成果/Result
- Self-assembly of mitochondria-specific peptide amphiphiles amplifying lung cancer cell death through targeting the VDAC1-hexokinase-II complex被引量：72收藏
- 作者：Liu, Dan Angelova, Angelina Liu, Jianwen Garamus, Vasil M. Angelov, Borislav Zhang, Xinlei Li, Yawen Feger, Guillaume Li, Na Zou, Aihua
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ Paris Saclay;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MATERIALS CHEMISTRY B 2019
- 关键词：Circular dichroism spectroscopy - Self assembly - Diseases - X ray scattering - Dichroism - Cell death - Peptides - Biological organs
- HDAC inhibitor DWP0016 suppresses miR-22 to induce growth inhibition and apoptosis via p53-independent PTEN activation in neuroblastoma SH-SY5Y cells被引量：66收藏
- 作者：Jin, Hui Liu, Lifeng Deng, Weiping Lu, Yanhua Tian, Jianhui Li, Hegeng Liu, Jianwen
- 机构： State Key Laboratory of Bioreactor Engineering; Department of Oncology; School of Life Sciences and Technology
- 来源：Process Biochemistry 2013
- 关键词：Acetylation - RNA
- A collagen-based multicellular tumor spheroid model for evaluation of the efficiency of nanoparticle drug delivery被引量：49收藏
- 作者：Van-Minh Le Lang, Mei-Dong Shi, Wei-Bin Liu, Jian-Wen
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY 2016
- 关键词：tissue engineering drug delivery system nanoparticles three dimensional model cancer
- Doxorubicin hydrochloride-olEIc acid conjugate loaded nanostructured lipid carriers for tumor specific drug release被引量：47收藏
- 作者：Zhao, Shuangni Le Van Minh Li, Na Gararnus, Vasil M. Handge, Ulrich A. Liu, Jianwen Zhang, Rongguang Willumeit-Roemer, Regine Zou, Aihua
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Natl Ctr Prot Sci Shanghai
- 来源：COLLOIDS AND SURFACES B-BIOINTERFACES 2016
- 关键词：DOX OlEIc acid NLCs SAXS pH-dependent drug release
- 阿胶酶解成分对贫血小鼠造血系统的保护机制被引量：41收藏
- 作者：吴宏忠 杨帆 崔书亚 秦玉峰 张元兴 刘建文
- 机构：华东理工大学生物反应器工程国家重点实验室;山东东阿阿胶集团;华东理工大学药学院
- 来源：《华东理工大学学报（自然科学版）》 2008
- 关键词：阿胶 活性成分制备 补血机理
- 摘要：运用5-氟脲嘧啶制备的小鼠贫血模型研究降解分离后所得阿胶有效组分A、B的升高红、白血球的作用机制。结果显示:体外消化液中提取的A、B组分能促进贫血小鼠外周血白细胞和红细胞的升高,促进骨髓和脾造血干/祖细胞集落BFU-E,...
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- Novel perfluoroalkyl phthalocyanine metal derivatives: Synthesis and photodynamic activities被引量：38收藏
- 作者：Qiu, Tao Xu, Xiaoyong Liu, Jianwen Qian, Xuhong
- 机构：E China Univ Sci & Technol;Jiangsu Polytech Univ
- 来源：DYES AND PIGMENTS 2009
- 关键词：Perfluoroalkyl phthalocyanines Synthesis Photosensitizer Photodynamic therapy HL-60 leukemic cell A375 melanotic cancer cell
- THE COMBINED EFFECTS OF HEMATOPORPHYRIN MONOMETHYL ETHER-SDT AND DOXORUBICIN ON THE PROLIFERATION OF QBC939 CELL LINES被引量：38收藏
- 作者：Liang, Lei Xie, Sheng Jiang, Lin Jin, Hui Li, Songgang Liu, Jianwen
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：ULTRASOUND IN MEDICINE AND BIOLOGY 2013
- 关键词：HMME-SDT DOX Synergistic effect DNA damage Drug combination
- Antimetastatic effect of ganoderic acid T in vitro through inhibition of cancer cell invasion被引量：34收藏
- 作者：Xu, Ke Liang, Xin Gao, Feng Zhong, Jianjiang Liu, Jianwen
- 机构： State Key Laboratory of Bioreactor Engineering and School of Pharmacy
- 来源：Process Biochemistry 2010
- 关键词：Lead compounds - Polymerase chain reaction - Tumors - Enzyme activity - High performance liquid chromatography - Cytology - Pathology
- Preparation of polysaccharide derivates chitosan-graft-poly(e-caprolactone) amphiphilic copolymer micelles for 5-fluorouracil drug delivery被引量：33收藏
