成果/Result
- Biomarkers of aging被引量：333收藏
- 作者：Aging Biomarker Consortium Bao, Hainan Cao, Jiani Chen, Mengting Chen, Min Chen, Wei Chen, Xiao Chen, Yanhao Chen, Yu Chen, Yutian Chen, Zhiyang Chhetri, Jagadish K. Ding, Yingjie Feng, Junlin Guo, Jun Guo, Mengmeng He, Chuting Jia, Yujuan Jiang, Haiping Jing, Ying Li, Dingfeng Li, Jiaming Li, Jingyi Liang, Qinhao Liang, Rui Liu, Xiaoqian Liu, Zuojun Luo, Oscar Junhong Lv, Jianwei Ma, Jingyi Mao, Kehang Nie, Jiawei Qiao, Xinhua Sun, Xinpei Tang, Xiaoqiang Wang, Jianfang Wang, Qiaoran Wang, Siyuan Wang, Xuan Wang, Yaning Wang, Yuhan Wu, Rimo Xia, Kai Xiao, Fu-Hui Xu, Lingyan Xu, Yingying Yan, Haoteng Yang, Liang Yang, Ruici Yang, Yuanxin Ying, Yilin Zhang, Le Zhang, Weiwei Zhang, Wenwan Zhang, Xing Zhang, Zhuo Zhou, Min Zhou, Rui Zhu, Qingchen Zhu, Zhengmao Cao, Feng Cao, Zhongwei Chan, Piu Chen, Chang Chen, Guobing Chen, Hou-Zao Chen, Jun Ci, Weimin Ding, Bi-Sen Ding, Qiurong Gao, Feng Han, Jing-Dong J. Huang, Kai Ju, Zhenyu Kong, Qing-Peng Li, Ji Li, Jian Li, Xin Liu, Baohua Liu, Feng Liu, Lin Liu, Qiang Liu, Xingguo Liu, Yong Luo, Xianghang Ma, Shuai Ma, Xinran Mao, Zhiyong Nie, Jing Peng, Yaojin Qu, Jing Ren, Jie Ren, Ruibao Song, Moshi Zhou Songyang Sun, Yi Eve Sun, Yu Tian, Mei Wang, Shusen Wang, Si Wang, Xia Wang, Xiaoning Wang, Yan-Jiang Wang, Yunfang Wong, Catherine C. L. Xiang, Andy Peng Xiao, Yichuan Xie, Zhengwei Xu, Daichao Ye, Jing Yue, Rui Zhang, Cuntai Zhang, Hongbo Zhang, Liang Zhang, Weiqi Zhang, Yong Zhang, Yun-Wu Zhang, Zhuohua Zhao, Tongbiao Zhao, Yuzheng Zhu, Dahai Zou, Weiguo Pei, Gang Liu, Guang-Hui
- 机构：Aging Biomarker Consortium ABC;Chinese Acad Sci;China Natl Ctr Bioinformat;Chinese Acad Sci;Cent South Univ
- 来源：SCIENCE CHINA-LIFE SCIENCES 2023
- 关键词：aging senescence biomarker clock
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- Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression被引量：152收藏
- 作者：Qi, Meiyan Xia, Yun Wu, Yanjun Zhang, Zhuo Wang, Xinyu Lu, Liying Dai, Cheng Song, Yanan Xu, Keying Ji, Weiwei Zhan, Lixing
- 机构：Chinese Acad Sci;Huazhong Univ Sci & Technol;East China Univ Sci & Technol
- 来源：NATURE COMMUNICATIONS 2022
- Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease被引量：106收藏
- 作者：Li, Xi Zhang, Yinan Xu, Lingya Wang, Aoxue Zou, Yejun Li, Ting Huang, Li Chen, Weicai Liu, Shuning Jiang, Kun Zhang, Xiuze Wang, Dongmei Zhang, Lijuan Zhang, Zhuo Zhang, Zeyi Chen, Xianjun Jia, Wei Zhao, Aihua Yan, Xinfeng Zhou, Haimeng Zhu, Linyong Ma, Xinran Ju, Zhenyu Jia, Weiping Wang, Congrong Loscalzo, Joseph Yang, Yi Zhao, Yuzheng
- 机构：East China Univ Sci & Technol;Chinese Acad Med Sci;Chinese Acad Sci;Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6;East China Normal Univ
- 来源：CELL METABOLISM 2023
- Illuminating NAD+ Metabolism in Live Cells and In Vivo Using a Genetically Encoded Fluorescent Sensor被引量：95收藏
