成果/Result
- Engineered monoculture and co-culture of methylotrophic yeast for de novo production of monacolin J and lovastatin from methanol被引量：123收藏
- 作者：Liu, Yiqi Tu, Xiaohu Xu, Qin Bai, Chenxiao Kong, Chuixing Liu, Qi Yu, Jiahui Peng, Qiangqiang Zhou, Xiangshan Zhang, Yuanxing Cai, Menghao
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：METABOLIC ENGINEERING 2018
- 关键词：Methanol Methylotrophic yeast Co-culture Heterologous biosynthesis Monacolin J Lovastatin
- Mit1 Transcription Factor Mediates Methanol Signaling and Regulates the Alcohol Oxidase 1 (AOX1) Promoter in Pichia pastoris被引量：95收藏
- 作者：Wang, Xiaolong Wang, Qi Wang, Jinjia Bai, Peng Shi, Lei Shen, Wei Zhou, Mian Zhou, Xiangshan Zhang, Yuanxing Cai, Menghao
- 机构：E China Univ Sci & Technol;SCICB
- 来源：JOURNAL OF BIOLOGICAL CHEMISTRY 2016
- 关键词：DNA-protEIn interaction protEIn domain signal transduction transcription coactivator transcription regulation AOX1 promoter Mit1 Pichia pastoris glycerol repression methanol induction
- Structure and physicochemical properties of amphiphilic agar modified with octenyl succinic anhydride被引量：56收藏
- 作者：Chen, Huijing Chen, Fuquan Xiao, Qiong Cai, Menghao Yang, Qiuming Weng, Huifen Xiao, Anfeng
- 机构：Jimei Univ;East China Univ Sci & Technol;Natl R&D Ctr Red Alga Proc Technol;Fujian Prov Engn Technol Res Ctr Marine Funct Foo
- 来源：CARBOHYDRATE POLYMERS 2021
- 关键词：Agar Octenyl succinic anhydride Characterization Rheology
- Engineered ethanol-driven biosynthetic system for improving production of acetyl-CoA derived drugs in Crabtree-negative yeast被引量：45收藏
- 作者：Liu, Yiqi Bai, Chenxiao Liu, Qi Xu, Qin Qian, Zhilan Peng, Qiangqiang Yu, Jiahui Xu, Mingqiang Zhou, Xiangshan Zhang, Yuanxing Cai, Menghao
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：METABOLIC ENGINEERING 2019
- 关键词：Ethanol Crabtree-negative yeast Acetyl-CoA Monacolin J Metabolic engineering Coculture
- Regulating unfolded protEIn response activator HAC1p for production of thermostable raw-starch hydrolyzing α-amylase in Pichia pastoris被引量：39收藏
- 作者：Huang, Mengmeng Gao, Yanyun Zhou, Xiangshan Zhang, Yuanxing Cai, Menghao
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：BIOPROCESS AND BIOSYSTEMS ENGINEERING 2017
- 关键词：Unfolded protEIn response HAC1p Heterologous expression P. pastoris Raw-starch hydrolyzing alpha-amylase
- PpNrg1 is a transcriptional repressor for glucose and glycerol repression of AOX1 promoter in methylotrophic yeast Pichia pastoris被引量：38收藏
- 作者：Wang, Xiaolong Cai, Menghao Shi, Lei Wang, Qi Zhu, Jinxiang Wang, Jinjia Zhou, Mian Zhou, Xiangshan Zhang, Yuanxing
- 机构：E China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：BIOTECHNOLOGY LETTERS 2016
- 关键词：AOX1 promoter Catabolite repression Glucose Glycerol PpNrg1 Pichia pastoris Transcriptional regulation
- Methylotrophic yeast Pichia pastoris as a chassis organism for polyketide synthesis via the full citrinin biosynthetic pathway被引量：36收藏
- 作者：Xue, Ying Kong, Chuixing Shen, Wei Bai, Chenxiao Ren, Yanna Zhou, Xiangshan Zhang, Yuanxing Cai, Menghao
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：JOURNAL OF BIOTECHNOLOGY 2017
- 关键词：Polyketides Pichia pastoris Heterologous biosynthesis Citrinin Biosynthetic pathway
- A programmable high-expression yeast platform responsive to user-defined signals被引量：35收藏
- 作者：Liu, Qi Song, Lili Peng, Qiangqiang Zhu, Qiaoyun Shi, Xiaona Xu, Mingqiang Wang, Qiyao Zhang, Yuanxing Cai, Menghao
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：SCIENCE ADVANCES 2022
- 关键词：Recombinant protEIns - Transcription
- Identified biosynthetic pathway of aspergiolide A and a novel strategy to increase its production in a marine-derived fungus Aspergillus glaucus by feeding of biosynthetic precursors and inhibitors simultaneously被引量：35收藏
- 作者：Sun, Xueqian Zhou, Xiangshan Cai, Menghao Tao, Kejing Zhang, Yuanxing
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Bioresource Technology 2009
- 关键词：Ketones - Biosynthesis - Metabolites
- Preparation, characterization, and application of high-whiteness agar bleached with hydrogen peroxide被引量：35收藏
- 作者：An, Ding Xiao, Qiong Zhang, Cong Cai, Menghao Zhang, Yonghui Weng, Huifen Chen, Fuquan Xiao, Anfeng