- 作者：Gu, Chunhua Le, Vanminh Lang, Meidong Liu, Jianwen
- 机构： Key Laboratory for Ultrafine Materials of Ministry of Education; State Key Laboratory of Bioreactor Engineering
- 来源：Colloids and Surfaces B: Biointerfaces 2014
- 关键词：Particle size - Biodegradable polymers - Controlled drug delivery - Targeted drug delivery - Grafting (chemical) - Ring opening polymerization - Solutions - Biocompatibility - Graft copolymers - Fourier transform infrared spectroscopy - Cell death - Micelles
- Enhanced anticancer efficacy and tumor targeting through folate-PEG modified nanoliposome loaded with 5-fluorouracil被引量：33收藏
- 作者：Le, Van Minh Nho, Trung Duc Tran Ly, Hai Trieu Vo, Thanh Sang Nguyen, Hoang Dung Phung, Thi Thu Huong Zou, Aihua Liu, Jianwen
- 机构： NTT Hi-Tech Institute; Research Center of Ginseng and Medicinal Materials ; Institute of Applied Chemistry; Department of Molecular and Cellular Pharmacology; Institute of Tropical Biology
- 来源：Advances in Natural Sciences: Nanoscience and Nanotechnology 2017
- 关键词：Controlled drug delivery - Organic acids - Liposomes - Diseases - Cell death - Tumors
- Immunosuppression effect of Withangulatin A from Physalis angulata via heme oxygenase 1-dependent pathways被引量：30收藏
- 作者：Sun, Lijuan Liu, Jianwen Liu, Ping Yu, Youjun Ma, Lei Hu, Lihong
- 机构： State Key Laboratory of Bioreactor Engineering; LongHua Hospital; Shanghai Innovative Research Center of Traditional Chinese Medicine
- 来源：Process Biochemistry 2011
- 关键词：Porphyrins
- Preparation of immunomagnetic nanoparticles and thEIr application in the separation of mouse CD34+ hematopoietic stem cells被引量：24收藏
- 作者：Liang, Xin Xu, Ke Xu, Jianhe Chen, Wei Shen, Hebai Liu, Jianwen
- 机构： School of Pharmacy; Life and Environment Science College
- 来源：Journal of Magnetism and Magnetic Materials 2009
- 关键词：Magnetic materials - Stem cells - Nanomagnetics - Cytology - Monoclonal antibodies - Transmission electron microscopy - Separation - Synthesis (chemical) - Mammals - Nanoparticles - Scanning electron microscopy
- Effects of Ganoderic acid Me on inhibiting multidrug resistance and inducing apoptosis in multidrug resistant colon cancer cells被引量：24收藏
- 作者：Jiang, Zijing Jin, Tiantian Gao, Feng Liu, Jianwen Zhong, Jianjiang Zhao, Heng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Chest Hosp
- 来源：PROCESS BIOCHEMISTRY 2011
- 关键词：Ganoderic acid Me Multidrug resistance MDR1 MRPs Apoptosis
- Photodynamic Therapy-mediated Cancer Vaccination Enhances Stem-like Phenotype and Immune Escape, Which Can Be Blocked by Thrombospondin-1 Signaling through CD47 Receptor ProtEIn被引量：20收藏
- 作者：Zheng, Yuanhong Zou, Fangyuan Wang, Jingjing Yin, Guifang Le, Vanminh Fei, Zhewei Liu, Jianwen
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：JOURNAL OF BIOLOGICAL CHEMISTRY 2015
- 关键词：Cell signaling - Cells - Diseases - Vaccines - Cytology - Tumors
- Micelle controlled release of 5-fluorouracil: Follow the guideline for good polymer-drug compatibility被引量：18收藏
- 作者：Yuan, Ming Xiao, Yan Vanminh Le Wei, Chao Fu, Yutong Liu, Jianwen Lang, Meidong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 2014
- 关键词：Poly(epsilon-carprolactone) 5-Fluorouracil Polymer-drug compatibility Flory-Huggins interaction parameter Drug delivery system