- 作者：Zou, Yejun Wang, Aoxue Huang, Li Zhu, Xudong Hu, Qingxun Zhang, Yinan Chen, Xianjun Li, Fengwen Wang, Qiaohui Wang, Hu Liu, Renmei Zuo, Fangting Li, Ting Yao, Jing Qian, Yajin Shi, Mei Yue, Xiao Chen, Weicai Zhang, Zhuo Wang, Congrong Zhou, Yong Zhu, Linyong Ju, Zhenyu Loscalzo, Joseph Yang, Yi Zhao, Yuzheng
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;East China Univ Sci & Technol;Hangzhou Normal Univ;Shanghai Jiao Tong Univ
- 来源：DEVELOPMENTAL CELL 2020
- Sequential Heterotrophy-Dilution-Photoinduction Cultivation of Haematococcus pluvialis for efficient production of astaxanthin被引量：85收藏
- 作者：Wan, Minxi Zhang, Zhen Wang, Jun Huang, Jianke Fan, Jianhua Yu, Anquan Wang, Weiliang Li, Yuanguang
- 机构：E China Univ Sci & Technol;Jiaxing Zeyuan Bioprod Ltd Co
- 来源：BIORESOURCE TECHNOLOGY 2015
- 关键词：Haematococcus pluvialis Heterotrophy Dilution Photoinduction Astaxanthin
- Analysis of redox landscapes and dynamics in living cells and in vivo using genetically encoded fluorescent sensors被引量：83收藏
- 作者：Zou, Yejun Wang, Aoxue Shi, Mei Chen, Xianjun Liu, Renmei Li, Ting Zhang, Chenxia Zhang, Zhuo Zhu, Linyong Ju, Zhenyu Loscalzo, Joseph Yang, Yi Zhao, Yuzheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Jinan Univ;Harvard Med Sch
- 来源：NATURE PROTOCOLS 2018
- A New Paradigm for Producing Astaxanthin From the Unicellular Green Alga Haematococcus pluvialis被引量：74收藏
- 作者：Zhang, Zhen Wang, Baobei Hu, Qiang Sommerfeld, Milton Li, Yuanguang Han, Danxiang
- 机构：East China Univ Sci & Technol;Arizona State Univ;Chinese Acad Sci;Xiamen Univ
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2016
- 关键词：astaxanthin Haematococcus pluvialis heterotrophy acclimation
- Lighting Up Live-Cell and In Vivo Central Carbon Metabolism with Genetically Encoded Fluorescent Sensors被引量：63收藏
- 作者：Zhang, Zhuo Cheng, Xiawei Zhao, Yuzheng Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 13 2020
- 关键词：central carbon metabolism genetically encoded fluorescent sensors real-time monitoring fluorescence imaging
- Optogenetic control of RNA function and metabolism using engineered light-switchable RNA-binding proteins被引量：60收藏
- 作者：Liu, Renmei Yang, Jing Yao, Jing Zhao, Zhou He, Wei Su, Ni Zhang, Zeyi Zhang, Chenxia Zhang, Zhuo Cai, Haibo Zhu, Linyong Zhao, Yuzheng Quan, Shu Chen, Xianjun Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：NATURE BIOTECHNOLOGY 2022
- 关键词：Proteins - Cell culture
- Discovery of an Imine Reductase for Reductive Amination of Carbonyl Compounds with Sterically Challenging Amines被引量：54收藏
- 作者：Chen, Fei-Fei He, Xue-Feng Zhu, Xin-Xin Zhang, Zhi Shen, Xin-Yuan Chen, Qi Xu, Jian-He Turner, Nicholas J. Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol;Univ Manchester
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2023
- 关键词：Carbonyl compounds - Nucleophiles - Substrates - Synthesis (chemical)
- A novel paradigm for the high-efficient production of phycocyanin from Galdieria sulphuraria被引量：45收藏
- 作者：Wan, Minxi Wang, Zhenyang Zhang, Zhen Wang, Jun Li, Shulan Yu, Anquan Li, Yuanguang
