成果/Result
- Sulfated oligosaccharide activates endothelial Notch for inducing macrophage- associated arteriogenesis to treat ischemic diseases被引量：144收藏
- 作者：Yu, Yuanman Wang, Shuang Chen, Xinye Gao, Zehua Dai, Kai Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2023
- 关键词：ischemic diseases in situ regeneration therapeutic arteriogenesis sulfated oligosaccharide perivascular macrophage
- Biomaterial design for regenerating aged bone: materiobiological advances and paradigmatic shifts被引量：51收藏
- 作者：Dai, Kai Geng, Zhen Zhang, Wenchao Wei, Xue Wang, Jing Nie, Guangjun Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Univ
- 来源：NATIONAL SCIENCE REVIEW 2024
- 关键词：materiobiology biomaterial design aging bone regeneration artificial intelligence
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- A BMP-2-triggered in vivo osteo-organoid for cell therapy被引量：38收藏
- 作者：Dai, Kai Zhang, Qinghao Deng, Shunshu Yu, Yuanman Zhu, Fuwei Zhang, Shuang Pan, YuanZhong Long, Dandan Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：SCIENCE ADVANCES 2023
- 关键词：Bone - Cell culture - Flowcharting - Mammals - Proteins - Scaffolds (biology)
- Recapitulation of growth factor-enriched microenvironment via BMP receptor activating hydrogel被引量：36收藏
- 作者：Zhang, Qinghao Liu, Yuanda Li, Jie Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOACTIVE MATERIALS 2023
- 关键词：BMP-2 Sulfonated acids BMP receptor Activation Endogenous growth factor acquisition Bone regeneration
- Effect of sulfated chitosan hydrogel on vascularization and osteogenesis被引量：32收藏
- 作者：Jiang, Ming Pan, Yuanzhong Liu, Yuanda Dai, Kai Zhang, Qinghao Wang, Jing
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CARBOHYDRATE POLYMERS 2022
- 关键词：Sulfated chitosan Mesenchymal stem cells Bone regeneration Vascularization
- Dual-function injectable fibrin gel incorporated with sulfated chitosan nanoparticles for rhBMP-2-induced bone regeneration被引量：25收藏
- 作者：Chen, Xinye Wang, Shuang Zhang, Xiaohui Yu, Yuanman Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：APPLIED MATERIALS TODAY 2022
- 关键词：BMP-2 Sulfated chitosan Immunomodulation Bone regeneration
- Porous PLGA/MBG scaffold enhanced bone regeneration through osteoimmunomodulation被引量：22收藏
- 作者：Liu, Yang Zhang, Shuang Zhang, Xiaohui Ji, Luli Yu, Hongmeng Wang, Jing Liu, Changsheng
- 机构：Fudan Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Med Sci;Fudan Univ
- 来源：COMPOSITES PART B-ENGINEERING 2024
- 关键词：Osteoimmunomodulation Macrophage Mesoporous bioactive glass (MBG) Bone repair and regeneration
- Osteoinductive hybrid hydrogel membranes for in situ bone regeneration in hyperglycemia被引量：17收藏
- 作者：Liu, Yuanda Wang, Jing Jiang, Ming Li, Xueyan Zhang, Qinghao He, Hongyan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Eye & Ent Hosp Fudan Univ
- 来源：COLLOIDS AND SURFACES B-BIOINTERFACES 2022
- 关键词：Hyperglycemia Vascularization Bone regeneration Amorphous calcium phosphate Biomineralization
- Regulating the bioactivity of non-glycosylated recombinant human bone morphogenetic protein-2 to enhance bone regeneration被引量：4收藏
- 作者：Yu, Yuanman Chen, Rui Chen, Xinye Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOACTIVE MATERIALS 2024
- 关键词：Recombinant human bone morphogenetic protein-2 Osteogenic activity Protein stability Sulfated polysaccharide
- Injured bone-triggered osteokines secretion promotes diabetic wound healing被引量：4收藏
- 作者：Shen, Tong Dai, Kai Zhang, Shuang Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BONE RESEARCH 2025
- Biomaterial-assisted therapeutic cell production and modi fi cation in vivo被引量：3收藏
- 作者：Dai, Kai Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：EXPERIMENTAL HEMATOLOGY 2024
- Amphiphilic cytokine traps remodel marrow adipose tissue for hematopoietic microenvironment amelioration被引量：2收藏
- 作者：Deng, Shunshu Zhang, Shuang Shen, Tong Wang, Xuanlin Gao, Zehua Zhang, Wenchao Dai, Kai Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;Tongji Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOACTIVE MATERIALS 2024
- 关键词：Adipocytes Hematopoiesis In vivo osteo-organoids Stem cell factor Sulfated chitosan Tissue regeneration
- In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells被引量：2收藏
- 作者：Zhang, Wenchao Wei, Xue Wang, Qingliang Dai, Kai Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOVE-JOURNAL OF VISUALIZED EXPERIMENTS 2024
- Friction-adaptive hydrogel coating for mechanical-immune synergy in ligament-to-bone integration被引量：0收藏
- 作者：Wang, Shuang Chen, Tianwu Li, Yong Zhang, Lei Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Fudan Univ;Kunming Univ Sci & Technol
- 来源：BIOMATERIALS 2026
- 关键词：PET artificial ligament Foreign body reaction Anterior cruciate ligament Hydrogel coating
- Sulfated chitosan mitigates acute lung injury induced bone loss via immunoregulation被引量：0收藏
- 作者：Liu, Yongxian Ji, Luli Zhu, Fuwei Yu, Jiaze Huang, Dongao Cui, Jingyuan Wang, Xiaogang Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BONE RESEARCH 2026
- Development-based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction被引量：0收藏
- 作者：Zhang, Wenchao Dai, Kai Shen, Tong Gao, Zehua Yan, Fengying Feng, Yuke Wang, Xuanlin Zhang, Shaozhen Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ADVANCED SCIENCE 2026
- 关键词：in vivo bioreactor developmental engineering segmental bone defect aging
- A sulfated chitosan-driven immune-ECM reprogramming strategy to break the vicious cycle of aged wound healing被引量：0收藏
- 作者：Zhang, Xiaohui Wang, Siyi Liu, Yongqing Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOACTIVE MATERIALS 2026
- 关键词：Sulfated chitosan Synthetic glycosaminoglycan Macrophage polarization Extracellular matrix degradation Sulfonate groups Aged wound healing
- Sulfated polysaccharide prevents senescent adipocyte-driven osteonecrosis by stem cell fate reprogramming被引量：0收藏
- 作者：Zhang, Shuang Deng, Shunshu Dai, Kai Liu, Yang Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Fudan Univ
- 来源：BIOACTIVE MATERIALS 2026
- 关键词：Osteonecrosis Sulfated polysaccharide Aging Adipocyte Glucocorticoid
- Machine learning-guided design of cooperative multi-size hydrogel microspheres for osteoarthritis therapy被引量：0收藏
- 作者：Chen, Xinye Yu, Yuanman He, Zirui Pan, Lina Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOMATERIALS 2027
- 关键词：Osteoarthritis Hydrogel microsphere Machine learning
- Materiobiology-guided regulation of mesenchymal stromal cell fate for aging-related diseases: From basic parameter design to clinical application被引量：0收藏
- 作者：Feng, Yuke Qiu, Yuqian Zhang, Shaozhen Dai, Kai Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOACTIVE MATERIALS 2026
- 关键词：Mesenchymal stromal cell Materiobiology Cell fate regulation Biomaterial design Anti-aging
