成果/Result
- NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux被引量：1044收藏
- 作者：He, Yuan Zeng, Melody Y. Yang, Dahai Metro, Benny Nunez, Gabriel
- 机构：Univ Michigan;Univ Michigan;E China Univ Sci & Technol;Bar Ilan Univ
- 来源：NATURE 2016
- Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock被引量：496收藏
- 作者：Yang, Dahai He, Yuan Munoz-Planillo, Raul Liu, Qin Nunez, Gabriel
- 机构：Univ Michigan;Univ Michigan;E China Univ Sci & Technol
- 来源：IMMUNITY 2015
- Biodegradable Nanoparticles of Polyacrylic Acid-Stabilized Amorphous CaCO3 for Tunable pH-Responsive Drug Delivery and Enhanced Tumor Inhibition被引量：158收藏
- 作者：Xu, Chengyuan Yan, Yunfeng Tan, Jinchao Yang, Dahai Jia, Xianjing Wang, Lu Xu, Yisheng Cao, Song Sun, Shengtong
- 机构：East China Univ Sci & Technol;Zhejiang Univ Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Donghua Univ
- 来源：ADVANCED FUNCTIONAL MATERIALS 2019
- 关键词：amorphous calcium carbonate biodegradation drug delivery pH-responsive tumor inhibition
- The Bacterial T6SS Effector EvpP Prevents NLRP3 Inflammasome Activation by Inhibiting the Ca2+-Dependent MAPK-Jnk Pathway被引量：140收藏
- 作者：Chen, Hao Yang, Dahai Han, Fajun Tan, Jinchao Zhang, Lingzhi Xiao, Jingfan Zhang, Yuanxing Liu, Qin
- 机构：East China Univ Sci & Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：CELL HOST & MICROBE 2017
- Zebrafish GSDMEb Cleavage-Gated Pyroptosis Drives Septic Acute Kidney Injury In Vivo被引量：88收藏
- 作者：Wang, Zhuang Gu, Zhaoyan Hou, Qing Chen, Weijie Mu, Di Zhang, Yuanxing Liu, Qin Liu, Zhihong Yang, Dahai
- 机构：East China Univ Sci & Technol;Nanjing Univ;Shanghai Engn Res Ctr Maricultured Anim Vaccines;Qingdao Natl Lab Marine Sci & Technol
- 来源：JOURNAL OF IMMUNOLOGY 2020
- Gene expression profiling in live attenuated Edwardsiella tarda vaccine immunized and challenged zebrafish: Insights into the basic mechanisms of protection seen in immunized fish被引量：71收藏
- 作者：Yang, Dahai Liu, Qin Ni, Chunshan Li, Shuai Wu, Haizhen Wang, Qiyao Xiao, Jinfan Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 2013
- 关键词：Zebrafish Edwardsiella tarda Live attenuated vaccine Immune responses CTLs
- leSensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zbrafish被引量：61收藏
- 作者：Yang, Dahai Zheng, Xin Chen, Shouwen Wang, Zhuang Xu, Wenting Tan, Jinchao Hu, Tianjian Hou, Mingyu Wang, Wenhui Gu, Zhaoyan Wang, Qiyao Zhang, Ruilin Zhang, Yuanxing Liu, Qin
- 机构：East China Univ Sci & Technol;Qingdao Natl Lab Marine Sci & Technol;Shanghai Engn Res Ctr Marine Cultured Anim Vaccin;Shanghai Collaborat Innovat Ctr Biomfg;Fudan Univ
- 来源：NATURE COMMUNICATIONS 2018
- RNA-seq liver transcriptome analysis reveals an activated MHC-I pathway and an inhibited MHC-II pathway at the early stage of vaccine immunization in zebrafish被引量：58收藏
- 作者：Yang, Dahai Liu, Qin Yang, Minjun Wu, Haizhen Wang, Qiyao Xiao, Jingfan Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：BMC GENOMICS 2012
- Dysregulated hemolysin liberates bacteria outer membrane vesicles for cytosolic lipopolysaccharide sensing被引量：52收藏
- 作者：Chen, Shouwen Yang, Dahai Wen, Ying Jiang, Zhiwei Zhang, Lingzhi Jiang, Jiatiao Chen, Yaozhen Hu, Tianjian Wang, Qiyao Zhang, Yuanxing Liu, Qin