- Glutathione-responsive core cross-linked micelles for controlled cabazitaxel delivery被引量：16收藏
- 作者：Han, Xiaoxiong Gong, Feirong Sun, Jing Li, Yueqi Liu, XiaoFei Chen, Dan Liu, Jianwen Shen, Yaling
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF NANOPARTICLE RESEARCH 2018
- 关键词：Cabazitaxel Glutathione-responsive Polymeric micelles Solubility Endocytosis mechanism Biomedicine
- Fe3+-induced bioinspired chitosan hydrogels for the sustained and controlled release of doxorubicin被引量：15收藏
- 作者：Zhang, Jinmao Tao, Xinyi Liu, Jianwen Wei, Dongzhi Ren, Yuhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：RSC ADVANCES 2016
- 关键词：Addition reactions - Hydrogels - Targeted drug delivery - Amino acids - Controlled drug delivery - Gelation
- 胡黄连糖甙对拟痴呆模型小鼠的神经保护作用被引量：13收藏
- 作者：李婷 刘建文 曹艳 张小东 魏东芝 卢艳花
- 机构：华东理工大学药学院;华东理工大学生物反应器工程国家重点实验室
- 来源：《华东理工大学学报（自然科学版）》 2006
- 关键词：胡黄连糖甙 拟痴呆模型 学习记忆障碍 抗氧化 阿尔茨海默氏病
- 摘要：联合应用半乳糖和亚硝酸钠使小鼠拟痴呆,研究胡黄连糖甙对小鼠的神经保护作用。通过水迷宫试验,组织病理学检查,超氧化物歧化酶(SOD)和丙二醛(MDA)的测定等结果表明:模型组小鼠的学习记忆功能明显受到障碍,表现出阿尔茨海默...
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- Hyaluronic acid-coated liposome for active targeting on CD44 expressing tumors被引量：12收藏
- 作者：Tian, Zhenfen Liu, Jianwen Li, Na Garamus, Vasil M. Zou, Aihua
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Inst Biochem & Cell Biol
- 来源：JOURNAL OF NANOPARTICLE RESEARCH 2018
- 关键词：DOX Liposome HA CD44 Target
- Cancer-targeted and glutathione-responsive micellar carriers for controlled delivery of cabazitaxel被引量：8收藏
- 作者：Han, Xiaoxiong Gong, Feirong Chi, Lili Feng, Caochuan Sun, Jing Chen, Yiyang Liu, Jianwen Shen, Yaling
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shandong Univ Tradit Chinese Med;East China Univ Sci & Technol
- 来源：NANOTECHNOLOGY 2019
- 关键词：GSH-responsive tumor-targeting peptide cabazitaxel polymeric micelles
- 3,4,5-O-tricaffeoylquinic acid alleviates ionizing radiation-induced injury in vitro and in vivo through regulating ROS/JNK/p38 signaling被引量：7收藏
- 作者：Liu, Jiajun Hu, Wen Ma, Xiaoying Liang, Xin Lin, Long Huang, Jianming Liu, Jianwen
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Fudan Univ
- 来源：ENVIRONMENTAL TOXICOLOGY 2022
- 关键词：3 4 5-O-tricaffeoylquinic acid apoptosis ionizing radiation MAPKs ROS
- Synthesis and immunomodulatory activity of the sulfated tetrasaccharide motif of type B ulvanobiuronic acid 3-sulfate被引量：7收藏
- 作者：Zhang, Liangliang Wang, Xiaotong Hua, Qingting Wang, Junchang Liu, Jianwen Yang, You
- 机构：East China Univ Sci & Technol
- 来源：ORGANIC & BIOMOLECULAR CHEMISTRY 2020
- 关键词：Gold compounds
- An effective method based on real time fluorescence quenching for single nucleotide polymorphism detection被引量：3收藏
- 作者：Xu, Yichun Han, Shuai Huang, Xinhua Zhuo, Shichao Dai, Huiqing Wang, Ke Li, Zhou Liu, Jianwen
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Southern Med Univ;Shanghai Univ Tradit Chinese Med;Shanghai Aoyin Biotechnol Res & Dev Ltd Corp
- 来源：JOURNAL OF BIOTECHNOLOGY 2014
- 关键词：Single nucleotide polymorphisms (SNPs) Fluorescence quenching Sensitivity PCR
- Protection effect of 20(S)-ginsenoside Rg2 extracted from cultured Panax notoginseng cells on hydrogen peroxide-induced cytotoxity of human umbilical cord vEIn endothelial cells in vitro被引量：0收藏
- 作者：Xin, Xiujuan Zhong, Jianjiang Wei, Dongzhi Liu, Jianwen
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Process Biochemistry 2005
- 关键词：Oxygen
