成果/Result
- Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs被引量：249收藏
- 作者：Chen, Xianjun Zhang, Dasheng Su, Ni Bao, Bingkun Xie, Xin Zuo, Fangting Yang, Lipeng Wang, Hui Jiang, Li Lin, Qiuning Fang, Mengyue Li, Ningfeng Hua, Xin Chen, Zhengda Bao, Chunyan Xu, Jinjin Du, Wenli Zhang, Lixin Zhao, Yuzheng Zhu, Linyong Loscalzo, Joseph Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：NATURE BIOTECHNOLOGY 2019
- 关键词：Cells - Enzyme kinetics - Fluorescence - Mammals - Cytology
- A versatile biosensing platform coupling CRISPR-Cas12a and aptamers for detection of diverse analytes被引量：88收藏
- 作者：Zhao, Xiangxiang Li, Shanshan Liu, Guang Wang, Zhong Yang, Zhiheng Zhang, Quanwei Liang, Mindong Liu, Jiakun Li, Zilong Tong, Yaojun Zhu, Guoliang Wang, Xinye Jiang, Lan Wang, Weishan Tan, Gao-Yi Zhang, Lixin
- 机构：East China Univ Sci & Technol ECUST;East China Univ Sci & Technol ECUST;Chinese Acad Agr Sci;Chinese Acad Sci;Shanghai Jiao Tong Univ
- 来源：SCIENCE BULLETIN 2021
- 关键词：CRISPR-Cas12a Aptamer Biosensing platform Diverse analyte Alpha fetoprotEIn detection Cocaine detection
- Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p被引量：58收藏
- 作者：Tong, Yaojun Zhang, Jingyu Sun, Nuo Wang, Xiang-Ming Wei, Qi Zhang, Yu Huang, Ren Pu, Yingying Dai, Huanqin Ren, Biao Pei, Gang Song, Fuhang Zhu, Guoliang Wang, Xinye Xia, Xuekui Chen, Xiangyin Jiang, Lan Wang, Shenlin Ouyang, Liming Xie, Ning Zhang, Buchang Jiang, Yuanying Liu, Xueting Calderone, Richard Bai, Fan Zhang, Lixin Alterovitz, Gil
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Peking Univ;Georgetown Univ
- 来源：SCIENCE BULLETIN 2021
- 关键词：Candida albicans Berberine Multidrug-resistance Drug excretion transporter Mitochondria
- THE COMBINED EFFECTS OF HEMATOPORPHYRIN MONOMETHYL ETHER-SDT AND DOXORUBICIN ON THE PROLIFERATION OF QBC939 CELL LINES被引量：38收藏
- 作者：Liang, Lei Xie, Sheng Jiang, Lin Jin, Hui Li, Songgang Liu, Jianwen
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：ULTRASOUND IN MEDICINE AND BIOLOGY 2013
- 关键词：HMME-SDT DOX Synergistic effect DNA damage Drug combination
- A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137被引量：24收藏
- 作者：Zhang, Jingyu Li, Bixiao Qin, Yujie Karthik, Loganathan Zhu, Guoliang Hou, Chengjian Jiang, Lan Liu, Miaomiao Ye, Xin Liu, Mei Hsiang, Tom Dai, Huanqin Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Anhui Univ;Chinese Acad Sci;Sri Shakthi Inst Engn & Technol Autonomous;Griffith Univ
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Abyssomicin Proximicin Marine-derived Verrucosispora sp OSMAC Anti-influenza A virus
- Genome- and MS-based mining of antibacterial chlorinated chromones and xanthones from the phytopathogenic fungus Bipolaris sorokiniana strain 11134被引量：23收藏
- 作者：Han, Jianying Zhang, Jingyu Song, Zhijun Liu, Miaomiao Hu, Jiansen Hou, Chengjian Zhu, Guoliang Jiang, Lan Xia, Xuekui Quinn, Ronald J. Feng, Yunjiang Zhang, Lixin Hsiang, Tom Liu, Xueting
- 机构：Chinese Acad Sci;Griffith Univ;Univ Chinese Acad Sci;East China Univ Sci & Technol;Qilu Univ Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2019
- 关键词：Genome-based mining Halogenase Phytopathogenic fungus Bipolaris sorokiniana Antibacterial activity
- Recent advances in biotechnology for marine enzymes and molecules被引量：21收藏
- 作者：Zhang, Jingyu Jiang, Lan Chen, Xiangyin Lv, Kangjie Basiony, Mostafa Zhu, Guoliang Karthik, Loganathan Ouyang, Liming Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Salem Microbes Private Ltd
