成果/Result
- Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces被引量：143收藏
- 作者：Wang, Weishan Li, Shanshan Li, Zilong Zhang, Jingyu Fan, Keqiang Tan, Gaoyi Ai, Guomin Lam, Sin Man Shui, Guanghou Yang, Zhiheng Lu, Hongzhong Jin, Pinjiao Li, Yihong Chen, Xiangyin Xia, Xuekui Liu, Xueting Dannelly, H. Kathleen Yang, Chen Yang, Yi Zhang, Siliang Alterovitz, Gil Xiang, Wensheng Zhang, Lixin
- 机构：Chinese Acad Sci;East China Univ Sci & Technol;Chinese Acad Agr Sci;Chinese Acad Sci;Qilu Univ Technol
- 来源：NATURE BIOTECHNOLOGY 2020
- 关键词：Ketones - Metabolism - Biochemistry - Bacteria - Metabolites - Glycerol
- Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p被引量：58收藏
- 作者：Tong, Yaojun Zhang, Jingyu Sun, Nuo Wang, Xiang-Ming Wei, Qi Zhang, Yu Huang, Ren Pu, Yingying Dai, Huanqin Ren, Biao Pei, Gang Song, Fuhang Zhu, Guoliang Wang, Xinye Xia, Xuekui Chen, Xiangyin Jiang, Lan Wang, Shenlin Ouyang, Liming Xie, Ning Zhang, Buchang Jiang, Yuanying Liu, Xueting Calderone, Richard Bai, Fan Zhang, Lixin Alterovitz, Gil
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Peking Univ;Georgetown Univ
- 来源：SCIENCE BULLETIN 2021
- 关键词：Candida albicans Berberine Multidrug-resistance Drug excretion transporter Mitochondria
- Chrysomycin A Derivatives for the Treatment of Multi-Drug-Resistant Tuberculosis被引量：54收藏
- 作者：Wu, Fan Zhang, Jing Song, Fuhang Wang, Sanshan Guo, Hui Wei, Qi Dai, Huanqin Chen, Xiangyin Xia, Xuekui Liu, Xueting Zhang, Lixin Yu, Jin-Quan Lei, Xiaoguang
- 机构：Peking Univ;Peking Univ;Chinese Acad Sci;East China Univ Sci & Technol;Qilu Univ Technol
- 来源：ACS CENTRAL SCIENCE 2020
- Characterizing Y224 conformational flexibility in FtmOx1-catalysis using 19F NMR spectroscopy被引量：36收藏
- 作者：Wang, Xinye Yang, Lingyun Wang, Shenlin Wang, Jun Li, Kelin Naowarojna, Nathchar Ju, Yi Ye, Ke Han, Yuchen Yan, Wupeng Liu, Xueting Zhang, Lixin Liu, Pinghua
- 机构： State Key Laboratory of Bioreactor Engineering; iHuman Institute; School of Life Sciences and Biotechnology; Department of Chemistry; Program of Chemistry
- 来源：Catalysis Science and Technology 2024
- 关键词：Biosynthesis - Complexation - Conformations - Nuclear magnetic resonance spectroscopy
- High-yield porphyrin production through metabolic engineering and biocatalysis被引量：34收藏
- 作者：Chen, Haihong Wang, Yaohong Wang, Weishan Cao, Ting Zhang, Lu Wang, Zhengduo Chi, Xuran Shi, Tong Wang, Huangwei He, Xinwei Liang, Mindong Yang, Mengxue Jiang, Wenyi Lv, Dongyuan Yu, Jiaming Zhu, Guoliang Xie, Yongtao Gao, Bei Wang, Xinye Liu, Xueting Li, Youyuan Ouyang, Limin Zhang, Jingyu Liu, Huimin Li, Zilong Tong, Yaojun Xia, Xuekui Tan, Gao-Yi Zhang, Lixin
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Shanghai Jiao Tong Univ;Qilu Univ Technol
- 来源：NATURE BIOTECHNOLOGY 2025
- 关键词：Catalysis - Diagnosis - Fermentation - Medical applications - Metabolic engineering
- Genome-based mining of new antimicrobial meroterpenoids from the phytopathogenic fungus Bipolaris sorokiniana strain 11134被引量：32收藏
- 作者：Han, Jianying Zhang, Jingyu Song, Zhijun Zhu, Guoliang Liu, Miaomiao Dai, Huanqin Hsiang, Tom Liu, Xueting Zhang, Lixin Quinn, Ronald J. Feng, Yunjiang
- 机构：Griffith Univ;Chinese Acad Sci;East China Univ Sci & Technol;Univ Guelph
