成果/Result
- First-generation species-selective chemical probes for fluorescence imaging of human senescence-associated β-galactosidase被引量：76收藏
- 作者：Li, Xiaokang Qiu, Wenjing Li, Jinwen Chen, Xi Hu, Yulu Gao, Ying Shi, Donglei Li, Xinming Lin, Huiling Hu, Zelan Dong, Guoqiang Sheng, Chunquan Jiang, Bei Xia, Conglong Kim, Chu-Young Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;Second Mil Med Univ;Dali Univ;Univ Texas El Paso
- 来源：CHEMICAL SCIENCE 2020
- 关键词：Probes - Fluorescence imaging - Enzymes - Fluorescence spectroscopy - Mammals
- Characterization of cellular senescence in doxorubicin-induced aging mice被引量：54收藏
- 作者：Sun, Tianyue Zhang, Lanxin Feng, Jiali Bao, Lingyuan Wang, Jiqun Song, Zhouzhi Mao, Zhifan Li, Jian Hu, Zelan
- 机构：East China Univ Sci & Technol;Dali Univ;Tongji Univ
- 来源：EXPERIMENTAL GERONTOLOGY 2022
- 关键词：Doxorubicin Senescence Mice Metformin
- Osteopontin-enriched formula feeding improves the T-cell-dependent humoral immune responses in infant rats被引量：41收藏
- 作者：Chen, Xiaoyan Fang, Meirong Xing, Shuli Zuo, Daming Zhang, Ping Hu, Zelan
- 机构：East China Univ Sci & Technol;Southern Med Univ;Fourth Mil Med Univ
- 来源：INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION 2018
- 关键词：Osteopontin infant formula immunity postnatal rats
- ZFX knockdown inhibits growth and migration of non-small cell lung carcinoma cell line H1299被引量：34收藏
- 作者：Li, Kui Zhu, Zhi-Chuan Liu, Yong-Jie Liu, Ji-Wei Wang, Hong-Tao Xiong, Zhi-Qi Shen, Xu Hu, Ze-Lan Zheng, Jing
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 2013
- 关键词：ZFX non-small cell lung carcinoma growth migration senescence
- ZFX regulates glioma cell proliferation and survival in vitro and in vivo被引量：33收藏
- 作者：Zhu, Zhichuan Li, Kui Xu, Dafeng Liu, Yongjie Tang, Hailiang Xie, Qing Xie, Liqian Liu, Jiwei Wang, Hongtao Gong, Ye Hu, Zelan Zheng, Jing
- 机构：E China Univ Sci & Technol;Fudan Univ
- 来源：JOURNAL OF NEURO-ONCOLOGY 2013
- 关键词：Glioma ZFX Proliferation Survival Xenografted tumor
- Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility被引量：30收藏
- 作者：Zhu, Zhichuan Liu, Yongjie Li, Kui Liu, Jiwei Wang, Hongtao Sun, Bing Xiong, Zhiqi Jiang, Hualiang Zheng, Jing Hu, Zelan
- 机构：E China Univ Sci & Technol;Fudan Univ;Chinese Acad Sci
- 来源：CARCINOGENESIS 2014
- Verapamil extends lifespan in Caenorhabditis elegans by inhibiting calcineurin activity and promoting autophagy被引量：26收藏
- 作者：Liu, Wenwen Lin, Huiling Mao, Zhifan Zhang, Lanxin Bao, Keting Jiang, Bei Xia, Conglong Li, Wenjun Hu, Zelan Li, Jian
- 机构：East China Univ Sci & Technol;Dali Univ;Dali Univ;Natl Inst Biol Sci
- 来源：AGING-US 2020
- 关键词：verapamil Caenorhabditis elegans anti-aging cell senescence autophagy
- Notch-Rbpj signaling is required for the development of noradrenergic neurons in the mouse locus coeruleus被引量：19收藏
- 作者：Shi, Ming Hu, Ze-Lan Zheng, Min-Hua Song, Ning-Ning Huang, Ying Zhao, Gang Han, Hua Ding, Yu-Qiang
- 机构：Tongji Univ;Tongji Univ;Fourth Mil Med Univ;E China Univ Sci & Technol;Fourth Mil Med Univ
- 来源：JOURNAL OF CELL SCIENCE 2012
- 关键词：Rbpj Notch signaling Locus coeruleus Rhombomere 1 Hes1 Ascl1
- Anti-aging effects of chlorpropamide depend on mitochondrial complex-II and the production of mitochondrial reactive oxygen species被引量：19收藏
- 作者：Mao, Zhifan Liu, Wenwen Huang, Yunyuan Sun, Tianyue Bao, Keting Feng, Jiali Moskalev, Alexey Hu, Zelan Li, Jian
- 机构：East China Univ Sci & Technol;Russian Acad Sci;Dali Univ;Tongji Univ
- 来源：ACTA PHARMACEUTICA SINICA B 2022
- 关键词：Sulfonylureas Chlorpropamide Anti-aging Mitochondrial complex II Mitochondrial reactive oxygen species ATP sensitive potassium channels Senescence Succinate dehydrogenase
- Antiaging Effects of Vicatia thibetica de Boiss Root Extract on Caenorhabditis elegans and Doxorubicin-Induced Premature Aging in Adult Mice被引量：11收藏
- 作者：Liu, Wenwen Guan, Yunhui Qiao, Sicong Wang, Jiqun Bao, Keting Mao, Zhifan Liao, Liang Moskalev, Alexey Jiang, Bei Zhu, Jin Xia, Conglong Li, Jian Hu, Zelan
- 机构：East China Univ Sci & Technol;Dali Univ;Russian Acad Sci;Dali Univ;Tongji Univ
