- Enhancement of IL-2 and IFN-γ expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo被引量：105收藏
- 作者：Wang, Guan Zhao, Jian Liu, Jianwen Huang, Yongping Zhong, Jian-Jiang Tang, Wen
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：INTERNATIONAL IMMUNOPHARMACOLOGY 2007
- 关键词：ganoderic acid Me NK cells activity IL-2 IFN-gamma NF-kappa B Lewis lung carcinoma
- 质疑
- Developing a Computational Framework To Advance Bioprocess Scale-Up被引量：87收藏
- 作者：Wang, Guan Haringa, Cees Noorman, Henk Chu, Ju Zhuang, Yingping
- 机构：East China Univ Sci & Technol ECUST;DSM Biotechnol Ctr;Delft Univ Technol
- 来源：TRENDS IN BIOTECHNOLOGY 2020
- 关键词：Metabolism
- 质疑
- Integration of microbial kinetics and fluid dynamics toward model-driven scale-up of industrial bioprocesses被引量：81收藏
- 作者：Wang, Guan Tang, Wenjun Xia, Jianye Chu, Ju Noorman, Henk van Gulik, Walter M.
- 机构： State Key Laboratory of Bioreactor Engineering; DSM Biotechnology Center; Department of Biotechnology
- 来源：Engineering in Life Sciences 2020
- 关键词：Metabolism - Mass transfer - Mixing - Metabolic engineering - Batch data processing - Kinetics - Carbon dioxide
- 质疑
- Integration of microbial kinetics and fluid dynamics toward model-driven scale-up of industrial bioprocesses被引量：74收藏
- 作者：Wang, Guan Tang, Wenjun Xia, Jianye Chu, Ju Noorman, Henk van Gulik, Walter M.
- 机构：E China Univ Sci & Technol;DSM Biotechnol Ctr;Delft Univ Technol
- 来源：ENGINEERING IN LIFE SCIENCES 2015
- 关键词：Computational fluid dynamics Heterogeneity Mathematical model Scale down Scale up
- 质疑
- A 9-pool metabolic structured kinetic model describing days to seconds dynamics of growth and product formation by Penicillium chrysogenum被引量：45收藏
- 作者：Tang, Wenjun Deshmukh, Amit T. Haringa, Cees Wang, Guan van Gulik, Walter van Winden, Wouter Reuss, Matthias Heijnen, Joseph J. Xia, Jianye Chu, Ju Noorman, Henk J.
- 机构：East China Univ Sci & Technol;DSM Biotechnol Ctr;Delft Univ Technol;Univ Stuttgart
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2017
- 关键词：structured model black box model feast-famine kinetics Penicillium chrysogenum
- 质疑
- Effect of temperature and surfactant on biomass growth and higher-alcohol production during syngas fermentation by Clostridium carboxidivorans P7被引量：40收藏
- 作者：Shen, Shaohuang Wang, Guan Zhang, Ming Tang, Yin Gu, Yang Jiang, Weihong Wang, Yonghong Zhuang, Yingping
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：BIORESOURCES AND BIOPROCESSING 2020
- 关键词：Clostridium carboxidivorans P7 Higher alcohol Two-step temperature culture Surfactant Comparative transcriptome
- 质疑
- Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains被引量：40收藏
- 作者：Xia, Jianye Wang, Guan Fan, Meng Chen, Min Wang, Zeyu Zhuang, Yingping
- 机构：East China Univ Sci & Technol
- 来源：CHINESE JOURNAL OF CHEMICAL ENGINEERING 2021
- 关键词：Fermentation Scale-up Bioreactors Gas-liquid flow Kinetics
- 质疑
- Advances and Practices of Bioprocess Scale-up被引量：36收藏
- 作者：Xia, Jianye Wang, Guan Lin, Jihan Wang, Yonghong Chu, Ju Zhuang, Yingping Zhang, Siliang
- 机构：East China Univ Sci & Technol
- 来源：BIOREACTOR ENGINEERING RESEARCH AND INDUSTRIAL APPLICATIONS II 2016
- 关键词：Bioprocess engineering Scale-up Bioprocess monitoring Fluid dynamics Microbial kinetics Mathematical model
- 质疑
- Comparative performance of different scale-down simulators of substrate gradients in Penicillium chrysogenum cultures: the need of a biological systems response analysis被引量：31收藏
- 作者：Wang, Guan Zhao, Junfei Haringa, Cees Tang, Wenjun Xia, Jianye Chu, Ju Zhuang, Yingping Zhang, Siliang Deshmukh, Amit T. van Gulik, Walter Heijnen, Joseph J. Noorman, Henk J.