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Meroterpenoids Phytopathogenic fungus Bipolaris sorokiniana Genome-based mining Antimicrobial activity
- A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137被引量：24收藏
- 作者：Zhang, Jingyu Li, Bixiao Qin, Yujie Karthik, Loganathan Zhu, Guoliang Hou, Chengjian Jiang, Lan Liu, Miaomiao Ye, Xin Liu, Mei Hsiang, Tom Dai, Huanqin Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Anhui Univ;Chinese Acad Sci;Sri Shakthi Inst Engn & Technol Autonomous;Griffith Univ
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Abyssomicin Proximicin Marine-derived Verrucosispora sp OSMAC Anti-influenza A virus
- Genome- and MS-based mining of antibacterial chlorinated chromones and xanthones from the phytopathogenic fungus Bipolaris sorokiniana strain 11134被引量：23收藏
- 作者：Han, Jianying Zhang, Jingyu Song, Zhijun Liu, Miaomiao Hu, Jiansen Hou, Chengjian Zhu, Guoliang Jiang, Lan Xia, Xuekui Quinn, Ronald J. Feng, Yunjiang Zhang, Lixin Hsiang, Tom Liu, Xueting
- 机构：Chinese Acad Sci;Griffith Univ;Univ Chinese Acad Sci;East China Univ Sci & Technol;Qilu Univ Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2019
- 关键词：Genome-based mining Halogenase Phytopathogenic fungus Bipolaris sorokiniana Antibacterial activity
- Recent advances in biotechnology for marine enzymes and molecules被引量：21收藏
- 作者：Zhang, Jingyu Jiang, Lan Chen, Xiangyin Lv, Kangjie Basiony, Mostafa Zhu, Guoliang Karthik, Loganathan Ouyang, Liming Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Salem Microbes Private Ltd
- 来源：CURRENT OPINION IN BIOTECHNOLOGY 2021
- 关键词：Synthetic biology - Ecosystems - Metabolic engineering - Marine applications - Molecules
- Dissecting the Mechanism of the Nonheme Iron Endoperoxidase FtmOx1 Using Substrate Analogues被引量：19收藏
- 作者：Zhu, Guoliang Yan, Wupeng Wang, Xinye Cheng, Ronghai Naowarojna, Nathchar Wang, Kun Wang, Jun Song, Heng Wang, Yuyang Liu, Hairong Xia, Xuekui Costello, Catherine E. Liu, Xueting Zhang, Lixin Liu, Pinghua
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Boston Univ;Wuhan Univ;Qilu Univ Technol
- 来源：JACS AU 2022
- 关键词：FtmOx1 nonheme iron enzymes endoperoxidation hydroxylation dehydrogenation X-ray structure
- New cryptotanshinone derivatives with anti-influenza A virus activities obtained via biotransformation by Mucor rouxii被引量：19收藏
- 作者：He, Wenni Li, Yao Qin, Yuejie Tong, Xiaomei Song, Zhijun Zhao, Yu Wei, Ran Li, Li Dai, Huanqin Wang, Wenzhao Luo, Houwei Ye, Xin Zhang, Lixin Liu, Xueting
- 机构：Chinese Acad Sci;Chinese Acad Med Sci;Peking Union Med Coll;Univ Chinese Acad Sci;Chinese Acad Med Sci
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2017
- 关键词：Cryptotanshinone Biotransformation Mucor rouxii Anti-influenza A virus activity
- Antibacterial polyene-polyol macrolides and cyclic peptides from the marine-derived Streptomyces sp. MS110128被引量：18收藏
- 作者：Jiang, Lan Huang, Pei Ren, Biao Song, Zhijun Zhu, Guoliang He, Wenni Zhang, Jingyu Oyeleye, Ayokunmi Dai, Huanqin Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Zunyi Med Univ;Sichuan Univ;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2021
- 关键词：Marine-derived Actinomycete Candida albicans Polyene Cyclic peptides
