成果/Result
- Magnesium modification of a calcium phosphate cement alters bone marrow stromal cell behavior via an integrin-mediated mechanism被引量：191收藏
- 作者：Zhang, Jing Ma, Xiaoyu Lin, Dan Shi, Hengsong Yuan, Yuan Tang, Wei Zhou, Huanjun Guo, Han Qian, Jiangchao Liu, Changsheng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOMATERIALS 2015
- 关键词：Magnesium/calcium phosphate cements Cell adhesion Osteogenic differentiation Fibronectin Integrin
- RhBMP-2-loaded calcium silicate/calcium phosphate cement scaffold with hierarchically porous structure for enhanced bone tissue regeneration被引量：133收藏
- 作者：Zhang, Jing Zhou, Huanjun Yang, Kai Yuan, Yuan Liu, Changsheng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOMATERIALS 2013
- 关键词：Calcium silicate/calcium phosphate cement rhBMP-2 Bone regeneration Hierarchical porosity
- Antimetastatic effect of prodigiosin through inhibition of tumor invasion被引量：90收藏
- 作者：Zhang, J Shen, YL Liu, JW Wei, DZ
- 机构：E China Univ Sci & Technol
- 来源：BIOCHEMICAL PHARMACOLOGY 2005
- 关键词：prodigiosin metastasis invasion MMPs RhoA
- Systematic manipulation of glutathione metabolism in Escherichia coli for improved glutathione production被引量：85收藏
- 作者：Zhang, Jing Quan, Cong Wang, Cheng Wu, Hui Li, Zhimin Ye, Qin
- 机构：E China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：MICROBIAL CELL FACTORIES 2016
- 关键词：Escherichia coli Glutathione Systematic manipulation Bifunctional glutathione synthetase Fed-batch fermentation
- MBG-Modified β-TCP Scaffold Promotes Mesenchymal Stem Cells Adhesion and Osteogenic Differentiation via a FAK/MAPK Signaling Pathway被引量：51收藏
- 作者：Liu, Yutong Ma, Yifan Zhang, Jing Xie, Qing Wang, Zi Yu, Shuang Yuan, Yuan Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：ACS APPLIED MATERIALS & INTERFACES 2017
- 关键词：MBG-modified beta-TCP scaffolds mechanical strength microstructure cell affinity and osteogenic capacity FAK/MAPK signaling pathway
- Magnesium modification up-regulates the bioactivity of bone morphogenetic protein-2 upon calcium phosphate cement via enhanced BMP receptor recognition and Smad signaling pathway被引量：50收藏
- 作者：Ding, Sai Zhang, Jing Tian, Yu Huang, Baolin Yuan, Yuan Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：COLLOIDS AND SURFACES B-BIOINTERFACES 2016
- 关键词：Magnesium Calcium phosphate cement Smad signaling pathway Bone morphogenetic protein-2 Bioactivity
- Heterologous gshF gene expression in various vector systems in Escherichia coli for enhanced glutathione production被引量：25收藏
- 作者：Wang, Cheng Zhang, Jing Wu, Hui Li, Zhimin Ye, Qin
- 机构：E China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2015
- 关键词：Antioxidant Glutathione Escherichia coil Bifunctional glutathione synthetase Fed-batch fermentation
- Direct reductive amination of ketones with amines by reductive aminases被引量：24收藏
- 作者：Li, Bo-Bo Zhang, Jing Chen, Fei-Fei Chen, Qi Xu, Jian-He Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：GREEN SYNTHESIS AND CATALYSIS 2021
- 关键词：Biocatalysis Reductive amination Reductive aminases Protein engineering Chiral amines
- Alternative Sigma Factor RpoX Is a Part of the RpoE Regulon and Plays Distinct Roles in Stress Responses, Motility, Biofilm Formation, and Hemolytic Activities in the Marine Pathogen Vibrio alginolyticus被引量：23收藏
- 作者：Gu, Dan Zhang, Jun Hao, Yuan Xu, Rongjing Zhang, Yuanxing Ma, Yue Wang, Qiyao
- 机构：East China Univ Sci & Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines;Yangzhou Univ;Yantai Tianyuan Aquat Co & Td
- 来源：APPLIED AND ENVIRONMENTAL MICROBIOLOGY 2019
- 关键词：ChIP-seq RNA-seq RpoE RpoX Vibrio alginolyticus virulence
