成果/Result
- The yeast peroxisome: A dynamic storage depot and subcellular factory for squalene overproduction被引量：194收藏
- 作者：Liu, Guo-Song Li, Tian Zhou, Wei Jiang, Min Tao, Xin-Yi Liu, Min Zhao, Ming Ren, Yu-Hong Gao, Bei Wang, Feng-Qing Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol
- 来源：METABOLIC ENGINEERING 2020
- 关键词：Synthetic biology Saccharomyces cerevisiae Peroxisome Storage depot Subcellular factory Terpene
- Long-circulating polymeric nanoparticles bearing a combinatorial coating of PEG and water-soluble chitosan被引量：191收藏
- 作者：Sheng, Yan Liu, Changsheng Yuan, Yuan Tao, Xinyi Yang, Fan Shan, Xiaoqian Zhou, Huanjun Xu, Feng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOMATERIALS 2009
- 关键词：Polymeric nanoparticles Polyethylene glycol Water-soluble chitosan Long-circulating Biodistribution
- In vitro macrophage uptake and in vivo biodistribution of PLA-PEG nanoparticles loaded with hemoglobin as blood substitutes: effect of PEG content被引量：123收藏
- 作者：Sheng, Yan Yuan, Yuan Liu, Changsheng Tao, Xinyi Shan, Xiaoqian Xu, Feng
- 机构：E China Univ Sci & Technol; E China Univ Sci & Technol
- 来源：JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 2009
- 关键词：Polyethylene oxides - Hydrophilicity - Nanoparticles - Encapsulation - Macrophages - Blood - Drug delivery - Efficiency - Pharmacokinetics - Biocompatibility
- Metabolic compartmentalization in yeast mitochondria: Burden and solution for squalene overproduction被引量：115收藏
- 作者：Zhu, Zhan-Tao Du, Meng-Meng Gao, Bei Tao, Xin-Yi Zhao, Ming Ren, Yu-Hong Wang, Feng-Qing Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol
- 来源：METABOLIC ENGINEERING 2021
- 关键词：Saccharomyces cerevisiae Mitochondrial engineering Metabolic burden Squalene Dual engineering
- Preparation of hemoglobin-loaded nano-sized particles with porous structure as oxygen carriers被引量：89收藏
- 作者：Zhao, Jian Liu, Chang-Sheng Yuan, Yuan Tao, Xin-Yi Shan, Xiao-Qian Sheng, Yan Wu, Fan
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOMATERIALS 2007
- 关键词：nanoparticles hemoglobin encapsulation efficiency pore-connecting efficiency oxygen-carrying capacity circulation time
- Epidermal Growth Factor-Ferritin H-Chain ProtEIn Nanoparticles for Tumor Active Targeting被引量：79收藏
- 作者：Li, Xu Qiu, Lihui Zhu, Pei Tao, Xinyi Imanaka, Tadayuki Zhao, Jing Huang, Youguo Tu, Yaping Cao, Xuni
- 机构：Creighton Univ;E China Univ Sci & Technol;Chinese Acad Sci
- 来源：SMALL 2012
- 关键词：Diseases - Tumors - Cytology - Controlled drug delivery - ProtEIns - Cells - Mammals - Safety factor - Targeted drug delivery - Cancer cells - Chains
- Metabolic Engineering of Saccharomyces cerevisiae To Overproduce Squalene被引量：71收藏
- 作者：Li, Tian Liu, Guo-Song Zhou, Wei Jiang, Min Ren, Yu-Hong Tao, Xin-Yi Liu, Min Zhao, Ming Wang, Feng-Qing Gao, Bei Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2020
- 关键词：Saccharomyces cerevisiae metabolic engineering squalene overproduction ethanol carbon source utilization
- Simple and Cheap CRISPR/Cas12a Biosensor Based on Plug-and-Play of DNA Aptamers for the Detection of Endocrine-Disrupting Compounds被引量：65收藏
