成果/Result
- Catalytic asymmetric michael reactions of α,β-unsaturated ketones with sulfonyl-containing nucleophiles: Chiral synthesis of (R)-muscone and (S)-celery ketone被引量：68收藏
- 作者：Sun, Xiaomin Yu, Feng Ye, Tingting Liang, Xinmiao Ye, Jinxing
- 机构： Engineering Research Center of Pharmaceutical Process Chemistry
- 来源：Chemistry - A European Journal 2011
- 关键词：Nucleophiles - Sulfur - Stereochemistry - Addition reactions - Catalysis - Enantioselectivity
- Br?nsted acid cocatalysis in photocatalytic intramolecular coupling of tertiary amines: Efficient synthesis of 2-arylindols被引量：64收藏
- 作者：Yuan, Xiaoqian Wu, Xinxin Dong, Shupeng Wu, Guibing Ye, Jinxing
- 机构： Engineering Research Centre of Pharmaceutical Process Chemistry
- 来源：Organic and Biomolecular Chemistry 2016
- 关键词：Amines
- Copper on Charcoal: Tempo Free Cu0 Nanoparticles Catalyzed Aerobic Oxidation of Alcohols被引量：61收藏
- 作者：Wang, Zhiwei Zhao, Rong Lin, Jia Liu, Chaoyang Jia, Qiang Chu, Changhu
- 机构： Engineering Research Centre of Pharmaceutical Process Chemistry; Seasons Biotechnology Co.
- 来源：SSRN 2023
- 关键词：Catalytic oxidation - Charcoal - Copper - Ketones - Nanoparticles
- Theoretical Exploration of Mechanism and Ligand Effects of Asymmetric Hydrogenation of β-Amino Ketone Catalyzed by an Iridium-PNN Catalyst被引量：59收藏
- 作者：Xiong, Yan Liu, Chengyu Zhang, Lei Wang, Xin Yang, Jiaxin Liu, Zhen Ye, Jinxing Cheng, Ruihua
- 机构： School of Chemical Engineering; Engineering Research Centre of Pharmaceutical Process Chemistry; School of Biomedical and Pharmaceutical Sciences
- 来源：Organometallics 2023
- 关键词：Amides - Amines - Binding energy - Catalysts - Chemical bonds - Density functional theory - Enantioselectivity - Iridium - Ketones - Ligands - Phosphorus compounds - Scaffolds - Sodium compounds
- Development of a gliclazide ionic liquid and its mesoporous silica particles: An effective formulation strategy to improve oral absorption properties被引量：58收藏
- 作者：Zhou, Bijian Teng, Dan Li, Jinghui Zhang, Yanhong Qi, Minghui Hong, Minghuang Ren, Guo-Bin
- 机构： Engineering Research Centre of Pharmaceutical Process Chemistry; Shanghai Key Laboratory of New Drug Design; State Key Laboratory of Bioreactor Engineering
- 来源：RSC Advances 2022
- 关键词：Silica - Targeted drug delivery - Molecules - Controlled drug delivery - Encapsulation - Solubility - Positive ions - Mesoporous materials - Physicochemical properties - Supersaturation
- Chemically bonded maltose via click chemistry as stationary phase for HILIC被引量：52收藏
- 作者：Fu, Qing Guo, Zhimou Liang, Tu Zhang, Xiuli Xu, Qing Liang, Xinmiao
- 机构： Key Lab of Separation Science for Analytical Chemistry; Engineering Research Center of Pharmaceutical Process Chemistry
- 来源：Analytical Methods 2010
- 关键词：Hydrophilicity - Liquid chromatography - Synthesis (chemical) - Maltose - Hydrogen bonds - Silica
- Br?nsted acid-catalyzed aza-Mannich reaction of N-Boc aminals: access to multifunctional rhodanine/hydantoin derivatives被引量：51收藏
- 作者：Zou, Kaihe Wu, Xin-Yan Ye, Jinxing
- 机构： Key Laboratory for Advanced Materials and Institute of Fine Chemicals; Engineering Research Centre of Pharmaceutical Process Chemistry; Shanghai Key Laboratory of New Drug Design
- 来源：Research on Chemical Intermediates 2017