- 机构：Jimei Univ;East China Univ Sci & Technol;Natl R&D Ctr Red Alga Proc Technol;Fujian Prov Engn Technol Res Ctr Marine Funct Foo
- 来源：FOOD HYDROCOLLOIDS 2021
- 关键词：High-whiteness agar Hydrogen peroxide Bleaching Quality promotion Diversified application
- Significance of seed culture methods on mycelial morphology and production of a novel anti-cancer anthraquinone by marine mangrove endophytic fungus Halorosellinia sp. (No. 1403)被引量：34收藏
- 作者：Yu, Chao Cai, Menghao Kang, Li Zhang, Yuanxing Zhou, Xiangshan
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Process Biochemistry 2012
- 关键词：Mycelium - Aromatic compounds - Biomass - Bottles - Diseases - Ketones
- Significant stimulation of o-phthalic acid in biosynthesis of aspergiolide A by a marine fungus Aspergillus glaucus被引量：34收藏
- 作者：Sun, Xueqian Zhou, Xiangshan Cai, Menghao Zhou, Jiushun Zhang, Yuanxing
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Bioresource Technology 2010
- 关键词：Carboxylic acids - Biosynthesis - Ketones - Biochemistry
- Statistical optimization of medium composition for aspergiolide A production by marine-derived fungus Aspergillus glaucus被引量：30收藏
- 作者：Cai, Meng-Hao Zhou, Xiang-Shan Sun, Xue-Qian Tao, Ke-Jing Zhang, Yuan-Xing
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Journal of Industrial Microbiology and Biotechnology 2009
- 关键词：Carbon - Nitrogen - Sodium - Statistical methods - Yeast
- Modulation of acetate utilization in Komagataella phaffii by metabolic engineering of tolerance and metabolism被引量：30收藏
- 作者：Xu, Qin Bai, Chenxiao Liu, Yiqi Song, Lili Tian, Lin Yan, Yunfeng Zhou, Jinfeng Zhou, Xiangshan Zhang, Yuanxing Cai, Menghao
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：BIOTECHNOLOGY FOR BIOFUELS 2019
- 关键词：Komagataella phaffii Acetate utilization Acetyl-CoA Kinase screening Metabolic engineering
- Roles of cobalt in biosynthesis stimulation of a cytotoxic compound from marine-derived Aspergillus glaucus被引量：30收藏
- 作者：Cai, Menghao Sun, Xueqian Zhou, Xiangshan Zhang, Yuanxing
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Process Biochemistry 2012
- 关键词：Aspergillus - Biochemistry - Biosynthesis - Cobalt - Ketones - Trace elements
- Polyketides in Aspergillus terreus: biosynthesis pathway discovery and application被引量：29收藏
- 作者：Yin, Ying Cai, Menghao Zhou, Xiangshan Li, Zhiyong Zhang, Yuanxing
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2016
- 关键词：Polyketide Aspergillus terreus Biosynthesis pathway Gene cluster Heterologous expression
- Efficient strategy for enhancing aspergiolide A production by citrate feedings and its effects on sexual development and growth of marine-derived fungus Aspergillus glaucus被引量：28收藏
- 作者：Cai, Menghao Zhou, Xiangshan Zhou, Jiushun Niu, Chuanpeng Kang, Li Sun, Xueqian Zhang, Yuanxing
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Bioresource Technology 2010
- 关键词：Biochemistry - Sodium compounds - pH effects - Citric acid
- A novel pH–precursor–glucose synergic control strategy for dinactin biosynthesis by an arctic actinomycete Streptomyces sp.被引量：25收藏
- 作者：He, Hao Xue, Ying Xu, Ning Yin, Ying Lu, Jian Cai, Menghao Zhang, Yuanxing
- 机构： State Key Laboratory of Bioreactor Engineering; Shanghai Collaborative Innovation Center for Biomanufacturing
- 来源：Process Biochemistry 2016
- 关键词：Bacteria - Gene encoding - Biochemistry - Glucose
- An Integrated Control Strategy for the Fermentation of the Marine-Derived Fungus Aspergillus glaucus for the Production of Anti-cancer Polyketide被引量：20收藏
- 作者：Cai, Menghao Zhou, Xiangshan Lu, Jian Fan, Weimin Zhou, Jiushun Niu, Chuanpeng Kang, Li Sun, Xueqian Zhang, Yuanxing
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Marine Biotechnology 2012
- 关键词：Biochemistry - Bioreactors - Shear stress - Aspergillus - Bioconversion - Metabolites - Sodium hydroxide - Diseases - Dissolved oxygen - Ketones
- Biosynthetic origin of the carbon skeleton of a novel anti-tumor compound, haloroquinone, from a marine-derived fungus, Halorosellinia sp.被引量：17收藏
- 作者：Niu, Chuanpeng Cai, Menghao Zhang, Yuanxing Zhou, Xiangshan
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Biotechnology Letters 2012
