夏建业 收藏
( 任职于 生物工程学院)
副研究员，2008年获得华东理工大学生物化工专业博士学位，主要研究领域为生物反应器流场特性的实验及数值模拟研究与基于细胞生理特性与反应器流场特性的生物过程放大方法的理论与应用技术研究。2008年7月留校担任教职。先后承担973项目子课题一项，863项目子课题一项，科技部支撑计划项目子课题一项，自然科学基金青年基金一项，教育部中央高校探索基金一项。2016年获得国家留学基金委资助赴瑞典查尔姆斯理工大学Jens Nielsen教授的系统生物学实验室进行为期一年的访问学者。科研之外还注重将科研成果向产业化的应用... 详细>>
- Euler-Lagrange computational fluid dynamics for (bio)reactor scale down: An analysis of organism lifelines被引量：104收藏
- 作者：Haringa, Cees Tang, Wenjun Deshmukh, Amit T. Xia, Jianye Reuss, Matthias Heijnen, Joseph J. Mudde, Robert F. Noorman, Henk J.
- 机构：Delft Univ Technol;ECUST;DSM Biotechnol Ctr;Univ Stuttgart;Delft Univ Technol
- 来源：ENGINEERING IN LIFE SCIENCES 2016
- 关键词：CFD Euler-Lagrange Fermentation Industrial scale Scale down
- 质疑
- Integration of microbial kinetics and fluid dynamics toward model-driven scale-up of industrial bioprocesses被引量：81收藏
- 作者：Wang, Guan Tang, Wenjun Xia, Jianye Chu, Ju Noorman, Henk van Gulik, Walter M.
- 机构： State Key Laboratory of Bioreactor Engineering; DSM Biotechnology Center; Department of Biotechnology
- 来源：Engineering in Life Sciences 2020
- 关键词：Metabolism - Mass transfer - Mixing - Metabolic engineering - Batch data processing - Kinetics - Carbon dioxide
- 质疑
- Integration of microbial kinetics and fluid dynamics toward model-driven scale-up of industrial bioprocesses被引量：74收藏
- 作者：Wang, Guan Tang, Wenjun Xia, Jianye Chu, Ju Noorman, Henk van Gulik, Walter M.
- 机构：E China Univ Sci & Technol;DSM Biotechnol Ctr;Delft Univ Technol
- 来源：ENGINEERING IN LIFE SCIENCES 2015
- 关键词：Computational fluid dynamics Heterogeneity Mathematical model Scale down Scale up
- 质疑
- Fluid dynamics investigation of variant impeller combinations by simulation and fermentation experiment被引量：61收藏
- 作者：Xia, Jian-Ye Wang, Yong-Hong Zhang, Si-Liang Chen, Ning Yin, Peng Zhuang, Ying-Ping Chu, Ju
- 机构：E China Univ Chem Technol
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2009
- 关键词：Dissolved oxygen Fluid mechanics Gas-liquid mass transfer Mixing Mycelia fermentation Shear environment
- 质疑
- The Impact of Systems Biology on Bioprocessing被引量：60收藏
- 作者：Campbell, Kate Xia, Jianye Nielsen, Jens
- 机构：Chalmers Univ Technol;East China Univ Sci & Technol;Tech Univ Denmark
- 来源：TRENDS IN BIOTECHNOLOGY 2017
- 关键词：Creep - Plant shutdowns - Computational methods - Fossil fuels - Data handling - Genes - Learning systems - Information analysis - Digital storage - Physiology
- 质疑
- Flow Pattern, Mixing, Gas Hold-Up and Mass Transfer Coefficient of Triple-Impeller Configurations in Stirred Tank Bioreactors被引量：60收藏
- 作者：Xie, Minghui Xia, Jianye Zhou, Zhen Chu, Ju Zhuang, Yingping Zhang, Siliang
- 机构：E China Univ Sci & Technol
- 来源：INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 2014
- 关键词：Gases - Liquids - Mixing - Pumps - Turbine components - Flow patterns - Mass transfer - Turbomachine blades - Velocity
