成果/Result
- A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules被引量：378收藏
- 作者：Liang, Mindong Li, Zilong Wang, Weishan Liu, Jiakun Liu, Leshi Zhu, Guoliang Karthik, Loganathan Wang, Man Wang, Ke-Feng Wang, Zhong Yu, Jing Shuai, Yuting Yu, Jiaming Zhang, Lu Yang, Zhiheng Li, Chuan Zhang, Qian Shi, Tong Zhou, Liming Xie, Feng Dai, Huanqin Liu, Xueting Zhang, Jingyu Liu, Guang Zhuo, Ying Zhang, Buchang Liu, Chenli Li, Shanshan Xia, Xuekui Tong, Yaojun Liu, Yanwen Alterovitz, Gil Tan, Gao-Yi Zhang, Li-Xin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Anhui Univ;Chinese Acad Sci;Chinese Acad Sci
- 来源：NATURE COMMUNICATIONS 2019
- Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces被引量：143收藏
- 作者：Wang, Weishan Li, Shanshan Li, Zilong Zhang, Jingyu Fan, Keqiang Tan, Gaoyi Ai, Guomin Lam, Sin Man Shui, Guanghou Yang, Zhiheng Lu, Hongzhong Jin, Pinjiao Li, Yihong Chen, Xiangyin Xia, Xuekui Liu, Xueting Dannelly, H. Kathleen Yang, Chen Yang, Yi Zhang, Siliang Alterovitz, Gil Xiang, Wensheng Zhang, Lixin
- 机构：Chinese Acad Sci;East China Univ Sci & Technol;Chinese Acad Agr Sci;Chinese Acad Sci;Qilu Univ Technol
- 来源：NATURE BIOTECHNOLOGY 2020
- 关键词：Ketones - Metabolism - Biochemistry - Bacteria - Metabolites - Glycerol
- Recent examples of -ketoglutarate-dependent mononuclear non-haem iron enzymes in natural product biosyntheses被引量：137收藏
- 作者：Gao, Shu-Shan Naowarojna, Nathchar Cheng, Ronghai Liu, Xueting Liu, Pinghua
- 机构：Chinese Acad Sci;Boston Univ;East China Univ Sci & Technol
- 来源：NATURAL PRODUCT REPORTS 2018
- Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p被引量：58收藏
- 作者：Tong, Yaojun Zhang, Jingyu Sun, Nuo Wang, Xiang-Ming Wei, Qi Zhang, Yu Huang, Ren Pu, Yingying Dai, Huanqin Ren, Biao Pei, Gang Song, Fuhang Zhu, Guoliang Wang, Xinye Xia, Xuekui Chen, Xiangyin Jiang, Lan Wang, Shenlin Ouyang, Liming Xie, Ning Zhang, Buchang Jiang, Yuanying Liu, Xueting Calderone, Richard Bai, Fan Zhang, Lixin Alterovitz, Gil
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Peking Univ;Georgetown Univ
- 来源：SCIENCE BULLETIN 2021
- 关键词：Candida albicans Berberine Multidrug-resistance Drug excretion transporter Mitochondria
- Chrysomycin A Derivatives for the Treatment of Multi-Drug-Resistant Tuberculosis被引量：54收藏
- 作者：Wu, Fan Zhang, Jing Song, Fuhang Wang, Sanshan Guo, Hui Wei, Qi Dai, Huanqin Chen, Xiangyin Xia, Xuekui Liu, Xueting Zhang, Lixin Yu, Jin-Quan Lei, Xiaoguang
- 机构：Peking Univ;Peking Univ;Chinese Acad Sci;East China Univ Sci & Technol;Qilu Univ Technol
- 来源：ACS CENTRAL SCIENCE 2020
- Activating cryptic biosynthetic gene cluster through a CRISPR-Cas12a-mediated direct cloning approach被引量：54收藏
- 作者：Liang, Mindong Liu, Leshi Xu, Fei Zeng, Xiaoqian Wang, Runjun Yang, Jinling Wang, Weishan Karthik, Loganathan Liu, Jiakun Yang, Zhiheng Zhu, Guoliang Wang, Shuliu Bai, Linquan Tong, Yaojun Liu, Xueting Wu, Min Zhang, Li-Xin Tan, Gao-Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Zhejiang Univ;Zhejiang Univ;Huzhou Univ
- 来源：NUCLEIC ACIDS RESEARCH 2022
