai Univ TCM
- 来源：AGING-US 2021
- 关键词：triple-negative breast cancer microRNA 155-5p cetuximab apoptosis pyroptosis
- 质疑
- miR-297 modulates multidrug resistance in human colorectal carcinoma by down-regulating MRP-2被引量：69收藏
- 作者：Xu, Ke Liang, Xin Shen, Ke Cui, Daling Zheng, Yuanhong Xu, Jianhua Fan, Zhongze Qiu, Yanyan Li, Qi Ni, Lei Liu, Jianwen
- 机构：Shanghai Univ Tradit Chinese Med;Shanghai Univ Tradit Chinese Med;E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：BIOCHEMICAL JOURNAL 2012
- 关键词：colorectal carcinoma microRNA (miRNA) microRNA array multidrug resistance (MDR) multictrug resistance-associated protein 2 (MRP-2)
- 质疑
- MiR-320a is Downregulated in Patients with Myasthenia Gravis and Modulates Inflammatory Cytokines Production by Targeting Mitogen-activated Protein Kinase 1被引量：69收藏
- 作者：Cheng, Zhuoan Qiu, Shaobo Jiang, Lin Zhang, Anle Bao, Wenjing Liu, Ping Liu, Jianwen
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med;Liaoning Univ Tradit Chinese Med
- 来源：JOURNAL OF CLINICAL IMMUNOLOGY 2013
- 关键词：Myasthenia gravis miR-320a MAPK1 cytokine COX-2
- 质疑
- HDAC inhibitor DWP0016 suppresses miR-22 to induce growth inhibition and apoptosis via p53-independent PTEN activation in neuroblastoma SH-SY5Y cells被引量：66收藏
- 作者：Jin, Hui Liu, Lifeng Deng, Weiping Lu, Yanhua Tian, Jianhui Li, Hegeng Liu, Jianwen
- 机构： State Key Laboratory of Bioreactor Engineering; Department of Oncology; School of Life Sciences and Technology
- 来源：Process Biochemistry 2013
- 关键词：Acetylation - RNA
- 质疑
- MiR-222 modulates multidrug resistance in human colorectal carcinoma by down-regulating ADAM-17被引量：65收藏
- 作者：Xu, Ke Liang, Xin Shen, Ke Sun, Liyun Cui, Daling Zhao, Yuxia Tian, Jianhui Ni, Lei Liu, Jianwen
- 机构：Shanghai Univ Tradit Chinese Med;E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：EXPERIMENTAL CELL RESEARCH 2012
- 关键词：Colorectal carcinoma Multidrug-resistance (MDR) MiR-222 ADAM-17 TGF-alpha EGFR
- 质疑
- Photodynamic therapy induces autophagy-mediated cell death in human colorectal cancer cells via activation of the ROS/JNK signaling pathway被引量：65收藏
- 作者：Song, Changfeng Xu, Wen Wu, Hongkun Wang, Xiaotong Gong, Qianyi Liu, Chang Liu, Jianwen Zhou, Lin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Naval Med Univ
- 来源：CELL DEATH & DISEASE 2020
- 质疑
- miR-27a-3p regulates proliferation and apoptosis of colon cancer cells by potentially targeting BTG1被引量：64收藏
- 作者：Su, Chang Huang, Dong-Ping Liu, Jian-Wen Liu, Wei-Yan Cao, Yi-Ou
- 机构：Fudan Univ;Peoples Hosp Putuo Dist;East China Univ Sci & Technol
- 来源：ONCOLOGY LETTERS 2019
- 关键词：microRNA B-cell translocation gene 1 colorectal cancer
- 质疑
