成果/Result
- Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism被引量：269收藏
- 作者：Tao, Rongkun Zhao, Yuzheng Chu, Huanyu Wang, Aoxue Zhu, Jiahuan Chen, Xianjun Zou, Yejun Shi, Mei Liu, Renmei Su, Ni Du, Jiulin Zhou, Hai-Meng Zhu, Linyong Qian, Xuhong Liu, Haiyan Loscalzo, Joseph Yang, Yi
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;East China Univ Sci & Technol;Univ Sci & Technol China;Tsinghua Univ
- 来源：NATURE METHODS 2017
- Illuminating NAD+ Metabolism in Live Cells and In Vivo Using a Genetically Encoded Fluorescent Sensor被引量：95收藏
- 作者：Zou, Yejun Wang, Aoxue Huang, Li Zhu, Xudong Hu, Qingxun Zhang, Yinan Chen, Xianjun Li, Fengwen Wang, Qiaohui Wang, Hu Liu, Renmei Zuo, Fangting Li, Ting Yao, Jing Qian, Yajin Shi, Mei Yue, Xiao Chen, Weicai Zhang, Zhuo Wang, Congrong Zhou, Yong Zhu, Linyong Ju, Zhenyu Loscalzo, Joseph Yang, Yi Zhao, Yuzheng
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;East China Univ Sci & Technol;Hangzhou Normal Univ;Shanghai Jiao Tong Univ
- 来源：DEVELOPMENTAL CELL 2020
- Analysis of redox landscapes and dynamics in living cells and in vivo using genetically encoded fluorescent sensors被引量：83收藏
- 作者：Zou, Yejun Wang, Aoxue Shi, Mei Chen, Xianjun Liu, Renmei Li, Ting Zhang, Chenxia Zhang, Zhuo Zhu, Linyong Ju, Zhenyu Loscalzo, Joseph Yang, Yi Zhao, Yuzheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Jinan Univ;Harvard Med Sch
- 来源：NATURE PROTOCOLS 2018
- Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells被引量：71收藏
- 作者：Liu, Ru-Ming Zhong, Jian-Jiang
- 机构：Shanghai Jiao Tong Univ;E China Univ Sci & Technol
- 来源：PHYTOMEDICINE 2011
- 关键词：Ganoderma lucidum Ganoderic acid Mf (GA-Mf) Ganoderic acid S (GA-S) Mitochondria HeLa cells Apoptosis
- Optogenetic control of RNA function and metabolism using engineered light-switchable RNA-binding proteins被引量：60收藏
- 作者：Liu, Renmei Yang, Jing Yao, Jing Zhao, Zhou He, Wei Su, Ni Zhang, Zeyi Zhang, Chenxia Zhang, Zhuo Cai, Haibo Zhu, Linyong Zhao, Yuzheng Quan, Shu Chen, Xianjun Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：NATURE BIOTECHNOLOGY 2022
- 关键词：Proteins - Cell culture
- Large Stokes shift fluorescent RNAs for dual-emission fluorescence and bioluminescence imaging in live cells被引量：58收藏
- 作者：Jiang, Li Xie, Xin Su, Ni Zhang, Dasheng Chen, Xianjun Xu, Xiaochen Zhang, Bibi Huang, Kaiyi Yu, Jingwei Fang, Mengyue Bao, Bingkun Zuo, Fangting Yang, Lipeng Zhang, Rui Li, Huiwen Huang, Xinyi Chen, Zhengda Zeng, Qingmei Liu, Renmei Lin, Qiuning Zhao, Yuzheng Ren, Aiming Zhu, Linyong Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Fluorescence Diag Shanghai Biotech Co Ltd;Zhejiang Univ
- 来源：NATURE METHODS 2023
- Cytotoxic and pro-apoptotic effects of novel ganoderic acid derivatives on human cervical cancer cells in vitro被引量：57收藏
- 作者：Liu, Ru-Ming Li, Ying-Bo Zhong, Jian-Jiang
- 机构：E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：EUROPEAN JOURNAL OF PHARMACOLOGY 2012
