- A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules被引量：378收藏
- 作者：Liang, Mindong Li, Zilong Wang, Weishan Liu, Jiakun Liu, Leshi Zhu, Guoliang Karthik, Loganathan Wang, Man Wang, Ke-Feng Wang, Zhong Yu, Jing Shuai, Yuting Yu, Jiaming Zhang, Lu Yang, Zhiheng Li, Chuan Zhang, Qian Shi, Tong Zhou, Liming Xie, Feng Dai, Huanqin Liu, Xueting Zhang, Jingyu Liu, Guang Zhuo, Ying Zhang, Buchang Liu, Chenli Li, Shanshan Xia, Xuekui Tong, Yaojun Liu, Yanwen Alterovitz, Gil Tan, Gao-Yi Zhang, Li-Xin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Anhui Univ;Chinese Acad Sci;Chinese Acad Sci
- 来源：NATURE COMMUNICATIONS 2019
- 质疑
- A versatile biosensing platform coupling CRISPR-Cas12a and aptamers for detection of diverse analytes被引量：88收藏
- 作者：Zhao, Xiangxiang Li, Shanshan Liu, Guang Wang, Zhong Yang, Zhiheng Zhang, Quanwei Liang, Mindong Liu, Jiakun Li, Zilong Tong, Yaojun Zhu, Guoliang Wang, Xinye Jiang, Lan Wang, Weishan Tan, Gao-Yi Zhang, Lixin
- 机构：East China Univ Sci & Technol ECUST;East China Univ Sci & Technol ECUST;Chinese Acad Agr Sci;Chinese Acad Sci;Shanghai Jiao Tong Univ
- 来源：SCIENCE BULLETIN 2021
- 关键词：CRISPR-Cas12a Aptamer Biosensing platform Diverse analyte Alpha fetoprotein detection Cocaine detection
- 质疑
- Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p被引量：58收藏
- 作者：Tong, Yaojun Zhang, Jingyu Sun, Nuo Wang, Xiang-Ming Wei, Qi Zhang, Yu Huang, Ren Pu, Yingying Dai, Huanqin Ren, Biao Pei, Gang Song, Fuhang Zhu, Guoliang Wang, Xinye Xia, Xuekui Chen, Xiangyin Jiang, Lan Wang, Shenlin Ouyang, Liming Xie, Ning Zhang, Buchang Jiang, Yuanying Liu, Xueting Calderone, Richard Bai, Fan Zhang, Lixin Alterovitz, Gil
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Peking Univ;Georgetown Univ
- 来源：SCIENCE BULLETIN 2021
- 关键词：Candida albicans Berberine Multidrug-resistance Drug excretion transporter Mitochondria
- 质疑
- Activating cryptic biosynthetic gene cluster through a CRISPR-Cas12a-mediated direct cloning approach被引量：54收藏
- 作者：Liang, Mindong Liu, Leshi Xu, Fei Zeng, Xiaoqian Wang, Runjun Yang, Jinling Wang, Weishan Karthik, Loganathan Liu, Jiakun Yang, Zhiheng Zhu, Guoliang Wang, Shuliu Bai, Linquan Tong, Yaojun Liu, Xueting Wu, Min Zhang, Li-Xin Tan, Gao-Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Zhejiang Univ;Zhejiang Univ;Huzhou Univ
- 来源：NUCLEIC ACIDS RESEARCH 2022
- 质疑
- Diketopiperazine and Diphenylether Derivatives from Marine Algae-Derived Aspergillus versicolor OUCMDZ-2738 by Epigenetic Activation被引量：39收藏
- 作者：Liu, Wen Wang, Liping Wang, Bin Xu, Yanchao Zhu, Guoliang Lan, Mengmeng Zhu, Weiming Sun, Kunlai
- 机构：Zhejiang Ocean Univ;Guizhou Med Univ;Ocean Univ China;East China Univ Sci & Technol;Pilot Natl Lab Marine Sci & Technol Qingdao
- 来源：MARINE DRUGS 2019
- 关键词：chemical-epigenetic method endophytic fungus Aspergillus versicolor enantiomer antimicrobial activity
- 质疑
- High-yield porphyrin production through metabolic engineering and biocatalysis被引量：34收藏
