- Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces被引量：143收藏
- 作者：Wang, Weishan Li, Shanshan Li, Zilong Zhang, Jingyu Fan, Keqiang Tan, Gaoyi Ai, Guomin Lam, Sin Man Shui, Guanghou Yang, Zhiheng Lu, Hongzhong Jin, Pinjiao Li, Yihong Chen, Xiangyin Xia, Xuekui Liu, Xueting Dannelly, H. Kathleen Yang, Chen Yang, Yi Zhang, Siliang Alterovitz, Gil Xiang, Wensheng Zhang, Lixin
- 机构：Chinese Acad Sci;East China Univ Sci & Technol;Chinese Acad Agr Sci;Chinese Acad Sci;Qilu Univ Technol
- 来源：NATURE BIOTECHNOLOGY 2020
- 关键词：Ketones - Metabolism - Biochemistry - Bacteria - Metabolites - Glycerol
- 质疑
- Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p被引量：58收藏
- 作者：Tong, Yaojun Zhang, Jingyu Sun, Nuo Wang, Xiang-Ming Wei, Qi Zhang, Yu Huang, Ren Pu, Yingying Dai, Huanqin Ren, Biao Pei, Gang Song, Fuhang Zhu, Guoliang Wang, Xinye Xia, Xuekui Chen, Xiangyin Jiang, Lan Wang, Shenlin Ouyang, Liming Xie, Ning Zhang, Buchang Jiang, Yuanying Liu, Xueting Calderone, Richard Bai, Fan Zhang, Lixin Alterovitz, Gil
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Peking Univ;Georgetown Univ
- 来源：SCIENCE BULLETIN 2021
- 关键词：Candida albicans Berberine Multidrug-resistance Drug excretion transporter Mitochondria
- 质疑
- Chrysomycin A Derivatives for the Treatment of Multi-Drug-Resistant Tuberculosis被引量：54收藏
- 作者：Wu, Fan Zhang, Jing Song, Fuhang Wang, Sanshan Guo, Hui Wei, Qi Dai, Huanqin Chen, Xiangyin Xia, Xuekui Liu, Xueting Zhang, Lixin Yu, Jin-Quan Lei, Xiaoguang
- 机构：Peking Univ;Peking Univ;Chinese Acad Sci;East China Univ Sci & Technol;Qilu Univ Technol
- 来源：ACS CENTRAL SCIENCE 2020
- 质疑
- FeCl3-catalyzed selective acylation of amines with 1,3-diketones via C-C bond cleavage被引量：28收藏
- 作者：Wang, Sinan Yu, Yang Chen, Xuyun Zhu, Haipan Du, Peile Liu, Guohua Lou, Liguang Li, Hao Wang, Wei
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Acad Sci;Shanghai Normal Univ;Univ New Mexico
- 来源：TETRAHEDRON LETTERS 2015
- 关键词：FeCl3 Acylation 1,3-Diketones C-C bond cleavage
- 质疑
- Dual-function injectable fibrin gel incorporated with sulfated chitosan nanoparticles for rhBMP-2-induced bone regeneration被引量：25收藏
- 作者：Chen, Xinye Wang, Shuang Zhang, Xiaohui Yu, Yuanman Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：APPLIED MATERIALS TODAY 2022
- 关键词：BMP-2 Sulfated chitosan Immunomodulation Bone regeneration
- 质疑
- Integrating PCR-free amplification and synergistic sensing for ultrasensitive and rapid CRISPR/Cas12a-based SARS-CoV-2 antigen detection被引量：24收藏
- 作者：Zhao, Xiangxiang Wang, Zhengduo Yang, Bowen Li, Zilong Tong, Yaojun Bi, Yuhai Li, Zhenghong Xia, Xuekui Chen, Xiangyin Zhang, Lixin Wang, Weishan Tan, Gao-Yi
- 机构：East China Univ Sci & Technol ECUST;East China Univ Sci & Technol ECUST;Chinese Acad Sci;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2021
- 关键词：CRISPR Cas12a Aptamer Antigen detection SARS-CoV-2 PCR-Free amplification Synergistic sensing
- 质疑
- Recent advances in biotechnology for marine enzymes and molecules被引量：21收藏
