成果/Result
- Rational Exploration of Novel SDHI Fungicide through an Amide-?-ketonitrile Bioisosteric Replacement Strategy被引量：42收藏
- 作者：Zhou, Cong Sun, Xujuan Fu, Wen Li, Zhong Cheng, Jiagao Maienfisch, Peter
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2023
- 关键词：?-ketonitriles succinate dehydrogenase inhibitors fungicidal activity bioisosteric replacement molecular docking 3D-QSAR
- Application of photopharmacology in agrochemicals被引量：35收藏
- 作者：Fu, Wen Li, Zhong Shao, Xusheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ADVANCED AGROCHEM 2023
- 关键词：Photopharmacology Agrochemicals Photochromic ligands Optical control Ligand-receptor interactions
- Synthesis and Biological Activity of Novel Antifungal Leads: 3,5-Dichlorobenzyl Ester Derivatives被引量：29收藏
- 作者：Du, Shaoqing Yuan, Qinglong Hu, Xueping Fu, Wen Xu, Qi Wei, Ziyi Xu, Jiazheng Shao, Xusheng Qian, Xuhong
- 机构：East China Univ Sci & Technol;Zhejiang Univ;East China Normal Univ
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2021
- 关键词：succinate dehydrogenase inhibitors fungicidal activity molecular dynamic simulations 3,5-dichlorobenzyl ester
- Reversible Regulation of Succinate Dehydrogenase by Tools of Photopharmacology被引量：28收藏
- 作者：Fu, Wen Shao, Zhongli Sun, Xujuan Zhou, Cong Xu, Zhiping Zhang, Yang Cheng, Jiagao Li, Zhong Shao, Xusheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2022
- 关键词：regulation SDH photochromic ligands azobenzene optical control
- Azo-incorporating Increases Inhibitory Activity of Succinate Dehydrogenase被引量：26收藏
- 作者：Fu, Wen Hu, Xinyue Yuan, Qinglong Sun, Xujuan Xu, Zhiping Zhang, Yang Cheng, Jiagao Ye, Yonghao Li, Zhong Shao, Xusheng
- 机构：East China Univ Sci & Technol;Nanjing Agr Univ;East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2021
- 关键词：azobenzene activity fungicide succinate dehydrogenase
- Azobenzene-Semicarbazone Enables Optical Control of Insect Sodium Channels and Behavior被引量：17收藏
- 作者：Qiao, Zhi Fu, Wen Zhang, Yongchao Chen, Ruijia Xu, Zhiping Li, Zhong Shao, Xusheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2021
- 关键词：photopharmacology sodium channels photoswitches metaflumizone invertebrates
- Novel SDH Inhibitors as Antifungal Leads: From Azobenzene Derivatives to the 1,2,4-Oxadiazole Compounds被引量：14收藏
- 作者：Fu, Wen Yuan, Qinglong Zhang, Hangji Li, Xiaoyan Lu, Yiming Yan, Wenming Ye, Yonghao Liu, Xili Li, Zhong Shao, Xusheng
- 机构：East China Univ Sci & Technol;Guizhou Univ;Yantai Inst China Agr Univ;Shandong Yingxin Chem Co Ltd;Nanjing Agr Univ
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2024
- 关键词：SDH azobenzene 1,2,4-oxadiazole antifungal lead structural optimization
- Design, synthesis and bioassay of the emerging photo-responsive fungicides被引量：11收藏
- 作者：Fu, Wen Hu, Xinyue Yuan, Qinglong Xu, Zhiping Cheng, Jiagao Li, Zhong Shao, Xusheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CHINESE CHEMICAL LETTERS 2023
- 关键词：Phenamacril Controlled release Photoremovable protecting groups Spatiotemporal Significant difference
- The potential immunotoxicity of emamectin benzoate on the human THP-1 macrophages被引量：10收藏
- 作者：Wei, Ziyi Wang, Weiguo Fu, Wen Zhang, Ping Feng, Hao Xu, Wenping Tao, Liming Li, Zhong Zhang, Yang Shao, Xusheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ENVIRONMENTAL TOXICOLOGY 2023
- 关键词：emamectin benzoate immunotoxicity NF-kappa B pathway pesticide THP-1 macrophages
- Dual photo-controlled release system for fipronil and dinotefuran被引量：8收藏
- 作者：Fu, Wen Du, Kang Xu, Zhiping Cheng, Jiagao Li, Zhong Shao, Xusheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES 2023
- 关键词：Dual release TNB-insecticides Light Synergistic effect Pesticide delivery
- Optical Regulation of GABA Receptor by Visible Light via Azobenzene-Phenylpyrazole被引量：7收藏
- 作者：Qiao, Zhi Fu, Wen Huang, Qiutang Li, Zhong Zhao, Chunqing Shao, Xusheng
- 机构：East China Univ Sci & Technol;Nanjing Agr Univ;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2022