- Molecular networking assisted discovery and biosynthesis elucidation of the antimicrobial spiroketals epicospirocins被引量：18收藏
- 作者：Zhu, Guoliang Hou, Chengjian Yuan, Weize Wang, Zhenzhen Zhang, Jingyu Jiang, Lan Karthik, Loganathan Li, Bixiao Ren, Biao Lv, Kangjie Lu, Wanying Cong, Zhanren Dai, Huanqin Hsiang, Tom Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Salem Microbes Private Ltd;Sichuan Univ;Sichuan Univ;Chinese Acad Sci
- 来源：CHEMICAL COMMUNICATIONS 2020
- 关键词：Biochemistry - Chirality
- Genome-guided investigation of anti-inflammatory sesterterpenoids with 5-15 trans-fused ring system from phytopathogenic fungi被引量：15收藏
- 作者：Jiang, Lan Zhu, Guoliang Han, Jianying Hou, Chengjian Zhang, Xue Wang, Zhixin Yuan, Weize Lv, Kangjie Cong, Zhanren Wang, Xinye Chen, Xiangyin Karthik, Loganathan Yang, Huanting Wang, Xuyuan Tan, Gaoyi Liu, Guang Zhao, Liya Xia, Xuekui Liu, Xiangyang Gao, Shushan Ma, Lei Liu, Mei Ren, Biao Dai, Huanqin Quinn, Ronald J. Hsiang, Tom Zhang, Jingyu Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Griffith Univ;Qilu Univ Technol;T3 Biosci LLC
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2021
- 关键词：Fungi Bifunctional terpene synthases Terpenoids Anti-inflammatory
- Characterization of anti-BCG benz[α]anthraquinones and new siderophores from a Xinjiang desert-isolated rare actinomycete Nocardia sp. XJ31被引量：12收藏
- 作者：Zhang, Li Zhang, Jingyu Ren, Biao Lu, Wanying Hou, Chengjian Wang, Jian Ma, Xiaolong Ma, Rong Liu, Mei Liu, Zhiheng Li, Jin-Ping Ding, Kan Dai, Huanqin Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Boston Univ;Sichuan Univ;Sichuan Univ
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Xinjiang desert Nocardiasp Anti-BCG Brasiliquinone Nocardimicin
- Biochemical and Structural Characterization of OvoA Th2 : A Mononuclear Nonheme Iron Enzyme from Hydrogenimonas thermophila for Ovothiol Biosynthesis被引量：12收藏
- 作者：Wang, Xinye Hu, Sha Wang, Jun Zhang, Tao Ye, Ke Wen, Aiwen Zhu, Guoliang Vegas, Arturo Zhang, Lixin Yan, Wupeng Liu, Xueting Liu, Pinghua
- 机构：East China Univ Sci & Technol;Boston Univ;Shanghai Jiao Tong Univ
- 来源：ACS CATALYSIS 2023
- 关键词：nonheme iron enzyme ovothiol ergothionEIne X-ray structure regioselectivity sulfur-containingnatural products
- Schultriene and nigtetraene: two sesterterpenes characterized from pathogenetic fungi via genome mining approach被引量：12收藏
- 作者：Jiang, Lan Yang, Huanting Zhang, Xue Li, Xiaoying Lv, Kangjie Zhang, Weiyan Zhu, Guoliang Liu, Chengwei Wang, Yongheng Hsiang, Tom Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci Technol;Northeast Forestry Univ;Jinan Univ;Univ Guelph
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2022
- 关键词：Bifunctional terpene synthases Sesterterpene Genome mining Heterologous expression Cyclization mechanisms
- Function Switch of a Fungal Sesterterpene Synthase through Molecular Dynamics Simulation Assisted Alteration of an Aromatic Residue Cluster in the Active Pocket of PfNS被引量：11收藏
- 作者：Zhang, Weiyan Wang, Xinye Zhu, Guoliang Zhu, Bin Peng, Kaitong Hsiang, Tom Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Ludong Univ;Univ Guelph
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2024