- Binding site profiles and N-terminal minor groove interactions of the master quorum-sensing regulator LuxR enable flexible control of gene activation and repression被引量：22收藏
- 作者：Zhang, Jun Liu, Bing Gu, Dan Hao, Yuan Chen, Mo Ma, Yue Zhou, Xiaohui Reverter, David Zhang, Yuanxing Wang, Qiyao
- 机构：East China Univ Sci & Technol;Qingdao Natl Lab Marine Sci & Technol;Southern Marine Sci & Engn Guangdong Lab Zhuhai;Shanghai Engn Res Ctr Maricultured Anim Vaccines;Univ Autonoma Barcelona
- 来源：NUCLEIC ACIDS RESEARCH 2021
- Fabrication and clinical application of easy-to-operate pre-cured CPC/rhBMP-2 micro-scaffolds for bone regeneration被引量：20收藏
- 作者：Lin, Dan Zhang, Jing Bai, Feng Cao, Xuehua Fan, Cunyi Yuan, Yuan Wang, Jinwu Zhang, Jian Liu, Changsheng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Jiao Tong Univ;451st Mil Hosp
- 来源：AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 2016
- 关键词：CPC rhBMP-2 bone regeneration scaffolds
- MviN mediates the regulation of environmental osmotic pressure on esrB to control the virulence in the marine fish pathogen Edwardsiella piscicida被引量：19收藏
- 作者：Yin, Kaiyu Zhang, Jin Ma, Jiabao Jin, Peng Ma, Yue Zhang, Yuanxing Liu, Xiaohong Wang, Qiyao
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines
- 来源：MICROBIOLOGICAL RESEARCH 2020
- 关键词：Edwardsiella piscicida EsrB Lipid II flippase Osmotic pressure In vivo colonization
- A novel strategy for the aqueous synthesis of down-/up-conversion nanocomposites for dual-modal cell imaging and drug delivery被引量：18收藏
- 作者：Zhao, Peng Zhang, Jing Zhu, Yihua Yang, Xiaoling Jiang, Xin Yuan, Yuan Liu, Changsheng Li, Chunzhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：JOURNAL OF MATERIALS CHEMISTRY B 2014
- 关键词：Molecular biology - Semiconductor quantum dots - Ytterbium compounds - Diseases - Luminescence - Silver compounds - Controlled drug delivery - Targeted drug delivery - Uranium compounds - II-VI semiconductors - Sodium compounds
- Molecular phylogenetic diversity of the microbial community associated with a high-temperature petroleum reservoir at an offshore oilfield被引量：12收藏
- 作者：Li H Yang SZ Mu BZ Rong ZF Zhang J
- 机构：E China Univ Sci ＆ Technol;E China Univ Sci ＆ Technol
- 来源：Chinese Biological Abstracts 2007
- 关键词：petroleum reservoir 16S rRNA gene diversity microbial commmunity clone library RIBOSOMAL-RNA GENES CONTINENTAL HIGH-TEMPERATURE SULFATE-REDUCING BACTER/A SPNOV. DEEP SUBSURFACE PCR WATER BIAS BIOREMEDIATION SUBTERRANEUS
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- One-pot process of 2'-deoxyguanylic acid catalyzed by a multi-enzyme system被引量：12收藏
- 作者：Li, Yanyu Ding, Qingbao Ou, Ling Qian, Yahui Zhang, Jiao
- 机构：E China Univ Sci & Technol
- 来源：BIOTECHNOLOGY AND BIOPROCESS ENGINEERING 2015
- 关键词：2 '-deoxyguanylic acid N-deoxyribosyltransferase purine nucleoside phosphorylase deoxyguanosine kinase acetate kinase
- Edwardsiella piscicida Interferes with Classical Endocytic Trafficking and Replicates in a Specialized Replication-Permissive Niche in Nonphagocytic Cells被引量：12收藏
- 作者：Zhang, Lingzhi Jiang, Jiatiao Zhang, Jin Liu, Xiaohong Yang, Dahai Zhang, Yuanxing Liu, Qin
- 机构：East China Univ Sci & Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：JOURNAL OF BACTERIOLOGY 2021
- 关键词：Edwardsiella piscicida T3SS effector intracellular trafficking
- Transposon insertion sequencing analysis unveils novel genes involved in luxR expression and quorum sensing regulation in Vibrio alginolyticus被引量：9收藏
- 作者：Zhang, Yibei Wu, Xiao Cai, Jingxiao Chen, Mo Zhang, Jun Shao, Shuai Zhang, Yuanxing Ma, Yue Wang, Qiyao