- 作者：Wang, Feng-Qing Zhao, Yunqiu Zhu, Lin Ding, Yaxue Ji, Weiting Liu, Kun Liu, Ke Gao, Bei Tao, Xinyi Dong, Yu-Guo Wei, Dongzhi
- 机构： State Key Laboratory of Bioreactor Engineering; Key Laboratory of Biocatalysis and Intelligent Manufacturing
- 来源：SSRN 2023
- 关键词：DNA - Endocrine disrupters - Phenols
- Significantly Enhanced Production of Patchoulol in Metabolically Engineered Saccharomyces cerevisiae被引量：53收藏
- 作者：Ma, Bin Liu, Min Li, Zhen-Hai Tao, Xinyi Wei, Dong-Zhi Wang, Feng-Qing
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2019
- 关键词：patchoulol sesquiterpene metabolic engineering Saccharomyces cerevisiae terpenoids
- Reversion of multidrug resistance by tumor targeted delivery of antisense oligodeoxynucleotides in hydroxypropyl-chitosan nanoparticles被引量：52收藏
- 作者：Wang, Jiaqi Tao, Xinyi Zhang, Yufei Wei, Dongzhi Ren, Yuhong
- 机构：E China Univ Sci & Technol
- 来源：BIOMATERIALS 2010
- 关键词：Hydroxypropyl-chitosan nanoparticles Tumor-targeted Antisense oligodeoxynucleotides Multidrug resistance
- Ammonia-containing dimethyl sulfoxide: An improved solvent for the dissolution of formazan crystals in the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay被引量：51收藏
- 作者：Wang, Hengwei Wang, Fengqing Tao, Xinyi Cheng, Hairong
- 机构：Shanghai Jiao Tong Univ;E China Univ Sci & Technol
- 来源：ANALYTICAL BIOCHEMISTRY 2012
- 关键词：MTT assay Formazan Dimethyl sulfoxide Ammonia pH Viability
- Metabolic engineering of Pichia pastoris for the production of dammarenediol-II被引量：51收藏
- 作者：Liu, Xin-Bin Liu, Min Tao, Xin-Yi Zhang, Zhong-Xi Wang, Feng-Qing Wei, Dong-Zhi
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2015
- 关键词：Dammarenediol-II Metabolic engineering Pichia pastoris Ginsenosides 2,3-Oxidosqualene
- Influence of PEG chain on the complement activation suppression and longevity in vivo prolongation of the PCL biomedical nanoparticles被引量：40收藏
- 作者：Shan, Xiaoqian Yuan, Yuan Liu, Changsheng Tao, Xinyi Sheng, Yan Xu, Feng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOMEDICAL MICRODEVICES 2009
- 关键词：PEGylation NPs Prolong longevity in vivo Biodistribution Complement activation
- Development of a fed-batch process for the production of anticancer drug TATm-survivin(T34A) in Escherichia coli被引量：40收藏
- 作者：Zhang, Haiyi Zheng, Yu Liu, Qinghai Tao, Xinyi Zheng, Wenyun Ma, Xingyuan Wei, Dongzhi
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Biochemical Engineering Journal 2009
- 关键词：Batch cell culture - Controlled drug delivery - Recombinant protEIns - Batch data processing - Gene expression
- In vitro macrophage uptake and in vivo biodistribution of long-circulation nanoparticles with poly(ethylene-glycol)-modified PLA (BAB type) triblock copolymer被引量：35收藏
- 作者：Shan, Xiaoqian Liu, Changsheng Yuan, Yuan Xu, Feng Tao, Xinyi Sheng, Yan Zhou, Huanjun
- 机构： The State Key Laboratory of Bioreactor Engineering; Key Laboratory for Ultrafine Materials; Engineering Research Center for Biomedical Materials
- 来源：Colloids and Surfaces B: Biointerfaces 2009