- 关键词：aromatic residue cluster sesterterpene synthase molecular dynamics mutagenesis terpenoids
- Expanding catalytic promiscuity of a bifunctional terpene synthase through a single mutation-induced change in hydrogen-bond network within the catalytic pocket被引量：8收藏
- 作者：Wang, Xinye Huang, Yiyi Zhang, Weiyan Lv, Kangjie Li, Xiaoying Wang, Zhixin Zhang, Li Hsiang, Tom Zhang, Lixin Ouyang, Liming Liu, Xueting
- 机构：East China Univ Sci & Technol;Boston Univ;Univ Guelph
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2024
- 关键词：Bifunctional terpene synthase Sesterterpene Carbocation transportation Density functional theory calculations Molecular dynamics simulations
- Chemical control over the conversion between bicyclic and polycyclic terpenes by fungal bifunctional terpene synthases被引量：8收藏
- 作者：Wang, Xinye Wang, Zhixin Zhu, Guoliang Jiang, Lan Zhang, Weiyan Huang, Yiyi Cong, Zhanren Zhao, Yi-Lei Xu, Jian-He Hsiang, Tom Zhang, Lixin Chen, Qi Liu, Xueting
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;Univ Guelph
- 来源：CHEMICAL COMMUNICATIONS 2022
- 关键词：Catalysis - Terpenes
- Scalable secondary metabolite production in Streptomyces using a plug-and-play system被引量：5收藏
- 作者：Yang, Bowen Li, Zilong Zhang, Jingyu Qiu, Shiwen Liu, Xueting Liang, Zonglin Yan, Hao Zhang, Yanyan Liu, Lihong Xia, Bing Bao, Lianqun Li, Defeng Zhou, Shanshan Corre, Christophe Zhang, Chengyu Lu, Yinhua Tan, Gao-Yi Xia, Xuekui Li, Shanshan Zhang, Lixin Wang, Weishan
- 机构：East China Univ Sci & Technol ECUST;East China Univ Sci & Technol ECUST;Chinese Acad Sci;Beijing Key Lab Genet Element Biosourcing & Intell;Chinese Acad Agr Sci
- 来源：NATURE BIOTECHNOLOGY 2025
- 关键词：Biomolecules - Strain
- Serine 85 functions as a catalytic acid in the reprotonation process during EvAS-catalyzed astellifadiene biosynthesis被引量：3收藏
- 作者：Zhang, Weiyan Peng, Kaitong Lan, Keying Xu, Kangwei Wu, Ruibo Hsiang, Tom Nie, Shaoping Zhang, Lixin Wang, Xinye Liu, Xueting
- 机构：East China Univ Sci & Technol;Sun Yat Sen Univ;Univ Guelph;Nanchang Univ;Ludong Univ
- 来源：CHEMICAL COMMUNICATIONS 2024
- 关键词：Biosynthesis - Catalysis
- NPtagM: A Tailoring Enzyme Genome Mining Toolkit and Its Application in Terpenoid P450s from Phytopathogenic Fungi被引量：3收藏
- 作者：Cong, Zhanren Mukoma, Njeru Joe Yin, Qiang Zhu, Bin She, Lingwei Hsiang, Tom Zhang, Lixin Jiang, Lan Liu, Xueting
- 机构：East China Univ Sci Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Beijing Inst Technol;Univ Guelph
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2024
- 关键词：NPtagM tailoring enzyme genome mining terpenoids cytochrome P450 phytopathogenic fungi
- Identifying sesterterpenoids via feature-based molecular networking and small-scale fermentation被引量：2收藏
- 作者：Lv, Kangjie Duan, Yuyang Li, Xiaoying Wang, Xinye Xing, Cuiping Lan, Keying Zhu, Bin Zhu, Guoliang Qiu, Yuyang Li, Songwei Hsiang, Tom Zhang, Lixin Jiang, Lan Liu, Xueting
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shandong Univ Finance & Econ;Shanghai Univ;Univ Guelph
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2024
- 关键词：Bifunctional terpene synthases Feature-based molecular networking Cytochrome P450 Aspergillus oryzae Heterologous expression