- 机构：East China Univ Sci & Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines;Univ Michigan;Univ Michigan;Xijing Hosp
- 来源：PLOS PATHOGENS 2018
- Morphology Tuning of Aggregation-Induced Emission Probes by Flash Nanoprecipitation: Shape and Size Effects on in Vivo Imaging被引量：51收藏
- 作者：Wang, Mingwei Xu, Yisheng Liu, Yajing Gu, Kaizhi Tan, Jinchao Shi, Ping Yang, Dahai Guo, Zhiqian Zhu, Weihong Guo, Xuhong Stuart, Martien A. Cohen
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Shihezi Univ
- 来源：ACS APPLIED MATERIALS & INTERFACES 2018
- 关键词：aggregation-induced emission quinolinemalononitrile nanoparticle morphology flash nanoprecipitation in vivo imaging fluorescence
- A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications被引量：49收藏
- 作者：He, Haihong Xia, Yang Qi, Yingxue Wang, Hong-Yin Wang, Zhuang Bao, Jianming Zhang, Ziqian Wu, Fu-Gen Wang, Haolu Chen, Daijie Yang, Dahai Liang, Xiaowen Chen, Jinquan Zhou, Shengmin Liang, Xin Qian, Xuhong Yang, Youjun
- 机构：East China Univ Sci & Technol;Univ Queensland;East China Normal Univ;Shanghai Jiao Tong Univ;Southeast Univ
- 来源：BIOCONJUGATE CHEMISTRY 2018
- Intramacrophage Infection Reinforces the Virulence of Edwardsiella tarda被引量：48收藏
- 作者：Zhang, Lingzhi Ni, Chunshan Xu, Wenting Dai, Tongcheng Yang, Dahai Wang, Qiyao Zhang, Yuanxing Liu, Qin
- 机构：E China Univ Sci & Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines
- 来源：JOURNAL OF BACTERIOLOGY 2016
- Fabrication of Charge-Conversion Nanoparticles for Cancer Imaging by Flash Nanoprecipitation被引量：46收藏
- 作者：Li, Meng Xu, Yisheng Sun, Jinli Wang, Mingwei Yang, Dahai Guo, Xuhong Song, Haiyun Cao, Song Yan, Yunfeng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Zhejiang Univ Technol
- 来源：ACS APPLIED MATERIALS & INTERFACES 2018
- 关键词：charge conversion flash nanoprecipitation cancer imaging nanoparticle aggregation-induced emission
- Characterization of the Japanese flounder NLRP3 inflammasome in restricting Edwardsiella piSCIcida colonization in vivo被引量：44收藏
- 作者：Chen, Hao Ding, Shuangfei Tan, Jinchao Yang, Dahai Zhang, Yuanxing Liu, Qin
- 机构：East China Univ Sci & Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines
- 来源：FISH & SHELLFISH IMMUNOLOGY 2020
- 关键词：Japanese flounder NLRP3 inflammasome Edwardsiella piSCIcida Bacterial colonization
- Pyroptosis Mediates Neutrophil Extracellular Trap Formation during Bacterial Infection in Zebrafish被引量：37收藏
- 作者：Chen, Weijie Zhao, Jingjing Mu, Di Wang, Zhuang Liu, Qin Zhang, Yuanxing Yang, Dahai
- 机构：East China Univ Sci & Technol;Qingdao Natl Lab Marine Sci & Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines
- 来源：JOURNAL OF IMMUNOLOGY 2021
- Neutrophil plays critical role during Edwardsiella piSCIcida immersion infection in zebrafish larvae被引量：34收藏
- 作者：Wang, Zhuang Lin, Lingyun Chen, Weijie Zheng, Xin Zhang, Yuanxing Liu, Qin Yang, Dahai
- 机构：East China Univ Sci & Technol;Zhejiang Inst Freshwater Fisheries;Shanghai Engn Res Ctr Marine Cultured Anim Vaccin
- 来源：FISH & SHELLFISH IMMUNOLOGY 2019
- 关键词：Edwardsiella piSCIcida Zebrafish larvae Neutrophil Bacterial clearance
- Inhibition of HDAC6 With CAY10603 Ameliorates Diabetic Kidney Disease by Suppressing NLRP3 Inflammasome被引量：33收藏