- 来源：OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2021
- 关键词：Antioxidants - Free radicals - Plants (botany) - Heat resistance - Mammals
- Androglobin knockdown inhibits growth of glioma cell lines被引量：11收藏
- 作者：Huang, Bo Lu, Yi-Sheng Li, Xia Zhu, Zhi-Chuan Li, Kui Liu, Ji-Wei Zheng, Jing Hu, Ze-Lan
- 机构：E China Univ Sci & Technol;PLA;Yi Ji Shan Hosp
- 来源：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 2014
- 关键词：Androglobin glioma proliferation apoptosis
- DSTYK kinase domain ablation impaired the mice capabilities of learning and memory in water maze test被引量：11收藏
- 作者：Li, Kui Liu, Ji-Wei Zhu, Zhi-Chuan Wang, Hong-Tao Zu, Yong Liu, Yong-Jie Yang, Yan-Hong Xiong, Zhi-Qi Shen, Xu Chen, Rui Zheng, Jing Hu, Ze-Lan
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Baylor Coll Med
- 来源：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 2014
- 关键词：DSTYK knockout mice brain development learning and memory
- Lactose induced redox-dependent senescence and activated Nrf2 pathway被引量：8收藏
- 作者：Xing, Shuli Zhang, Lanxin Lin, Huiling Mao, Zhifan Bao, Keting Hao, Peng Pei, Zhe Li, Jian Hu, Zelan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Duke Univ
- 来源：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 2019
- 关键词：Lactose ROS oxidative stress cellular senescence Nrf2
- Effects of sleeve gastrectomy on lipid and energy metabolism in ZDF rats via PI3K/AKT pathway被引量：8收藏
- 作者：Feng, Ying Zhong, Chen Niu, Jianxiang Zhang, Lin Zhao, Yang Wang, Wen Hu, Zelan Wang, Hui He, Ping Ning, Qinjie Xu, JingJing Zheng, Jing
- 机构：East China Univ Sci & Technol;Inner Mongolia Med Univ;East China Univ Sci & Technol
- 来源：AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 2018
- 关键词：Sleeve gastrectomy Zucker diabetes fatty rats lipid metabolism energy metabolism PI3K/Akt pathway
- Glibenclamide targets MDH2 to relieve aging phenotypes through metabolism-regulated epigenetic modification被引量：8收藏
- 作者：Mao, Zhifan Liu, Wenwen Zou, Rong Sun, Ling Huang, Shuman Wu, Lingyu Chen, Liru Wu, Jiale Lu, Shijie Song, Zhouzhi Li, Xie Huang, Yunyuan Rao, Yong Huang, Yi-You Li, Baoli Hu, Zelan Li, Jian
- 机构：East China Univ Sci & Technol;Hainan Univ;Cent China Normal Univ;Shihezi Univ
- 来源：SIGNAL TRANSDUCTION AND TARGETED THERAPY 2025
- Nicandra physalodes Extract Exerts Antiaging Effects in Multiple Models and Extends the Lifespan of Caenorhabditis elegans via DAF-16 and HSF-1被引量：6收藏
- 作者：Wang, Jiqun Huang, Yunyuan Shi, Kaixuan Bao, Lingyuan Xiao, Chaojiang Sun, Tianyue Mao, Zhifan Feng, Jiali Hu, Zelan Guo, Zhenghan Li, Jing Jiang, Bei Liu, Wenwen Li, Jian
- 机构：East China Univ Sci & Technol;Cent China Normal Univ;Dali Univ;Hainan Univ;Tongji Univ
- 来源：OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2022
- 关键词：Cell culture - Diagnosis - Mammals - Plant extracts
- Inactivation of β-catenin results in the reduction of postnatal body weight gain被引量：4收藏
- 作者：Wang, Hong-Tao Zeng, Lin Zhang, Xin Li, Kui Zu, Yong Liu, Ji-wei Liu, Yong-jie Zhu, Zhi-chuan Xiong, Zhi-Qi Zheng, Jing Hu, Ze-Lan
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：BRAIN RESEARCH BULLETIN 2014
- 关键词：Arcuate nucleus of hypothalamus beta-Catenin NPY POMC Body weight
- Purification, structural characterization, and anti-ulcerative colitis activity of a novel pectin-like polysaccharide AH-H4-1 from Alhagi honey被引量：4收藏
- 作者：Wang, Zhe Chi, Yaping Wang, Menghua Zhou, Qianqian Yan, Zexiang Xue, Rui Cai, Xiaoxia Tian, Jing Yu, Wei Yaermaimaiti, Saimijiang Turghun, Chimengul Sun, Yakun Song, Wangdi Du, Daohai Luo, Cheng Hu, Zelan Han, Bo
- 机构：Shihezi Univ;East China Univ Sci & Technol;Shandong Univ;Chinese Acad Sci
- 来源：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2025
- 关键词：Alhagi honey Pectin-like polysaccharide DSS-induced UC model Structural characterization
- β-CATENIN IS REQUIRED FOR MAINTAINING HIPPOCAMPAL MORPHOLOGY DURING THE PERINATAL PERIOD被引量：3收藏
- 作者：Wang, H. -T. Zeng, L. Chen, Q. Zhang, X. Liu, J. -W. Lu, T. -J. Xiong, Z. -Q. Zheng, J. Hu, Z. -L.