- 来源：CURRENT OPINION IN BIOTECHNOLOGY 2021
- 关键词：Synthetic biology - Ecosystems - Metabolic engineering - Marine applications - Molecules
- Chaetoglobosins and azaphilones from Chaetomium globosum associated with Apostichopus japonicus被引量：21收藏
- 作者：Qi, Jun Jiang, Lan Zhao, Peipei Chen, Haiyan Jia, Xiaopeng Zhao, Liya Dai, Huanqin Hu, Jiansen Liu, Changheng Shim, Sang Hee Xia, Xuekui Zhang, Lixin
- 机构：Qilu Univ Technol;East China Univ Sci & Technol;Guangxi Univ;Duksung Womens Univ;Duksung Womens Univ
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Apostichopus japonicus Chaetomium globosum Genome mining Chaetoglobosins Azaphilones Antimicrobial activity
- Molecular networking assisted discovery and biosynthesis elucidation of the antimicrobial spiroketals epicospirocins被引量：18收藏
- 作者：Zhu, Guoliang Hou, Chengjian Yuan, Weize Wang, Zhenzhen Zhang, Jingyu Jiang, Lan Karthik, Loganathan Li, Bixiao Ren, Biao Lv, Kangjie Lu, Wanying Cong, Zhanren Dai, Huanqin Hsiang, Tom Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Salem Microbes Private Ltd;Sichuan Univ;Sichuan Univ;Chinese Acad Sci
- 来源：CHEMICAL COMMUNICATIONS 2020
- 关键词：Biochemistry - Chirality
- Antibacterial polyene-polyol macrolides and cyclic peptides from the marine-derived Streptomyces sp. MS110128被引量：18收藏
- 作者：Jiang, Lan Huang, Pei Ren, Biao Song, Zhijun Zhu, Guoliang He, Wenni Zhang, Jingyu Oyeleye, Ayokunmi Dai, Huanqin Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Zunyi Med Univ;Sichuan Univ;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2021
- 关键词：Marine-derived Actinomycete Candida albicans Polyene Cyclic peptides
- Genome-guided investigation of anti-inflammatory sesterterpenoids with 5-15 trans-fused ring system from phytopathogenic fungi被引量：15收藏
- 作者：Jiang, Lan Zhu, Guoliang Han, Jianying Hou, Chengjian Zhang, Xue Wang, Zhixin Yuan, Weize Lv, Kangjie Cong, Zhanren Wang, Xinye Chen, Xiangyin Karthik, Loganathan Yang, Huanting Wang, Xuyuan Tan, Gaoyi Liu, Guang Zhao, Liya Xia, Xuekui Liu, Xiangyang Gao, Shushan Ma, Lei Liu, Mei Ren, Biao Dai, Huanqin Quinn, Ronald J. Hsiang, Tom Zhang, Jingyu Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Griffith Univ;Qilu Univ Technol;T3 Biosci LLC
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2021
- 关键词：Fungi Bifunctional terpene synthases Terpenoids Anti-inflammatory
- Visible-light activatable coumarin-based phototriggers for fluorescence imaging with ultra-high photolysis efficiency被引量：12收藏
- 作者：Zhou, Renjie Yang, Lipeng Chen, Zhengda Jiang, Li Liu, Tuan Wang, Zhiqiang Huang, Xinyi Lin, Qiuning Gong, Xueqing Yang, Yi Zhu, Linyong
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：PHYSICAL CHEMISTRY CHEMICAL PHYSICS 2023
- 关键词：Efficiency - Fluorescence imaging - Scaffolds - Signal to noise ratio
- Schultriene and nigtetraene: two sesterterpenes characterized from pathogenetic fungi via genome mining approach被引量：12收藏
- 作者：Jiang, Lan Yang, Huanting Zhang, Xue Li, Xiaoying Lv, Kangjie Zhang, Weiyan Zhu, Guoliang Liu, Chengwei Wang, Yongheng Hsiang, Tom Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci Technol;Northeast Forestry Univ;Jinan Univ;Univ Guelph
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2022
- 关键词：Bifunctional terpene synthases Sesterterpene Genome mining Heterologous expression Cyclization mechanisms
- Chemical control over the conversion between bicyclic and polycyclic terpenes by fungal bifunctional terpene synthases被引量：8收藏