- 作者：Zhang, Jingyu Jiang, Lan Chen, Xiangyin Lv, Kangjie Basiony, Mostafa Zhu, Guoliang Karthik, Loganathan Ouyang, Liming Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Salem Microbes Private Ltd
- 来源：CURRENT OPINION IN BIOTECHNOLOGY 2021
- 关键词：Synthetic biology - Ecosystems - Metabolic engineering - Marine applications - Molecules
- 质疑
- Hyper-Synergistic Antifungal Activity of Rapamycin and Peptide-Like Compounds against Candida albicans Orthogonally via Tor1 Kinase被引量：16收藏
- 作者：Tong, Yaojun Zhang, Jingyu Wang, Luoqiang Wang, Qinqin Huang, Huang Chen, Xiangyin Zhang, Qing Li, Hantian Sun, Nuo Liu, Guang Zhang, Buchang Song, Fuhang Alterovitz, Gil Dai, Huanqin Zhang, Lixin
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Anhui Univ;Chinese Acad Sci;Georgetown Univ
- 来源：ACS INFECTIOUS DISEASES 2021
- 关键词：Candida albicans multidrug resistance rapamycin drug combination synergism TOR kinase
- 质疑
- Genome-guided investigation of anti-inflammatory sesterterpenoids with 5-15 trans-fused ring system from phytopathogenic fungi被引量：15收藏
- 作者：Jiang, Lan Zhu, Guoliang Han, Jianying Hou, Chengjian Zhang, Xue Wang, Zhixin Yuan, Weize Lv, Kangjie Cong, Zhanren Wang, Xinye Chen, Xiangyin Karthik, Loganathan Yang, Huanting Wang, Xuyuan Tan, Gaoyi Liu, Guang Zhao, Liya Xia, Xuekui Liu, Xiangyang Gao, Shushan Ma, Lei Liu, Mei Ren, Biao Dai, Huanqin Quinn, Ronald J. Hsiang, Tom Zhang, Jingyu Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Griffith Univ;Qilu Univ Technol;T3 Biosci LLC
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2021
- 关键词：Fungi Bifunctional terpene synthases Terpenoids Anti-inflammatory
- 质疑
- Binding Free Energy Calculation Based on the Fragment Molecular Orbital Method and Its Application in Designing Novel SHP-2 Allosteric Inhibitors被引量：13收藏
- 作者：Yuan, Zhen Chen, Xingyu Fan, Sisi Chang, Longfeng Chu, Linna Zhang, Ying Wang, Jie Li, Shuang Xie, Jinxin Hu, Jianguo Miao, Runyu Zhu, Lili Zhao, Zhenjiang Li, Honglin Li, Shiliang
- 机构：East China Univ Sci & Technol;East China Normal Univ;Lingang Lab
- 来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2024
- 关键词：binding free energy fragment molecular orbital method SHP2
- 质疑
- Generation of Fluorinated Amychelin Siderophores against Pseudomonas aeruginosa Infections by a Combination of Genome Mining and Mutasynthesis被引量：13收藏
- 作者：Xie, Feng Dai, Shengwang Zhao, Yu Huang, Pei Yu, Shen Ren, Biao Wang, Qiushui Ji, Zengchun Alterovitz, Gil Zhang, Qi Zhang, Jingyu Chen, Xiangyin Jiang, Lan Song, Fuhang Liu, Hongwei Ausubel, Frederick M. Liu, Xueting Dai, Huanqin Zhang, Lixin
- 机构：Chinese Acad Sci;East China Univ Sci & Technol;Chinese Acad Sci;Massachusetts Gen Hosp;Sichuan Univ
- 来源：CELL CHEMICAL BIOLOGY 2020
- 质疑
- Regio- and stereo-selective amination of fatty acids to d-amino acids by a three-step one-pot cascade被引量：13收藏
- 作者：Yu, Xing Chen, Xin-Yi Yu, Hui-Lei Xu, Jian-He Zhang, Zhi-Jun
- 机构：East China Univ Sci & Technol
- 来源：GREEN CHEMISTRY 2023
- 关键词：Amination - Amines - Amino acids - Recycling - Stereochemistry
- 质疑