- 作者：Hou, Qing Kan, Shuyan Wang, Zhuang Shi, Jinsong Zeng, Caihong Yang, Dahai Jiang, Song Liu, Zhihong
- 机构：Southeast Univ Sch Med;Nanjing Univ Sch Med;East China Univ Sci & Technol
- 来源：FRONTIERS IN PHARMACOLOGY 2022
- 关键词：connectivity map diabetic nephropathy HDAC6 NLRP3 inflammasome tubular injury
- Zebrafish gasdermin E cleavage-engaged pyroptosis by inflammatory and apoptotic caspases被引量：32收藏
- 作者：Chen, Hao Wu, Xiaomin Gu, Zhaoyan Chen, Shouwen Zhou, Xiangshan Zhang, Yuanxing Liu, Qin Wang, Zhuang Yang, Dahai
- 机构：East China Univ Sci & Technol;Southern Marine Sci & Engn Guangdong Lab Zhuhai;Shanghai Engn Res Ctr Maricultured Anim Vaccines
- 来源：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 2021
- 关键词：Zebrafish Gsdme Pyroptosis Inflammatory caspases Apoptotic caspases
- Identification and functional characterization of EseH, a new effector of the type III secretion system of Edwardsiella piSCIcida被引量：32收藏
- 作者：Hou, Mingyu Chen, Ran Yang, Dahai Nunez, Gabriel Wang, Zhuang Wang, Qiyao Zhang, Yuanxing Liu, Qin
- 机构：East China Univ Sci & Technol;Shanghai Engn Res Ctr Marine Cultured Anim Vaccin;Shanghai Collaborat Innovat Ctr Biomfg;Univ Michigan;Univ Michigan
- 来源：CELLULAR MICROBIOLOGY 2017
- Caspase-mediated LPS sensing and pyroptosis signaling in Hydra被引量：31收藏
- 作者：Chen, Shouwen Li, Shuxin Chen, Hao Gong, Yuxin Yang, Dahai Zhang, Yuanxing Liu, Qin
- 机构：East China Univ Sci & Technol;Qingdao Natl Lab Marine Sci & Technol;Southern Marine Sci & Engn Guangdong Lab Zhuhai
- 来源：SCIENCE ADVANCES 2023
- 关键词：Network security
- Lactobacillus rhamnosus GG triggers intestinal epithelium injury in zebrafish revealing host dependent beneficial effects被引量：30收藏
- 作者：Zhang, Zhen Zhang, Hong-Ling Yang, Da-Hai Hao, Qiang Yang, Hong-Wei Meng, De-Long de Vos, Willem Meindert Guan, Le-Luo Liu, Shu-Bin Teame, Tsegay Gao, Chen-Chen Ran, Chao Yang, Ya-Lin Yao, Yuan-Yuan Ding, Qian-Wen Zhou, Zhi-Gang
- 机构：Chinese Acad Agr Sci;Univ British Columbia;Chinese Acad Agr Sci;East China Univ Sci & Technol;Wageningen Univ & Res
- 来源：IMETA 2024
- 关键词：intestinal mucosal damage Lactobacillus rhamnosus GG probiotic safety SpaC zebrafish
- Single-Cell Transcriptomic Analysis Reveals Neutrophil as Orchestrator during b-Glucan-Induced Trained Immunity in a Teleost Fish被引量：28收藏
- 作者：Mu, Di Yang, Jin Jiang, Yu Wang, Zhuang Chen, Weijie Huang, Jianchang Zhang, Yuanxing Liu, Qin Yang, Dahai
- 机构：East China Univ Sci & Technol;Southern Marine Sci & Engn Guangdong Lab Zhuhai;Qingdao Natl Lab Marine Sci & Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines;East China Univ Sci & Technol
- 来源：JOURNAL OF IMMUNOLOGY 2022
- Dual function of a turbot inflammatory caspase in mediating both canonical and non-canonical inflammasome activation被引量：28收藏
- 作者：Chen, Shouwen Jin, Peng Chen, Hao Wu, Di Li, Shuxin Zhang, Yuanxing Liu, Qin Yang, Dahai
- 机构：East China Univ Sci & Technol;Southern Marine Sci & Engn Guangdong Lab Zhuhai;Shanghai Engn Res Ctr Marine Cultured Anim Vaccin
- 来源：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 2021
- 关键词：Turbot Inflammatory caspase Cytosolic LPS receptor NLRP3 inflammasome GSDME Pyroptosis Antibacterial activity
- A Photo-triggered and photo-calibrated nitric oxide donor: Rational design, spectral characterizations, and biological applications被引量：27收藏
