成果/Result
- Risk assessment of antibiotic resistance genes in the drinking water system被引量：104收藏
- 作者：Hu, Yaru Jiang, Lei Sun, Xiaoyan Wu, Jianqiang Ma, Lei Zhou, Yanbo Lin, Kuangfei Luo, Yi Cui, Changzheng
- 机构：East China Univ Sci & Technol;Shanghai Inst Pollut Control & Ecol Secur;Natl Engn Res Ctr Urban Water Resources;East China Univ Sci & Technol;Shanghai Acad Environm Sci
- 来源：SCIENCE OF THE TOTAL ENVIRONMENT 2021
- 关键词：Antibiotic resistance genes Chlorine-resistant Drinking water system Resistance risk ranking in drinking water system ((RDW)-D-3) Risk assessment Trace level antibiotics
- Occurrence, distribution, and seasonal variation of antibiotics in an artificial water source reservoir in the Yangtze River delta, East China被引量：64收藏
- 作者：Cui, Changzheng Han, Qi Jiang, Lei Ma, Lei Jin, Lei Zhang, Dong Lin, Kuangfei Zhang, Tianyang
- 机构：East China Univ Sci & Technol;Natl Engn Res Ctr Urban Water Resources;East China Univ Sci & Technol
- 来源：ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 2018
- 关键词：Antibiotics Variation Risk assessment Artificial water source reservoir
- An efficient and environmentally friendly procedure for synthesis of pyrimidinone derivatives by use of a Biginelli-type reaction被引量：49收藏
- 作者：Lei, Min Ma, Lei Hu, Lihong
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：MONATSHEFTE FUR CHEMIE 2010
- 关键词：Multicomponent reactions Aldehyde Organocatalyst Green chemistry
- FeCl3 and morpholine as efficient cocatalysts for the one-step synthesis of quinoxalines from α-hydroxyketones and 1,2-diamines被引量：47收藏
- 作者：Liu, Peng Lei, Min You, Hanyun Chen, Xubing Chen, Hu Ma, Lei Hu, Lihong
- 机构： School of Pharmacy; Shanghai Institute of Materia Medica
- 来源：Synthetic Communications 2012
- 关键词：Chlorine compounds - Conversion efficiency - Hydrogen bonds - Ketones
- Thiamine Hydrochloride-Catalyzed One-Pot Synthesis of 1,4-Dihydropyridine Derivatives Under Solvent-Free Conditions被引量：41收藏
- 作者：Lei, Min Ma, Lei Hu, Lihong
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：SYNTHETIC COMMUNICATIONS 2011
- 关键词：Aldehydes 1 4-dihydropyridines Hantzsch reaction -keto ester thiamine hydrochloride (VB1)
- One-pot synthesis of 1 H-benzimidazole derivatives using thiamine hydrochloride as a reusable organocatalyst被引量：39收藏
- 作者：Lei, Min Ma, Lei Hu, Lihong
- 机构： Shanghai Research Center for Modernization of Traditional Chinese Medicine; School of Pharmacy; Shanghai Institute of Materia Medica
- 来源：Synthetic Communications 2012
- 关键词：Aldehydes - Aromatic compounds - Dimethylformamide - Metal ions - Metal recovery
- HIGHLY CHEMOSELECTIVE CONDENSATION OF β-NAPHTHOL, ALDEHYDE, AND UREA CATALYZed BY THIAMINE HYDROCHLORIDE被引量：35收藏
- 作者：Lei, Min Ma, Lei Hu, Lihong
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：SYNTHETIC COMMUNICATIONS 2011
- 关键词：Catalysis chemoselective multicomponent reactions (MCRs) beta-naphthol thiamine hydrochloride (VB1)
- Development of a method for trace level determination of antibiotics in drinking water sources by high performance liquid chromatography-tandem mass spectrometry被引量：33收藏
