成果/Result
- Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease被引量：106收藏
- 作者：Li, Xi Zhang, Yinan Xu, Lingya Wang, Aoxue Zou, Yejun Li, Ting Huang, Li Chen, Weicai Liu, Shuning Jiang, Kun Zhang, Xiuze Wang, Dongmei Zhang, Lijuan Zhang, Zhuo Zhang, Zeyi Chen, Xianjun Jia, Wei Zhao, Aihua Yan, Xinfeng Zhou, Haimeng Zhu, Linyong Ma, Xinran Ju, Zhenyu Jia, Weiping Wang, Congrong Loscalzo, Joseph Yang, Yi Zhao, Yuzheng
- 机构：East China Univ Sci & Technol;Chinese Acad Med Sci;Chinese Acad Sci;Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6;East China Normal Univ
- 来源：CELL METABOLISM 2023
- Illuminating NAD+ Metabolism in Live Cells and In Vivo Using a Genetically Encoded Fluorescent Sensor被引量：95收藏
- 作者：Zou, Yejun Wang, Aoxue Huang, Li Zhu, Xudong Hu, Qingxun Zhang, Yinan Chen, Xianjun Li, Fengwen Wang, Qiaohui Wang, Hu Liu, Renmei Zuo, Fangting Li, Ting Yao, Jing Qian, Yajin Shi, Mei Yue, Xiao Chen, Weicai Zhang, Zhuo Wang, Congrong Zhou, Yong Zhu, Linyong Ju, Zhenyu Loscalzo, Joseph Yang, Yi Zhao, Yuzheng
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;East China Univ Sci & Technol;Hangzhou Normal Univ;Shanghai Jiao Tong Univ
- 来源：DEVELOPMENTAL CELL 2020
- Analysis of redox landscapes and dynamics in living cells and in vivo using genetically encoded fluorescent sensors被引量：83收藏
- 作者：Zou, Yejun Wang, Aoxue Shi, Mei Chen, Xianjun Liu, Renmei Li, Ting Zhang, Chenxia Zhang, Zhuo Zhu, Linyong Ju, Zhenyu Loscalzo, Joseph Yang, Yi Zhao, Yuzheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Jinan Univ;Harvard Med Sch
- 来源：NATURE PROTOCOLS 2018
- 一种用微孔板筛选alpha-葡萄糖苷酶抑制剂的方法(英文)被引量：49收藏
- 作者：李婷 张小东 宋聿文 刘建文
- 机构：华东理工大学药学院;华东理工大学生物工程学院
- 来源：《中国临床药理学与治疗学》 2005
- 关键词：阿卡波糖 alpha-葡萄糖苷酶抑制剂 药物筛选 微孔板方法 餐后血糖
- 摘要：目的：建立敏感的微孔板方法检测alpha-葡萄糖苷酶抑制活性，以进行抑制剂体外高通量筛选。方法：调整酶和底物适当配比，通过标准曲线、波长扫描、动力学分析以及最佳反应条件的研究，用阿卡波糖验证所建方法。结果：确定反应步骤，...
- 下载全文在线阅读
- Synergistic protective effect of picroside II and NGF on PC12 cells against oxidative stress induced by H2O2被引量：42收藏
- 作者：Liu, Jian-Wen Yu, You-Jun Zheng, Pei-yong Zhang, Xiao-dong Li, Ting Cao, Yan Guo, Ming-chuan
- 机构：E China Univ Sci & Technol;Shanghai Tradit Chinese Med Univ
- 来源：PHARMACOLOGICAL REPORTS 2007
- 关键词：hydrogen peroxide nerve growth factor PC12 cells picroside II reactive oxygen species
- Synthetic dual-input mammalian genetic circuits enable tunable and stringent transcription control by chemical and light被引量：36收藏
- 作者：Chen, Xianjun Li, Ting Wang, Xue Du, Zengmin Liu, Renmei Yang, Yi
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：NUCLEIC ACIDS RESEARCH 2016
- A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice被引量：34收藏
- 作者：Li, Ting Chen, Xianjun Qian, Yajie Shao, Jiawei Li, Xie Liu, Shuning Zhu, Linyong Zhao, Yuzheng Ye, Haifeng Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;East China Normal Univ;East China Normal Univ