- 关键词：Polyethylene oxides - Biocompatibility - Macrophages - Ethylene glycol - Antigen-antibody reactions - Drug delivery - Nanoparticles - Polyvinyl alcohols - Hydrophilicity - Polyols
- Engineering Saccharomyces cerevisiae for Hyperproduction of β-Amyrin by Mitigating the Inhibition Effect of Squalene on β-Amyrin Synthase被引量：35收藏
- 作者：Du, Meng-Meng Zhu, Zhan-Tao Zhang, Ge-Ge Zhao, Yun-Qiu Gao, Bei Tao, Xin-Yi Liu, Min Ren, Yu-Hong Wang, Feng-Qing Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2022
- 关键词：beta-amyrin squalene inhibition peroxisome compartmentalization competition pathway Saccharomyces cerevisiae
- New compounds from a hydrothermal vent crab-associated fungus Aspergillus versicolor XZ-4被引量：33收藏
- 作者：Pan, Chengqian Shi, Yutong Chen, Xuegang Chen, Chen-Tung Arthur Tao, Xinyi Wu, Bin
- 机构：Zhejiang Univ;Natl Sun Yat Sen Univ;East China Univ Sci & Technol
- 来源：ORGANIC & BIOMOLECULAR CHEMISTRY 2017
- 关键词：Amino acids - Quantum chemistry - Aspergillus - Molluscs - Nuclear magnetic resonance spectroscopy - Musculoskeletal system - Stereochemistry - Hot springs
- Engineered 3-ketosteroid 9a-hydroxylases in Mycobacterium neoaurum: An efficient platform for production of steroid drugs被引量：30收藏
- 作者：Liu, Hao-Hao Xu, Li-Qin Yao, Kang Xiong, Liang-Bin Tao, Xin-Yi Liu, Min Wang, Feng-Qing Wei, Dong-Zhi
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Applied and Environmental Microbiology 2018
- 关键词：Metabolic engineering - Lipids - Alcohols - Metabolism
- Soluble expression, rapid purification, and characterization of human interleukin-24 (IL-24) using a MBP-SUMO dual fusion system in Escherichia coli被引量：25收藏
- 作者：Zhang, Jian Lv, Xinxin Xu, Rui Tao, Xinyi Dong, Yuguo Sun, Aiyou Wei, Dongzhi
- 机构：E China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2015
- 关键词：Interleukin-24 (IL-24) Small ubiquitin-related modifier (SUMO) Maltose-binding protEIn (MBP) Soluble expression One-step purification Apoptosis
- Integrated Transcriptome and Proteome Studies Reveal the Underlying Mechanisms for Sterol Catabolism and Steroid Production in Mycobacterium neoaurum被引量：24收藏
- 作者：Liu, Min Xiong, Liang-Bin Tao, Xinyi Liu, Qing-Hai Wang, Feng-Qing Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2018
- 关键词：sterol catabolism transcriptome proteome Mycobacterium
- Isolation and Antibiotic Screening of Fungi from a Hydrothermal Vent Site and Characterization of Secondary Metabolites from a Penicillium Isolate被引量：22收藏
- 作者：Pan, Chengqian Shi, Yutong Auckloo, Bibi Nazia ul Hassan, Syed Shams Akhter, Najeeb Wang, Kuiwu Ye, Ying Chen, Chen-Tung Arthur Tao, Xinyi Wu, Bin
- 机构：Zhejiang Univ;Zhejiang Gongshang Univ;Natl Sun Yat Sen Univ;East China Univ Sci & Technol
- 来源：MARINE BIOTECHNOLOGY 2017
- 关键词：Marine fungi Isocoumarin Antibacterial New skeleton
- Design and evaluation of a phospholipase D based drug delivery strategy of novel phosphatidyl-prodrug被引量：22收藏
- 作者：Tao, Xinyi Jia, Ning Cheng, Nenghui Ren, Yuhong Cao, Xuni Liu, Min Wei, Dongzhi Wang, Feng-Qing
- 机构：East China Univ Sci & Technol
- 来源：BIOMATERIALS 2017
- 关键词：Phosphatidyl-prodrug Phospholipase D Doxorubicin Triggered release Reverse multidrug resistance