- 作者：Cheng, Wenhuan Jiang, Lei Lu, Ning Ma, Lei Sun, Xiaoyan Luo, Yi Lin, Kuangfei Cui, Changzheng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Natl Engn Res Ctr Urban Water Resources;Naikai Univ
- 来源：ANALYTICAL METHODS 2015
- 关键词：Extraction - Phase separation - Mass spectrometry - High performance liquid chromatography - Potable water - Trace analysis - Water quality
- Metabolic pathway for degradation of anthracene by halophilic Martelella sp AD-3被引量：33收藏
- 作者：Cui, Changzheng Ma, Lei Shi, Jie Lin, Kuangfei Luo, Qishi Liu, Yongdi
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Acad Environm Sci
- 来源：INTERNATIONAL BIODETERIORATION & BIODEGRADATION 2014
- 关键词：Anthracene Biodegradation Moderate halophilic bacteria Metabolic pathway 3-Hydroxy-2-naphthoic acid
- Cu(ClO4)2.6H2O as an efficient catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones under solvent-free conditions被引量：32收藏
- 作者：Lei, Min Ma, Lei Hu, Lihong
- 机构： School of Pharmacy; Shanghai Institute of Materia Medica
- 来源：Synthetic Communications 2011
- 关键词：Urea
- A facile protocol for the synthesis of 4-aryl-1,4,7,8-tetrahydro-3,5- dimethyldipyrazolo[3,4-b:4′,3′-e]pyridine derivatives by a Hantzsch-type reaction被引量：32收藏
- 作者：Zhao, Kun Lei, Min Ma, Lei Hu, Lihong
- 机构： Shanghai Research Center for Modernization of Traditional Chinese Medicine; School of Pharmacy
- 来源：Monatshefte fur Chemie 2011
- 关键词：Catalysts - Condensation reactions - Environmental impact - Pyridine - Synthesis (chemical)
- HClO4-SiO2 as an efficient and recyclable catalyst for the synthesis of amide derivatives被引量：31收藏
- 作者：Song, Weibin Ma, Lei Hu, Lihong
- 机构： School of Pharmacy; Shanghai Institute of Materia Medica
- 来源：Synthetic Communications 2011
- 关键词：Alkylation - Catalysts - Chlorine compounds - Condensation - Silica - Sulfur compounds
- Immunosuppression effect of Withangulatin A from Physalis angulata via heme oxygenase 1-dependent pathways被引量：30收藏
- 作者：Sun, Lijuan Liu, Jianwen Liu, Ping Yu, Youjun Ma, Lei Hu, Lihong
- 机构： State Key Laboratory of Bioreactor Engineering; LongHua Hospital; Shanghai Innovative Research Center of Traditional Chinese Medicine
- 来源：Process Biochemistry 2011
- 关键词：Porphyrins
- C21 steroidal glycosides from Cynanchum wilfordii被引量：27收藏
- 作者：Xiang, Wen-Juan Ma, Lei Hu, Li-Hong
- 机构： School of Pharmacy; Shanghai Research Center for Modernization of Traditional Chinese Medicine
- 来源：Helvetica Chimica Acta 2009
- 关键词：Glycosides - Nuclear magnetic resonance spectroscopy - Sugars
- Six new C21 steroidal glycosides from Cynanchum bungEI Decne被引量：22收藏
- 作者：Gan, Hao Xiang, Wen-Juan Ma, Lei Hu, Li-Hong
- 机构： School of Pharmacy; Shanghai Research Center for Modernization of Traditional Chinese Medicine
- 来源：Helvetica Chimica Acta 2008
- 关键词：Sugars - Nuclear magnetic resonance spectroscopy - Glycosides
- Genome-guided investigation of anti-inflammatory sesterterpenoids with 5-15 trans-fused ring system from phytopathogenic fungi被引量：15收藏