- 质疑
- Industrial bioprocess control and optimization in the context of systems biotechnology被引量：56收藏
- 作者：Wang, Yong Chu, Ju Zhuang, Yingping Wang, Yonghong Xia, Jianye Zhang, Siliang
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Biotechnology Advances 2009
- 质疑
- Proteome allocations change linearly with the specific growth rate of Saccharomyces cerevisiae under glucose limitation被引量：51收藏
- 作者：Xia, Jianye Sanchez, Benjamin J. Chen, Yu Campbell, Kate Kasvandik, Sergo Nielsen, Jens
- 机构：East China Univ Sci & Technol;Chalmers Univ Technol;Chinese Acad Sci;Univ Tartu;BioInnovat Inst
- 来源：NATURE COMMUNICATIONS 2022
- 质疑
- CFD analysis of the turbulent flow in baffled shake flasks被引量：49收藏
- 作者：Li, Chao Xia, Jian-Ye Chu, Ju Wang, Yong-Hong Zhuang, Ying-Ping Zhang, Si-Liang
- 机构：E China Univ Sci & Technol
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2013
- 关键词：Shake flask Hydrodynamics Mass transfer Mixing Shear force Power consumption
- 质疑
- Application of Euler-Lagrange CFD for quantitative evaluating the effect of shear force on Carthamus tinctorius L. cell in a stirred tank bioreactor被引量：49收藏
- 作者：Liu, Yu Wang, Ze-Jian Xia, Jian-Ye Haringa, Cees Liu, Ya-Ping Chu, Ju Zhuang, Ying-Ping Zhang, Si-Liang
- 机构：East China Univ Sci & Technol;Dalian Pract Biotechnol Co Ltd;Delft Univ Technol
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2016
- 关键词：Plant cell culture Fluid mechanics Agitation Power consumption C tinctorius L. cell Stress thresholds
- 质疑
- Power consumption, local and average volumetric mass transfer coefficient in multiple-impeller stirred bioreactors for xanthan gum solutions被引量：48收藏
- 作者：Xie, Ming-hui Xia, Jian-ye Zhou, Zhen Zhou, Guo-zhong Chu, Ju Zhuang, Ying-ping Zhang, Si-liang Noorman, Henk
- 机构：E China Univ Sci & Technol;Wenzhou Great Wall Mixer Design Inst;DSM Biotechnol Ctr
- 来源：CHEMICAL ENGINEERING SCIENCE 2014
- 关键词：Power Mass transfer Xanthan gum Non-Newtonian fluid Impeller combination
- 质疑
- Enzymatic Preparation of the Chiral (S)-Sulfoxide Drug Esomeprazole at Pilot-Scale Levels被引量：45收藏
- 作者：Xu, Na Zhu, Jun Wu, Yin-Qi Zhang, Yan Xia, Jian-Ye Zhao, Qian Lin, Guo-Qiang Yu, Hui-Lei Xu, Jian-He
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Jiangsu Aosaikang Pharmaceut Co Ltd
- 来源：ORGANIC PROCESS RESEARCH & DEVELOPMENT 2020
- 关键词：prazole sulfide monooxygenase esomeprazole asymmetric oxidation oxygen mass transfer reaction regulation
- 质疑
- A 9-pool metabolic structured kinetic model describing days to seconds dynamics of growth and product formation by Penicillium chrysogenum被引量：45收藏
- 作者：Tang, Wenjun Deshmukh, Amit T. Haringa, Cees Wang, Guan van Gulik, Walter van Winden, Wouter Reuss, Matthias Heijnen, Joseph J. Xia, Jianye Chu, Ju Noorman, Henk J.