- 关键词：Ganoderma lucidum Ganoderic acid derivative Cervical cancer Cell apoptosis Mitochondrial membrane potential Caspase
- An extraordinary stringent and sensitive light-switchable gene expression system for bacterial cells被引量：54收藏
- 作者：Chen, Xianjun Liu, Renmei Ma, Zhengcai Xu, Xiaopei Zhang, Haoqian Xu, Jianhe Ouyang, Qi Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Peking Univ;Peking Univ
- 来源：CELL RESEARCH 2016
- A single-component light sensor system allows highly tunable and direct activation of gene expression in bacterial cells被引量：52收藏
- 作者：Li, Xie Zhang, Changcheng Xu, Xiaopei Miao, Jun Yao, Jing Liu, Renmei Zhao, Yuzheng Chen, Xianjun Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;East China Univ Sci & Technol
- 来源：NUCLEIC ACIDS RESEARCH 2020
- A new ganoderic acid from Ganoderma lucidum mycelia and its stability被引量：45收藏
- 作者：Li, Ying-Bo Liu, Ru-Ming Zhong, Jian-Jiang
- 机构：E China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ
- 来源：FITOTERAPIA 2013
- 关键词：Ganoderma lucidum Ganoderic acid Cytotoxicity Stability
- Synthetic dual-input mammalian genetic circuits enable tunable and stringent transcription control by chemical and light被引量：36收藏
- 作者：Chen, Xianjun Li, Ting Wang, Xue Du, Zengmin Liu, Renmei Yang, Yi
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：NUCLEIC ACIDS RESEARCH 2016
- A Single-Component Optogenetic System Allows Stringent Switch of Gene Expression in Yeast Cells被引量：35收藏
- 作者：Xu, Xiaopei Du, Zhaoxia Liu, Renmei Li, Ting Zhao, Yuzheng Chen, Xianjun Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：ACS SYNTHETIC BIOLOGY 2018
- 关键词：yeast optogenetic gene expression protein stability
- Design of a palette of SNAP-tag mimics of fluorescent proteins and their use as cell reporters被引量：23收藏
- 作者：Zhang, Dasheng Chen, Zhengda Du, Zengmin Bao, Bingkun Su, Ni Chen, Xianjun Ge, Yihui Lin, Qiuning Yang, Lipeng Hua, Yujie Wang, Shuo Hua, Xin Zuo, Fangting Li, Ningfeng Liu, Renmei Jiang, Li Bao, Chunyan Zhao, Yuzheng Loscalzo, Joseph Yang, Yi Zhu, Linyong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Harvard Med Sch
- 来源：CELL DISCOVERY 2023
- A new ganoderic acid from Ganoderma lucidum mycelia被引量：18收藏
- 作者：Wang, Jia-Le Li, Ying-Bo Liu, Ru-Ming Zhong, Jian-Jiang
- 机构：Shanghai Jiao Tong Univ;E China Univ Sci & Technol
- 来源：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 2010
- 关键词：Ganoderma lucidum Ganodermataceae 7-O-ethyl GA-O ethoxyl cytotoxicity
- Anti-Proliferation and Induced Mitochondria-Mediated Apoptosis of Ganoderic Acid Mk From Ganoderma lucidum Mycelia in Cervical Cancer HeLa Cells被引量：13收藏
- 作者：Liu, Ru-Ming Li, Ying-Bo Zhong, Jian-Jiang
- 机构：E China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ
- 来源：LATIN AMERICAN JOURNAL OF PHARMACY 2012
- 关键词：Anti-proliferation Apoptosis Ganoderic acid Mk (GA-Mk) HeLa cells Mitochondria
- 为细菌的房间的一个非凡的紧、敏感的光可切换的基因表达式系统被引量：9收藏