- Characterizing Y224 conformational flexibility in FtmOx1-catalysis using 19F NMR spectroscopy被引量：36收藏
- 作者：Wang, Xinye Yang, Lingyun Wang, Shenlin Wang, Jun Li, Kelin Naowarojna, Nathchar Ju, Yi Ye, Ke Han, Yuchen Yan, Wupeng Liu, Xueting Zhang, Lixin Liu, Pinghua
- 机构： State Key Laboratory of Bioreactor Engineering; iHuman Institute; School of Life Sciences and Biotechnology; Department of Chemistry; Program of Chemistry
- 来源：Catalysis Science and Technology 2024
- 关键词：Biosynthesis - Complexation - Conformations - Nuclear magnetic resonance spectroscopy
- High-yield porphyrin production through metabolic engineering and biocatalysis被引量：34收藏
- 作者：Chen, Haihong Wang, Yaohong Wang, Weishan Cao, Ting Zhang, Lu Wang, Zhengduo Chi, Xuran Shi, Tong Wang, Huangwei He, Xinwei Liang, Mindong Yang, Mengxue Jiang, Wenyi Lv, Dongyuan Yu, Jiaming Zhu, Guoliang Xie, Yongtao Gao, Bei Wang, Xinye Liu, Xueting Li, Youyuan Ouyang, Limin Zhang, Jingyu Liu, Huimin Li, Zilong Tong, Yaojun Xia, Xuekui Tan, Gao-Yi Zhang, Lixin
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Shanghai Jiao Tong Univ;Qilu Univ Technol
- 来源：NATURE BIOTECHNOLOGY 2025
- 关键词：Catalysis - Diagnosis - Fermentation - Medical applications - Metabolic engineering
- Genome-Based Discovery of Enantiomeric Pentacyclic Sesterterpenes Catalyzed by Fungal Bifunctional Terpene Synthases被引量：33收藏
- 作者：Jiang, Lan Zhang, Xue Sato, Yuya Zhu, Guoliang Minami, Atsushi Zhang, Weiyan Ozaki, Taro Zhu, Bin Wang, Zhixin Wang, Xinye Lv, Kangjie Zhang, Jingyu Wang, Yongheng Gao, Shushan Liu, Chengwei Hsiang, Tom Zhang, Lixin Oikawa, Hideaki Liu, Xueting
- 机构：East China Univ Sci Technol;Hokkaido Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;Jinan Univ
- 来源：ORGANIC LETTERS 2021
- Genome-based mining of new antimicrobial meroterpenoids from the phytopathogenic fungus Bipolaris sorokiniana strain 11134被引量：32收藏
- 作者：Han, Jianying Zhang, Jingyu Song, Zhijun Zhu, Guoliang Liu, Miaomiao Dai, Huanqin Hsiang, Tom Liu, Xueting Zhang, Lixin Quinn, Ronald J. Feng, Yunjiang
- 机构：Griffith Univ;Chinese Acad Sci;East China Univ Sci & Technol;Univ Guelph
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Meroterpenoids Phytopathogenic fungus Bipolaris sorokiniana Genome-based mining Antimicrobial activity
- Genome-Inspired Chemical Exploration of Marine FungusAspergillus fumigatusMF071被引量：31收藏
- 作者：Han, Jianying Liu, Miaomiao Jenkins, Ian D. Liu, Xueting Zhang, Lixin Quinn, Ronald J. Feng, Yunjiang
- 机构：Griffith Univ;Chinese Acad Sci;East China Univ Sci & Technol
- 来源：MARINE DRUGS 2020
- 关键词：Aspergillus fumigatus genome mining chemical diversity antimicrobial activity biosynthetic gene cluster prenyltransferase
- Anti-mycobacterial natural products and mechanisms of action被引量：28收藏
- 作者：Han, Jianying Liu, Xueting Zhang, Lixin Quinn, Ronald J. Feng, Yunjiang
- 机构：Griffith Univ;East China Univ Sci & Technol
- 来源：NATURAL PRODUCT REPORTS 2022
- A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137被引量：24收藏
