成果/Result
- A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules被引量：378收藏
- 作者：Liang, Mindong Li, Zilong Wang, Weishan Liu, Jiakun Liu, Leshi Zhu, Guoliang Karthik, Loganathan Wang, Man Wang, Ke-Feng Wang, Zhong Yu, Jing Shuai, Yuting Yu, Jiaming Zhang, Lu Yang, Zhiheng Li, Chuan Zhang, Qian Shi, Tong Zhou, Liming Xie, Feng Dai, Huanqin Liu, Xueting Zhang, Jingyu Liu, Guang Zhuo, Ying Zhang, Buchang Liu, Chenli Li, Shanshan Xia, Xuekui Tong, Yaojun Liu, Yanwen Alterovitz, Gil Tan, Gao-Yi Zhang, Li-Xin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Anhui Univ;Chinese Acad Sci;Chinese Acad Sci
- 来源：NATURE COMMUNICATIONS 2019
- Interactions of graphene and graphene oxide with proteins and peptides被引量：207收藏
- 作者：Zhang, Yan Wu, Congyu Guo, Shouwu Zhang, Jingyan
- 机构：Shanghai Jiao Tong Univ;E China Univ Sci & Technol
- 来源：NANOTECHNOLOGY REVIEWS 2013
- 关键词：enzyme graphene graphene oxide interaction peptide protein
- Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces被引量：143收藏
- 作者：Wang, Weishan Li, Shanshan Li, Zilong Zhang, Jingyu Fan, Keqiang Tan, Gaoyi Ai, Guomin Lam, Sin Man Shui, Guanghou Yang, Zhiheng Lu, Hongzhong Jin, Pinjiao Li, Yihong Chen, Xiangyin Xia, Xuekui Liu, Xueting Dannelly, H. Kathleen Yang, Chen Yang, Yi Zhang, Siliang Alterovitz, Gil Xiang, Wensheng Zhang, Lixin
- 机构：Chinese Acad Sci;East China Univ Sci & Technol;Chinese Acad Agr Sci;Chinese Acad Sci;Qilu Univ Technol
- 来源：NATURE BIOTECHNOLOGY 2020
- 关键词：Ketones - Metabolism - Biochemistry - Bacteria - Metabolites - Glycerol
- DNA Cleavage System of Nanosized Graphene Oxide Sheets and Copper Ions被引量：127收藏
- 作者：Ren, Hongliu Wang, Chong Zhang, Jiali Zhou, Xuejiao Xu, Dafeng Zheng, Jing Guo, Shouwu Zhang, Jingyan
- 机构：Shanghai Jiao Tong Univ;E China Univ Sci & Technol
- 来源：ACS NANO 2010
- 关键词：graphene oxide DNA Intercalation DNA cleavage copper ion metal ions
- Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p被引量：58收藏
- 作者：Tong, Yaojun Zhang, Jingyu Sun, Nuo Wang, Xiang-Ming Wei, Qi Zhang, Yu Huang, Ren Pu, Yingying Dai, Huanqin Ren, Biao Pei, Gang Song, Fuhang Zhu, Guoliang Wang, Xinye Xia, Xuekui Chen, Xiangyin Jiang, Lan Wang, Shenlin Ouyang, Liming Xie, Ning Zhang, Buchang Jiang, Yuanying Liu, Xueting Calderone, Richard Bai, Fan Zhang, Lixin Alterovitz, Gil
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Peking Univ;Georgetown Univ
- 来源：SCIENCE BULLETIN 2021
- 关键词：Candida albicans Berberine Multidrug-resistance Drug excretion transporter Mitochondria
- Graphene quantum dots in photodynamic therapy被引量：49收藏
- 作者：Chen, Jiayi Wu, Wentian Zhang, Fangwei Zhang, Jiali Liu, Hui Zheng, Jing Guo, Shouwu Zhang, Jingyan
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：NANOSCALE ADVANCES 2020
- 关键词：Medical applications - Graphene - Irradiation - Photosensitizers - Nanocrystals - Semiconductor quantum dots - Aromatic compounds
- Effect of substrate (ZnO) morphology on enzyme immobilization and its catalytic activity被引量：41收藏
- 作者：Zhang, Yan Wu, Haixia Huang, Xuelei Zhang, Jingyan Guo, Shouwu
- 机构：Shanghai Jiao Tong Univ;E China Univ Sci & Technol
- 来源：NANOSCALE RESEARCH LETTERS 2011
- High-yield porphyrin production through metabolic engineering and biocatalysis被引量：34收藏
- 作者：Chen, Haihong Wang, Yaohong Wang, Weishan Cao, Ting Zhang, Lu Wang, Zhengduo Chi, Xuran Shi, Tong Wang, Huangwei He, Xinwei Liang, Mindong Yang, Mengxue Jiang, Wenyi Lv, Dongyuan Yu, Jiaming Zhu, Guoliang Xie, Yongtao Gao, Bei Wang, Xinye Liu, Xueting Li, Youyuan Ouyang, Limin Zhang, Jingyu Liu, Huimin Li, Zilong Tong, Yaojun Xia, Xuekui Tan, Gao-Yi Zhang, Lixin
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Shanghai Jiao Tong Univ;Qilu Univ Technol
- 来源：NATURE BIOTECHNOLOGY 2025
- 关键词：Catalysis - Diagnosis - Fermentation - Medical applications - Metabolic engineering