- 作者：Chen, Haihong Wang, Yaohong Wang, Weishan Cao, Ting Zhang, Lu Wang, Zhengduo Chi, Xuran Shi, Tong Wang, Huangwei He, Xinwei Liang, Mindong Yang, Mengxue Jiang, Wenyi Lv, Dongyuan Yu, Jiaming Zhu, Guoliang Xie, Yongtao Gao, Bei Wang, Xinye Liu, Xueting Li, Youyuan Ouyang, Limin Zhang, Jingyu Liu, Huimin Li, Zilong Tong, Yaojun Xia, Xuekui Tan, Gao-Yi Zhang, Lixin
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Shanghai Jiao Tong Univ;Qilu Univ Technol
- 来源：NATURE BIOTECHNOLOGY 2025
- 关键词：Catalysis - Diagnosis - Fermentation - Medical applications - Metabolic engineering
- 质疑
- Genome-Based Discovery of Enantiomeric Pentacyclic Sesterterpenes Catalyzed by Fungal Bifunctional Terpene Synthases被引量：33收藏
- 作者：Jiang, Lan Zhang, Xue Sato, Yuya Zhu, Guoliang Minami, Atsushi Zhang, Weiyan Ozaki, Taro Zhu, Bin Wang, Zhixin Wang, Xinye Lv, Kangjie Zhang, Jingyu Wang, Yongheng Gao, Shushan Liu, Chengwei Hsiang, Tom Zhang, Lixin Oikawa, Hideaki Liu, Xueting
- 机构：East China Univ Sci Technol;Hokkaido Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;Jinan Univ
- 来源：ORGANIC LETTERS 2021
- 质疑
- Genome-based mining of new antimicrobial meroterpenoids from the phytopathogenic fungus Bipolaris sorokiniana strain 11134被引量：32收藏
- 作者：Han, Jianying Zhang, Jingyu Song, Zhijun Zhu, Guoliang Liu, Miaomiao Dai, Huanqin Hsiang, Tom Liu, Xueting Zhang, Lixin Quinn, Ronald J. Feng, Yunjiang
- 机构：Griffith Univ;Chinese Acad Sci;East China Univ Sci & Technol;Univ Guelph
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Meroterpenoids Phytopathogenic fungus Bipolaris sorokiniana Genome-based mining Antimicrobial activity
- 质疑
- A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137被引量：24收藏
- 作者：Zhang, Jingyu Li, Bixiao Qin, Yujie Karthik, Loganathan Zhu, Guoliang Hou, Chengjian Jiang, Lan Liu, Miaomiao Ye, Xin Liu, Mei Hsiang, Tom Dai, Huanqin Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Anhui Univ;Chinese Acad Sci;Sri Shakthi Inst Engn & Technol Autonomous;Griffith Univ
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Abyssomicin Proximicin Marine-derived Verrucosispora sp OSMAC Anti-influenza A virus
- 质疑
- Genome- and MS-based mining of antibacterial chlorinated chromones and xanthones from the phytopathogenic fungus Bipolaris sorokiniana strain 11134被引量：23收藏
- 作者：Han, Jianying Zhang, Jingyu Song, Zhijun Liu, Miaomiao Hu, Jiansen Hou, Chengjian Zhu, Guoliang Jiang, Lan Xia, Xuekui Quinn, Ronald J. Feng, Yunjiang Zhang, Lixin Hsiang, Tom Liu, Xueting
- 机构：Chinese Acad Sci;Griffith Univ;Univ Chinese Acad Sci;East China Univ Sci & Technol;Qilu Univ Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2019
- 关键词：Genome-based mining Halogenase Phytopathogenic fungus Bipolaris sorokiniana Antibacterial activity
- 质疑
- Mechanism of the Potential Therapeutic Candidate Bacillus subtilis BSXE-1601 Against Shrimp Pathogenic Vibrios and Multifunctional Metabolites Biosynthetic Capability of the Strain as Predicted by Genome Analysis被引量：23收藏
- 作者：Wang, Dongdong Li, Jiahui Zhu, Guoliang Zhao, Kun Jiang, Wenwen Li, Haidong Wang, Wenjun Kumar, Vikash Dong, Shuanglin Zhu, Weiming Tian, Xiangli