- 作者：Zhang, Jingyu Li, Bixiao Qin, Yujie Karthik, Loganathan Zhu, Guoliang Hou, Chengjian Jiang, Lan Liu, Miaomiao Ye, Xin Liu, Mei Hsiang, Tom Dai, Huanqin Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Anhui Univ;Chinese Acad Sci;Sri Shakthi Inst Engn & Technol Autonomous;Griffith Univ
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Abyssomicin Proximicin Marine-derived Verrucosispora sp OSMAC Anti-influenza A virus
- Genome- and MS-based mining of antibacterial chlorinated chromones and xanthones from the phytopathogenic fungus Bipolaris sorokiniana strain 11134被引量：23收藏
- 作者：Han, Jianying Zhang, Jingyu Song, Zhijun Liu, Miaomiao Hu, Jiansen Hou, Chengjian Zhu, Guoliang Jiang, Lan Xia, Xuekui Quinn, Ronald J. Feng, Yunjiang Zhang, Lixin Hsiang, Tom Liu, Xueting
- 机构：Chinese Acad Sci;Griffith Univ;Univ Chinese Acad Sci;East China Univ Sci & Technol;Qilu Univ Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2019
- 关键词：Genome-based mining Halogenase Phytopathogenic fungus Bipolaris sorokiniana Antibacterial activity
- Recent advances in biotechnology for marine enzymes and molecules被引量：21收藏
- 作者：Zhang, Jingyu Jiang, Lan Chen, Xiangyin Lv, Kangjie Basiony, Mostafa Zhu, Guoliang Karthik, Loganathan Ouyang, Liming Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Salem Microbes Private Ltd
- 来源：CURRENT OPINION IN BIOTECHNOLOGY 2021
- 关键词：Synthetic biology - Ecosystems - Metabolic engineering - Marine applications - Molecules
- Dissecting the Mechanism of the Nonheme Iron Endoperoxidase FtmOx1 Using Substrate Analogues被引量：19收藏
- 作者：Zhu, Guoliang Yan, Wupeng Wang, Xinye Cheng, Ronghai Naowarojna, Nathchar Wang, Kun Wang, Jun Song, Heng Wang, Yuyang Liu, Hairong Xia, Xuekui Costello, Catherine E. Liu, Xueting Zhang, Lixin Liu, Pinghua
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Boston Univ;Wuhan Univ;Qilu Univ Technol
- 来源：JACS AU 2022
- 关键词：FtmOx1 nonheme iron enzymes endoperoxidation hydroxylation dehydrogenation X-ray structure
- New cryptotanshinone derivatives with anti-influenza A virus activities obtained via biotransformation by Mucor rouxii被引量：19收藏
- 作者：He, Wenni Li, Yao Qin, Yuejie Tong, Xiaomei Song, Zhijun Zhao, Yu Wei, Ran Li, Li Dai, Huanqin Wang, Wenzhao Luo, Houwei Ye, Xin Zhang, Lixin Liu, Xueting
- 机构：Chinese Acad Sci;Chinese Acad Med Sci;Peking Union Med Coll;Univ Chinese Acad Sci;Chinese Acad Med Sci
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2017
- 关键词：Cryptotanshinone Biotransformation Mucor rouxii Anti-influenza A virus activity
- Antibacterial polyene-polyol macrolides and cyclic peptides from the marine-derived Streptomyces sp. MS110128被引量：18收藏
- 作者：Jiang, Lan Huang, Pei Ren, Biao Song, Zhijun Zhu, Guoliang He, Wenni Zhang, Jingyu Oyeleye, Ayokunmi Dai, Huanqin Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Zunyi Med Univ;Sichuan Univ;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2021
- 关键词：Marine-derived Actinomycete Candida albicans Polyene Cyclic peptides
- Molecular networking assisted discovery and biosynthesis elucidation of the antimicrobial spiroketals epicospirocins被引量：18收藏