- 关键词：Drug products - Ketones - Biosynthesis - Alkylation - Carbon - Musculoskeletal system
- Engineered dynamic distribution of malonyl-CoA flux for improving polyketide biosynthesis in Komagataella phaffii被引量：15收藏
- 作者：Wen, Jiao Tian, Lin Liu, Qi Zhang, Yuanxing Cai, Menghao
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：JOURNAL OF BIOTECHNOLOGY 2020
- 关键词：Komagataella phaffii FapR/fapO Malonyl-CoA Dynamic control Synthetic biology
- Nutrition and bioprocess development for efficient biosynthesis of an antitumor compound from marine-derived fungus被引量：14收藏
- 作者：Zhou, Weiqiang Cai, Menghao Zhou, Jiushun Jiang, Tao Zhou, Jiao Wang, Meixia Zhou, Xiangshan Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY 2013
- 关键词：Halorosellinia sp (no. 1403) Medium optimization 1403C Fermentation process Antitumor
- Enhancing aspergiolide A production from a shear-sensitive and easy-foaming marine-derived filamentous fungus Aspergillus glaucus by oxygen carrier addition and impeller combination in a bioreactor被引量：13收藏
- 作者：Cai, Menghao Zhou, Xiangshan Lu, Jian Fan, Weimin Niu, Chuanpeng Zhou, Jiushun Sun, Xueqian Kang, Li Zhang, Yuanxing
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Bioresource Technology 2011
- 关键词：Oxygen - Turbomachine blades - Biomass - Bioconversion - Bioreactors - Turbine components - Impellers
- Improved methanol-derived lovastatin production through enhancement of the biosynthetic pathway and intracellular lovastatin efflux in methylotrophic yeast被引量：13收藏
- 作者：Liu, Yiqi Bai, Chenxiao Xu, Qin Yu, Jiahui Zhou, Xiangshan Zhang, Yuanxing Cai, Menghao
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：BIORESOURCES AND BIOPROCESSING 2018
- 关键词：Enhanced biosynthetic pathway Lovastatin Methanol Pichia pastoris Statin pump protEIn
- Improved production of the anticancer compound 1403C by glucose pulse feeding of marine Halorosellinia sp. (No. 1403) in submerged culture被引量：13收藏
- 作者：Kang, Li Cai, Menghao Yu, Chao Zhang, Yuanxing Zhou, Xiangshan
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Bioresource Technology 2011
- 关键词：Batch cell culture - Fungi
- AI 赋能虚实递进的生物医药新工科实习教学体系的构建被引量：12收藏
- 作者：Wan, Junfen Cai, Menghao Wang, Qiyao
- 机构： Department of Bioengineering
- 来源：[1] Department of Bioengineering, School of Bioengineering, East China University of Science and Technology, Shanghai, 200237, China 2026
- Evaluation of a novel self-emulsifiable dodecenyl succinylated agarose in microencapsulation of docosahexaenoic acid (DHA) through spray-chilling process被引量：12收藏
- 作者：Xiao, Qiong Chen, Guo Zhang, Yonghui Weng, Huifen Cai, Menghao Xiao, Anfeng
- 机构：Jimei Univ;Huaqiao Univ;Natl R&D Ctr Red Alga Proc Technol;Fujian Prov Engn Technol Res Ctr Marine Funct Foo;East China Univ Sci & Technol
- 来源：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2020
- 关键词：Agarose sodium dodecenyl succinate Spray-chilling process Docosahexaenoic acid microencapsulation
- Engineering substrate and energy metabolism for living cell production of cytidine-5′-diphosphocholine被引量：12收藏
- 作者：Ren, Yanna Liu, Qi Liu, Haifeng Zhou, Xiangshan Zhang, Yuanxing Cai, Menghao
- 机构：East China Univ Sci & Technol;China Resources Angde Biotech Pharmaceut Co Ltd;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2020
- 关键词：ATP generation choline transport cytidine-5 '-diphosphocholine metabolic engineering Pichia pastoris
- A light-dark shift strategy derived from light-responded metabolic behaviors for polyketides production in marine fungus Halorosellinia sp.被引量：9收藏
- 作者：Zhang, Xiaoxu He, Hao Yin, Ying Zhou, Weiqiang Cai, Menghao Zhou, Xiangshan Zhang, Yuanxing
- 机构：E China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：JOURNAL OF BIOTECHNOLOGY 2016
- 关键词：Fermentation Light regulation Light-dark shift Anticancer polyketide Halorosellinia sp. Marine fungus
- Mixed carbon source control strategy for enhancing alginate lyase production by marine Vibrio sp QY102被引量：8收藏
- 作者：Zhou, Jiushun Cai, Menghao Jiang, Tao Zhou, Weiqiang Shen, Wei Zhou, Xiangshan Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：BIOPROCESS AND BIOSYSTEMS ENGINEERING 2014
- 关键词：Alginate induction Alginate lyase Vibrio sp QY102 Medium optimization Mixed carbon source