- 来源：NATURE COMMUNICATIONS 2021
- The neuroprotective effect of picroside II from Hu-Huang-Lian against oxidative stress被引量：33收藏
- 作者：Li, Ting Liu, Jian-Wen Zhang, Xiao-Dong Guo, Ming-Chuan Ji, Guang
- 机构：E China Univ Sci & Technol;Shanghai Univ TCM
- 来源：AMERICAN JOURNAL OF CHINESE MEDICINE 2007
- 关键词：neuroprotection oxidative stress pricroside II Hu-Huang-Lian aluminium glutamate
- Antidiabetic activity of lipophilic (-)-epigallocatechin-3-gallate derivative under its role of α-glucosidase inhibition被引量：33收藏
- 作者：Li, Ting Liu, Jianwen Zhang, Xiaodong Ji, Guang
- 机构：E China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med
- 来源：BIOMEDICINE & PHARMACOTHERAPY 2007
- 关键词：alpha-glucosidase inhibitor blood glucose postprandial hyperglycemia
- Comprehensive multiscale analysis of lactate metabolic dynamics in vitro and in vivo using highly responsive biosensors被引量：27收藏
- 作者：Wang, Aoxue Zou, Yejun Liu, Shuning Zhang, Xiuze Li, Ting Zhang, Lijuan Wang, Ruwen Xia, Yale Li, Xie Zhang, Zhuo Liu, Tiemin Ju, Zhenyu Wang, Ru Loscalzo, Joseph Yang, Yi Zhao, Yuzheng
- 机构：East China Univ Sci & Technol;Chinese Acad Med Sci;Shanghai Univ Sport;Fudan Univ;Jinan Univ
- 来源：NATURE PROTOCOLS 2024
- Lighting up arginine metabolism reveals itsfunctional diversity in physiology and pathology被引量：21收藏
- 作者：Li, Rui Li, Yan Jiang, Kun Zhang, Lijuan Li, Ting Zhao, Aihua Zhang, Zhuo Xia, Yale Ge, Kun Chen, Yaqiong Wang, Chengnuo Tang, Weitao Liu, Shuning Lin, Xiaoxi Song, Yuqin Mei, Jie Xiao, Chun Wang, Aoxue Zou, Yejun Li, Xie Chen, Xianjun Ju, Zhenyu Jia, Wei Loscalzo, Joseph Sun, Yu Fang, Wei Yang, Yi Zhao, Yuzheng
- 机构：East China Univ Sci & Technol;Chinese Acad Med Sci;Univ Chinese Acad Sci;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ
- 来源：CELL METABOLISM 2025
- Monitoring NAD(H) and NADP(H) dynamics during organismal development with genetically encoded fluorescent biosensors被引量：21收藏
- 作者：Li, Ting Zou, Yejun Liu, Shuning Yang, Yi Zhang, Zhuo Zhao, Yuzheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Med Sci
- 来源：CELL REGENERATION 2022
- 关键词：Cell metabolism NAD(H) and NADP(H) Genetically encoded fluorescent sensors Real-time monitoring Organismal development
- Thermo-responsive gold nanorod vesicles for combined NIR-II photothermal therapy and chemotherapy of solid tumors被引量：19收藏
- 作者：Xing, Wenqian Li, Ting Yang, Guangze Wu, Shuqin Pang, Bailu Xu, Yufang Qian, Xuhong Zhu, Weiping
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACTA BIOMATERIALIA 2025
- 关键词：Gold nanorod vesicle Upper critical solution temperature Near-infrared-II Photothermal therapy Controlled-release
- 胡黄连甙Ⅱ和神经生长因子对H202损伤的PCI2细胞的协同保护作用被引量：16收藏
- 作者：张小东 刘建文 李婷 曹艳 郭明川
- 机构：华东理工大学药学院
- 来源：《中国临床药理学与治疗学》 2007
- 关键词：双氧水 神经生长因子 胡黄连甙Ⅱ 活性氧
- 摘要：目的:考察胡黄连甙II和NGF对双氧水损伤细胞的协同保护作用。方法:以CDCFH方法评价活性氧水平,MTT方法、细胞形态观察以及LDH漏出实验评价药物对细胞损伤的修复作用。结果:25μg/mL胡黄连甙II和2 ng/mL...