- 机构：ECUST;Delft Univ Technol;DSM Biotechnol Ctr;Delft Univ Technol;Delft Univ Technol
- 来源：MICROBIAL BIOTECHNOLOGY 2018
- 质疑
- Prelude to rational scale-up of penicillin production: a scale-down study被引量：28收藏
- 作者：Wang, Guan Chu, Ju Noorman, Henk Xia, Jianye Tang, Wenjun Zhuang, Yingping Zhang, Siliang
- 机构：E China Univ Sci & Technol;DSM Biotechnol Ctr
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2014
- 关键词：Scale-down Scale-up Gradients Model Computational Penicillin P. chrysogenum
- 质疑
- Hsa_circ_0033155: A potential novel biomarker for non-small cell lung cancer被引量：23收藏
- 作者：Gu, Xiaohua Wang, Gang Shen, Hui Fei, Xiaoyun
- 机构：Shanghai Jiao Tong Univ;East China Univ Sci & Technol
- 来源：EXPERIMENTAL AND THERAPEUTIC MEDICINE 2018
- 关键词：circular RNA biomarker hsa_circ_0033155 phosphatase and tensin homolog deleted on chromosome 10 non-small cell lung cancer
- 质疑
- Develop Dynamic Hybrid Modeling of Fuel Ethanol Fermentation Process by Integrating Biomass Concentration XGBoost Model and Kinetic Parameters Artificial Neural Network Model into Mechanism Model被引量：22收藏
- 作者：Li, Xinzhe Dong, Yufeng Chang, Lu Chen, Lifan Wang, Guan Zhuang, Yingping Yan, Xuefeng
- 机构： Key Laboratory of Smart Manufacturing in Energy Chemical Process; State Key Laboratory of Bioreactor Engineering
- 来源：SSRN 2022
- 关键词：Biomass - Ethanol - Fermentation - Forecasting - Fuels - Glucose - Kinetic parameters - Process control
- 质疑
- Coupled metabolic-hydrodynamic modeling enabling rational scale-up of industrial bioprocesses被引量：21收藏
- 作者：Wang, Guan Haringa, Cees Tang, Wenjun Noorman, Henk Chu, Ju Zhuang, Yingping Zhang, Siliang
- 机构：East China Univ Sci & Technol;Delft Univ Technol;DSM Biotechnol Ctr;Delft Univ Technol
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2020
- 关键词：CFD Euler-Langrange metabolic model metabolomics population heterogeneity scale down
- 质疑
- A dynamic model-based preparation of uniformly-13C-labeled internal standards facilitates quantitative metabolomics analysis of Penicillium chrysogenum被引量：20收藏
- 作者：Wang, Guan Chu, Ju Zhuang, Yingping van Gulik, Walter Noorman, Henk
- 机构：East China Univ Sci & Technol;Delft Univ Technol;DSM Biotechnol Ctr;Delft Univ Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2019
- 关键词：Dynamic Fed-batch model Isotope dilution mass spectrometry (IDMS) Perturbation Metabolomics Penicillium chrysogenum
- 质疑
- Power input effects on degeneration in prolonged penicillin chemostat cultures: A systems analysis at flux, residual glucose, metabolite, and transcript levels被引量：18收藏
- 作者：Wang, Guan Wu, Baofeng Zhao, Junfei Haringa, Cees Xia, Jianye Chu, Ju Zhuang, Yingping Zhang, Siliang Heijnen, Joseph J. van Gulik, Walter Deshmukh, Amit T. Noorman, Henk J.