- Discovery of a novel SHP2 allosteric inhibitor using virtual screening, FMO calculation, and molecular dynamic simulation被引量：5收藏
- 作者：Yuan, Zhen Zhang, Manzhan Chang, Longfeng Chen, Xingyu Ruan, Shanshan Shi, Shanshan Zhang, Yiqing Zhu, Lili Li, Honglin Li, Shiliang
- 机构：East China Univ Sci & Technol;East China Normal Univ;Lingang Lab
- 来源：JOURNAL OF MOLECULAR MODELING 2024
- 关键词：SHP2 Allosteric inhibitor Fragment molecular orbital method Virtual screening Molecular dynamics simulation
- 质疑
- Regulating the bioactivity of non-glycosylated recombinant human bone morphogenetic protein-2 to enhance bone regeneration被引量：4收藏
- 作者：Yu, Yuanman Chen, Rui Chen, Xinye Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOACTIVE MATERIALS 2024
- 关键词：Recombinant human bone morphogenetic protein-2 Osteogenic activity Protein stability Sulfated polysaccharide
- 质疑
- Molecular Characterization of Resistance and Virulence Factors of Trueperella pyogenes Isolated from Clinical Bovine Mastitis Cases in China被引量：4收藏
- 作者：Zheng, Ya Yu, Qunli Han, Ling Chen, Xinyi
- 机构：Gansu Agr Univ;East China Univ Sci & Technol
- 来源：INFECTION AND DRUG RESISTANCE 2024
- 关键词：Trueperella pyogenes resistance integrons gene cassette bovine mastitis
- 质疑
- Dual-Modular Hydrogel Microparticles with Precision-Modulation of Inflammatory Microenvironment Dictate Full-Thickness Cartilage Regeneration for Osteoarthritis Repair被引量：4收藏
- 作者：Chen, Xinye Yu, Yuanman He, Zirui Pan, Lina Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ADVANCED SCIENCE 2025
- 关键词：cartilage regeneration hydrogel microparticles inflammatory modulation osteoarthritis
- 质疑
- Lactiplantibacillus plantarum X7022 ameliorates loperamide-induced constipation and modulates gut microbiota in mice被引量：3收藏
- 作者：Chen, Xingye Liu, Guang Zhao, Li Du, Lei Xie, Jingli Wei, Dongzhi
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg SCICB
- 来源：FOOD BIOENGINEERING 2022
- 关键词：constipation gut microbiota Lactiplantibacillus plantarum X7022
- 质疑
- Computational prediction and validation of specific EmbR binding site on PknH被引量：3收藏
- 作者：Na, Insung Dai, Huanqin Li, Hantian Gupta, Anvita Kreda, David Zhang, Powell Chen, Xiangyin Zhang, Lixin Alterovitz, Gil
- 机构：Harvard Med Sch;Harvard Med Sch;Inst Microbiol;Stanford Univ;Harvard Med Sch
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2021
- 关键词：Disorder-to-order transition Protein intrinsic disorder Binding site prediction Drug resistance Molecular simulation
- 质疑
- Enhancing methanol biotransformation for overproducing fatty acid derivatives被引量：2收藏
- 作者：Chen, Xiangyin Yu, Jiaming Zhang, Lixin
- 机构：East China Univ Sci & Technol
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2022
- 质疑
- Machine learning-guided design of cooperative multi-size hydrogel microspheres for osteoarthritis therapy被引量：0收藏
- 作者：Chen, Xinye Yu, Yuanman He, Zirui Pan, Lina Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOMATERIALS 2027
- 关键词：Osteoarthritis Hydrogel microsphere Machine learning
- 质疑
