成果/Result
- FRET-Based Mito-Specific Fluorescent Probe for Ratiometric Detection and Imaging of Endogenous Peroxynitrite: Dyad of Cy3 and Cy5被引量：316收藏
- 作者：Jia, Xiaotong Chen, Qiangqiang Yang, Yingfang Tang, Yao Wang, Rui Xu, Yufang Zhu, Weiping Qian, Xuhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2016
- 关键词：Fluorescence spectroscopy - Probes
- A dual-response BODIPY-based fluorescent probe for the discrimination of glutathione from cystein and homocystein被引量：264收藏
- 作者：Wang, Feiyi Zhou, Li Zhao, Chunchang Wang, Rui Fei, Qiang Luo, Sihang Guo, Zhiqian Tian, He Zhu, Wei-Hong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：CHEMICAL SCIENCE 2015
- 关键词：Cyclization - Probes - Covalent bonds - Fluorescence imaging - Peptides - Sulfur compounds
- Fluorescent In Situ Targeting Probes for Rapid Imaging of Ovarian-Cancer-Specific γ-Glutamyltranspeptidase被引量：184收藏
- 作者：Wang, Feiyi Zhu, Ying Zhou, Li Pan, Liang Cui, Zhifen Fei, Qiang Luo, Sihang Pan, Dun Huang, Qing Wang, Rui Zhao, Chunchang Tian, He Fan, Chunhai
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Acad Sci;E China Univ Sci & Technol
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2015
- 关键词：aromatic hydrocarbon transfer enzymes fluorescence photophysics tumor cells
- Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2被引量：151收藏
- 作者：Xiong, Rui Zhang, Leike Li, Shiliang Sun, Yuan Ding, Minyi Wang, Yong Zhao, Yongliang Wu, Yan Shang, Weijuan Jiang, Xiaming Shan, Jiwei Shen, Zihao Tong, Yi Xu, Liuxin Chen, Yu Liu, Yingle Zou, Gang Lavillete, Dimitri Zhao, Zhenjiang Wang, Rui Zhu, Lili Xiao, Gengfu Lan, Ke Li, Honglin Xu, Ke
- 机构：Wuhan Univ;East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：PROTEIN & CELL 2020
- 关键词：de novopyrimidine biosynthesis DHODH inhibitors SARS-CoV-2 influenza viruses virus replication immuno-regulation
- Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain被引量：136收藏
- 作者：Wang, Suqing Wang, Rui Chen, Lang Bennett, David A. Dickson, Dennis W. Wang, Deng-Shun
- 机构：Univ Wisconsin;Wuhan Univ;E China Univ Sci & Technol;Rush Univ;Mayo Clin
- 来源：JOURNAL OF NEUROCHEMISTRY 2010
- 关键词：Alzheimer's disease Alzheimer's disease brain amyloid-degrading enzymes degradation endothelin-converting enzyme insulin-degrading enzyme neprilysin beta-amyloid
- A dual-emission and large Stokes shift fluorescence probe for real-time discrimination of ROS/RNS and imaging in live cells被引量：106收藏
- 作者：Guo, Ting Cui, Lei Shen, Jiaoning Wang, Rui Zhu, Weiping Xu, Yufang Qian, Xuhong
- 机构：E China Univ Sci & Technol
- 来源：CHEMICAL COMMUNICATIONS 2013
- Enzymatic Cleavage and Subsequent Facile Intramolecular Transcyclization for in Situ Fluorescence Detection of γ-Glutamyltranspetidase Activities被引量：78收藏
- 作者：Tong, Hongjuan Zheng, Yongjun Zhou, Li Li, Xiangmin Qian, Rui Wang, Rui Zhao, Jianhong Lou, Kaiyan Wang, Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ New Mexico
- 来源：ANALYTICAL CHEMISTRY 2016
- 关键词：Cancer cells - Cells - Diseases - Diagnosis - Cytology - Fluorescence spectroscopy - Probes - Enzymes - Product design