- 关键词：photopharmacology GABARs azobenzene phenylpyrazole photoregulation
- Design, synthesis, and biological activity of heterocyclic methyl esters被引量：6收藏
- 作者：Yuan, Qinglong Zhang, Yongchao Du, Shaoqing Fu, Wen Xu, Zhiping Cheng, Jiagao Li, Zhong Shao, Xusheng
- 机构：East China Univ Sci & Technol;Shandong Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF HETEROCYCLIC CHEMISTRY 2023
- Light Regulation of Insect Behavior by Azobenzene-modified Flonicamid as Novel Molecular Tools被引量：5收藏
- 作者：Sheng, Zhubo Fu, Wen Zhang, Hangji Wang, Weiguo Li, Xiaoyan Xu, Zhiping Li, Zhong Shao, Xusheng
- 机构：East China Univ Sci & Technol;Guizhou Univ;China Agr Univ;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2024
- 关键词：photopharmacology azobenzene photoregulation Naam AlphaFold2
- Acid-promoted reaction of N-(cyanomethyl) amide with nitrosation reagent: Facile synthesis of 1,2,4-oxadiazole-3-carboxamide被引量：5收藏
- 作者：Du, Shaoqing Li, Jin Fu, Wen Xu, Xiaoyong Shao, Xusheng Qian, Xuhong
- 机构：East China Univ Sci & Technol;East China Normal Univ
- 来源：TETRAHEDRON LETTERS 2021
- 关键词：N-(Cyanomethyl)amide 1 2 4-Oxadiazole-3-carboxamide Methyl 1 2 4-oxadiazole-3-carboxylate N0-Hydroxycarbamimidoyl cyanide
- Discovery of Novel Nicotinamide Derivatives by a Two-Step Strategy of Azo-Incorporating and Bioisosteric Replacement被引量：5收藏
- 作者：Ru, Yifan Fu, Wen Guo, Sifan Li, Xiaoyan Zhou, Cong Xu, Zhiping Cheng, Jiagao Li, Zhong Shao, Xusheng
- 机构：East China Univ Sci & Technol;Yantai Inst China Agr Univ;East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2024
- 关键词：nicotinamide azo-incorporating bioisostericreplacement fungicidal spectrum SDH
- Application of TNB in dual photo-controlled release of phenamacril, imidacloprid, and imidacloprid synergist被引量：4收藏
- 作者：Yin, Qi Fu, Wen Hu, Xinyue Xu, Zhiping Li, Zhong Shao, Xusheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：PHOTOCHEMISTRY AND PHOTOBIOLOGY 2024
- 关键词：dual photo-controlled release fungicide insecticide synergist TNB
- Optical Regulation of Sodium Channels by the Azobenzene Pyrethrins被引量：4收藏
- 作者：Fu, Wen Ji, Yunfan Zhang, Yanan Xu, Jiazheng Xu, Zhiping Cheng, Jiagao Li, Zhong Shao, Xusheng
- 机构：East China Univ Sci & Technol;East China Normal Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACS AGRICULTURAL SCIENCE & TECHNOLOGY 2022
- 关键词：azobenzene pyrethrins optical control insecticidal activities sodium channel
- Optical Control of Insect Behavior and Receptors with Azobenzene-Bridged Fipronil and Imidacloprid被引量：4收藏
- 作者：Fu, Wen Sheng, Zhubo Qiao, Zhi Xu, Zhiping Li, Meng Guan, Ying Li, Zhong Shao, Xusheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Joint Inst Tobacco & Hlth
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2024
- 关键词：azobenzene bridge multiphoton insect receptorand behavior spatiotemporal regulation
- Enantioselective synthesis of 2-amino-4H-chromene derivatives with antifungal activities on phytopathogenic fungi被引量：3收藏
- 作者：Zhang, Man Ru, Yifan Wang, Shilin Fu, Wen Li, Tianyu Shao, Xusheng Li, Zhong Yang, Wu-Lin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ORGANIC CHEMISTRY FRONTIERS 2024
- 关键词：Fungi - Iridium - Iridium compounds - Lead compounds
- Carbonyl-bridged trifluoromethyl pyridine derivatives for pest control and mechanistic investigations被引量：3收藏
- 作者：Sheng, Zhubo Deng, Jie Yuan, Qinglong Fu, Wen Xu, Zhiping Li, Xiaoyan Li, Zhong Shao, Xusheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Guizhou Univ
- 来源：ADVANCED AGROCHEM 2026
- 关键词：TFMP Carbonyl-bridged Structure-activity relationships Molecular docking Calcium ion
- O-nitrobenzyl Caged Molecule Enables Photo-controlled Release of Thiabendazole被引量：3收藏
- 作者：Fu, Wen Shao, Zhongli Xu, Zhiping Li, Zhong Shao, Xusheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CHEMBIOCHEM 2024
- 关键词：Photo-controlled release O-nitrobenzyl Thiabendazole Fungicidal activity Micromorphology
