成果/Result
- Total Synthesis and Stereochemical Assignment of Delavatine A: Rh-Catalyzed Asymmetric Hydrogenation of Indene-Type Tetrasubstituted Olefins and Kinetic Resolution through Pd Catalyzed Triflamide-Directed C-H Olefination被引量：77收藏
- 作者：Zhang, Zhongyin Wang, Jinxin Li, Jian Yang, Fan Liu, Guodu Tang, Wenjun He, Weiwei Fu, Jian-Jun Shen, Yun-Heng Li, Ang Zhang, Wei-Dong
- 机构：East China Univ Sci & Technol;Second Mil Med Univ;Chinese Acad Sci
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2017
- 关键词：Synthesis (chemical) - Cell culture - Kinetics - Olefins - Reaction intermediates - Stereochemistry - Palladium compounds - Polycyclic aromatic hydrocarbons - Catalysis - Hydrogenation - Sulfur compounds
- An acidic medium-compatible deep-near-infrared dye for in vivo imaging被引量：31收藏
- 作者：Dong, Yan Zou, Ye Jia, Xiaotong Yin, Lei He, Weiwei Luo, Xiao Qian, Xuhong Yang, Youjun
- 机构：East China Univ Sci & Technol
- 来源：SMART MOLECULES 2023
- 关键词：acidic medium gastrointestinal tract In vivo imaging near infrared fluorophore
- CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS被引量：24收藏
- 作者：Sun, Litao Wei, Na Kuhle, Bernhard Blocquel, David Novick, Scott Matuszek, Zaneta Zhou, Huihao He, Weiwei Zhang, Jingjing Weber, Thomas Horvath, Rita Latour, Philippe Pan, Tao Schimmel, Paul Griffin, Patrick R. Yang, Xiang-Lei
- 机构：Scripps Res Inst;Sun Yat Sen Univ;Scripps Res Inst;Univ Chicago;Sun Yat Sen Univ
- 来源：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2021
- 关键词：Charcot-Marie-Tooth disease neuropilin 1 AlaRS
- Astragaloside IV Attenuates Glutamate-Induced Neurotoxicity in PC12 Cells through Raf-MEK-ERK Pathway被引量：22收藏
- 作者：Yue, Rongcai Li, Xia Chen, Bingyang Zhao, Jing He, Weiwei Yuan, Hu Yuan, Xing Gao, Na Wu, Guozhen Jin, Huizi Shan, Lei Zhang, Weidong
- 机构：Second Mil Med Univ;Shanghai Jiao Tong Univ;Logist Engn Univ;E China Univ Sci & Technol
- 来源：PLOS ONE 2015
- (-) and (+)-Merrilliaquinone, a pair of new quinone enantiomers from Illicium merrillianum and their distinctive effect on human hepatoma and hepatic cells被引量：16收藏
- 作者：Tian, Xinhui Li, Li Pei, Jinpeng Yue, Rongcai Fang, Xin Zhang, Jianping He, Weiwei Shan, Lei Shen, Yunheng Zhang, Weidong
- 机构：Second Mil Med Univ;Chinese Acad Med Sci;Peking Union Med Coll;E China Univ Sci & Technol;Shanghai Inst Pharmaceut Ind
- 来源：RSC ADVANCES 2015
- 关键词：Chirality - Enantiomers - Spectroscopic analysis - Cell culture - Quantum theory - Mitochondria - Cell death - Cell membranes
- Celastrol as a tool for the study of the biological events of metabolic diseases被引量：14收藏
- 作者：Lan, Gongcai Zhang, Jie Ye, Wenbo Yang, Fan Li, Ang He, Weiwei Zhang, Wei-Dong
- 机构：Guangdong Pharmaceut Univ;East China Univ Sci & Technol;Chinese Acad Sci;Second Mil Med Univ;Jiangxi Qingfeng Pharmaceut Co Ltd
- 来源：SCIENCE CHINA-CHEMISTRY 2019
- 关键词：celastrol obesity type 2 diabetes endoplasmic reticulum stress inflammation
- Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid被引量：13收藏
- 作者：Li, Yuanyuan Yuan, Xing Shen, Yunheng Zhao, Jing Yue, Rongcai Liu, Fang He, Weiwei Wang, Rui Shan, Lei Zhang, Weidong
- 机构：Second Mil Med Univ;Logist Engn Univ;E China Univ Sci & Technol;Shanghai Inst Pharmaceut Ind
- 来源：AGING-US 2016
- 关键词：Bacopaside I Alzheimer's disease beta-amyloid immune phagocytosis APP/PS1 mice
- Delavatine A, a structurally unusual cyclopenta[de]isoquinoline alkaloid from Incarvillea delavayi被引量：13收藏
- 作者：Zhang, Zhongyin Yang, Fan Fu, Jian-Jun Shen, Yun-Heng He, Weiwei Zhang, Wei-Dong
- 机构：Second Mil Med Univ;East China Univ Sci & Technol
- 来源：RSC ADVANCES 2016
- 关键词：Bioactivity - Drug products - Metabolites - Cell culture - Spectroscopic analysis
- Worm Generator: A System for High-Throughput in Vivo Screening被引量：8收藏
- 作者：Yang, Anqi Lin, Xiang Liu, Zijian Duan, Xin Yuan, Yurou Zhang, Jiaxuan Liang, Qilin Ji, Xianglin Sun, Nannan Yu, Huajun He, Weiwei Zhu, Lili Xu, Bingzhe Lin, Xudong