- 机构：East China Univ Sci & Technol;DSM Biotechnol Ctr;Delft Univ Technol;Univ Stuttgart
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2017
- 关键词：structured model black box model feast-famine kinetics Penicillium chrysogenum
- 质疑
- Real-time and on-line monitoring of ethanol fermentation process by viable cell sensor and electronic nose被引量：42收藏
- 作者：Feng, Yao Tian, Xiwei Chen, Yang Wang, Zeyu Xia, Jianye Qian, Jiangchao Zhuang, Yingping Chu, Ju
- 机构：East China Univ Sci & Technol
- 来源：BIORESOURCES AND BIOPROCESSING 2021
- 关键词：Ethanol On-line Viable cell sensor Electronic nose
- 质疑
- Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains被引量：40收藏
- 作者：Xia, Jianye Wang, Guan Fan, Meng Chen, Min Wang, Zeyu Zhuang, Yingping
- 机构：East China Univ Sci & Technol
- 来源：CHINESE JOURNAL OF CHEMICAL ENGINEERING 2021
- 关键词：Fermentation Scale-up Bioreactors Gas-liquid flow Kinetics
- 质疑
- Industrial bioprocess control and optimization in the context of systems biotechnology被引量：38收藏
- 作者：Wang, Yong Chu, Ju Zhuang, Yingping Wang, Yonghong Xia, Jianye Zhang, Siliang
- 机构：E China Univ Sci & Technol
- 来源：BIOTECHNOLOGY ADVANCES 2009
- 关键词：Industrial bioprocess Systems biotechnology Bioprocess control and optimization
- 质疑
- Advances and Practices of Bioprocess Scale-up被引量：36收藏
- 作者：Xia, Jianye Wang, Guan Lin, Jihan Wang, Yonghong Chu, Ju Zhuang, Yingping Zhang, Siliang
- 机构：East China Univ Sci & Technol
- 来源：BIOREACTOR ENGINEERING RESEARCH AND INDUSTRIAL APPLICATIONS II 2016
- 关键词：Bioprocess engineering Scale-up Bioprocess monitoring Fluid dynamics Microbial kinetics Mathematical model
- 质疑
- Multi-omics integrative analysis with genome-scale metabolic model simulation reveals global cellular adaptation of Aspergillus niger under industrial enzyme production condition被引量：36收藏
- 作者：Lu, Hongzhong Cao, Weiqiang Liu, Xiaoyun Sui, Yufei Ouyang, Liming Xia, Jianye Huang, Mingzhi Zhuang, Yingping Zhang, Siliang Noorman, Henk Chu, Ju
- 机构：East China Univ Sci & Technol;DSM Biotechnol Ctr
- 来源：SCIENTIFIC REPORTS 2018
- 质疑
- Integrated isotope-assisted metabolomics and 13C metabolic flux analysis reveals metabolic flux redistribution for high glucoamylase production by Aspergillus niger被引量：35收藏
- 作者：Lu, Hongzhong Liu, Xiaoyun Huang, Mingzhi Xia, Jianye Chu, Ju Zhuang, Yingping Zhang, Siliang Noorman, Henk
- 机构：E China Univ Sci & Technol;DSM Biotechnol Ctr
- 来源：MICROBIAL CELL FACTORIES 2015
- 关键词：Aspergillus niger Glucoamylase C-13 metabolic flux analysis Metabolomics Cofactor metabolism
- 质疑
- Comparative performance of different scale-down simulators of substrate gradients in Penicillium chrysogenum cultures: the need of a biological systems response analysis被引量：31收藏
- 作者：Wang, Guan Zhao, Junfei Haringa, Cees Tang, Wenjun Xia, Jianye Chu, Ju Zhuang, Yingping Zhang, Siliang Deshmukh, Amit T. van Gulik, Walter Heijnen, Joseph J. Noorman, Henk J.
- 机构：ECUST;Delft Univ Technol;DSM Biotechnol Ctr;Delft Univ Technol;Delft Univ Technol
- 来源：MICROBIAL BIOTECHNOLOGY 2018
- 质疑
- Computational investigation of fluid dynamics in a recently developed centrifugal impeller bioreactor被引量：30收藏
- 作者：Xia, Jian-Ye Wang, Si-Jing Zhang, Si-Liang Zhong, Jian-Jiang
- 机构：E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2008
- 关键词：CFD centrifugal impeller velocity profile shear force fluid circulation circulation time distribution
- 质疑
- Prelude to rational scale-up of penicillin production: a scale-down study被引量：28收藏
- 作者：Wang, Guan Chu, Ju Noorman, Henk Xia, Jianye Tang, Wenjun Zhuang, Yingping Zhang, Siliang
- 机构：E China Univ Sci & Technol;DSM Biotechnol Ctr
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2014
- 关键词：Scale-down Scale-up Gradients Model Computational Penicillin P. chrysogenum
- 质疑