- Genome-Based Discovery of Enantiomeric Pentacyclic Sesterterpenes Catalyzed by Fungal Bifunctional Terpene Synthases被引量：33收藏
- 作者：Jiang, Lan Zhang, Xue Sato, Yuya Zhu, Guoliang Minami, Atsushi Zhang, Weiyan Ozaki, Taro Zhu, Bin Wang, Zhixin Wang, Xinye Lv, Kangjie Zhang, Jingyu Wang, Yongheng Gao, Shushan Liu, Chengwei Hsiang, Tom Zhang, Lixin Oikawa, Hideaki Liu, Xueting
- 机构：East China Univ Sci Technol;Hokkaido Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;Jinan Univ
- 来源：ORGANIC LETTERS 2021
- Genome-based mining of new antimicrobial meroterpenoids from the phytopathogenic fungus Bipolaris sorokiniana strain 11134被引量：32收藏
- 作者：Han, Jianying Zhang, Jingyu Song, Zhijun Zhu, Guoliang Liu, Miaomiao Dai, Huanqin Hsiang, Tom Liu, Xueting Zhang, Lixin Quinn, Ronald J. Feng, Yunjiang
- 机构：Griffith Univ;Chinese Acad Sci;East China Univ Sci & Technol;Univ Guelph
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Meroterpenoids Phytopathogenic fungus Bipolaris sorokiniana Genome-based mining Antimicrobial activity
- Coordination modes of bridge carboxylates in dinuclear manganese compounds determine their catalase-like activities被引量：31收藏
- 作者：Jiang, Xiaojun Liu, Hui Zheng, Bing Zhang, Jingyan
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：DALTON TRANSACTIONS 2009
- 关键词：Catalyst activity - Carboxylation - Manganese compounds - Ions - Electron spin resonance spectroscopy - Deprotonation - X ray diffraction
- A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137被引量：24收藏
- 作者：Zhang, Jingyu Li, Bixiao Qin, Yujie Karthik, Loganathan Zhu, Guoliang Hou, Chengjian Jiang, Lan Liu, Miaomiao Ye, Xin Liu, Mei Hsiang, Tom Dai, Huanqin Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Anhui Univ;Chinese Acad Sci;Sri Shakthi Inst Engn & Technol Autonomous;Griffith Univ
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Abyssomicin Proximicin Marine-derived Verrucosispora sp OSMAC Anti-influenza A virus
- Genome- and MS-based mining of antibacterial chlorinated chromones and xanthones from the phytopathogenic fungus Bipolaris sorokiniana strain 11134被引量：23收藏
- 作者：Han, Jianying Zhang, Jingyu Song, Zhijun Liu, Miaomiao Hu, Jiansen Hou, Chengjian Zhu, Guoliang Jiang, Lan Xia, Xuekui Quinn, Ronald J. Feng, Yunjiang Zhang, Lixin Hsiang, Tom Liu, Xueting
- 机构：Chinese Acad Sci;Griffith Univ;Univ Chinese Acad Sci;East China Univ Sci & Technol;Qilu Univ Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2019
- 关键词：Genome-based mining Halogenase Phytopathogenic fungus Bipolaris sorokiniana Antibacterial activity
- Recent advances in biotechnology for marine enzymes and molecules被引量：21收藏
- 作者：Zhang, Jingyu Jiang, Lan Chen, Xiangyin Lv, Kangjie Basiony, Mostafa Zhu, Guoliang Karthik, Loganathan Ouyang, Liming Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Salem Microbes Private Ltd
- 来源：CURRENT OPINION IN BIOTECHNOLOGY 2021
- 关键词：Synthetic biology - Ecosystems - Metabolic engineering - Marine applications - Molecules
- Molecular networking assisted discovery and biosynthesis elucidation of the antimicrobial spiroketals epicospirocins被引量：18收藏
- 作者：Zhu, Guoliang Hou, Chengjian Yuan, Weize Wang, Zhenzhen Zhang, Jingyu Jiang, Lan Karthik, Loganathan Li, Bixiao Ren, Biao Lv, Kangjie Lu, Wanying Cong, Zhanren Dai, Huanqin Hsiang, Tom Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Salem Microbes Private Ltd;Sichuan Univ;Sichuan Univ;Chinese Acad Sci
- 来源：CHEMICAL COMMUNICATIONS 2020
- 关键词：Biochemistry - Chirality
- Antibacterial polyene-polyol macrolides and cyclic peptides from the marine-derived Streptomyces sp. MS110128被引量：18收藏
- 作者：Jiang, Lan Huang, Pei Ren, Biao Song, Zhijun Zhu, Guoliang He, Wenni Zhang, Jingyu Oyeleye, Ayokunmi Dai, Huanqin Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Zunyi Med Univ;Sichuan Univ;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2021