- 作者：Jiang, Lan Zhu, Guoliang Han, Jianying Hou, Chengjian Zhang, Xue Wang, Zhixin Yuan, Weize Lv, Kangjie Cong, Zhanren Wang, Xinye Chen, Xiangyin Karthik, Loganathan Yang, Huanting Wang, Xuyuan Tan, Gaoyi Liu, Guang Zhao, Liya Xia, Xuekui Liu, Xiangyang Gao, Shushan Ma, Lei Liu, Mei Ren, Biao Dai, Huanqin Quinn, Ronald J. Hsiang, Tom Zhang, Jingyu Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Griffith Univ;Qilu Univ Technol;T3 Biosci LLC
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2021
- 关键词：Fungi Bifunctional terpene synthases Terpenoids Anti-inflammatory
- A three-dimensional (3D) liver-kidney on a chip with a biomimicking circulating system for drug safety evaluation被引量：15收藏
- 作者：Huang, Qihong Yang, Tianhao Song, Yunpeng Sun, Wenxuan Xu, Jian Cheng, Ya Yin, Ruixue Zhu, Lili Zhang, Mengting Ma, Lei Li, Honglin Zhang, Hongbo
- 机构：East China Univ Sci & Technol;East China Normal Univ;East China Univ Sci & Technol
- 来源：LAB ON A CHIP 2024
- 关键词：Animals - Cell culture - Drug products - Etching - Metabolism - Metabolites - Ultrafast lasers
- Cassane-type diterpenoids from the seeds of Caesalpinia magnifoliolata被引量：9收藏
- 作者：Yin, Hua Ma, Lei Hu, Li-Hong
- 机构： Shanghai Research Center for Modernization of Traditional Chinese Medicine; School of Pharmacy
- 来源：Helvetica Chimica Acta 2008
- 关键词：Spectroscopic analysis - Nuclear magnetic resonance spectroscopy
- Extracts from Chinese herbs with anti-amyloid and neuroprotective activities被引量：9收藏
- 作者：Bednarikova, Zuzana Gancar, Miroslav Wang, Rui Zheng, Lulu Tang, Yun Luo, Yating Huang, Yan Spodniakova, Barbora Ma, Lei Gazova, Zuzana
- 机构：Slovak Acad Sci;East China Univ Sci & Technol
- 来源：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2021
- 关键词：Amyloid beta(42) peptide Fibrils destruction Chinese herbs Neuroprotection
- Synthesis-accessibility-oriented design of c-Jun N-terminal kinase 1 inhibitor被引量：8收藏
- 作者：Qian, Hewen Ding, Yuanqing Deng, Xingyu Huang, Weiwei Li, Zhenzhen Liu, Fengling Zhang, Jie Wang, Lihui Liu, Junping Yuan, Yaxia Hou, Shurong Chen, Xiabin Ma, Lei
- 机构：East China Univ Sci & Technol;Hangzhou Normal Univ;Key Lab Elemene Class Anti Canc Chinese Med;Engn Lab Dev & Applicat Tradit Chinese Med;Hangzhou Normal Univ
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2023
- 关键词：Idiopathic pulmonary fibrosis c -Jun N-Terminal kinase Synthesis-accessibility Inhibitor Pyrimidine-2 4-diamine Structure-activity relationship Fragment-based drug design
- Investigation of Anti-AlzhEImer?s Mechanisms of Sarsasapogenin Derivatives by Network-Based Combining Structure-Based Methods被引量：6收藏
- 作者：Zhou, Moran Sun, Jiamin Yu, Zhuohang Wu, Zengrui Li, Weihua Liu, Guixia Ma, Lei Wang, Rui Tang, Yun
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING 2023
- 关键词：Association reactions - Atomic absorption spectrometry - Forecasting - Tensors
- Synthesis of 1,2-disubstituted 1,2-dihydropyrrolo[3,4-b]indol-3(4H)-one derivatives被引量：5收藏
- 作者：Ma, Fei Ma, Lei Lei, Min Hu, Lihong
- 机构：E China Univ Sci & Technol;Shanghai Inst Mat Med
- 来源：MONATSHEFTE FUR CHEMIE 2014
- 关键词：Aldehyde Amine 1H-Indole-2-carboxylic acid Mannich reaction