- 机构：ECUST;Delft Univ Technol;Delft Univ Technol;DSM Biotechnol Ctr;Delft Univ Technol
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2018
- 关键词：degeneration glucose transport power input redox energy metabolism scale down
- 质疑
- Leveraging and manufacturing in vitro multicellular spheroid-based tumor cell model as a preclinical tool for translating dysregulated tumor metabolism into clinical targets and biomarkers被引量：17收藏
- 作者：Wang, Tong Wang, Lin Wang, Guan Zhuang, Yingping
- 机构：East China Univ Sci & Technol ECUST
- 来源：BIORESOURCES AND BIOPROCESSING 2020
- 关键词：Multicellular tumor spheroids In vitro models Tumor metabolism Preclinical evaluation Cancer therapy Precision medicine
- 质疑
- Dynamic hybrid modeling of fuel ethanol fermentation process by integrating biomass concentration XGBoost model and kinetic parameter artificial neural network model into mechanism model被引量：16收藏
- 作者：Li, Xinzhe Dong, Yufeng Chang, Lu Chen, Lifan Wang, Guan Zhuang, Yingping Yan, Xuefeng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;POB 293
- 来源：RENEWABLE ENERGY 2023
- 关键词：Fuel ethanol fermentation process Hybrid model Mechanism model Extreme gradient boosting Artificial neural network
- 质疑
- A data enhancement method based on generative adversarial network for small sample-size with soft sensor application被引量：14收藏
- 作者：Zhang, Zhongyi Wang, Xueting Wang, Guan Jiang, Qingchao Yan, Xuefeng Zhuang, Yingping
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：COMPUTERS & CHEMICAL ENGINEERING 2024
- 关键词：Small sample-size Generating adversarial network Soft sensor Process modeling
- 质疑
- Understanding the effect of temperature downshift on CHO cell growth, antibody titer and product quality by intracellular metabolite profiling and in vivo monitoring of redox state被引量：14收藏
- 作者：Zhu, Ziyu Chen, Xiaoqian Li, Wenhao Zhuang, Yingping Zhao, Yuzheng Wang, Guan
- 机构：East China Univ Sci & Technol ECUST;East China Univ Sci & Technol ECUST;East China Univ Sci & Technol;Chinese Acad Med Sci;East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY PROGRESS 2023
- 关键词：antibody CHO cell culture intracellular sensor metabolomics NAD(+)/NADH ratio NADPH redox state temperature downshift
- 质疑
- Harnessing microbial metabolomics for industrial applications被引量：13收藏
- 作者：Zhao, Jiachen Wang, Guan Chu, Ju Zhuang, Yingping
- 机构：ECUST
- 来源：WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY 2020
- 关键词：Industrial fermentation Metabolomics Metabolic engineering Process optimization System biology Synthetic biology
- 质疑
- Quantitative metabolomics and metabolic flux analysis reveal impact of altered trehalose metabolism on metabolic phenotypes of Penicillium chrysogenum in aerobic glucose-limited chemostats被引量：13收藏
- 作者：Wang, Guan Zhao, Junfei Wang, Xinxin Wang, Tong Zhuang, Yingping Chu, Ju Zhang, Siliang Noorman, Henk J.
