成果/Result
- Regulation of Vibrio alginolyticus virulence by the LuxS quorum-sensing system被引量：59收藏
- 作者：Ye, J. Ma, Y. Liu, Q. Zhao, D. L. Wang, Q. Y. Zhang, Y. X.
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF FISH DISEASES 2008
- 关键词：autoinducer AI-2 luxS quorum sensing Vibrio alginolyticus virulence
- Global regulator BldA regulates morphological differentiation and lincomycin production in Streptomyces lincolnensis被引量：46收藏
- 作者：Hou, Bingbing Tao, Liyuan Zhu, Xiaoyu Wu, Wei Guo, Meijin Ye, Jiang Wu, Haizhen Zhang, Huizhan
- 机构： State Key Laboratory of Bioreactor Engineering; Department of Applied Biology
- 来源：Applied Microbiology and Biotechnology 2018
- 关键词：Encoding (symbols) - Amino acids - Bacteria - Metabolism
- The Novel Transcriptional Regulator LmbU Promotes Lincomycin Biosynthesis through Regulating Expression of Its Target Genes in Streptomyces lincolnensis被引量：40收藏
- 作者：Hou, Bingbing Lin, Yanwei Wu, Haizhen Guo, Meijin Petkovic, Hrvoje Tao, Liyuan Zhu, Xiaoyu Ye, Jiang Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ Ljubljana
- 来源：JOURNAL OF BACTERIOLOGY 2018
- 关键词：LmbU LmbU homologues Streptomyces cluster-situated regulator lincomycin regulatory protein
- Cloning and characterization of the ddsA gene encoding decaprenyl diphosphate synthase from Rhodobacter capsulatus B10被引量：31收藏
- 作者：Liu, Xinyi Wu, Haizhen Ye, Jiang Yuan, Qinsheng Zhang, Huizhan
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Canadian Journal of Microbiology 2006
- 关键词：Amino acids - Bacteria - Cloning - Enzymes - Gene expression - Polypeptides
- Identification of BagI as a positive transcriptional regulator of bagremycin biosynthesis in engineered Streptomyces sp. Tü 4128被引量：30收藏
- 作者：Liu, Feng Xu, Dakui Zhang, Yuchen Zhu, Yunxia Ye, Jiang Zhang, Huizhan
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Microbiological Research 2015
- 关键词：Bacteria - Metabolism - Polymerase chain reaction - Fungi - Biochemistry
- AdpAlin, a Pleiotropic Transcriptional Regulator, Is Involved in the Cascade Regulation of Lincomycin Biosynthesis in Streptomyces lincolnensis被引量：29收藏
- 作者：Kang, Yajing Wang, Yingying Hou, Bingbing Wang, Ruida Ye, Jiang Zhu, Xiaoyu Wu, Haizhen Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：FRONTIERS IN MICROBIOLOGY 2019
- 关键词：AdpA lincomycin Streptomyces lincolnensis transcriptional regulator cascade regulation
- Global regulator BldA regulates morphological differentiation and lincomycin production in Streptomyces lincolnensis被引量：26收藏
- 作者：Hou, Bingbing Tao, Liyuan Zhu, Xiaoyu Wu, Wei Guo, Meijin Ye, Jiang Wu, Haizhen Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2018
- 关键词：S. lincolnensis bldA Leucine codon Morphological differentiation Lincomycin production Regulatory pathway
- Characterization of the bagremycin biosynthetic gene cluster in Streptomyces sp. Tü 4128被引量：22收藏
- 作者：Ye, Jiang Zhu, Yunxia Hou, Bingbing Wu, Haizhen Zhang, Huizhan
- 机构： Key Laboratory of Bioreactor Engineering; Department of Applied Biology
- 来源：Bioscience, Biotechnology and Biochemistry 2019
- 关键词：Antibiotics - Biochemistry - Bacteria - Genes
- Cloning and characterization of a novel tyrosine ammonia lyase-encoding gene involved in bagremycins biosynthesis in Streptomyces sp.被引量：19收藏
- 作者：Zhu, Yunxia Liao, Siyi Ye, Jiang Zhang, Huizhan
- 机构：E China Univ Sci & Technol
- 来源：BIOTECHNOLOGY LETTERS 2012
- 关键词：Aromatic amino acid ammonia lyase Bagremycins trans-coumaric acid Streptomyces Tyrosine ammonia lyase
- Complete genome sequence of high-yield strain S. lincolnensis B48 and identification of crucial mutations contributing to lincomycin overproduction被引量：19收藏
- 作者：Wang, Ruida Kong, Fanjing Wu, Haizhen Hou, Bingbing Kang, Yajing Cao, Yuan Duan, Shiwei Ye, Jiang Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Ningbo Univ
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2020
- 关键词：Lincomycin Comparative genomics Regulation Overproduction
- 工科院校中生物化学教学模式探讨被引量：17收藏
- 作者：李素霞 欧伶 俞建瑛 宋聿文 叶江
- 机构：华东理工大学生物工程学院
- 来源：《微生物学通报》 2007
- 关键词：生物化学 应用生物化学 教学方法 教学改革
- 摘要：总结了在华东理工大学进行生物化学教学模式探索,包括结合培养目标,明确课程定位;构建知识框架,优化教学内容;采用多样化的教学手段;理论联系实际,突出应用生物化学的特点。在教学实践中,结合工科院校生物化学教学中"夯实基础、面...