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：NEUROSCIENCE 2015
- 关键词：beta-catenin hippocampal primordium radial glial scaffold ectopic cell perinatal stage GFAP
- ZFX regulates glioma cell proliferation and survival in vitro and in vivo (vol 112, pg 17, 2013)被引量：1收藏
- 作者：Zhu, Zhichuan Li, Kui Xu, Dafeng Liu, Yongjie Tang, Hailiang Xie, Qing Xie, Liqian Liu, Jiwei Wang, Hongtao Gong, Ye Hu, Zelan Zheng, Jing
- 机构：E China Univ Sci & Technol;Fudan Univ
- 来源：JOURNAL OF NEURO-ONCOLOGY 2013
- Conditional ablation of protein tyrosine phosphatase receptor U in midbrain dopaminergic neurons results in reduced neuronal size被引量：1收藏
- 作者：Liu, Jiwei Yang, Li Li, Han Cai, Yichuan Feng, Jiali Hu, Zelan
- 机构：Shanghai Jiao Tong Univ;Naval Medical Univ;East China Univ Sci & Technol
- 来源：JOURNAL OF CHEMICAL NEUROANATOMY 2022
- 关键词：protein tyrosine phosphatase receptor U reduced neuronal size mDA neurons orphan nuclear receptor tyrosine hydroxylase
- Delayed but not loss of gliogenesis in Rbpj-deficient trigeminal ganglion被引量：1收藏
- 作者：Hu, Ze-Lan Zhang, Xin Shi, Ming Tian, Zhi-Wen Huang, Ying Chen, Jia-Yin Ding, Yu-Qiang
- 机构：E China Univ Sci & Technol;Fourth Mil Med Univ;East Hosp;Tongji Univ
- 来源：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 2013
- 关键词：Dorsal root ganglion trigeminal ganglion Rbpj gliogenesis
- DSTYK knockout affects the architecture of F-actin cytoskeleton in mouse renal proximal convoluted tubules被引量：0收藏
- 作者：Liu, Ji-Wei Mao, Lin Zhu, Zhi-Chuan Li, Kui Liao, Lu-Jian Xiong, Zhi-Qi Hu, Ze-Lan Zheng, Jing
- 机构：East China Univ Sci & Technol;East China Normal Univ
- 来源：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 2017
- 关键词：DSTYK CAKUT F-actin proximal convoluted tubules Profilin 1 Profilin 2
- Discovery of Novel MDH2 Inhibitor
28i by Secondary Development of Glibenclamide with Potent Antiaging Activities被引量：0收藏 - 作者：Wu, Lingyu Zeng, Ru Huang, Shuman Wu, Jiale Ai, Yu Mao, Zhifan Yang, Zhiguo Liu, Dan Huang, Yi-You Li, Jian Liu, Wenwen Hu, Zelan Li, Baoli
- 机构：Hainan Univ;Hainan Univ;East China Univ Sci & Technol;Shenyang Pharmaceut Univ;Shihezi Univ
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2026
- 聚乙烯亚胺改性的双介孔氧化硅基因载体构建被引量：0收藏
- 作者：方美蓉 秦利梅 贾晓博 李永生 牛德超 胡泽岚
- 机构：华东理工大学药学院上海新药设计重点实验室;华东理工大学材料科学与工程学院
- 来源：《无机材料学报》 2020
- 关键词：双介孔氧化硅球 聚乙烯亚胺 基因治疗 恶性胶质瘤
- 摘要：为了开发一种新型的非病毒无机基因载体,采用3-氨丙基三乙氧基硅烷(APTMS)和聚乙烯亚胺(PEI)对嵌入型双介孔氧化硅球(EDMSNs)进行改性,分别得到EDMSNs-NH2和EDMSNs-PEI,并比较了两种载体结合...
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