- 机构：Ocean Univ China;Univ Ghent;East China Univ Sci & Technol;Ocean Univ China;Qingdao Natl Lab Marine Sci & Technol
- 来源：FRONTIERS IN MICROBIOLOGY 2020
- 关键词：amicoumacin A genome sequence Bacillus subtilis AHPND vibriosis Litopenaeus vannamei
- 质疑
- Recent advances in biotechnology for marine enzymes and molecules被引量：21收藏
- 作者：Zhang, Jingyu Jiang, Lan Chen, Xiangyin Lv, Kangjie Basiony, Mostafa Zhu, Guoliang Karthik, Loganathan Ouyang, Liming Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Salem Microbes Private Ltd
- 来源：CURRENT OPINION IN BIOTECHNOLOGY 2021
- 关键词：Synthetic biology - Ecosystems - Metabolic engineering - Marine applications - Molecules
- 质疑
- Dissecting the Mechanism of the Nonheme Iron Endoperoxidase FtmOx1 Using Substrate Analogues被引量：19收藏
- 作者：Zhu, Guoliang Yan, Wupeng Wang, Xinye Cheng, Ronghai Naowarojna, Nathchar Wang, Kun Wang, Jun Song, Heng Wang, Yuyang Liu, Hairong Xia, Xuekui Costello, Catherine E. Liu, Xueting Zhang, Lixin Liu, Pinghua
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Boston Univ;Wuhan Univ;Qilu Univ Technol
- 来源：JACS AU 2022
- 关键词：FtmOx1 nonheme iron enzymes endoperoxidation hydroxylation dehydrogenation X-ray structure
- 质疑
- Molecular networking assisted discovery and biosynthesis elucidation of the antimicrobial spiroketals epicospirocins被引量：18收藏
- 作者：Zhu, Guoliang Hou, Chengjian Yuan, Weize Wang, Zhenzhen Zhang, Jingyu Jiang, Lan Karthik, Loganathan Li, Bixiao Ren, Biao Lv, Kangjie Lu, Wanying Cong, Zhanren Dai, Huanqin Hsiang, Tom Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Salem Microbes Private Ltd;Sichuan Univ;Sichuan Univ;Chinese Acad Sci
- 来源：CHEMICAL COMMUNICATIONS 2020
- 关键词：Biochemistry - Chirality
- 质疑
- Antibacterial polyene-polyol macrolides and cyclic peptides from the marine-derived Streptomyces sp. MS110128被引量：18收藏
- 作者：Jiang, Lan Huang, Pei Ren, Biao Song, Zhijun Zhu, Guoliang He, Wenni Zhang, Jingyu Oyeleye, Ayokunmi Dai, Huanqin Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Zunyi Med Univ;Sichuan Univ;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2021
- 关键词：Marine-derived Actinomycete Candida albicans Polyene Cyclic peptides
- 质疑
- Genome-guided investigation of anti-inflammatory sesterterpenoids with 5-15 trans-fused ring system from phytopathogenic fungi被引量：15收藏
- 作者：Jiang, Lan Zhu, Guoliang Han, Jianying Hou, Chengjian Zhang, Xue Wang, Zhixin Yuan, Weize Lv, Kangjie Cong, Zhanren Wang, Xinye Chen, Xiangyin Karthik, Loganathan Yang, Huanting Wang, Xuyuan Tan, Gaoyi Liu, Guang Zhao, Liya Xia, Xuekui Liu, Xiangyang Gao, Shushan Ma, Lei Liu, Mei Ren, Biao Dai, Huanqin Quinn, Ronald J. Hsiang, Tom Zhang, Jingyu Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Griffith Univ;Qilu Univ Technol;T3 Biosci LLC
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2021
- 关键词：Fungi Bifunctional terpene synthases Terpenoids Anti-inflammatory
- 质疑
- Biochemical and Structural Characterization of OvoA Th2 : A Mononuclear Nonheme Iron Enzyme from Hydrogenimonas thermophila for Ovothiol Biosynthesis被引量：12收藏