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- Developmental regulator RamRsl controls both morphological development and lincomycin biosynthesis in Streptomyces lincolnensis被引量：16收藏
- 作者：Wang, Ruida Cao, Yuan Kong, Fanjing Hou, Bingbing Zhao, Jiaqi Kang, Yajing Ye, Jiang Wu, Haizhen Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF APPLIED MICROBIOLOGY 2022
- 关键词：lincomycin biosynthesis morphology RamR Streptomyces lincolnensis transcriptional regulation
- Characterization of Edwardsiella tarda rpoN: roles in σ70 family regulation, growth, stress adaption and virulence toward fish被引量：16收藏
- 作者：Wang, Keping Liu, Enfu Song, Shanshan Wang, Xiaobo Zhu, Yunxia Ye, Jiang Zhang, Huizhan
- 机构：E China Univ Sci & Technol
- 来源：ARCHIVES OF MICROBIOLOGY 2012
- 关键词：Edwardsiella tarda rpoN Biofilm formation Virulence
- AflQ1-Q2 represses lincomycin biosynthesis via multiple cascades in Streptomyces lincolnensis被引量：15收藏
- 作者：Wang, Ruida Zhou, Tianyu Kong, Fanjing Hou, Bingbing Ye, Jiang Wu, Haizhen Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2023
- 关键词：AflQ1-Q2 Streptomyces lincolnensis Two-component system Lincomycin biosynthesis Transcriptional regulation Aspartate metabolism
- ubiCA基因的强化表达及对大肠杆菌辅酶Q生物合成的影响被引量：15收藏
- 作者：叶江 马林 吴海珍 刘欣毅 张惠展
- 机构：华东理工大学生物反应器工程国家重点实验室
- 来源：《华东理工大学学报（自然科学版）》 2006
- 关键词：大肠杆菌 ubiCA 基因克隆 强化表达 辅酶Q
- 摘要：为调查大肠杆菌高产辅酶Q(CoQ)的可能性,首先研究大肠杆菌生物合成关键基因ubiCA强化表达对大肠杆菌CoQ产量的影响。本文构建了含有ubiCA基因的5个表达质粒,将其分别转入E.coli JM 83或BL 21(DE...
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- Molecular cloning of an insertion sequence-like element from Vibrio anguillarum and its functional identification in E. coli被引量：13收藏
- 作者：Liang, Na Wu, Haizhen Ye, Jiang Xu, Peng Zhang, Yuanxing Zhang, Huizhan
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Biotechnology Letters 2007
- 关键词：Cloning - Enzymes - Escherichia coli - Gene expression
- An alternative s factor sLsl regulates lincomycin production in Streptomyces lincolnensis被引量：13收藏
- 作者：Tu, Bingbing Mao, Yue Wang, Ruida Kang, Yajing Ye, Jiang Zhang, Huizhan Wu, Haizhen
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF BASIC MICROBIOLOGY 2023
- 关键词：alternative sigma factor lincomycin Streptomyces lincolnensis sigma(L)(sl)
- A putative redox-sensing regulator Rex regulates lincomycin biosynthesis in Streptomyces lincolnensis被引量：13收藏
- 作者：Hou, Bingbing Wang, Ruida Zou, Jingyun Zhang, Feixue Wu, Haizhen Ye, Jiang Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF BASIC MICROBIOLOGY 2021
- 关键词：Streptomyces lincolnensis lincomycin Rex transcriptional regulation
- A novel method to identify yak fiber in textile被引量：12收藏
- 作者：Lu, Weimin Fei, Jing Yang, Juan Tang, Minfeng Dong, Zhenglian Zhou, Zhiping Ye, Jiang Wu, Haizhen
- 机构：Shanghai Entry Exit Inspect & Quarantine Bur;E China Univ Sci & Technol
- 来源：TEXTILE RESEARCH JOURNAL 2013
- 关键词：yak fiber deoxyribonucleic acid TaqMan-polymerase chain reaction identify
- LmbU, a Cluster-Situated Regulator for Lincomycin, Consists of a DNA-Binding Domain, an Auto-Inhibitory Domain, and Forms Homodimer被引量：12收藏
- 作者：Hou, Bingbing Zhu, Xiaoyu Kang, Yajing Wang, Ruida Wu, Haizhen Ye, Jiang Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：FRONTIERS IN MICROBIOLOGY 2019
- 关键词：LmbU CSR functional domain HTH homodimer regulatory mechanism
- Characterization of a TetR-type positive regulator AtrA for lincomycin production in Streptomyces lincolnensis被引量：12收藏