- 机构：Sun Yat sen Univ;City Univ Hong Kong;Guangdong Med Univ;East China Univ Sci & Technol
- 来源：NANO LETTERS 2023
- 关键词：triboelectric nanogenerator microfluidics Caenorhabditis elegans high-throughput drug screening
- Distinctive effect on nerve growth factor-induced PC12 cell neurite outgrowth by two unique neolignan enantiomers from Illicium merrillianum被引量：7收藏
- 作者：Tian, Xinhui Yue, Rongcai Zeng, Huawu Li, Honglin Shan, Lei He, Weiwei Shen, Yunheng Zhang, Weidong
- 机构：Second Mil Med Univ;Shanghai Jiao Tong Univ;E China Univ Sci & Technol
- 来源：SCIENTIFIC REPORTS 2015
- Celastrol as a tool for the study of the biological events of metabolic diseases被引量：5收藏
- 作者：Gongcai Lan Jie Zhang Wenbo Ye Fan Yang Ang Li Weiwei He Wei-Dong Zhang
- 机构：Guangdong Pharmaceutical University;Shanghai Key Laboratory of New Drug Design;State Key Laboratory of Bioorganic and Natural Products Chemistry;Department of Phytochemistry;State Key Laboratory of Innovative Natural Medicine and Traditional Chinese Medicine Injections
- 来源：中国科学（化学英文版） 2019
- 关键词：celastrol obesity type 2 diabetes endoplasmic reticulum stress inflammation
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- Identification and Mechanistic Studies of a Cell Cycle Regulator JP18 from a Library of Synthetic Indole Terpenoid Mimics被引量：5收藏
- 作者：Pei, Jinpeng Zhou, Shupeng Yang, Fan Sun, Yu Li, Ang Zhang, Wei-Dong He, Weiwei
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Second Mil Med Univ
- 来源：CHEMISTRY-AN ASIAN JOURNAL 2016
- 关键词：CDK/cyclin complexes cell cycle arrest hybrid structures indoles terpenoids
- Hapalindole Q suppresses autophagosome-lysosome fusion by promoting YAP1 degradation via chaperon- mediated autophagy被引量：4收藏
- 作者：Wu, Yali Wang, Shaonan Guo, Zhicong Sun, Min Xu, Zhen Du, Yu Zhu, Fahui Su, Yajuan Xu, Zhou Xu, Yi Gong, Xu Fang, Ruan Hu, Jiaojiao Peng, Yan Ding, Zhaowen Liu, Cong Li, Ang He, Weiwei
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Sci
- 来源：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2024
- 关键词：natural product autophagy inhibitor YAP1 degradation chaperone- mediated autophagy
- Target Identification and Mechanistic Characterization of Indole Terpenoid Mimics: Proper Spindle Microtubule Assembly Is Essential for Cdh1-Mediated Proteolysis of CENP-A被引量：4收藏
- 作者：Peng, Yan Zhang, Yumeng Fang, Ruan Jiang, Hao Lan, Gongcai Xu, Zhou Liu, Yajie Nie, Zhaoyang Ren, Lu Wang, Fengcan Zhang, Shou-De Ma, Yuyong Yang, Peng Ge, Hong-Hua Zhang, Wei-Dong Luo, Cheng Li, Ang He, Weiwei
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Sci;Zhengzhou Univ;Zhengzhou Univ
- 来源：ADVANCED SCIENCE 2024
- 关键词：Cdh1 CENP-A regulation colchicine-binding site inhibitor indole terpenoid target identification
- Synthesis of a glucose conjugate of pristimerin and evaluation of its anticancer activity被引量：3收藏
- 作者：Yang, Fan Zhang, Jie Li, Jiacheng Ye, Wenbo Li, Ang He, Weiwei
- 机构：East China Univ Sci & Technol;Univ Chinese Acad Sci;Shanghai Univ Tradit Chinese Med
- 来源：CHINESE CHEMICAL LETTERS 2023
- 关键词：Glucose conjugation Warburg effect Pristimerin Extracellular stability
- Advancements in life-on-a-chip: The impact of "Beyond Limits Manufacturing" technology被引量：2收藏
- 作者：He, Weiwei Zhang, Hongbo Lin, Xudong Zhu, Lili Zheng, Tingting Pei, Hao Tian, Yang Zhang, Min Shi, Guoyue Wu, Lei Zhao, Jianlong Wumaier, Gulinuer Li, Shengqing Xu, Yufang Li, Honglin Qian, Xuhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Sun Yat Sen Univ;East China Normal Univ;Chinese Acad Sci
- 来源：CHINESE CHEMICAL LETTERS 2024
- 关键词：Beyond limit manufacturing Model-organism-on-a-chip Organ-on-a-chip
- 氯化两面针碱合成方法的改进被引量：1收藏
- 作者：许旭升 刘志千 邵文浩 叶霁 孙青龑 何薇薇 张卫东
- 机构：华东理工大学药学院;第二军医大学药学院
- 来源：《有机化学》 2015
- 关键词：氯化两面针碱 分子内Heck偶联反应 合成改进
- 摘要：以6-溴-3,4-二甲氧基苯甲醛和6,7-亚甲二氧基-1-萘胺为起始原料,经还原胺化、分子内Heck偶联、氧化芳构化、甲基化以及离子交换等五步反应,完成了氯化两面针碱的合成,并对关键步骤分子内Heck偶联反应条件进行了探...