- Insight into the effect of cocrystal polymorphism / stoichiomorphism on thermodynamic and photoluminescence properties: a case study被引量：45收藏
- 作者：Han, Xianyang Yin, Yu Zhu, Fan Yao, Yichen Hong, Minghuang Qi, Minghui Zhu, Bin Ren, Guobin
- 机构： Laboratory of Pharmaceutical Crystal Engineering & Technology; State Key Laboratory of Bioreactor Engineering
- 来源：SSRN 2025
- 关键词：Crystal structure - Fluorescence - Fluorescence spectroscopy - Optical properties - Phase transitions - Photoluminescence - Polymorphism - Single crystals - Thermoanalysis - X ray diffraction
- Isostructural Levamisole Hydrochloride Ionic Cocrystal Solvates: High Z″ with a Low Melting Point被引量：40收藏
- 作者：Yao, Yi-Chen Jin, Zhe Hong, Minghuang Zhu, Bin Ren, Guo-Bin Qi, Ming-Hui
- 机构： Laboratory of Pharmaceutical Crystal Engineering & Technology
- 来源：Crystal Growth and Design 2024
- 关键词：Melting point - Single crystals - Surface analysis - Thermoanalysis
- East China University of Science and Technology被引量：37收藏
- 作者：Wang, Fei Teng, Jiangge Li, Zixu Fang, Chao Ma, Kai Ke, Yanxiong Jia, Qiang Chu, Changhu
- 机构： Engineering Research Centre of Pharmaceutical Process Chemistry; Seasons Biotechnology Co.
- 来源：SSRN 2024
- 关键词：Catalyst activity - Chemical reactions - Metal halides
- Preparation of Polyvinyl Pyrrolidone Stationary Phase and its Application in Separation and Analysis of Flavonoids被引量：35收藏
- 作者：Chen, Xin Li, Juntao Gu, Mengting Miao, Yiyuan Ke, Yanxiong Zheng, Xiangwei Xu, Jian
- 机构： Engineering Research Center of Pharmaceutical Process Chemistry; Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine; Hubei Provincial Key Laboratory of Quality and Safety of Traditional Chinese Medicine Health Food
- 来源：SSRN 2023
- 关键词：Acetonitrile - Hydrogen bonds - Methanol - Silica
- Selective separation of flavonoid glycosides in Dalbergia odorifera by matrix solid-phase dispersion using titania被引量：34收藏
- 作者：Xu, Lingyan Shi, Hui Liang, Tu Feng, Jiatao Jin, Yu Ke, Yanxiong Liang, Xinmiao
- 机构： Engineering Research Center of Pharmaceutical Process Chemistry; Dalian Institute of Chemical Physics; School of Pharmacy
- 来源：Journal of Separation Science 2011
- 关键词：Separation - Acetonitrile - Dispersions - Titanium dioxide - Sugars - Flavonoids
- An Improved Subtraction Model Applied in Supercritical Fluid Chromatography to Characterize Polar Stationary Phases被引量：33收藏
- 作者：Ge, Dandan Lu, Jiahao Yu, Zimo Jin, Yu Ke, Yanxiong Fu, Qing Liang, Xinmiao
- 机构： Engineering Research Center of Pharmaceutical Process Chemistry; Key Lab of Separation Science for Analytical Chemistry
- 来源：SSRN 2024
- 关键词：Effluent treatment - Hydrophobicity - Silica - Supercritical fluids
- Preparation of a stationary phase with s-triazine ring embedded group for reversed phase high-performance LC被引量：26收藏
- 作者：Li, Yingyu Dai, Peichun Ke, Yanxiong Jin, Yu Liang, Xinmiao
- 机构： Engineering Research Center of Pharmaceutical Process Chemistry
- 来源：Journal of Separation Science 2010
- Cocrystals of Oxymatrine: Reducing Hygroscopicity and Affecting the Dissolution Rate被引量：25收藏
- 作者：Qi, Ming-Hui Li, Heng Zhu, Bin Hong, Minghuang Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2021
- 关键词：Dissolution - Hydrogen bonds - Metabolism