- 下载全文在线阅读
- A Single-Component Optogenetic Gal4-UAS System Allows Stringent Control of Gene Expression in Zebrafish and Drosophila被引量：15收藏
- 作者：Qian, Yajie Li, Ting Zhou, Siyu Chen, Xianjun Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACS SYNTHETIC BIOLOGY 2023
- 关键词：optogenetics single-component gene expression Gal4-UAS
- 胡黄连糖甙对拟痴呆模型小鼠的神经保护作用被引量：13收藏
- 作者：李婷 刘建文 曹艳 张小东 魏东芝 卢艳花
- 机构：华东理工大学药学院;华东理工大学生物反应器工程国家重点实验室
- 来源：《华东理工大学学报（自然科学版）》 2006
- 关键词：胡黄连糖甙 拟痴呆模型 学习记忆障碍 抗氧化 阿尔茨海默氏病
- 摘要：联合应用半乳糖和亚硝酸钠使小鼠拟痴呆,研究胡黄连糖甙对小鼠的神经保护作用。通过水迷宫试验,组织病理学检查,超氧化物歧化酶(SOD)和丙二醛(MDA)的测定等结果表明:模型组小鼠的学习记忆功能明显受到障碍,表现出阿尔茨海默...
- 下载全文在线阅读
- A light-switchable bidirectional expression module allowing simultaneous regulation of multiple genes被引量：10收藏
- 作者：Chen, Xianjun Li, Ting Wang, Xue Yang, Yi
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2015
- 关键词：Bidirectional Gene expression Light Simultaneous regulation
- Insights into the synergistic mechanism of target resistance: A case study of N. lugens RDL-GABA receptors and fipronil被引量：7收藏
- 作者：Li, Ting Zhou, Cong Zheng, Nan Yang, Hongbin Kuang, Guanglin Shao, Xusheng Li, Zhong Cheng, Jiagao
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOPHYSICAL CHEMISTRY 2020
- 关键词：Resistance RDL-GABA receptor Fipronil Molecular dynamics simulation Homology modelling
- Live-cell imaging reveals redox metabolic reprogramming during zygotic genome activation被引量：6收藏
- 作者：Sun, Hao Zhang, Zhuo Li, Tianda Li, Ting Chen, Weicai Pan, Tianshi Fang, Sen Liu, Chao Zhang, Ying Wang, Leyun Feng, Guihai Li, Wei Zhou, Qi Zhao, Yuzheng
- 机构：Chinese Acad Sci;Chinese Acad Sci;Beijing Inst Stem Cell & Regenerat Med;Univ Chinese Acad Sci;East China Univ Sci & Technol
- 来源：JOURNAL OF CELLULAR PHYSIOLOGY 2023
- 关键词：biosensor dynamic imaging embryo development metabolite detection single cell
- Transferrin-targeting pH-responsive and biodegradable mesoporous silica nanohybrid for nitric oxide-sensitized chemotherapy of cancer被引量：6收藏
- 作者：Li, Ting Cheng, Di Xu, Xiu Wang, Bin Xing, Wenqian Xu, Yufang Qian, Xuhong Yang, Youjun Zhu, Weiping
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：COLLOIDS AND SURFACES B-BIOINTERFACES 2025
- 关键词：PH-responsive Biodegradable mesoporous organosilica Nitric oxide sensitization Drug-resistant inhibition
- A Catalyst and Base Free Approach to Polycyclic Aromatic Compounds via Intramolecular [2+2] and retro-[2+2] Cycloadditions被引量：5收藏
- 作者：Lu, Aoyun Li, Tao Wang, Jiayi Song, Gonghua
- 机构：East China Univ Sci & Technol
- 来源：ASIAN JOURNAL OF ORGANIC CHEMISTRY 2021
- 关键词：polycyclic aromatic compounds catalyst-free microwave [2+2] cycloaddition retro-[2+2] cycloaddition
- NADPHnet: a novel strategy to predict compounds for regulation of NADPH metabolism via network-based methods被引量：4收藏
- 作者：Pan, Fei Wang, Cheng-nuo Yu, Zhuo-hang Wu, Zeng-rui Wang, Ze Lou, Shang Li, Wei-hua Liu, Gui-xia Li, Ting Zhao, Yu-zheng Tang, Yun
- 机构：East China Univ Sci & Technol
- 来源：ACTA PHARMACOLOGICA SINICA 2024
- 关键词：NADPH metabolism network-based inference natural product computational prediction
- Structural diversity derivatization and studies on the nematicidal activity of tropane derivatives被引量：1收藏
- 作者：Lu, Aoyun Zheng, Yiting Li, Tao Wang, Jiayi Song, Gonghua
- 机构：East China Univ Sci & Technol
- 来源：PHYTOCHEMISTRY LETTERS 2024
- 关键词：Nematicidal activity Tropane Lead optimization Bioisosteric replacement
- 计算机辅助药物设计——大学生创新项目实践与体会被引量：0收藏
- 作者：刘丽萍 李婷 廖承云 田成壮 刘桂霞 李卫华 唐赟
- 机构：华东理工大学药学院
- 来源：《科教文汇》 2019
- 关键词：学生创新性实验 计算机辅助药物设计 环糊精收获与体会
- 摘要：大学是学生全面发展的时期,只学习课本知识已经不能满足社会发展的需要。为了拓展自己的专业知识,提高专业水平,学生要积极投身各项创新实验中,找到自己感兴趣的方向,坚持不懈地在实践中提升自己。在互联网和大数据迅速发展的时代,计...