- 作者：Wang, Xinye Hu, Sha Wang, Jun Zhang, Tao Ye, Ke Wen, Aiwen Zhu, Guoliang Vegas, Arturo Zhang, Lixin Yan, Wupeng Liu, Xueting Liu, Pinghua
- 机构：East China Univ Sci & Technol;Boston Univ;Shanghai Jiao Tong Univ
- 来源：ACS CATALYSIS 2023
- 关键词：nonheme iron enzyme ovothiol ergothioneine X-ray structure regioselectivity sulfur-containingnatural products
- 质疑
- Schultriene and nigtetraene: two sesterterpenes characterized from pathogenetic fungi via genome mining approach被引量：12收藏
- 作者：Jiang, Lan Yang, Huanting Zhang, Xue Li, Xiaoying Lv, Kangjie Zhang, Weiyan Zhu, Guoliang Liu, Chengwei Wang, Yongheng Hsiang, Tom Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci Technol;Northeast Forestry Univ;Jinan Univ;Univ Guelph
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2022
- 关键词：Bifunctional terpene synthases Sesterterpene Genome mining Heterologous expression Cyclization mechanisms
- 质疑
- Function Switch of a Fungal Sesterterpene Synthase through Molecular Dynamics Simulation Assisted Alteration of an Aromatic Residue Cluster in the Active Pocket of PfNS被引量：11收藏
- 作者：Zhang, Weiyan Wang, Xinye Zhu, Guoliang Zhu, Bin Peng, Kaitong Hsiang, Tom Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Ludong Univ;Univ Guelph
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2024
- 关键词：aromatic residue cluster sesterterpene synthase molecular dynamics mutagenesis terpenoids
- 质疑
- Deciphering the Biosynthesis of TDP-β-L-oleandrose in Avermectin被引量：9收藏
- 作者：Tang, Yue Wang, Min Qin, Hua An, Xiangxiang Guo, Zhengyan Zhu, Guoliang Zhang, Lixin Chen, Yihua
- 机构：Chinese Acad Sci;Chinese Acad Sci;Univ Chinese Acad Sci;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF NATURAL PRODUCTS 2020
- 质疑
- Brocaeloid D, a novel compound isolated from a wheat pathogenic fungus, Microdochium majus 99049被引量：9收藏
- 作者：Zhang, Jingyu Wang, Zhenzhen Song, Zhijun Karthik, Loganathan Hou, Chengjian Zhu, Guoliang Jiang, Lan Han, Jianying Ma, Rong Li, Li Zhang, Lixin Liu, Xueting Hsiang, Tom
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Med Sci & Peking Union Med Coll;Univ Guelph;Univ Chinese Acad Sci
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2019
- 关键词：Wheat pathogenic fungus Anticancer Antibacterial Natural product
- 质疑
- Chemical control over the conversion between bicyclic and polycyclic terpenes by fungal bifunctional terpene synthases被引量：8收藏
- 作者：Wang, Xinye Wang, Zhixin Zhu, Guoliang Jiang, Lan Zhang, Weiyan Huang, Yiyi Cong, Zhanren Zhao, Yi-Lei Xu, Jian-He Hsiang, Tom Zhang, Lixin Chen, Qi Liu, Xueting
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;Univ Guelph
- 来源：CHEMICAL COMMUNICATIONS 2022
- 关键词：Catalysis - Terpenes
- 质疑
- 构建“合成生物学”课程群培养面向生物制造的复合型创新人才被引量：8收藏
- 作者：谭高翼 张立新 张敬宇 王启要 吴辉 庄英萍 欧阳立明 朱国良 王馨叶 刘雪婷
- 机构：华东理工大学生物工程学院
- 来源：《生物工程学报》 2024
- 关键词：合成生物学 课程群 复合型创新人才 国际基因工程机器大赛
- 摘要：合成生物学(Synthetic Biology)作为一门新兴学科,广受关注且发展迅速,深刻影响着整个生命科学及工程技术领域的发展。与此同时,随着新工科建设的发展,加快培养复合型创新人才是对我国高等教育提出的新任务和新使命...