- 机构：East China Univ Sci & Technol;Southern Marine Sci & Engn Guangdong Lab Zhuhai;Shanghai Engn Res Ctr Maricultured Anim Vaccines
- 来源：MICROBIOLOGICAL RESEARCH 2023
- 关键词：Vibrio alginolyticus LuxR Temperature Transposon insertion sequencing (Tn-seq)
- Inhibitive effect of prodigiosin on the proliferation of human malignant pancreatic cancer cells被引量：8收藏
- 作者：Zhang, J Liu, JW Shen, YL Wei, DZ Li, K
- 机构：E China Univ Sci & Technol
- 来源：MEDICINAL CHEMISTRY RESEARCH 2005
- Association study of TAC3 and TACR3 gene polymorphisms with idiopathic precocious puberty in Chinese girls被引量：8收藏
- 作者：Xin, Xiujuan Zhang, Jing Chang, Yaning Wu, Yixin
- 机构：E China Univ Sci & Technol;Hamamatsu Univ Sch Med
- 来源：JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM 2015
- 关键词：association study genotyping idiopathic puberty TAC3 TACR3
- Identification, Characterization, and Computer-Aided Rational Design of a Novel Thermophilic Esterase from Geobacillus subterraneus, and Application in the Synthesis of Cinnamyl Acetate被引量：6收藏
- 作者：Zhang, Jin Lin, Lin Wei, Wei Wei, Dongzhi
- 机构：East China Univ Sci & Technol;Shanghai Inst Technol;Natl Engn Res Ctr Nanotechnol
- 来源：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 2024
- 关键词：Thermophilic esterase Rational design Thermal stability ADAP strategy Cinnamyl acetate
- A Type I Pullulanase from Geobacillus subterraneus: Functional Expression in Escherichia coli, Enzyme Characterization, Truncation, and Application被引量：5收藏
- 作者：Chen, Mianhui Zhang, Jin Wang, Jingjing Lin, Lin Wei, Wei Shen, Yaling Wei, Dongzhi
- 机构：East China Univ Sci & Technol;Shanghai Inst Technol;Natl Engn Res Ctr Nanotechnol
- 来源：STARCH-STARKE 2022
- 关键词：Geobacillus subterraneus pullulanase structure truncation
- Enzymatic Manufacture of Deoxythymidine-5′-Triphosphate with Permeable Intact Cells of E-coli Coexpressing Thymidylate Kinase and Acetate Kinase被引量：4收藏
- 作者：Zhang, Jiao Qian, Yahui Ding, Qingbao Ou, Ling
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY 2015
- 关键词：Deoxythymidine-5 '-triphosphate thymidylate kinase coexpression permeabilization ATP regeneration
- VqsA controls exotoxin production by directly binding to the promoter of asp in the pathogen Vibrio alginolyticus被引量：4收藏
- 作者：Zhang, Jun Hao, Yuan Yin, Kaiyu Mao, Qiaoqiao Xu, Rongjing Zhang, Yuanxing Ma, Yue Wang, Qiyao
- 机构：East China Univ Sci & Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines;Yantai Dev Zone TianYuan Aquat Prod Co Ltd
- 来源：FEMS MICROBIOLOGY LETTERS 2019
- 关键词：Asp Vibrio alginolyticus VqsA QS virulence
- Computer-aided rational design strategy based on protein surface charge to improve the thermal stability of a novel esterase from Geobacillus jurassicus被引量：2收藏
- 作者：Song, Runfei Zhang, Jin Zhu, Mengyu Lin, Lin Wei, Wei Wei, Dongzhi
- 机构：East China Univ Sci & Technol;Shanghai Inst Technol;Natl Engn Res Ctr Nanotechnol
- 来源：BIOTECHNOLOGY LETTERS 2024
- 关键词：Surface charge protein engineering Thermostable esterase Site-directed mutagenesis Rational design
- Molecular analysis of the bacterial community in a continental hightemperature and water-flooded petroleum reservoir被引量：1收藏
- 作者：Li H Yang SZ Mu BZ Rong ZF Zhang J
- 机构：E China Univ Sci ＆ Technol;E China Univ Sci ＆ Technol
- 来源：Chinese Biological Abstracts 2007
- 关键词：petroleum reservoir 16S rRNA gene diversity restriction fragment length polymorphism bacterial community clone library Sulfate-reducing bacteria ribosomal-rna genes sp-nov north-sea microbial communities oil-reservoir diversity archaea pcr identification
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