- 机构：East China Univ Sci & Technol;DSM Biotechnol Ctr;Delft Univ Technol
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2019
- 关键词：Chemostat Genome-scale metabolic model Metabolomics Penicillium chrysogenum Trehalose metabolism Metabolic flux analysis
- 质疑
- Cloning and expression of a novel lipase gene from Pseudomonas fluorescens B52被引量：12收藏
- 作者：Jiang, ZB Zheng, YT Luo, Y Wang, G Wang, HP Ma, YS Wei, DZ
- 机构：E China Univ Sci & Technol
- 来源：MOLECULAR BIOTECHNOLOGY 2005
- 关键词：expression genome-walking lipase Pichia pastoris Pseudomonas fluorescens
- 质疑
- Comparative Fluxome and Metabolome Analysis of Formate as an Auxiliary Substrate for Penicillin Production in Glucose-Limited Cultivation of Penicillium chrysogenum被引量：12收藏
- 作者：Wang, Guan Wang, Xinxin Wang, Tong van Gulik, Walter Noorman, Henk J. Zhuang, Yingping Chu, Ju Zhang, Siliang
- 机构：ECUST;Delft Univ Technol;DSM Biotechnol Ctr;Delft Univ Technol
- 来源：BIOTECHNOLOGY JOURNAL 2019
- 关键词：auxiliary substrates chemostat metabolomics penicillin Penicillium chrysogenum
- 质疑
- Neural networks-based hybrid beneficial variable selection and modeling for soft sensing被引量：11收藏
- 作者：Zhang, Zhongyi Jiang, Qingchao Wang, Guan Pan, Chunjian Cao, Zhixing Yan, Xuefeng Zhuang, Yingping
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Univ Elect Power
- 来源：CONTROL ENGINEERING PRACTICE 2023
- 关键词：Deep neural network Variable selection Soft sensing Process modeling
- 质疑
- Application of a silica gel prolonged-release system for methanol in the production of biodiesel被引量：11收藏
- 作者：Luo, Yu Wang, Gang Ma, Yushu Wei, Dongzhi
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY 2006
- 关键词：biodiesel lipase prolonged release silica gel
- 质疑
- A systematic evaluation of quenching and extraction procedures for quantitative metabolome profiling of HeLa carcinoma cell under 2D and 3D cell culture conditions被引量：10收藏
- 作者：Wang, Tong Wang, Xueting Zhuang, Yingping Wang, Guan
- 机构：East China Univ Sci & Technol ECUST;East China Univ Sci & Technol;East China Univ Sci & Technol ECUST
- 来源：BIOTECHNOLOGY JOURNAL 2023
- 关键词：3D tumor spheroids extraction HeLa isotope dilution mass spectrometry metabolomics quenching sample preparation
- 质疑
- Improving cytosolic aspartate biosynthesis increases glucoamylase production in Aspergillus niger under oxygen limitation被引量：10收藏
- 作者：Cao, Weiqiang Wang, Guan Lu, Hongzhong Ouyang, Liming Chu, Ju Sui, Yufei Zhuang, Yingping
- 机构：East China Univ Sci & Technol
- 来源：MICROBIAL CELL FACTORIES 2020
- 关键词：Aspergillus niger Glucoamylase Limited amino acids Gene overexpression Multi-omics study
- 质疑
- Multi-omics analysis defines 5-fluorouracil drug resistance in 3D HeLa carcinoma cell model被引量：9收藏
- 作者：Wang, Lin Wang, Xueting Wang, Tong Zhuang, Yingping Wang, Guan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIORESOURCES AND BIOPROCESSING 2021
- 关键词：Drug resistance mechanism HeLa carcinoma cells Multicellular tumor spheroid Multi-omics analysis Preclinical evaluation Tumor metabolism
- 质疑
- Semi-supervised soft sensor method for fermentation processes based on physical monotonicity and variational autoencoders被引量：9收藏
- 作者：Cheng, Xinyue Yu, Zhenhua Wang, Guan Jiang, Qingchao Cao, Zhixing
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ENGINEERING APPLICATIONS OF ARTIFICIAL INTELLIGENCE 2024
- 关键词：Soft sensor Variational autoencoder Fermentation process Semi-supervised learning
- 质疑
- Impact of Altered Trehalose Metabolism on Physiological Response of Penicillium chrysogenum Chemostat Cultures during Industrially Relevant Rapid Feast/Famine Conditions被引量：8收藏
- 作者：Wang, Xinxin Zhao, Jiachen Xia, Jianye Wang, Guan Chu, Ju Zhuang, Yingping
- 机构：East China Univ Sci & Technol ECUST
- 来源：PROCESSES 2021
- 关键词：feast famine conditions industrial-scale bioreactor metabolomics metabolic response penicillin Penicillium chrysogenum scale-down
- 质疑