- 下载全文在线阅读质疑
- Biosynthesis of 4-Acyl-5-aminoimidazole Alkaloids Featuring a New Friedel-Crafts Acyltransferase被引量：7收藏
- 作者：Xia, Yuwei Zhu, Guoliang Zhang, Xingwang Li, Shengying Du, Lei Zhu, Weiming
- 机构：Ocean Univ China;East China Univ Sci & Technol;Shandong Univ;Laoshan Lab
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2023
- 关键词：Biochemistry - Biosynthesis - Catalysis - Catalyst activity - Chemical bonds - Genes - Reaction intermediates
- 质疑
- Norditerpenoids biosynthesized by variediene synthase-associated P450 machinery along with modifications by the host cell Aspergillus oryzae被引量：7收藏
- 作者：Jiang, Lan Lv, Kangjie Zhu, Guoliang Lin, Zhi Zhang, Xue Xing, Cuiping Yang, Huanting Zhang, Weiyan Wang, Zhixin Liu, Chengwei Qu, Xudong Hsiang, Tom Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci Technol;Shanghai Jiao Tong Univ;Northeast Forestry Univ;Univ Guelph
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2022
- 关键词：Bifunctional terpene synthases Norditerpenoids Cytochrome P450 Aspergillus oryzae Heterologous expression
- 质疑
- Taming Highly Enolizable Aldehydes via Enzyme Catalysis for Enantiocomplementary Construction of β-Hydroxyphosphonates被引量：7收藏
- 作者：Li, Huangong Zhu, Zheng Wu, Dongqi Ju, Yongyuan Li, Dan Zou, Keke Zhu, Chaonan Zhang, Jingyu Zhu, Guoliang Zhang, Lixin Chi, Yonggui Robin Xie, Yongtao
- 机构：East China Univ Sci & Technol;Nanyang Technol Univ;Guizhou Univ
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2025
- 关键词：Catalysis - Enantioselectivity
- 质疑
- Two novel aliphatic unsaturated alcohols isolated from a pathogenic fungus Fusarium proliferatum被引量：6收藏
- 作者：Lu, Wanying Zhu, Guoliang Yuan, Weize Han, Zhaoxi Dai, Huanqin Basiony, Mostafa Zhang, Lixin Liu, Xueting Hsiang, Tom Zhang, Jingyu
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Guelph
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2021
- 关键词：Pathogenic fungus Aliphatic unsaturated alcohols Antibacterial Natural products
- 质疑
- Exploring Verrucosidin Derivatives with Glucose-Uptake-Stimulatory Activity from Penicillium cellarum Using MS/MS-Based Molecular Networking被引量：6收藏
- 作者：Han, Junjie Chen, Baosong Zhang, Rui Zhang, Jinjin Dai, Huanqin Wang, Tao Sun, Jingzu Zhu, Guoliang Li, Wei Li, Erwei Liu, Xueting Yin, Wenbing Liu, Hongwei
- 机构：Chinese Acad Sci;Shenyang Pharmaceut Univ;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF FUNGI 2022
- 关键词：verrucosidins Penicillium cellarum glucose uptake-stimulating activity molecular networking
- 质疑
- Chrysomycins, Anti-Tuberculosis C-Glycoside Polyketides from Streptomyces sp. MS751被引量：5收藏
- 作者：Yu, Jiaming Guo, Hui Zhang, Jing Hu, Jiansen He, Hongtao Chen, Caixia Yang, Na Yang, Fan Lin, Zexu Dai, Huanqin Ouyang, Liming Liu, Cuihua Lei, Xiaoguang Zhang, Lixin Zhu, Guoliang Song, Fuhang
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Peking Univ;Peking Univ;Univ Chinese Acad Sci
- 来源：MARINE DRUGS 2024
- 关键词：tuberculosis Streptomyces antibiotics chrysomycin biomimetic synthesis
- 质疑
- New Polyketide Congeners with Antibacterial Activities from an Endophytic Fungus Stemphylium globuliferum 17035 (China General Microbiological Culture Collection Center No. 40666)被引量：4收藏
- 作者：Li, Yingying Zhu, Guoliang Wang, Jing Yu, Junjie Ye, Ke Xing, Cuiping Ren, Biao Zhu, Bin Chen, Simin Lai, Lijun Li, Yue Hsiang, Tom Zhang, Lixin Liu, Xueting Zhang, Jingyu
- 机构：East China Univ Sci & Technol;Sichuan Univ;Sichuan Univ;East China Univ Sci & Technol;Univ Guelph
- 来源：JOURNAL OF FUNGI 2024
- 关键词：endophytic fungus polyketides
Stemphylium globuliferum antibacterial anticancer OSMAC strategy - 质疑