- 关键词：Marine-derived Actinomycete Candida albicans Polyene Cyclic peptides
- Study of Pharmacokinetics for Ivermectin B1a from Beagle Dogs被引量：17收藏
- 作者：Chen, Yuyang Huang, Xiaofang Guo, Zizheng Zhang, Jingyu Zhang, Lixin Dai, Renke
- 机构： School of Pharmacy; Guangdong Ruigu Biotech Corporation; State Key Laboratory of Bioreactor Engineering
- 来源：Journal of Chromatographic Science 2025
- 关键词：Controlled drug delivery - Coronavirus - Pharmacokinetics - Pulmonary diseases
- Hyper-Synergistic Antifungal Activity of Rapamycin and Peptide-Like Compounds against Candida albicans Orthogonally via Tor1 Kinase被引量：16收藏
- 作者：Tong, Yaojun Zhang, Jingyu Wang, Luoqiang Wang, Qinqin Huang, Huang Chen, Xiangyin Zhang, Qing Li, Hantian Sun, Nuo Liu, Guang Zhang, Buchang Song, Fuhang Alterovitz, Gil Dai, Huanqin Zhang, Lixin
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Anhui Univ;Chinese Acad Sci;Georgetown Univ
- 来源：ACS INFECTIOUS DISEASES 2021
- 关键词：Candida albicans multidrug resistance rapamycin drug combination synergism TOR kinase
- Genome-guided investigation of anti-inflammatory sesterterpenoids with 5-15 trans-fused ring system from phytopathogenic fungi被引量：15收藏
- 作者：Jiang, Lan Zhu, Guoliang Han, Jianying Hou, Chengjian Zhang, Xue Wang, Zhixin Yuan, Weize Lv, Kangjie Cong, Zhanren Wang, Xinye Chen, Xiangyin Karthik, Loganathan Yang, Huanting Wang, Xuyuan Tan, Gaoyi Liu, Guang Zhao, Liya Xia, Xuekui Liu, Xiangyang Gao, Shushan Ma, Lei Liu, Mei Ren, Biao Dai, Huanqin Quinn, Ronald J. Hsiang, Tom Zhang, Jingyu Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Griffith Univ;Qilu Univ Technol;T3 Biosci LLC
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2021
- 关键词：Fungi Bifunctional terpene synthases Terpenoids Anti-inflammatory
- OvoAMtht from Methyloversatilis thermotolerans ovothiol biosynthesis is a bifunction enzyme: thiol oxygenase and sulfoxide synthase activities被引量：14收藏
- 作者：Cheng, Ronghai Weitz, Andrew C. Paris, Jared Tang, Yijie Zhang, Jingyu Song, Heng Naowarojna, Nathchar Li, Kelin Qiao, Lu Lopez, Juan Grinstaff, Mark W. Zhang, Lixin Guo, Yisong Elliott, Sean Liu, Pinghua
- 机构：Boston Univ;Carnegie Mellon Univ;East China Univ Sci & Technol
- 来源：CHEMICAL SCIENCE 2022
- 关键词：Enzymes - Amino acids - Biochemistry - Electronic properties - Iron - Porphyrins
- Generation of Fluorinated Amychelin Siderophores against Pseudomonas aeruginosa Infections by a Combination of Genome Mining and Mutasynthesis被引量：13收藏
- 作者：Xie, Feng Dai, Shengwang Zhao, Yu Huang, Pei Yu, Shen Ren, Biao Wang, Qiushui Ji, Zengchun Alterovitz, Gil Zhang, Qi Zhang, Jingyu Chen, Xiangyin Jiang, Lan Song, Fuhang Liu, Hongwei Ausubel, Frederick M. Liu, Xueting Dai, Huanqin Zhang, Lixin
- 机构：Chinese Acad Sci;East China Univ Sci & Technol;Chinese Acad Sci;Massachusetts Gen Hosp;Sichuan Univ
- 来源：CELL CHEMICAL BIOLOGY 2020
- A novel urinary oxalate determination method via a catalase model compound with oxalate oxidase被引量：13收藏
- 作者：Zuo, Guanke Jiang, Xiaojun Liu, Hui Zhang, Jingyan
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：ANALYTICAL METHODS 2010
- Characterization of anti-BCG benz[α]anthraquinones and new siderophores from a Xinjiang desert-isolated rare actinomycete Nocardia sp. XJ31被引量：12收藏
- 作者：Zhang, Li Zhang, Jingyu Ren, Biao Lu, Wanying Hou, Chengjian Wang, Jian Ma, Xiaolong Ma, Rong Liu, Mei Liu, Zhiheng Li, Jin-Ping Ding, Kan Dai, Huanqin Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Boston Univ;Sichuan Univ;Sichuan Univ
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Xinjiang desert Nocardiasp Anti-BCG Brasiliquinone Nocardimicin
- 响应面法设计优化阿维菌素化学合成发酵培养基被引量：10收藏
- 作者：胡栋 柯灵超 张敬宇 谭高翼 张立新 高强
- 机构：工业发酵微生物教育部重点实验室;生物反应器工程国家重点实验室
- 来源：《中国抗生素杂志》 2018
- 关键词：阿维链霉菌 阿维菌素 化学合成培养基 响应面法 设计优化
- 摘要：目的设计优化一种化学合成发酵培养基,为阿维菌素产生菌生理生化研究提供基础。方法在单因素实验的基础上运用响应面分析的方法,对9种因素进行Plackett-Burman设计筛选得到3个显著因子,并对其进行最陡爬坡试验和Box...