- Tailoring the P450 Monooxygenase Gene for FR-008/Candicidin Biosynthesis被引量：21收藏
- 作者：Chen, Shi Mao, Xiangzhao Shen, Yaling Zhou, Yongjun Li, Jialiang Wang, Lianrong Tao, Xinyi Yang, Liang Wang, Yuxiao Zhou, Xiufen Deng, Zixin Wei, Dongzhi
- 机构：Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;E China Univ Sci & Technol
- 来源：APPLIED AND ENVIRONMENTAL MICROBIOLOGY 2009
- 关键词：Biochemistry
- De novo design of a transcription factor for a progesterone biosensor被引量：20收藏
- 作者：Liu, Kun Zhang, Yunsen Liu, Ke Zhao, Yunqiu Gao, Bei Tao, Xinyi Zhao, Ming Wang, Feng-Qing Wei, Dongzhi
- 机构：East China Univ Sci & Technol;Chengdu Univ Tradit Chinese Med
- 来源：BIOSENSORS & BIOELECTRONICS 2022
- 关键词：Artificial transcription factor Molecular dynamics simulation Progesterone biosensor Whole-cell Diagnosis
- Boosting the epoxidation of squalene to produce triterpenoids in Saccharomyces cerevisiae被引量：20收藏
- 作者：Du, Meng-Meng Zhang, Ge-Ge Zhu, Zhan-Tao Zhao, Yun-Qiu Gao, Bei Tao, Xin-Yi Wang, Feng-Qing Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY FOR BIOFUELS AND BIOPRODUCTS 2023
- 关键词：2,3-Oxidosqualene 2,3:22,23-Dioxidosqualene Triterpenoid ERG7 Two-stage fermentation
- Transformation of phytosterols into pregnatetraenedione by a combined microbial and chemical process被引量：18收藏
- 作者：Liu, Yong-Jun Ji, Wei-ting Song, Lu Tao, Xin-Yi Zhao, Ming Gao, Bei Meng, Hao Wang, Feng-Qing Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol;Hunan Norchem Pharmaceut Co Ltd
- 来源：GREEN CHEMISTRY 2022
- 关键词：Alcohols - Carboxylation - Drug products - Metabolism - Metabolites - Polyols
- Structure-guided engineering of a flavin-containing monooxygenase for the efficient production of indirubin被引量：17收藏
- 作者：Sun, Bing-Yao Sui, Hua-Lu Liu, Zi-Wei Tao, Xin-Yi Gao, Bei Zhao, Ming Ma, Yu-Shu Zhao, Jian Liu, Min Wang, Feng-Qing Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol
- 来源：BIORESOURCES AND BIOPROCESSING 2022
- 关键词：Flavin-containing monooxygenase Indirubin Loop region Substrate tunnel Structure-guided enzyme engineering Microbial synthesis
- Display of adenoregulin with a novel Pichia pastoris cell surface display system被引量：17收藏
- 作者：Ren, Ren Jiang, Zhengbing Liu, Meiyun Tao, Xinyi Ma, Yushu Wei, Dongzhi
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Molecular Biotechnology 2007
- 关键词：Amino acids - Cells - Confocal microscopy - Enzyme kinetics - Flocculation - Yeast
- Production of sesquiterpene patchoulol in mitochondrion-engineered Saccharomyces cerevisiae被引量：16收藏
- 作者：Tao, Xin-Yi Lin, Yang-Chen Wang, Feng-Qing Liu, Qing-Hai Ma, Yu-Shu Liu, Min Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY LETTERS 2022
- 关键词：Patchoulol Mitochondria compartmentation S cerevisiae Metabolic engineering Sesquiterpene
- Fe3+-induced bioinspired chitosan hydrogels for the sustained and controlled release of doxorubicin被引量：15收藏
- 作者：Zhang, Jinmao Tao, Xinyi Liu, Jianwen Wei, Dongzhi Ren, Yuhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：RSC ADVANCES 2016
- 关键词：Addition reactions - Hydrogels - Targeted drug delivery - Amino acids - Controlled drug delivery - Gelation