- Analyte Regeneration Fluorescent Probes for Formaldehyde Enabled by Regiospecific Formaldehyde-Induced Intramolecularity被引量：72收藏
- 作者：Xu, Hang Xu, Huan Ma, Shengnan Chen, Xiani Huang, Lixian Chen, Junwei Gao, Feng Wang, Rui Lou, Kaiyan Wang, Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ Arizona;Univ Arizona
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2018
- 关键词：Fluorescence spectroscopy - Fluorescence - Probes - Molecules
- Transforming the recognition site of 4-hydroxyaniline into 4-methoxyaniline grafted onto a BODIPY core switches the selective detection of peroxynitrite to hypochlorous acid被引量：70收藏
- 作者：Zhao, Chunchang An, Jiancai Zhou, Li Fei, Qiang Wang, Feiyi Tan, Jie Shi, Ben Wang, Rui Guo, Zhiqian Zhu, Wei-Hong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：CHEMICAL COMMUNICATIONS 2016
- Salvanic acid B inhibits glycolysis in oral squamous cell carcinoma via targeting PI3K/AKT/HIF-1α signaling pathway被引量：68收藏
- 作者：Wei, Jie Wu, Jun Xu, Wen Nie, Hong Zhou, Ruiqing Wang, Rui Liu, Yang Tang, Guoyao Wu, Jianyong
- 机构：Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：CELL DEATH & DISEASE 2018
- An ESIPT-based fluorescent probe for sensitive detection of hydrazine in aqueous solution被引量：66收藏
- 作者：Zhou, Ji Shi, Ruiyan Liu, Jianxu Wang, Rui Xu, Yufang Qian, Xuhong
- 机构：E China Univ Sci & Technol
- 来源：ORGANIC & BIOMOLECULAR CHEMISTRY 2015
- 关键词：Fluorescence - Probes - Solutions - Lanthanum compounds
- A highly selective and sensitive near-infrared fluorescence probe for arylamine N-acetyltransferase 2 in vitro and in vivo被引量：65收藏
- 作者：Wang, Xin Cui, Lei Zhou, Nannan Zhu, Weiping Wang, Rui Qian, Xuhong Xu, Yufang
- 机构：E China Univ Sci & Technol
- 来源：CHEMICAL SCIENCE 2013
- Development of a BODIPY-based ratiometric fluorescent probe for hypochlorous acid and its application in living cells被引量：55收藏
- 作者：Wang, Xuzhe Zhou, Li Qiang, Fei Wang, Feiyi Wang, Rui Zhao, Chunchang
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：ANALYTICA CHIMICA ACTA 2016
- 关键词：Ratiometric detection Fluorescent probe Hypochlorous acid High selectivity pH-independency
- Discovery and Rational Design of Natural-Product-Derived 2-Phenyl-3,4-dihydro-2H-benzo[f]chromen-3-amine Analogs as Novel and Potent Dipeptidyl Peptidase 4 (DPP-4) Inhibitors for the Treatment of Type 2 Diabetes被引量：51收藏
- 作者：Li, Shiliang Xu, Hongling Cui, Shichao Wu, Fangshu Zhang, Youli Su, Mingbo Gong, Yinghui Qiu, Shaobing Jiao, Qian Qin, Chun Shan, Jiwei Zhang, Ming Wang, Jiawei Yin, Qiao Xu, Minghao Liu, Xiaofeng Wang, Rui Zhu, Lili Li, Jia Xu, Yufang Jiang, Hualiang Zhao, Zhenjiang Li, Jingya Li, Honglin
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2016
- A ratiometric fluorescent probe for fast and sensitive detection of peroxynitrite: a boronate ester as the receptor to initiate a cascade reaction被引量：50收藏
- 作者：Zhou, Ji Li, Yang Shen, Jiaoning Li, Qiang Wang, Rui Xu, Yufang Qian, Xuhong
- 机构：E China Univ Sci & Technol
- 来源：RSC ADVANCES 2014
- 关键词：Cyclization - Lanthanum compounds - Probes - Fluorescence