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- Visualization of the pH-dependent dynamic distribution of G2A in living cells被引量：10收藏
- 作者：Lan, Wanjun Yamaguchi, Satoshi Yamamoto, Teruyasu Yamahira, Shinya Tan, Modong Murakami, Naoka Zhang, Jingyan Nakamura, Motonao Nagamune, Teruyuki
- 机构：Univ Tokyo;Univ Tokyo;Univ Tokyo;E China Univ Sci & Technol
- 来源：FASEB JOURNAL 2014
- 关键词：GPCR internalization pH dependence pulse labeling
- Separating graphene quantum dots by lateral size through gel column chromatography被引量：10收藏
- 作者：Wu, Wentian Cao, Jiamin Zhong, Min Wu, Haixia Zhang, Fangwei Zhang, Jingyan Guo, Shouwu
- 机构：Shanghai Jiao Tong Univ;East China Univ Sci & Technol
- 来源：RSC ADVANCES 2019
- 关键词：Organic solar cells - Semiconductor quantum dots - Column chromatography - Graphene - Separation - Oxidation
- Insights into the client protein release mechanism of the ATP-independent chaperone Spy被引量：9收藏
- 作者：He, Wei Li, Xinming Xue, Hongjuan Yang, Yuanyuan Mencius, Jun Bai, Ling Zhang, Jiayin Xu, Jianhe Wu, Bin Xue, Yi Quan, Shu
- 机构：East China Univ Sci & Technol;Tsinghua Univ;Chinese Acad Sci;East China Univ Sci & Technol
- 来源：NATURE COMMUNICATIONS 2022
- Brocaeloid D, a novel compound isolated from a wheat pathogenic fungus, Microdochium majus 99049被引量：9收藏
- 作者：Zhang, Jingyu Wang, Zhenzhen Song, Zhijun Karthik, Loganathan Hou, Chengjian Zhu, Guoliang Jiang, Lan Han, Jianying Ma, Rong Li, Li Zhang, Lixin Liu, Xueting Hsiang, Tom
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Med Sci & Peking Union Med Coll;Univ Guelph;Univ Chinese Acad Sci
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2019
- 关键词：Wheat pathogenic fungus Anticancer Antibacterial Natural product
- A rapid nucleic acid detection platform based on phosphorothioate-DNA and sulfur binding domain被引量：9收藏
- 作者：Shuai, Yuting Ju, Yi Li, Yuanhang Ma, Dini Jiang, Lan Zhang, Jingyu Tan, Gao-Yi Liu, Xueting Wang, Shenlin Zhang, Lixin Liu, Guang
- 机构：East China Univ Sci & Technol ECUST;East China Univ Sci & Technol ECUST;Shanghai Jiao Tong Univ
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2023
- 关键词：Phosphorothioate Sulfur binding domain Nucleic acid detection
- Direct evidence for the role of imidazole in disproportionation of hydrogen peroxide by a mononuclear manganese salen complex被引量：8收藏
- 作者：Li, Rong Tian, Jinlei Liu, Hui Yan, Shiping Guo, Shouwu Zhang, Jingyan
- 机构：E China Univ Sci & Technol;Nankai Univ;Shanghai Jiao Tong Univ
- 来源：TRANSITION METAL CHEMISTRY 2011
- 关键词：Ultraviolet visible spectroscopy - Synthesis (chemical) - Manganese compounds - Oxidation - Catalyst activity - Ligands - X ray diffraction