- 机构：East China Univ Sci & Technol;Yunnan Shangrila Zeyuan Ltd Co Algal Hlth Technol;Jiaxing Zeyuan Bioprod Co Ltd
- 来源：BIORESOURCE TECHNOLOGY 2016
- 关键词：Sequential Heterotrophy-Dilution-Photoinduction Galdieria sulphuraria Phycocyanin
- Cellular Capacities for High-Light Acclimation and Changing Lipid Profiles across Life Cycle Stages of the Green Alga Haematococcus pluvialis被引量：44收藏
- 作者：Wang, Baobei Zhang, Zhen Hu, Qiang Sommerfeld, Milton Lu, Yinghua Han, Danxiang
- 机构：Xiamen Univ;Arizona State Univ;E China Univ Sci & Technol;Chinese Acad Sci
- 来源：PLOS ONE 2014
- Asymmetric Reductive Amination of Structurally Diverse Ketones with Ammonia Using a Spectrum-Extended Amine Dehydrogenase被引量：41收藏
- 作者：Wang, Dong-Hao Chen, Qi Yin, Sai-Nan Ding, Xu-Wei Zheng, Yu-Cong Zhang, Zhi Zhang, Yu-Hui Chen, Fei-Fei Xu, Jian-He Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACS CATALYSIS 2021
- 关键词：< em > reductive amination < em > < em > amine dehydrogenase < em > < em > protein engineering < em > < em > substrate scope < em > < em > chiral amine < em >
- Efficient heterotrophic cultivation of Chlamydomonas reinhardtii被引量：41收藏
- 作者：Zhang, Zhen Tan, Yingying Wang, Weiliang Bai, Wenmin Fan, Jianhua Huang, Jianke Wan, Minxi Li, Yuanguang
- 机构：East China Univ Sci & Technol;Jiaxing Zeyuan Bioprod Co Ltd
- 来源：JOURNAL OF APPLIED PHYCOLOGY 2019
- 关键词：Chlamydomonas reinhardtii Chlorophyceae Heterotrophy Scale-up Cultivation
- Redox metabolism maintains the leukemogenic capacity and drug resistance of AML cells被引量：28收藏
- 作者：Huang, Dan Zhang, Changcheng Xiao, Ming Li, Xie Chen, Weicai Jiang, Yu Yuan, Yamin Zhang, Yaping Zou, Yejun Deng, Lei Wang, Yang Sun, Yuying Dong, Wenping Zhang, Zhuo Xie, Li Yu, Zhuo Chen, Chiqi Liu, Ligen Wang, Jing Yang, Yi Yang, Jie Zhao, Yuzheng Zheng, Junke
- 机构：Shanghai Jiao Tong Univ;East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;Chinese Acad Med Sci
- 来源：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2023
- 关键词：redox metabolism AML leukemia-initiating cells drug resistance
- Comprehensive multiscale analysis of lactate metabolic dynamics in vitro and in vivo using highly responsive biosensors被引量：27收藏
- 作者：Wang, Aoxue Zou, Yejun Liu, Shuning Zhang, Xiuze Li, Ting Zhang, Lijuan Wang, Ruwen Xia, Yale Li, Xie Zhang, Zhuo Liu, Tiemin Ju, Zhenyu Wang, Ru Loscalzo, Joseph Yang, Yi Zhao, Yuzheng
- 机构：East China Univ Sci & Technol;Chinese Acad Med Sci;Shanghai Univ Sport;Fudan Univ;Jinan Univ
- 来源：NATURE PROTOCOLS 2024
- Visualization of Nicotine Adenine Dinucleotide Redox Homeostasis with Genetically Encoded Fluorescent Sensors被引量：25收藏
- 作者：Zhao, Yuzheng Zhang, Zhuo Zou, Yejun Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：ANTIOXIDANTS & REDOX SIGNALING 2018
- 关键词：NAD(+) NADH NADP(+) NADPH cell metabolism genetically encoded fluorescent sensors real-time monitoring imaging
- Effects of different glycerol feeding strategies on S-adenosyl-L-methionine biosynthesis by PGAP-driven Pichia pastoris overexpressing methionine adenosyltransferase被引量：22收藏