- Comprehensive reconstruction and in silico analysis of Aspergillus niger genome-scale metabolic network model that accounts for 1210 ORFs被引量：28收藏
- 作者：Lu, Hongzhong Cao, Weiqiang Ouyang, Liming Xia, Jianye Huang, Mingzhi Chu, Ju Zhuang, Yingping Zhang, Siliang Noorman, Henk
- 机构：East China Univ Sci & Technol;DSM Biotechnol Ctr
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2017
- 关键词：Aspergillus niger genome-scale metabolic model multi-omics glucoamylase
- 质疑
- Effects of flow field on the metabolic characteristics of Streptomyces lincolnensis in the industrial fermentation of lincomycin被引量：28收藏
- 作者：Li, Xiao Zhang, Jiang Tan, Ya-Li Li, Zhi-Hong Yu, Xue-Feng Xia, Jian-Ye Chu, Ju Ge, You-Qun
- 机构： College of Chemistry and Biology Science; Hubei Province Key Lab. of Yeast Function; State Key Laboratory of Bioreactor Engineering; Jiangxi GuoYao Pharmaceutical Limited Liability Company
- 来源：Journal of Bioscience and Bioengineering 2013
- 关键词：Axial flow - Bacteria - Dissolved oxygen - Fermentation - Fermenters - Flow fields - Impellers - Kinetic energy - Kinetics - Mass transfer - Metabolism - Radial flow - Shear flow - Volumetric analysis
- 质疑
- Integration of enzyme constraints in a genome-scale metabolic model of Aspergillus niger improves phenotype predictions被引量：27收藏
- 作者：Zhou, Jingru Zhuang, Yingping Xia, Jianye
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：MICROBIAL CELL FACTORIES 2021
- 关键词：Genome-scale metabolic model Proteome constraint GSMM Aspergillus niger Differential expression of enzymes
- 质疑
- Real-time fluid dynamics investigation and physiological response for erythromycin fermentation scale-up from 50 L to 132 m3 fermenter被引量：27收藏
- 作者：Zou, Xiang Xia, Jian-Ye Chu, Ju Zhuang, Ying-Ping Zhang, Si-Liang
- 机构： State Key Laboratory of Bioreactor Engineering; College of Pharmaceutical Sciences
- 来源：Bioprocess and Biosystems Engineering 2012
- 关键词：Physiological models - Physiology - Rheology - Antibiotics - Oxygen - Biochemistry - Flow measurement - Biosynthesis - Non Newtonian flow - Non Newtonian liquids - Viscous flow
- 质疑
- Quantitative evaluation of the shear threshold on Carthamus tinctorius L. cell growth with computational fluid dynamics in shaken flask bioreactors被引量：26收藏
- 作者：Liu, Yu Wang, Ze-Jian Zhang, JianWen Xia, Jian-ye Chu, Ju Zhang, Si-Liang Zhuang, Ying-Ping
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Delft Univ Technol
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2016
- 关键词：Fluid mechanics Power consumption Aggregation Plant cell bioreactors C. tinctorius L. cell Stress thresholds
- 质疑
- A novel impeller configuration to improve fungal physiology performance and energy conservation for cephalosporin C production被引量：25收藏
- 作者：Yang, Yiming Xia, Jianye Li, Jianhua Chu, Ju Li, Liang Wang, Yonghong Zhuang, Yingping Zhang, Siliang
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2012
- 关键词：Impeller configuration Cephalosporin C Morphology Computational fluid dynamics
- 质疑
- Real-time fluid dynamics investigation and physiological response for erythromycin fermentation scale-up from 50 L to 132 m3 fermenter被引量：24收藏
- 作者：Zou, Xiang Xia, Jian-ye Chu, Ju Zhuang, Ying-ping Zhang, Si-liang
- 机构：E China Univ Sci & Technol;Southwest Univ
- 来源：BIOPROCESS AND BIOSYSTEMS ENGINEERING 2012
- 关键词：Erythromycin biosynthesis Fermentation Fluid mechanics Non-Newtonian fluids Physiological response Scale-up
- 质疑
- Improvement of glucoamylase production using axial impellers with low power consumption and homogeneous mass transfer被引量：22收藏
- 作者：Tang, Wenjun Pan, Ao Lu, Hongzhong Xia, Jianye Zhuang, Yingping Zhang, Siliang Chu, Ju Noorman, Henk
- 机构：E China Univ Sci & Technol;DSM Biotechnol Ctr
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2015
- 关键词：Glucoamylase Impeller type Aspergillus niger Morphology analysis CFD
- 质疑