- 作者：He, Haihong Liu, Yuxin Zhou, Zhongneng Guo, Chunlei Wang, Hong-Yin Wang, Zhuang Wang, Xueli Zhang, Ziqian Wu, Fu-Gen Wang, Haolu Chen, Daijie Yang, Dahai Liang, Xiaowen Chen, Jinquan Zhou, Shengmin Liang, Xin Qian, Xuhong Yang, Youjun
- 机构：East China Univ Sci & Technol;Univ Queensland;East China Normal Univ;Shanghai Jiao Tong Univ;Southeast Univ
- 来源：FREE RADICAL BIOLOGY AND MEDICINE 2018
- 关键词：Nitrc oxide donors Photo-triggered Photo-calibrated Mesenchymal stem cell migration
- Balanced role of T3SS and T6SS in contribution to the full virulence of Edwardsiella piSCIcida被引量：24收藏
- 作者：Hu, Tianjian Chen, Ran Zhang, Lingzhi Wang, Zhuang Yang, Dahai Zhang, Yuanxing Liu, Xiaohong Liu, Qin
- 机构：East China Univ Sci & Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：FISH & SHELLFISH IMMUNOLOGY 2019
- 关键词：Edwardsiella piSCIcida Infection Live attenuated vaccine T3SS T6SS
- Systematic Identification of Intracellular-Translocated Candidate Effectors in Edwardsiella piSCIcida被引量：23收藏
- 作者：Zhang, Lingzhi Jiang, Zhiwei Fang, Shan Huang, Yajun Yang, Dahai Wang, Qiyao Zhang, Yuanxing Liu, Qin
- 机构：East China Univ Sci & Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines;Shanghai Collaborat Innovat Ctr Biomfg Technol;Qingdao Natl Lab Marine Sci & Technol
- 来源：FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 2018
- 关键词：effector Edwardsiella piSCIcida T3SS T6SS OMV
- Bacterial infection reinforces host metabolic flux from arginine to spermine for NLRP3 inflammasome evasion被引量：22收藏
- 作者：Jiang, Jiatiao Wang, Wenwen Sun, Fei Zhang, Yuanxing Liu, Qin Yang, Dahai
- 机构：East China Univ Sci & Technol;Southern Marine Sci & Engn Guangdong Lab Zhuhai;Qingdao Natl Lab Marine Sci & Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines
- 来源：CELL REPORTS 2021
- Novel T3SS effector EseK in Edwardsiella piSCIcida is chaperoned by EscH and EscS to express virulence被引量：19收藏
- 作者：Cao, Huifang Yang, Cuiting Quan, Shu Hu, Tianjian Zhang, Lingzhi Zhang, Yuanxing Yang, Dahai Liu, Qin
- 机构：East China Univ Sci & Technol;Qingdao Natl Lab Marine Sci & Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：CELLULAR MICROBIOLOGY 2018
- 关键词：chaperone Edwardsiella piSCIcida protein-protein interaction secretion translocation virulence factor
- The Edwardsiella piSCIcida thioredoxin-like protein inhibits ASK1-MAPKs signaling cascades to promote pathogenesis during infection被引量：19收藏
- 作者：Yang, Dahai Liu, Xiaohong Xu, Wenting Gu, Zhaoyan Yang, Cuiting Zhang, Lingzhi Tan, Jinchao Zheng, Xin Wang, Zhuang Quan, Shu Zhang, Yuanxing Liu, Qin
- 机构：East China Univ Sci & Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines;Qingdao Natl Lab Marine Sci & Technol
- 来源：PLOS PATHOGENS 2019
- EvpP inhibits neutrophils recruitment via Jnk-caspy inflammasome signaling in vivo被引量：19收藏
- 作者：Tan, Jinchao Yang, Dahai Wang, Zhuang Zheng, Xin Zhang, Yuanxing Liu, Qin
- 机构：East China Univ Sci & Technol;Qingdao Natl Lab Marine Sci & Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines
- 来源：FISH & SHELLFISH IMMUNOLOGY 2019
- 关键词：Edwardsiella piSCIcida T6SS effector Jnk-caspy inflammasome pathway Neutrophils recruitment