- 作者：Zhu, Guoliang Hou, Chengjian Yuan, Weize Wang, Zhenzhen Zhang, Jingyu Jiang, Lan Karthik, Loganathan Li, Bixiao Ren, Biao Lv, Kangjie Lu, Wanying Cong, Zhanren Dai, Huanqin Hsiang, Tom Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Salem Microbes Private Ltd;Sichuan Univ;Sichuan Univ;Chinese Acad Sci
- 来源：CHEMICAL COMMUNICATIONS 2020
- 关键词：Biochemistry - Chirality
- Development of Antibacterial Peptides with Membrane Disruption and Folate Pathway Inhibitory Activities against Methicillin-Resistant Staphylococcus aureus被引量：18收藏
- 作者：Li, Chunlei Zhou, Ziyi Wang, Weitao Zhao, Yanqiu Yin, Xin Meng, Yiwei Zhao, Peipei Wang, Mengmeng Liu, Xueting Wang, Xinye Wang, Shenlin Ren, Biao Zhang, Lixin Xia, Xuekui
- 机构：Qilu Univ Technol;Shandong Univ;Sichuan Univ;Sichuan Univ;East China Univ Sci & Technol
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2024
- Genome-guided investigation of anti-inflammatory sesterterpenoids with 5-15 trans-fused ring system from phytopathogenic fungi被引量：15收藏
- 作者：Jiang, Lan Zhu, Guoliang Han, Jianying Hou, Chengjian Zhang, Xue Wang, Zhixin Yuan, Weize Lv, Kangjie Cong, Zhanren Wang, Xinye Chen, Xiangyin Karthik, Loganathan Yang, Huanting Wang, Xuyuan Tan, Gaoyi Liu, Guang Zhao, Liya Xia, Xuekui Liu, Xiangyang Gao, Shushan Ma, Lei Liu, Mei Ren, Biao Dai, Huanqin Quinn, Ronald J. Hsiang, Tom Zhang, Jingyu Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Griffith Univ;Qilu Univ Technol;T3 Biosci LLC
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2021
- 关键词：Fungi Bifunctional terpene synthases Terpenoids Anti-inflammatory
- Heparin mimetics as potential intervention for COVID-19 and their bio-manufacturing被引量：13收藏
- 作者：Jiang, Lan Zhang, Tianji Lu, Hongzhong Li, Saijuan Lv, Kangjie Tuffour, Alex Zhang, Lixin Ding, Kan Li, Jin-Ping Li, Hongmei Liu, Xueting
- 机构：Nanjing Med Univ;East China Univ Sci & Technol;Natl Inst Metrol;Shanghai Jiao Tong Univ;Shanghai Inst Mat Med
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2023
- 关键词：Heparin Biosynthesis Biological activities Bio-production
- Generation of Fluorinated Amychelin Siderophores against Pseudomonas aeruginosa Infections by a Combination of Genome Mining and Mutasynthesis被引量：13收藏
- 作者：Xie, Feng Dai, Shengwang Zhao, Yu Huang, Pei Yu, Shen Ren, Biao Wang, Qiushui Ji, Zengchun Alterovitz, Gil Zhang, Qi Zhang, Jingyu Chen, Xiangyin Jiang, Lan Song, Fuhang Liu, Hongwei Ausubel, Frederick M. Liu, Xueting Dai, Huanqin Zhang, Lixin
- 机构：Chinese Acad Sci;East China Univ Sci & Technol;Chinese Acad Sci;Massachusetts Gen Hosp;Sichuan Univ
- 来源：CELL CHEMICAL BIOLOGY 2020
- Genomics-guided discovery of a new and significantly better source of anticancer natural drug FK228被引量：13收藏
- 作者：Liu, Xiangyang Xie, Feng Doughty, Leah B. Wang, Qi Zhang, Lixin Liu, Xueting Cheng, Yi-Qiang
- 机构：East China Univ Sci & Technol;Univ North Texas;Chinese Acad Sci;Univ Wisconsin
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2018
- 关键词：Burkholderia thailandensis MSMB43 Fermentation optimization FK228 Genome mining Natural product Productivity