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- Advancements in life-on-a-chip: The impact of “Beyond Limits Manufacturing” technology被引量：0收藏
- 作者：Weiwei He Hongbo Zhang Xudong Lin Lili Zhu Tingting Zheng Hao Pei Yang Tian Min Zhang Guoyue Shi Lei Wu Jianlong Zhao Gulinuer Wumaier Shengqing Li Yufang Xu Honglin Li Xuhong Qian
- 机构：Shanghai Key Laboratory of New Drug Design;School of Mechanical and Power Engineering;Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument;Shanghai Key Laboratory of Green Chemistry and Chemical Processes;Shanghai Institute of Microsystem and Information Technology
- 来源：中国化学快报（英文版） 2024
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- An acidic medium-compatible deep-near-infrared dye for in vivo imaging被引量：0收藏
- 作者：Yan Dong Ye Zou Xiaotong Jia Lei Yin Weiwei He Xiao Luo Xuhong Qian Youjun Yang
- 机构：School of Pharmacy
- 来源：智能分子（英文） 2023
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- Inverse-electron-demand Diels-Alder approach to densely substituted bicyclo[3.2.2]nonanes: Discovery of an autophagy regulator被引量：0收藏
- 作者：Li, Jiulong Ren, Pengxin Wang, Lin Zhang, Yuting Yang, Peng He, Weiwei Li, Ang
- 机构：Zhengzhou Univ;Zhengzhou Univ;Univ Chinese Acad Sci;East China Univ Sci & Technol
- 来源：CHINESE CHEMICAL LETTERS 2026
- 关键词：Bicyclo[3.2.2]nonane Benzo[2,3]tropone Inverse-electron-demand Diels-Alder reaction Autophagy regulation
- Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid (vol 8, pg 521, 2016)被引量：0收藏
- 作者：Li, Yuanyuan Yuan, Xing Shen, Yunheng Zhao, Jing Yue, Rongcai Liu, Fang He, Weiwei Wang, Rui Shan, Lei Zhang, Weidong
- 机构：Second Mil Med Univ;Logist Engn Univ;East China Univ Sci & Technol;Shanghai Inst Pharmaceut Ind
- 来源：AGING-US 2023
- 关键词：Bacopaside I Alzheimer's disease beta-amyloid immune phagocytosis APP/PS1mice
- Inverse-electron-demand Diels–Alder approach to densely substituted bicyclo[3.2.2]nonanes:Discovery of an autophagy regulator被引量：0收藏
- 作者：Jiulong Li Pengxin Ren Lin Wang Yuting Zhang Peng Yang Weiwei He Ang Li
- 机构：College of Chemistry&Henan Institute of Advanced Technology;State Key Laboratory of Chemical Biology;Shanghai Key Laboratory of New Drug Design
- 来源：中国化学快报(英文版) 2026
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- Synthesis of a glucose conjugate of pristimerin and evaluation of its anticancer activity被引量：0收藏
- 作者：Fan Yang Jie Zhang Jiacheng Li Wenbo Ye Ang Li Weiwei He
- 机构：Shanghai Key Laboratory of New Drug Design;State Key Laboratory of Bioorganic and Natural Product Chemistry;The Research Center of Chiral Drugs
- 来源：中国化学快报（英文版） 2023
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- Total Synthesis of Scholarisines A, I, T, and W and Identification of Scholarisine I as a Lysosome Inhibitor被引量：0收藏
- 作者：Guo, Rui Li, Fan Wang, Lin Ba, Mengyu Guo, Zhicong He, Weiwei Li, Ang
- 机构：Chinese Acad Sci;East China Univ Sci & Technol
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2026