- Design, Synthesis, Bioactivity, and Tentative Exploration of Action Mode for Benzyl Ester-Containing Derivatives被引量：3收藏
- 作者：Yuan, Qinglong Fu, Wen Li, Xiaoyan Xu, Zhiping Liu, Xili Li, Zhong Shao, Xusheng
- 机构：East China Univ Sci & Technol;China Agr Univ;Northwest A&F Univ;China Agr Univ;East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2024
- 关键词：benzyl ester antifungal activity active splicing structure-activity relationships action mode
- N-Difluoromethylthiophthalimide Reagents for Modular Synthesis of Diversified α-Difluoromethylthiolated Ketones被引量：2收藏
- 作者：Liang, Junqing Fu, Wen Dong, Lefeng Zhou, Cong Yuan, Qinglong Chang, Wenning Yang, Wu-Lin Xu, Xiaoyong Shao, Xusheng Li, Zhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ORGANIC LETTERS 2023
- A Terminal ModificationStrategy for Enhancing theDifference in Photoregulated Activity of Azobenzene-TolfenpyradHybrids被引量：0收藏
- 作者：Zhang, Yongchao Qiao, Zhi Zhou, Cuncun Yin, Qi Shi, Lei Li, Zhong Fu, Wen Shao, Xusheng
- 机构：East China Univ Sci & Technol;Yantai Lannacheng Biotechnol Co Ltd;East China Univ Sci & Technol;Hangzhou Sinotek Qual & Technol Serv Co Ltd;East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2026
- 关键词：photopharmacology tolfenpyrad photochromicligand azobenzene photoinduced activity enhancement photoinduced activity reduction
- Carbonyl-bridged trifluoromethyl pyridine derivatives for pest control and mechanistic investigations被引量：0收藏
- 作者：Zhubo Sheng Jie Deng Qinglong Yuan Wen Fu Zhiping Xu Xiaoyan Li Zhong Li Xusheng Shao
- 机构：Shanghai Key Laboratory of Chemical Biology;State Key Laboratory of Bioreactor Engineering;Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism;Engineering Research Center of Pharmaceutical Process Chemistry;National Key Laboratory of Green Pesticide
- 来源：现代农业化学(英文) 2026
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- Sustained-Release and Rapid-Release of Fenhexamid via the Two Different Photocages in a Light-Controllable Manner被引量：0收藏
- 作者：Yin, Qi Li, Zongying Shao, Zhongli He, Zetao Lv, Junjie Shao, Xiaoguang Shi, Lei Fu, Wen Shao, Xusheng
- 机构：East China Univ Sci & Technol;Shandong Univ;Agr Comprehens Serv Ctr Xiaqiu Town;Hangzhou Sinotek Qual & Technol Serv Co Ltd;Guizhou Univ
- 来源：ACS AGRICULTURAL SCIENCE & TECHNOLOGY 2026
- 关键词：release controllable photocage pesticide efficacy fenhexamid
- Application of photopharmacology in agrochemicals被引量：0收藏
- 作者：Wen Fu Zhong Li Xusheng Shao
- 机构：Shanghai Key Laboratory of Chemical Biology;State Key Laboratory of Bioreactor Engineering;Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism;Engineering Research Center of Pharmaceutical Process Chemistry
- 来源：现代农业化学（英文） 2023
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- 基于氯虫苯甲酰胺结构的PROTACs分子设计、合成及杀虫活性研究被引量：0收藏
- 作者：张振国 付稳 李忠 邵旭升
- 机构：华东理工大学药学院
- 来源：《农药学学报》 2025
- 关键词：蛋白降解靶向嵌合体 鱼尼丁受体 氯虫苯甲酰胺 泊马度胺 结构改造 杀虫活性
- 摘要：蛋白降解靶向嵌合体(proteolysis-targeting chimeras,PROTACs)技术作为生物医药前沿技术,可通过“事件驱动”(event driven)降解模式,特异性清除靶蛋白,因其高选择性和独特机制...
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- The photoswitchable ABAMIs for the future regulation of GWT1 in a spatiotemporal level被引量：0收藏
- 作者：Ding, Qian Li, Zongying Xiao, Zaiwei Zhang, Siting Liu, Zimai Shao, Xiaoguang Li, Zhong Fu, Wen Shao, Xusheng
- 机构：East China Univ Sci & Technol;Shandong Univ;Agr Comprehens Serv Ctr Xiaqiu Town;East China Univ Sci & Technol;Guizhou Univ
- 来源：SMART MOLECULES 2026
- 关键词：azobenzene-aminopyridine bioactivity GWT1 pesticide discovery photoswitchable
- Wavelength-tunable light regulates binding affinity of histone deacetylase inhibitors via azobenzene Photoswitches被引量：0收藏
- 作者：Ru, Yifan Guo, Sifan He, Yu Huang, Xiujuan Zhang, Zhenguo Shi, Lei Shao, Xiaoguang Li, Zhong Fu, Wen Shao, Xusheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Hangzhou Sinotek Qual & Technol Serv Co Ltd
- 来源：PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 2026
- 关键词：Photopharmacology Azobenzene Regulation Trifluoromethyloxadiazole HDAC Enzymatic assay