- Resurrecting the 'Disappearing Polymorph' of Rotigotine via Conformational Landscape Engineering被引量：25收藏
- 作者：Yi, Dongxu Qi, Minghui Xu, Shaohong Qi, Yonghua Xia, Ran Wu, Hao Ren, Guobin
- 机构： School of Pharmacy; School of Pharmacy; Children's Hospital Affiliated to Zhengzhou University; Henan Children’ s Hospital Zhengzhou Children’s Hospital; Engineering Research Centre of Pharmaceutical Process Chemistry
- 来源：SSRN 2025
- 关键词：Boltzmann equation - Conformations - Crystallization kinetics - Drug products - Engineering research - Molecular biology - Molecular physics - Polymorphism - Potential energy
- Preparation of "click" binaphthyl stationary phase and its application for separation of anthraquinones from Rheum palmatum L.被引量：24收藏
- 作者：Yu, Danhua Yu, Hui Wang, Xinliang Jin, Yu Ke, Yanxiong Liang, Xinmiao
- 机构： Engineering Research Center of Pharmaceutical Process Chemistry
- 来源：Journal of Separation Science 2011
- 关键词：Separation - Ketones - Polycyclic aromatic hydrocarbons - Silica - Medicine
- Pvp-I Catalyzed Oxidation of Benzylamines to Aryl Formamides被引量：23收藏
- 作者：Lu, Guangying Yuan, Xinxin Wang, Jian Sun, Xue-Qin Cao, Fu-Rong Ren, Jiangmeng Ke, Yanxiong Mu, Xin Bu-Bing, Zeng
- 机构： Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism; Engineering Research Centre of Pharmaceutical Process Chemistry
- 来源：SSRN 2023
- 关键词：Amides
- Carbonyl-Bridged Trifluoromethyl Pyridine Derivatives for Pest Control and Mechanistic Investigations被引量：22收藏
- 作者：Sheng, Zhubo Deng, Jie Yuan, Qinglong Fu, Wen Xu, Zhiping Li, Xiaoyan Li, Zhong Shao, Xusheng
- 机构： Shanghai Key Laboratory of Chemical Biology; State Key Laboratory of Bioreactor Engineering; Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism; Engineering Research Center of Pharmaceutical Process Chemistry; National Key Laboratory of Green Pesticide
- 来源：SSRN 2025
- 关键词：Synthesis (chemical)
- Combination of off-line two-dimensional hydrophilic interaction liquid chromatography for polar fraction and two-dimensional hydrophilic interaction liquid chromatography×reversed-phase liquid chromatography for medium-polar fraction in a traditional Chinese medicine被引量：20收藏
- 作者：Liang, Zheng Li, Kuiyong Wang, Xinliang Ke, Yanxiong Jin, Yu Liang, Xinmiao
- 机构： Engineering Research Center of Pharmaceutical Process Chemistry
- 来源：Journal of Chromatography A 2012
- 关键词：Liquid chromatography - Medicine - Phase separation - Liquids
- Synthesis and evaluation of a maltose-bonded silica gel stationary phase for hydrophilic interaction chromatography and its application in Ginkgo Biloba extract separation in two-dimensional systems被引量：18收藏
- 作者：Sheng, Qianying Yang, Kaiya Ke, Yanxiong Liang, Xinmiao Lan, Minbo
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF SEPARATION SCIENCE 2016
- 关键词：Ginkgo Biloba extract Hydrophilic interaction liquid chromatography Saccharide-modified stationary phases Separation selectivity Two-dimensional chromatography
- 华东地区某水源水中13种磺胺类抗生素的分布特征及人体健康风险评价被引量：17收藏
- 作者：金磊 姜蕾 韩琪 薛佳怡 叶辉 曹国民 林匡飞 崔长征
- 机构：华东理工大学资源与环境工程学院;上海城市水资源开发利用国家工程中心有限公司;华东理工大学药学院
- 来源：《环境科学》 2016
- 关键词：磺胺类抗生素 饮用水源水 分布特征 风险熵 健康风险评价
- 摘要：饮用水源水中残留微量抗生素对人体健康的潜在威胁日益引起广泛关注.采用固相萃取、高效液相串联质谱方法分析了13种磺胺类抗生素在华东地区某水源水中的分布特征.结果表明,13种磺胺类抗生素在水源水中均有不同程度检出,总浓度为1...