- Biochemical and Structural Characterization of OvoA Th2 : A Mononuclear Nonheme Iron Enzyme from Hydrogenimonas thermophila for Ovothiol Biosynthesis被引量：12收藏
- 作者：Wang, Xinye Hu, Sha Wang, Jun Zhang, Tao Ye, Ke Wen, Aiwen Zhu, Guoliang Vegas, Arturo Zhang, Lixin Yan, Wupeng Liu, Xueting Liu, Pinghua
- 机构：East China Univ Sci & Technol;Boston Univ;Shanghai Jiao Tong Univ
- 来源：ACS CATALYSIS 2023
- 关键词：nonheme iron enzyme ovothiol ergothioneine X-ray structure regioselectivity sulfur-containingnatural products
- Schultriene and nigtetraene: two sesterterpenes characterized from pathogenetic fungi via genome mining approach被引量：12收藏
- 作者：Jiang, Lan Yang, Huanting Zhang, Xue Li, Xiaoying Lv, Kangjie Zhang, Weiyan Zhu, Guoliang Liu, Chengwei Wang, Yongheng Hsiang, Tom Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci Technol;Northeast Forestry Univ;Jinan Univ;Univ Guelph
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2022
- 关键词：Bifunctional terpene synthases Sesterterpene Genome mining Heterologous expression Cyclization mechanisms
- Characterization of anti-BCG benz[α]anthraquinones and new siderophores from a Xinjiang desert-isolated rare actinomycete Nocardia sp. XJ31被引量：12收藏
- 作者：Zhang, Li Zhang, Jingyu Ren, Biao Lu, Wanying Hou, Chengjian Wang, Jian Ma, Xiaolong Ma, Rong Liu, Mei Liu, Zhiheng Li, Jin-Ping Ding, Kan Dai, Huanqin Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Boston Univ;Sichuan Univ;Sichuan Univ
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Xinjiang desert Nocardiasp Anti-BCG Brasiliquinone Nocardimicin
- Function Switch of a Fungal Sesterterpene Synthase through Molecular Dynamics Simulation Assisted Alteration of an Aromatic Residue Cluster in the Active Pocket of PfNS被引量：11收藏
- 作者：Zhang, Weiyan Wang, Xinye Zhu, Guoliang Zhu, Bin Peng, Kaitong Hsiang, Tom Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Ludong Univ;Univ Guelph
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2024
- 关键词：aromatic residue cluster sesterterpene synthase molecular dynamics mutagenesis terpenoids
- Anti-inflammatory aromadendrane- and cadinane-type sesquiterpenoids from the South China Sea sponge Acanthella cavernosa被引量：10收藏
- 作者：Shen, Shou-Mao Yang, Qing Zang, Yi Li, Jia Liu, Xueting Guo, Yue-Wei
- 机构：Nanjing Univ Chinese Med;Chinese Acad Sci;Nanchang Univ;Bohai Rim Adv Res Inst Drug Discovery;Pilot Natl Lab Marine Sci & Technol
- 来源：BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 2022
- 关键词：Acanthella cavernosa anti-inflammatory biosynthetic pathway chiral separation marine sponge sesquiterpenoid
- Brocaeloid D, a novel compound isolated from a wheat pathogenic fungus, Microdochium majus 99049被引量：9收藏
- 作者：Zhang, Jingyu Wang, Zhenzhen Song, Zhijun Karthik, Loganathan Hou, Chengjian Zhu, Guoliang Jiang, Lan Han, Jianying Ma, Rong Li, Li Zhang, Lixin Liu, Xueting Hsiang, Tom
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Med Sci & Peking Union Med Coll;Univ Guelph;Univ Chinese Acad Sci
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2019
- 关键词：Wheat pathogenic fungus Anticancer Antibacterial Natural product