- Design, Synthesis, X-ray Crystallographic Analysis, and Biological Evaluation of Thiazole Derivatives as Potent and Selective Inhibitors of Human Dihydroorotate Dehydrogenase被引量：47收藏
- 作者：Zhu, Junsheng Han, Le Diao, Yanyan Ren, Xiaoli Xu, Minghao Xu, Liuxin Li, Shiliang Li, Qiang Dong, Dong Huang, Jin Liu, Xiaofeng Zhao, Zhenjiang Wang, Rui Zhu, Lili Xu, Yufang Qian, Xuhong Li, Honglin
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2015
- Fluorescent theranostic agents for Hg2+ detection and detoxification treatment被引量：47收藏
- 作者：Song, Chao Yang, Wen Zhou, Nannan Qian, Rui Zhang, Yajun Lou, Kaiyan Wang, Rui Wang, Wei
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Univ New Mexico
- 来源：CHEMICAL COMMUNICATIONS 2015
- A highly selective turn-on fluorescent probe based on semi-cyanine for the detection of nitroreductase and hypoxic tumor cell imaging被引量：44收藏
- 作者：Yuan, Jun Xu, Yu-Qiong Zhou, Nan-Nan Wang, Rui Qian, Xu-Hong Xu, Yu-Fang
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：RSC ADVANCES 2014
- 关键词：Fluorescence - Tumors
- Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer's disease agents被引量：44收藏
- 作者：Yang, Gui-Xiang Huang, Yan Zheng, Lu-Lu Zhang, Li Su, Lin Wu, Yu-Hang Li, Jie Zhou, Li-Cheng Huang, Jin Tang, Yun Wang, Rui Ma, Lei
- 机构：East China Univ Sci & Technol
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2020
- 关键词：Alzheimer's disease Diosgenin Antioxidant Anti-inflammatory Anti-A beta activity Multi-target-directed ligands
- Neuroprotective effects of bacopaside I in ischemic brain injury被引量：40收藏
- 作者：Liu, Xiaojun Yue, Rongcai Zhang, Jigang Shan, Lei Wang, Rui Zhang, Weidong
- 机构：Second Mil Med Univ;E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：RESTORATIVE NEUROLOGY AND NEUROSCIENCE 2013
- 关键词：Bacopaside I stroke ischemic injury reactive oxygen radicals energy metabolism
- Macrocyclization of linear molecules by deep learning to facilitate macrocyclic drug candidates discovery被引量：40收藏
- 作者：Diao, Yanyan Liu, Dandan Ge, Huan Zhang, Rongrong Jiang, Kexin Bao, Runhui Zhu, Xiaoqian Bi, Hongjie Liao, Wenjie Chen, Ziqi Zhang, Kai Wang, Rui Zhu, Lili Zhao, Zhenjiang Hu, Qiaoyu Li, Honglin
- 机构：East China Univ Sci & Technol;East China Normal Univ;Lingang Lab
- 来源：NATURE COMMUNICATIONS 2023
- Rational construction of probes rendering ratiometric response to the cancer-specific enzyme NQO1被引量：38收藏
- 作者：Fei, Qiang Zhou, Li Wang, Feiyi Shi, Ben Li, Chunbao Wang, Rui Zhao, Chunchang
- 机构：Tianjin Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：DYES AND PIGMENTS 2017
- 关键词：Cancer biomarker Polymeric micelle Nanoprobe Ratiometric Cancer-specific NQO1
- Sarsasapogenin-AA13 ameliorates Aβ-induced cognitive deficits via improving neuroglial capacity on Aβ clearance and antiinflammation被引量：37收藏
- 作者：Huang, Cui Dong, Dong Jiao, Qian Pan, Hui Ma, Lei Wang, Rui
- 机构：East China Univ Sci & Technol
- 来源：CNS NEUROSCIENCE & THERAPEUTICS 2017
- 关键词：antiinflammation beta-amyloid clearance neuroglia phagocytosis sarsasapogenin-AA13