- 作者：Wu, Wei Kang, Yajing Hou, Bingbing Ye, Jiang Wang, Ruida Wu, Haizhen Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 2023
- 关键词：Streptomyces lincolnensis AtrA lincomycin production regulatory pathway
- Three new LmbU targets outside lmb cluster inhibit lincomycin biosynthesis in Streptomyces lincolnensis被引量：10收藏
- 作者：Mao, Yue Zhang, Xianyan Zhou, Tianyu Hou, Bingbing Ye, Jiang Wu, Haizhen Wang, Ruida Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：MICROBIAL CELL FACTORIES 2024
- 关键词：Streptomyces lincolnensis Lincomycin biosynthesis Transcriptional regulation LmbU Cluster-situated regulatory gene(s)
- DeoR regulates lincomycin production in Streptomyces lincolnensis被引量：10收藏
- 作者：Zou, Jingyun Mao, Yue Hou, Bingbing Kang, Yajing Wang, Ruida Wu, Haizhen Ye, Jiang Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY 2023
- 关键词：Streptomyces lincolnensis Lincomycin DeoR family Transcriptional regulation
- Impact of co-deficiency of RpoN and RpoS on stress tolerance, virulence and gene regulation in Edwardsiella tarda被引量：10收藏
- 作者：Liu, Enfu Ye, Jiang Song, ShanShan Wang, Keping Zhang, Yuanxing Zhang, Huizhan
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF BASIC MICROBIOLOGY 2014
- 关键词：Edwardsiella tarda EIB202 rpoN rpoS Stress tolerance Virulence Housekeeping genes
- AdpAlin regulates lincomycin and melanin biosynthesis by modulating precursors flux in Streptomyces lincolnensis被引量：10收藏
- 作者：Kang, Yajing Wu, Wei Zhang, Feixue Chen, Lei Wang, Ruida Ye, Jiang Wu, Haizhen Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF BASIC MICROBIOLOGY 2023
- 关键词：AdpA lincomycin melanin transcriptional regulation tyrosine oxidases
- LcbR1, a newly identified GntR family regulator, represses lincomycin biosynthesis in Streptomyces lincolnensis被引量：10收藏
- 作者：Wang, Ruida Zhao, Jiaqi Chen, Lei Ye, Jiang Wu, Haizhen Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2023
- 关键词：Streptomyces lincolnensis LcbR1 GntR family Lincomycin biosynthesis Transcriptional regulation
- EsrE-A yigP Locus-Encoded Transcript-Is a 3' UTR sRNA Involved in the Respiratory Chain of E.coli被引量：9收藏
- 作者：Xia, Hui Yang, Xichen Tang, Qiongwei Ye, Jiang Wu, Haizhen Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：FRONTIERS IN MICROBIOLOGY 2017
- 关键词：yigP locus aerobic growth Q(8) EsrE sRNA succinate dehydrogenase E. coli
- A yigP mutant strain is a small colony variant of E. coli and shows pleiotropic antibiotic resistance被引量：9收藏
- 作者：Xia, Hui Tang, Qiongwei Song, Jie Ye, Jiang Wu, Haizhen Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CANADIAN JOURNAL OF MICROBIOLOGY 2017
- 关键词：Escherichia coli small colony variants yigP locus microbial resistance collateral sensitivity
- 林可霉素生物合成基因lmbU的敲除及其遗传回补被引量：9收藏
- 作者：吕彩霞 杨捷 叶江 吴海珍 张惠展
- 机构：华东理工大学生物反应器工程国家重点实验室
- 来源：《华东理工大学学报（自然科学版）》 2008
- 关键词：同源重组 敲除 遗传回补 林可霉素生物合成
- 摘要：利用DNA同源重组原理敲除S.lincolnensisNRRL 2936中lmbU基因,筛选获得该基因缺陷株S.lincolnensisJLUa2,其不具备林可霉素生物合成能力。利用构建的不同重组质粒转化缺陷株,发现含有...
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- Structural and Functional Studies on Three Alginate Lyases from Vibrio alginolyticus被引量：9收藏
- 作者：Deng, Shuping Ye, Jiang Xu, Qingqing Zhang, Huizhan
- 机构：E China Univ Sci & Technol
- 来源：PROTEIN AND PEPTIDE LETTERS 2014
- 关键词：Alginate lyase chimeric protein ESI-MS NMR site-directed mutagenesis substrate specificity