- 下载全文在线阅读
- Combined heat and exercise stress disrupt gut microbiota and promote microbial translocation被引量：0收藏
- 作者：Min, Leizi Ablitip, Alimjan Wang, Qingyuan Li, Ting Di, Qian Ma, Xindong Fang, Wen
- 机构：East China Univ Sci & Technol;Tsinghua Univ;East China Univ Sci & Technol;Tsinghua Univ;Tsinghua Univ
- 来源：FRONTIERS IN MICROBIOLOGY 2026
- 关键词：bacterial translocation exertional heat stroke gut microbiota heat stress intestinal barrier
- 基于遗传编码荧光探针的精氨酸实时监测新技术被引量：0收藏
- 作者：李婷 黄瑾 张卓 赵玉政
- 机构：华东理工大学药学院;中国医学科学院细胞代谢监测成像新技术创新单元
- 来源：《科学通报》 2025
- 关键词：尿素 瓜氨酸 精氨酸 一氧化氮 代谢 鸟氨酸
- 摘要：精氨酸是氨基酸中的“多面手”,除了作为蛋白质和多肽的组成部分外,精氨酸可代谢产生尿素、鸟氨酸、瓜氨酸、一氧化氮、肌酸、胍丁胺等重要分子,在调节人体氮代谢稳态、心血管生理活动、免疫反应、生长繁殖等重要过程中发挥着关键作用[...
- 下载全文在线阅读
- Monitoring NAD(H) and NADP(H) dynamics during organismal development with genetically encoded fluorescent biosensors被引量：0收藏
- 作者：Ting Li Yejun Zou Shuning Liu Yi Yang Zhuo Zhang Yuzheng Zhao
- 机构：Optogenetics&Synthetic Biology Interdisciplinary Research Center;Shanghai Key Laboratory of New Drug Design;Research Unit of New Techniques for Live-cell Metabolic Imaging
- 来源：细胞再生（英文） 2022
- 下载全文在线阅读
- 基于靶标组结构差异的苯基吡唑类杀虫剂生态毒性机制研究被引量：0收藏
- 作者：江卓媛 何鲁珏 李婷 程家高 李忠
- 机构：华东理工大学药学院
- 来源：《上海市化学化工学会农用化学专业委员会2018 年会》 2018
- 关键词：苯基吡唑类杀虫剂 GABAR 生态毒性 结合模式 分子动力学模拟
- 摘要：苯基吡唑类杀虫剂因对蜜蜂和鱼类等非靶标有益生物的高毒性被限制使用，其生态毒性的根源在于不同物种间GABAR在结构上的相似性[1]。为了明晰苯基吡唑类杀虫剂与不同物种GABAR的作用模式差异，本研究综合采用了同源模建、分子...
- 胡黄连甙II和神经生长因子对H_2O_2损伤的PC12细胞的协同保护作用(英文)被引量：0收藏
- 作者：张小东 刘建文 李婷 曹艳 郭明川
- 机构：华东理工大学药学院
- 来源：《中国临床药理学与治疗学》 2007
- 关键词：双氧水 神经生长因子 胡黄连甙Ⅱ 活性氧
- 摘要：目的:考察胡黄连甙II和NGF对双氧水损伤细胞的协同保护作用。方法:以CDCFH方法评价活性氧水平,MTT方法、细胞形态观察以及LDH漏出实验评价药物对细胞损伤的修复作用。结果:25μg/mL胡黄连甙II和2 ng/mL...
- 下载全文在线阅读
- Novel lactate fluorescent protein sensors enable real-time in situ imaging of lactate in live cells被引量：0收藏
- 作者：Lin, Xu Zhang, Zhuo Zhao, Yuzheng Li, Ting
- 机构：East China Univ Sci & Technol;Chinese Acad Med Sci
- 来源：CHINESE SCIENCE BULLETIN-CHINESE 2026