- Design, synthesis, and biological evaluation of diosgenin-indole derivatives as dual-functional agents for the treatment of Alzheimer's disease被引量：34收藏
- 作者：Zhou, Li-Cheng Liang, Ying-Fan Huang, Yi Yang, Gui-Xiang Zheng, Lu-Lu Sun, Jia-Min Li, Yang Zhu, Fu-Li Qian, He-Wen Wang, Rui Ma, Lei
- 机构：East China Univ Sci & Technol
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2021
- 关键词：Diosgenin Antioxidant Anti-beta amyloid Alzheimer's disease
- Neonatal exposure to fluoxetine and fluvoxamine alteres spine density in mouse hippocampal CA1 pyramidal neurons被引量：34收藏
- 作者：Zheng, Jing Xu, Da-Feng Li, Kui Wang, Hong-Tao Shen, Peng-Cheng Lin, Min Cao, Xiao-Hua Wang, Rui
- 机构：E China Univ Sci & Technol;E China Normal Univ
- 来源：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 2011
- 关键词：SSRI dendritic spine density neuronal development fluoxetine fluvoxamine
- A novel "donor-two-acceptor" type fluorophore-based probe for fast detection and intracellular imaging of nitroreductase被引量：33收藏
- 作者：Li, Dandan Xu, Yuqiong Zhou, Nannan Liu, Jianxu Wang, Rui Cheng, Tao Tang, Yun Zhu, Weiping Xu, Yufang Qian, Xuhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：DYES AND PIGMENTS 2017
- 关键词：Probes - Solutions
- The characteristics of astrocyte on Aβ clearance altered in Alzheimer's disease were reversed by anti-inflammatory agent (+)-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeate被引量：31收藏
- 作者：Liu, Rui-Xuan Huang, Cui Bennett, David A. Li, Honglin Wang, Rui
- 机构：East China Univ Sci & Technol;Wuhan Univ;Rush Univ
- 来源：AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 2016
- 关键词：Alzheimer's disease astrocyte A beta clearance neprilysin inflammation HOEC
- Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes被引量：29收藏
- 作者：Li, Shiliang Qin, Chun Cui, Shichao Xu, Hongling Wu, Fangshu Wang, Jiawei Su, Mingbo Fang, Xiaoyu Li, Dan Jiao, Qian Zhang, Ming Xia, Chunmei Zhu, Lili Wang, Rui Li, Jia Jiang, Hualiang Zhao, Zhenjiang Li, Jingya Li, Honglin
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2019
- Sarsasapogenin-AA13 inhibits LPS-induced inflammatory responses in macrophage cells in vitro and relieves dimethylbenzene-induced ear edema in mice被引量：29收藏
- 作者：Dong, Dong Zhou, Nan-nan Liu, Rui-xuan Xiong, Jia-wei Pan, Hui Sun, Si-qi Ma, Lei Wang, Rui
- 机构：East China Univ Sci & Technol
- 来源：ACTA PHARMACOLOGICA SINICA 2017
- 关键词：sarsasapogenin AA13 antifani anti-inflammation inflammatory factor nuclear factor-kappa B mitogen-activated protein kinases ear edema
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- The antidepressant-like effect of bacopaside I: Possible involvement of the oxidative stress system and the noradrenergic system被引量：27收藏
- 作者：Liu, Xiaojun Liu, Fang Yue, Rongcai Li, Yuanyuan Zhang, Jigang Wang, Shuping Zhang, Shoude Wang, Rui Shan, Lei Zhang, Weidong
- 机构：Second Mil Med Univ;E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 2013
- 关键词：Bacopaside I Antidepressant-like effect Antioxidant activation Noradrenergic Forced swim Tail suspension