- Enhancing methanol biotransformation for overproducing fatty被引量：0收藏
- 作者：Xiangyin Chen Jiaming Yu Lixin Zhang
- 机构：State Key Laboratory of Bioreactor Engineering
- 来源：合成和系统生物技术（英文） 2022
- 下载全文在线阅读质疑
- Characterization of Streptomyces sp. LS462 with high productivity of echinomycin, a potent antituberculosis and synergistic antifungal antibiotic被引量：0收藏
- 作者：Chen, Caixia Chen, Xiangyin Ren, Biao Guo, Hui Abdel-Mageed, Wael M. Liu, Xueting Song, Fuhang Zhang, Lixin
- 机构：Chinese Acad Sci;East China Univ Sci & Technol;Sichuan Univ;Chinese Acad Sci;King Saud Univ
- 来源：JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY 2021
- 关键词：Streptomyces fuscichromogenes Echinomycin Antituberculosis Synergistic antifungal activity Posaconazole
- 质疑
- Computational prediction and validation of specific EmbR binding site on PknH被引量：0收藏
- 作者：Insung Na Huanqin Dai Hantian Li Anvita Gupta David Kreda Powell Zhang Xiangyin Chen Lixin Zhang Gil Alterovitz
- 机构：Computational Health Informatics Program;Department of Medicine;State Key Laboratory of Mycology;Department of Computer Sciences;Center for Biomedical Informatics
- 来源：合成和系统生物技术（英文） 2021
- 下载全文在线阅读质疑
- Glycosaminoglycan-Mimetic Sulfated Chitosan Promotes Extracellular Matrix Formation and Regulates Inflammation to Alleviate Osteoarthritis被引量：0收藏
- 作者：Chen, Xinye He, Zirui Yu, Yuanman Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOENGINEERING-BASEL 2026
- 关键词：polysaccharide osteoarthritis cartilage regeneration
- 质疑
- Efficient Synthesis of Ergothioneine in Escherichia coli Through Identification of Bacterial-Type Egt1 and Self-Assemble of Pathway Enzymes被引量：0收藏
- 作者：Chen, Xin-Yi Yan, Shuai Li, Hang-Cheng Liu, Hai-Ping Yu, Hui-Lei Xu, Jian-He Zhang, Zhi-Jun
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2026
- 关键词：biosynthesis ergothioneine fermentation genome mining protein self-assemble
- 质疑
- Enantiocomplementary synthesis of chiral 2,3-dihydroxy aryl ketones via ThDP-dependent enzymatic catalysis被引量：0收藏
- 作者：Li, Dan Zhu, Zheng Chen, Xiaoyu Chen, Xuesi Ouyang, Liming Li, Huangong Zhang, Lixin Xie, Yongtao
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：GREEN CHEMISTRY 2026
- 关键词：Biochemical engineering - Catalysis - Stereochemistry - Synthesis (chemical)
- 质疑
- Publisher Correction: Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces (Nature Biotechnology, (2020), 38, 1, (76-83), 10.1038/s41587-019-0335-4)被引量：-1收藏
- 作者：Wang, Weishan Li, Shanshan Li, Zilong Zhang, Jingyu Fan, Keqiang Tan, Gaoyi Ai, Guomin Lam, Sin Man Shui, Guanghou Yang, Zhiheng Lu, Hongzhong Jin, Pinjiao Li, Yihong Chen, Xiangyin Xia, Xuekui Liu, Xueting Dannelly, H. Kathleen Yang, Chen Yang, Yi Zhang, Siliang Alterovitz, Gil Xiang, Wensheng Zhang, Lixin
- 机构： State Key Laboratory of Microbial Resources; State Key Laboratory of Bioreactor Engineering; State Key Laboratory for Biology of Plant Diseases and Insect Pests; State Key Laboratory of Molecular Developmental Biology; Key Biosensor Laboratory of Shandong Province
- 来源：Nature Biotechnology 2020
- 质疑