- 作者：Wang, Xinye Wang, Zhixin Zhu, Guoliang Jiang, Lan Zhang, Weiyan Huang, Yiyi Cong, Zhanren Zhao, Yi-Lei Xu, Jian-He Hsiang, Tom Zhang, Lixin Chen, Qi Liu, Xueting
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;Univ Guelph
- 来源：CHEMICAL COMMUNICATIONS 2022
- 关键词：Catalysis - Terpenes
- Bright and Stable Cyan Fluorescent RNA Enables Multicolor RNA Imaging in Live Escherichia coli被引量：3收藏
- 作者：Jiang, Li Zuo, Fangting Pan, Yuanyuan Li, Ruilong Shi, Yajie Huang, Xinyi Zhang, Dasheng Zhuang, Yingping Zhao, Yuzheng Lin, Qiuning Yang, Yi Zhu, Linyong Chen, Xianjun
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Med Sci
- 来源：SMALL 2025
- 关键词：bioorthogonality cyan fluorescent RNA fluorophore RNA aptamer RNA imaging
- NPtagM: A Tailoring Enzyme Genome Mining Toolkit and Its Application in Terpenoid P450s from Phytopathogenic Fungi被引量：3收藏
- 作者：Cong, Zhanren Mukoma, Njeru Joe Yin, Qiang Zhu, Bin She, Lingwei Hsiang, Tom Zhang, Lixin Jiang, Lan Liu, Xueting
- 机构：East China Univ Sci Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Beijing Inst Technol;Univ Guelph
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2024
- 关键词：NPtagM tailoring enzyme genome mining terpenoids cytochrome P450 phytopathogenic fungi
- Identifying sesterterpenoids via feature-based molecular networking and small-scale fermentation被引量：2收藏
- 作者：Lv, Kangjie Duan, Yuyang Li, Xiaoying Wang, Xinye Xing, Cuiping Lan, Keying Zhu, Bin Zhu, Guoliang Qiu, Yuyang Li, Songwei Hsiang, Tom Zhang, Lixin Jiang, Lan Liu, Xueting
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shandong Univ Finance & Econ;Shanghai Univ;Univ Guelph
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2024
- 关键词：Bifunctional terpene synthases Feature-based molecular networking Cytochrome P450 Aspergillus oryzae Heterologous expression
- Genome Mining and Heterologous Expression-Guided Discovery of Mangicol Sesterterpenoids with Antimicrobial and Antineuroinflammatory Activities被引量：2收藏
- 作者：Xing, Cuiping Yang, Huanting Lv, Kangjie Lan, Keying Zhu, Guoliang Zhu, Bin Ren, Biao Jiang, Yi Jiang, Chenglin Dai, Huanqin Mo, Xuming Hsiang, Tom Abdelmageed, Wael M. Zhang, Lixin Jiang, Lan Liu, Xueting
- 机构：East China Univ Sci & Technol;Sichuan Univ;Sichuan Univ;Yunnan Univ;Chinese Acad Sci
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2025
- 关键词：phytopathogenic fungus sesterterpenoid heterologousexpression mangicol FBMN antibacterialactivity antineuroinflammatory
- DNA硫修饰结合蛋白识别序列的表征与拓展促进新型核酸检测技术发展被引量：0收藏
- 作者：帅玉婷 许安安 李甲乙 韩照晰 马蒂尼 段海容 王馨叶 蒋岚 张敬宇 谭高翼 刘雪婷 赵一雷 童垚俊 王申林 贺新义 邓子新 刘光 张立新
- 机构：East China Univ Sci & Technol ECUST;Shanghai Jiao Tong Univ
- 来源：《Science Bulletin》 2023
- 关键词：核酸检测技术 限制性核酸内切酶 SBD 序列模式 识别序列 防御系统 硫原子 抗氧化应激
- 摘要：DNA硫修饰是一种DNA磷酸骨架上的非桥接氧原子被硫原子所取代的修饰,属于原核生物表观遗传标志物之一,它对细菌防御系统、抗氧化应激和基因调控等生命过程具有重要影响.DNA硫修饰可以被硫修饰依赖限制性核酸内切酶的硫结合域S...
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- Genome Mining Guided Discovery of Macrocyclic Sesterterpenoids with Anti-MRSA and Anti-Neuroinflammatory Activities被引量：0收藏
- 作者：Lan, Keying Wang, Zhennan Lv, Kangjie Xing, Cuiping Li, Xiaoying Yin, Qiang Chen, Yuwei Mo, Xuming Mao, Xiaobo Wu, Weijie Hsiang, Tom Zhang, Lixin Dai, Huanqin Liu, Xueting Zhu, Guoliang Jiang, Lan
- 机构：East China Univ Sci Technol;Nanjing Tech Univ;Nanjing Med Univ;Nanjing Med Univ;Johns Hopkins Univ
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2025
- 关键词：bifunctional terpene synthases macrocyclic sesterterpenoids heterologous expression biosynthetic pathway antibacterial activity