- 作者：Chen, Xianjun Liu, Renmei Ma, Zhengcai Xu, Xiaopei Zhang, Haoqian Xu, Jianhe Ouyang, Qi Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Peking Univ;Peking Univ
- 来源：细胞研究（英文版） 2016
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- Spatiotemporal control of RNA metabolism and CRISPR-Cas functions using engineered photoswitchable RNA-binding proteins被引量：7收藏
- 作者：Liu, Renmei Yao, Jing Zhou, Siyu Yang, Jing Zhang, Yaqiang Yang, Xiaoyan Li, Leshi Zhang, Yunbin Zhuang, Yingping Yang, Yi Chen, Xianjun
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：NATURE PROTOCOLS 2024
- Multicoloured fluorescent indicators for live-cell and in vivo imaging of inorganic mercury dynamics被引量：6收藏
- 作者：Tao, Rongkun Shi, Mei Zou, Yejun Cheng, Di Wang, Qiaohui Liu, Renmei Wang, Aoxue Zhu, Jiahuan Deng, Lei Hu, Hanyang Chen, Xianjun Du, Jiulin Zhu, Weiping Zhao, Yuzheng Yang, Yi
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：FREE RADICAL BIOLOGY AND MEDICINE 2018
- 关键词：Inorganic mercury Multicoloured fluorescent indicators Live-cell imaging In vivo imaging Oxidative damage
- Development of Acrylamide-Based Rapid and Multicolor Fluorogenic Probes for High Signal-to-Noise Live Cell Imaging被引量：6收藏
- 作者：Zhang, Dasheng Liu, Renmei Bao, Chunyan Zhang, Chenxia Yang, Lipeng Deng, Lei Bao, Bingkun Yang, Jing Chen, Xianjun Lin, Qiuning Yang, Yi Zhu, Linyong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOCONJUGATE CHEMISTRY 2019
- 关键词：Amides - Cells - Proteins - Signal to noise ratio - Ligands - Cytology
- The status and challenges of optogenetic tools for precise spatiotemporal control of RNA metabolism and function被引量：3收藏
- 作者：Liu, Renmei Fang, Mengyue Chen, Xianjun Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CLINICAL AND TRANSLATIONAL MEDICINE 2022
- Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells (vol 18, pg 349, 2011)被引量：2收藏
- 作者：Liu, Ru-Ming Zhong, Jian-Jiang
- 机构：E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：PHYTOMEDICINE 2012
- RNA转录后代谢时空精密控制技术被引量：1收藏
- 作者：刘韧玫 李乐诗 杨小燕 陈显军 杨弋
- 机构：华东理工大学光遗传学与合成生物学交叉学科研究中心;华东理工大学药学院;华东理工大学生物工程学院
- 来源：《合成生物学》 2023
- 关键词：光遗传学 RNA代谢 RNA功能 时空精密控制 光控RNA结合蛋白
- 摘要：RNA种类繁多且功能多样,是细胞活动的核心分子之一。RNA代谢调控对于基因和RNA功能研究、细胞生命活动解析以及疾病治疗手段的开发都是至关重要的。为了深入研究RNA时间、空间分布以及功能机制,科学家们一直在追求可以在活细...
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- Simultaneous determination of four triterpenoids of Ganoderma lucidum by reverse-phase high-performance liquid chromatography-diode array detector被引量：0收藏
- 作者：Li, Ying-Bo Liang, Cui-Xia Liu, Ru-Ming Zhong, Jian-Jiang
- 机构：E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：JOURNAL OF BIOTECHNOLOGY 2008
- 原核细胞光控基因表达系统及合成细胞通讯被引量：0收藏
- 作者：陈显军 马正才 刘韧玫 杨弋
- 机构：华东理工大学
- 来源：《上海市细胞生物学学会第八次全体会员代表大会暨第九届CST细胞生物学青年论坛》 2013
- 关键词：光 基因表达系统 Lightoff Luminsensor
- 摘要：基因表达调控系统由于有着高的诱导倍数且容易操作等优点,使得它们成为功能基因组研究、药物发现以及基因治疗等领域必不可少的工具.在大肠杆菌中,很多基因表达系统已经被人们广泛应用,如pET系统和pBAD系统等.然而,这些系统中...