- TCMFVis: A visual analytics system toward bridging together traditional Chinese medicine and modern medicine被引量：4收藏
- 作者：Jin, Yichao Zhu, Fuli Li, Jianhua Ma, Lei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：VISUAL INFORMATICS 2023
- 关键词：Traditional Chinese medicine Visual analytics Set visualization Molecular mechanism
- A validated UPLC-MS/MS method for quantitative determination of a potent neuroprotective agent Sarsasapogenin-AA13 in rat plasma: Application to pharmacokinetic studies被引量：3收藏
- 作者：Pei, Lixia Ye, Yiyi Zhao, Wenshu Ye, Qun Ge, Songlan Jiang, Zi-wei Liang, Xiao-qiang Gan, Hai-xian Ma, Lei
- 机构：Shanghai Univ Tradit Chinese Med;East China Univ Sci & Technol
- 来源：BIOMEDICAL CHROMATOGRAPHY 2020
- 关键词：pharmacokinetics neuroprotective effect sarsasapogenin-AA13 UPLC-MS MS
- Crystal Structure Prediction Synergizes with Crystallization Tendency Analysis: A Case Study in Polymorph Screening of a Novel PRMT5 Inhibitor被引量：0收藏
- 作者：Zhou, Yanfeng Zhang, Yizu Song, Zhengtian Liu, Xiang Yao, Jia Zeng, Qun Sun, Guangxu Li, Mingxi Yang, Zhuocen Ma, Lei
- 机构：East China Univ Sci & Technol;Shanghai Apeiron Therapeut Co Ltd;XtalPi Inc
- 来源：CRYSTAL GROWTH & DESIGN 2026
- 关键词：Polymorphism - Thermodynamics
- Development of cocaine esterase W/O/W nanoemulsions by a novel low-temperature double emulsification approach for cocaine abuse treatment被引量：0收藏
- 作者：Wang, Weimin Deng, Xingyu Xu, Nuo Li, Hualing Lai, Suitian Li, Zhenzhen Hu, Qi Chi, Man Liu, Fengling Ma, Lei Liu, Junjun Chen, Wenwen Hou, Shurong Chen, Xiabin
- 机构：Hangzhou Normal Univ;East China Univ Sci & Technol;Westlake Univ;Huazhong Univ Sci & Technol
- 来源：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2025
- 关键词：Cocaine esterase Enzyme preparations Nanoemulsions Detoxification Stability Half-life
- Development and validation of a UPLC-MS/MS method for determination of Sarsasapogenin-AA22 in rat plasma and its application to a pharmacokinetic study被引量：0收藏
- 作者：Pei, Lixia Ge, Songlan Ye, Yiyi Jiang, Ziwei Liang, Xiaoqiang Zhao, Wenshu Ma, Lei
- 机构：Shanghai Univ Tradit Chinese Med;East China Univ Sci & Technol
- 来源：BIOMEDICAL CHROMATOGRAPHY 2018
- 关键词：diosgenin LC MS MS pharmacokinetics sarsasapogenin-AA22
- CO2-Promoted Direct Oxygenation of Benzylic sp3 C-H Bonds Using Sodium Chlorite被引量：0收藏
- 作者：Liu, Chaoyang Xu, Ning Zhang, Lanling Gu, Wenjing Chu, Changhu Ma, Lei
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF ORGANIC CHEMISTRY 2025
- 关键词：Oxygenation - pH - Sodium
- Computationally guided cross-linking overcomes interfacial mismatch in protEIn dimerization: Creating a long-acting cocaine esterase被引量：0收藏
- 作者：Deng, Xingyu Wang, Zhiguo Hou, Yuxin Xu, Nuo Li, Zhenzhen Hu, Qi Mo, Nan Ren, Ziying Chen, Cong Hou, Shurong Chen, Xiabin Ma, Lei
- 机构：East China Univ Sci & Technol;Hangzhou Normal Univ;Hangzhou Normal Univ
- 来源：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2026
- 关键词：Cocaine esterase ProtEIn stability BMOE cross-linking Pharmacokinetics ProtEIn therapy ProtEIn engineering