- 作者：Hu, Xiao-Qing Chu, Ju Zhang, Zhuo Zhang, Si-Liang Zhuang, Ying-Ping Wang, Yong-Hong Guo, Mei-Jin Chen, Hua-Xin Yuan, Zhong-Yi
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2008
- 关键词：P-GAP S-adenosyl-L-methionine Pulsed feeding Residual glycerol Oxygen transfer rate Volumetric oxygen transfer coefficient
- Lighting up arginine metabolism reveals itsfunctional diversity in physiology and pathology被引量：21收藏
- 作者：Li, Rui Li, Yan Jiang, Kun Zhang, Lijuan Li, Ting Zhao, Aihua Zhang, Zhuo Xia, Yale Ge, Kun Chen, Yaqiong Wang, Chengnuo Tang, Weitao Liu, Shuning Lin, Xiaoxi Song, Yuqin Mei, Jie Xiao, Chun Wang, Aoxue Zou, Yejun Li, Xie Chen, Xianjun Ju, Zhenyu Jia, Wei Loscalzo, Joseph Sun, Yu Fang, Wei Yang, Yi Zhao, Yuzheng
- 机构：East China Univ Sci & Technol;Chinese Acad Med Sci;Univ Chinese Acad Sci;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ
- 来源：CELL METABOLISM 2025
- Spatiotemporal Imaging of Cellular Energy Metabolism with Genetically-Encoded Fluorescent Sensors in Brain被引量：18收藏
- 作者：Zhang, Zhuo Chen, Weicai Zhao, Yuzheng Yang, Yi
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;East China Univ Sci & Technol
- 来源：NEUROSCIENCE BULLETIN 2018
- 关键词：Energy metabolism Astrocyte Neuron Genetically encoded fluorescent sensor Real time monitoring
- High-yield cultivation of Botryococcus braunii for biomass and hydrocarbons被引量：18收藏
- 作者：Wan, Minxi Zhang, Zhen Wang, Ruixuan Bai, Wenmin Huang, Jianke Wang, Weiliang Shen, Guomin Yu, Anquan Li, Yuanguang
- 机构：East China Univ Sci & Technol;Jiaxing Zeyuan Bioprod Co Ltd;Yunnan Baoshan Zeyuan Microalgae Hlth Technol Co
- 来源：BIOMASS & BIOENERGY 2019
- 关键词：Botryococcus braunii Hydrocarbon Heterotrophy Photoautotrophy
- RNAi screens identify HES4 as a regulator of redox balance supporting pyrimidine synthesis and tumor growth被引量：12收藏
- 作者：He, Jing Wang, Aoxue Zhao, Qin Zou, Yejun Zhang, Zhuo Sha, Nannan Hou, Guofang Zhou, Bei Yang, Yi Chen, Tao Zhao, Yuzheng Jiang, Yuhui
- 机构：Shanghai Jiao Tong Univ;East China Univ Sci & Technol;Chinese Acad Med Sci;Tongji Univ;Tongji Univ
- 来源：NATURE STRUCTURAL & MOLECULAR BIOLOGY 2024
- Comparative study on light attenuation models of Galdieria sulphuraria for efficient production of phycocyanin被引量：12收藏
- 作者：Wang, Haohua Zhang, Zhen Wan, Minxi Wang, Ruixuan Huang, Jianke Zhang, Kaikai Guo, Jiacai Bai, Wenmin Li, Yuanguang
- 机构：East China Univ Sci & Technol;Jiaxing Zeyuan Bioprod Co Ltd
- 来源：JOURNAL OF APPLIED PHYCOLOGY 2020
- 关键词：Galdieria sulphuraria Rhodophyta Phycocyanin Scale-up Light attenuation Volume-averaged light intensity
- 防治白菜根肿病的新型海洋微生物农药——解淀粉芽孢杆菌Txc2-1可湿性粉剂配方优化及药效研究被引量：10收藏
- 作者：张致军 罗远婵 章真 李淑兰 田黎 杨佩文 李元广
- 机构：华东理工大学生物反应器工程国家重点实验室;上海泽元海洋生物技术有限公司;云南省农业科学院农业环境资源研究所
- 来源：《农药学学报》 2020
- 关键词：根肿病 海洋微生物 微生物农药 解淀粉芽孢杆菌 可湿性粉剂 混料设计 防治效果
- 摘要：根肿病是十字花科作物的全球性重大病害之一,但可供选择的防治药剂非常有限。以本课题组筛选出的一株对十字花科白菜根肿病具有显著拮抗作用的海洋生境芽孢杆菌Txc2-1为研究对象,通过对载体和助剂的筛选以及采用混料设计确定Txc...