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- Iodine-Catalysed Conversion of Decahydrophenothiazines into Phenothiazines被引量：15收藏
- 作者：Zhao, Yinglin Luo, Jiayue Wang, Ruitong Yuan, Yuqin Chu, Changhu Liu, Renhua
- 机构： Engineering Research Centre of Pharmaceutical Process Chemistry
- 来源：SSRN 2024
- 关键词：Insecticides - Iodine - Sulfur
- 本芴醇的合成工艺改进被引量：14收藏
- 作者：Yang, Kang Zheng, Qun Wu, Weiting Chen, Xuxiang Zhao, Jianhong
- 机构： Engineering Research Center of Pharmaceutical Process Chemistry
- 来源：[1] Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China 2024
- Purification of compounds from Lignum Dalbergia Odorifera using two-dimensional preparative chromatography with Click oligo (ethylene glycol) and C18 column被引量：11收藏
- 作者：Feng, Jiatao Xiao, Yuansheng Guo, Zhimou Yu, Danhua Jin, Yu Liang, Xinmiao
- 机构： Dalian Institute of Chemical Physics; Engineering Research Centre of Pharmaceutical Process Chemistry
- 来源：Journal of Separation Science 2011
- 关键词：Column chromatography - Ethylene glycol - Separation - Ethylene - Medicine - Polyols
- 不同灵芝菌丝体水提物对乙醇诱导LO2肝细胞损伤的保护作用被引量：0收藏
- 作者：陈亚平 刘利平 冯杰 刘艳芳 唐传红 颜梦秋 张劲松 韩伟
- 机构：华东理工大学药学院制药工程与过程化学教育部工程研究中心;上海市农业科学院食用菌研究所
- 来源：《食品工业科技》 2024
- 关键词：灵芝 菌丝体 水提物 乙醇性肝损伤 保肝作用
- 摘要：为了探讨不同灵芝菌丝体水提物对乙醇诱导LO2肝细胞损伤的保护作用,本文分析了7种不同灵芝菌株发酵菌丝体水提物对乙醇诱导LO2细胞损伤的保护作用。利用乙醇诱导LO2细胞建立体外肝损伤模型,并以细胞存活率、谷丙转氨酶(Ala...
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- 三电极电致膜阴离子抑制器的构建被引量：0收藏
- 作者：黄颖芬 孙玥 杨丙成 章飞芳
- 机构：华东理工大学药学院
- 来源：《分析试验室》 2021
- 关键词：离子色谱 电致膜抑制器 碳酸根淋洗液 三电极 噪声
- 摘要：制作了一个三电极电致膜抑制器,考察了加电方式、串连电阻阻值、电极间距对改善噪声的影响。相较于传统两电极抑制器,优化得到的三电极抑制器在抑制CO32--淋洗液时在噪声(~2.5倍)和信噪比(2.5~3.6倍)方面皆有一定程...
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- 新型分子印迹聚合物修饰的选择性离子源结合电喷雾电离质谱快速检测莠灭净和莠去津被引量：0收藏
- 作者：马洪悦 杨敏莉 张峰 杨丙成 章飞芳
- 机构：华东理工大学药学院;中国检验检疫科学研究院国家市场监管重点实验室(食品质量与安全)
- 来源：《食品科学》 2022
- 关键词：莠灭净 莠去津 分子印迹聚合物 敞开式质谱离子源 电喷雾电离质谱
- 摘要：基于分子印迹聚合物修饰铁片(molecularly imprinted polymer modified iron sheet,MIPIS)制备了一种选择性的敞开式质谱离子源,结合电喷雾电离质谱,构建一种快速检测食品基质...
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