- Genome Mining and Heterologous Expression-Guided Discovery of Mangicol Sesterterpenoids with Antimicrobial and Antineuroinflammatory Activities被引量：2收藏
- 作者：Xing, Cuiping Yang, Huanting Lv, Kangjie Lan, Keying Zhu, Guoliang Zhu, Bin Ren, Biao Jiang, Yi Jiang, Chenglin Dai, Huanqin Mo, Xuming Hsiang, Tom Abdelmageed, Wael M. Zhang, Lixin Jiang, Lan Liu, Xueting
- 机构：East China Univ Sci & Technol;Sichuan Univ;Sichuan Univ;Yunnan Univ;Chinese Acad Sci
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2025
- 关键词：phytopathogenic fungus sesterterpenoid heterologousexpression mangicol FBMN antibacterialactivity antineuroinflammatory
- G2 Helix as the Plastic Region Modulating Diastereoselectivity of Cyclization in Fungal Bifunctional Sesterterpene Synthases被引量：2收藏
- 作者：Zhang, Weiyan Xu, Kangwei Lan, Keying Xu, Wujue Peng, Kaitong Lv, Kangjie Zhang, Yanye Zhang, Jingyu Nie, Shaoping Jiang, Yi Hsiang, Tom Zhang, Lixin Wu, Ruibo Liu, Xueting
- 机构：East China Univ Sci & Technol;Sun Yat Sen Univ;Nanchang Univ;Yunnan Univ;Univ Guelph
- 来源：ACS CATALYSIS 2025
- 关键词：G2 helix fungal sesterterpenesynthase diastereoselectivity mutagenesis conformational flexibility
- Correspondence on "Structural Insight into the Catalytic Mechanism of the Endoperoxide Synthase FtmOx1"被引量：1收藏
- 作者：Zhang, Lixin Liu, Xueting Wang, Xinye Zhu, Guoliang Song, Heng Cheng, Ronghai Naowarojna, Nathchar Costello, Catherine E. E. Liu, Pinghua
- 机构：East China Univ Sci & Technol;Wuhan Univ;Boston Univ
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2023
- 关键词：Biosynthesis Endoperoxides FtmOx1 Iron Non-heme enzymes
- Reprogramming ThDP Enzymes for Z-Alkenes: Overriding Thermodynamic Preference via Noncovalent Controls被引量：0收藏
- 作者：Li, Huangong Yang, Tairan Zhao, Yilong Pan, Rui Peng, Jinmin Lai, Yinhong Zhang, Jingyu Liu, Xueting Zhu, Guoliang Zhang, Lixin Chi, Yonggui Robin Xie, Yongtao
- 机构：East China Univ Sci & Technol;Nanyang Technol Univ;Guizhou Univ;Chinese Acad Sci
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2026
- 关键词：C (programming language) - Chelation - Chemical bonds - Complexation - Dehalogenation - Enzymes - Ligands - Plants (botany) - Scaffolds - Stereochemistry - Thermodynamics
- Genome Mining Guided Discovery of Macrocyclic Sesterterpenoids with Anti-MRSA and Anti-Neuroinflammatory Activities被引量：0收藏
- 作者：Lan, Keying Wang, Zhennan Lv, Kangjie Xing, Cuiping Li, Xiaoying Yin, Qiang Chen, Yuwei Mo, Xuming Mao, Xiaobo Wu, Weijie Hsiang, Tom Zhang, Lixin Dai, Huanqin Liu, Xueting Zhu, Guoliang Jiang, Lan
- 机构：East China Univ Sci Technol;Nanjing Tech Univ;Nanjing Med Univ;Nanjing Med Univ;Johns Hopkins Univ
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2025
- 关键词：bifunctional terpene synthases macrocyclic sesterterpenoids heterologous expression biosynthetic pathway antibacterial activity
- Boosting mRNA Therapeutics: pHLIP Enhances Endosomal Escape and Gene Expression in Lipid Nanoparticle被引量：0收藏
- 作者：Liu, Caixia Zhang, Kaixiang Ge, Ruijie Wang, Wenya Liu, Xueting Li, Xuan Hao, Pei Li, Honglin
- 机构：Lingang Lab;Chinese Acad Sci;East China Univ Sci Technol;ChemPartner PharmaTech Co Ltd;Chinese Acad Sci
- 来源：ADVANCED HEALTHCARE MATERIALS 2026
- 关键词：endosomal escape lipid nanoparticles mRNA delivery mRNA vaccine pHLIP