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- Regulation of leukemogenesis via redox metabolism被引量：6收藏
- 作者：Zhang, Zhuo Chen, Chiqi Li, Xie Zheng, Junke Zhao, Yuzheng
- 机构：East China Univ Sci & Technol;Chinese Acad Med Sci;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ
- 来源：TRENDS IN CELL BIOLOGY 2024
- Live-cell imaging reveals redox metabolic reprogramming during zygotic genome activation被引量：6收藏
- 作者：Sun, Hao Zhang, Zhuo Li, Tianda Li, Ting Chen, Weicai Pan, Tianshi Fang, Sen Liu, Chao Zhang, Ying Wang, Leyun Feng, Guihai Li, Wei Zhou, Qi Zhao, Yuzheng
- 机构：Chinese Acad Sci;Chinese Acad Sci;Beijing Inst Stem Cell & Regenerat Med;Univ Chinese Acad Sci;East China Univ Sci & Technol
- 来源：JOURNAL OF CELLULAR PHYSIOLOGY 2023
- 关键词：biosensor dynamic imaging embryo development metabolite detection single cell
- 纤细裸藻培养及其产物功能的研究与展望被引量：5收藏
- 作者：张凯凯 万民熙 章真 张道敬 王伟良 樊飞 谢静莉 周焜鹏 李元广
- 机构：华东理工大学生物反应器工程国家重点实验室;云南保山泽元藻业健康科技有限公司
- 来源：《生物工程学报》 2024
- 关键词：纤细裸藻 裸藻多糖 培养 功能
- 摘要：纤细裸藻(Euglena gracilis)是一类介于动物和植物之间的单细胞真核生物,在自然界中分布广泛。纤细裸藻兼具动植物细胞的特征,可进行光合自养、混养和异养培养,细胞内含有丰富的营养物质。近年来随着对纤细裸藻生物特...
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- P38 activation induces the dissociation of tristetraprolin from Argonaute 2 to increase ARE-mRNA stabilization被引量：5收藏
- 作者：Qi, Mei-Yan Song, Jing-Wen Zhang, Zhuo Huang, Shuang Jing, Qing
- 机构：Chinese Acad Sci;Changhai Hosp;East China Univ Sci & Technol
- 来源：MOLECULAR BIOLOGY OF THE CELL 2018
- Simultaneous quantification of intracellular pH and lactate at the single-cell level using a genetically encoded fluorescence lifetime biosensor被引量：1收藏
- 作者：Zhou, Huangmei Zou, Yejun Song, Yike Zhang, Zhuo Chen, Kai Deng, Lunhua Li, Xie Zhang, Sanjun Zhao, Yuzheng
- 机构：East China Normal Univ;East China Univ Sci & Technol;Tongji Univ;Chinese Acad Med Sci;Shanxi Univ
- 来源：SENSORS AND ACTUATORS B-CHEMICAL 2025
- 关键词：Genetically encoded fluorescent biosensors Fluorescent proteins Fluorescence lifetime imaging Lactate metabolism pH homeostasis
- Comparative N-glycoproteomics Characterization of N-glycoproteins of H3N8 Viruses Produced in Chicken Embryos versus MDCK Cells被引量：0收藏
- 作者：Wang, Honglin Zhang, Zheng Zhang, Xu Zhao, Liang Liu, Xuping Ye, Qian Tan, Wen-Song
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg;Shanghai BioEngine Scitech Co Ltd;Qingdao Inst Technol
- 来源：ACS OMEGA 2025
