成果/Result
- Metabolic engineering coupled with adaptive evolution strategies for the efficient production of high-quality L-lactic acid by Lactobacillus paracasei被引量：65收藏
- 作者：Tian, Xiwei Liu, Xuehua Zhang, Yifan Chen, Yang Hang, Haifeng Chu, Ju Zhuang, Yingping
- 机构：East China Univ Sci & Technol
- 来源：BIORESOURCE TECHNOLOGY 2021
- 关键词：Lactobacillus paracasei Lactic acid CRISPR Cas9 adaptive evolution Open fermentation
- Oxygen uptake rate optimization with nitrogen regulation for erythromycin production and scale-up from 50 L to 372 m3 scale被引量：64收藏
- 作者：Zou, Xiang Hang, Hai-feng Chu, Ju Zhuang, Ying-ping Zhang, Si-liang
- 机构：E China Univ Sci & Technol;Southwest Univ
- 来源：BIORESOURCE TECHNOLOGY 2009
- 关键词：Erythromycin Industrial scale Metabolic flux Oxygen uptake rate Scale-up
- Xanthan-Curdlan nexus for synthesizing edible food packaging films被引量：61收藏
- 作者：Mohsin, Ali Zaman, Waqas Qamar Guo, Meijin Ahmed, Waheed Khan, Imran Mahmood Niazi, Sobia Rehman, Abdur Hang, Haifeng Zhuang, Yingping
- 机构：East China Univ Sci & Technol;Natl Univ Sci & Technol NUST;Jiangnan Univ
- 来源：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2020
- 关键词：Xanthangum Curdlan Blendfilms
- Sustainable biosynthesis of curdlan from orange waste by using Alcaligenes faecalis: A systematically modeled approach被引量：48收藏
- 作者：Mohsin, Ali Sun, Jingyun Khan, Imran Mahmood Hang, Haifeng Tariq, Muhammad Tian, Xiwei Ahmed, Waqas Niazi, Sobia Zhuang, Yingping Chu, Ju Mohsin, Muhammad Zubair Salim-ur-Rehman Guo, Meijin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Jiangnan Univ;Univ Agr Faisalabad;Univ Agr Faisalabad
- 来源：CARBOHYDRATE POLYMERS 2019
- 关键词：Sustainable biosynthesis Orange peels Kinetics Curdlan Batch culture fermentation
- Effect of glycosylation on biochemical characterization of recombinant phytase expressed in Pichia pastoris被引量：44收藏
- 作者：Guo, Meijin Hang, Haifeng Zhu, Taicheng Zhuang, Yingping Chu, Ju Zhang, Siliang
- 机构：E China Univ Sci & Technol;Jiangxi Agr Univ
- 来源：ENZYME AND MICROBIAL TECHNOLOGY 2008
- 关键词：phytase glycosylation biochemical characterization thermostability micro-heterogeneity
- Enhancement of erythromycin A production with feeding available nitrogen sources in erythromycin biosynthesis phase被引量：36收藏
- 作者：Zou, Xiang Hang, Hai-feng Chu, Ju Zhuang, Ying-ping Zhang, Si-liang
- 机构：E China Univ Sci & Technol;Southwest Univ
- 来源：BIORESOURCE TECHNOLOGY 2009
- 关键词：Available nitrogen sources Biosynthesis phase Erythromycin A Industrial scale Scale up
- Kinetic analysis of curdlan production by Alcaligenes faecalis with maltose, sucrose, glucose and fructose as carbon sources被引量：33收藏
- 作者：Zhang, Qin Sun, Jingyun Wang, Zejian Hang, Haifeng Zhao, Wei Zhuang, Yingping Chu, Ju
- 机构：East China Univ Sci & Technol;Shan Dong Fu Yang Biol Technol Co Ltd
- 来源：BIORESOURCE TECHNOLOGY 2018
- 关键词：Alcaligenes faecalis Carbon sources Curdlan Kinetics
- Rationally optimized generation of integrated Escherichia coli with stable and high yield lycopene biosynthesis from heterologous mevalonate (MVA) and lycopene expression pathways被引量：32收藏
- 作者：Hussain, Muhammad Hammad Hong, Qi Zaman, Waqas Qamar Mohsin, Ali Wei, Yanlong Zhang, Ning Fang, Hongqing Wang, Zejian Hang, Haifeng Zhuang, Yingping Guo, Meijin
- 机构：East China Univ Sci & Technol;Natl Univ Sci & Technol NUST;Beijing Inst Biotechnol
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2021
- 关键词：Escherichia coli Lycopene biosynthesis Rational model of expression pathways Integrated MVA pathway Fermentation
- Mixomics analysis of Bacillus subtilis: effect of oxygen availability on riboflavin production被引量：28收藏
- 作者：Hu, Junlang Lei, Pan Mohsin, Ali Liu, Xiaoyun Huang, Mingzhi Li, Liang Hu, Jianhua Hang, Haifeng Zhuang, Yingping Guo, Meijin
- 机构：East China Univ Sci & Technol;Shanghai Acebright Pharmaceut Grp Co Ltd
- 来源：MICROBIAL CELL FACTORIES 2017
- 关键词：Riboflavin Bacillus subtilis Oxygen availability C-13 metabolic flux analysis Metabolomics Transcriptomics
- Efficient generation of male germ-like cells derived during co-culturing of adipose-derived mesenchymal stem cells with Sertoli cells under retinoic acid and testosterone induction被引量：21收藏
- 作者：Luo, Yanxia Xie, Lili Mohsin, Ali Ahmed, Waqas Xu, Chenze Peng, Yan Hang, Haifeng Zhuang, Yingping Chu, Ju Guo, Meijin
- 机构：East China Univ Sci & Technol
- 来源：STEM CELL RESEARCH & THERAPY 2019
- 关键词：adipose-derived mesenchymal stem cells Germ cell Sertoli cell Signaling pathways Retinoic acid Testosterone Synergistic effect
- Kinetic analysis of sodium gluconate production by Aspergillus niger with different inlet oxygen concentrations被引量：18收藏
- 作者：Tian, Xiwei Shen, Yuting Zhuang, Yingping Zhao, Wei Hang, Haifeng Chu, Ju
- 机构：East China Univ Sci & Technol;Shan Dong Fuyang Biol Technol Co Ltd
- 来源：BIOPROCESS AND BIOSYSTEMS ENGINEERING 2018
- 关键词：Aspergillus niger Sodium gluconate Oxygen Kinetics
- Application of oxygen uptake rate and response surface methodology for erythromycin production by Saccharopolyspora erythraea被引量：18收藏
- 作者：Zou, Xiang Hang, Hai-feng Chen, Chang-fa Chu, Ju Zhuang, Ying-ping Zhang, Si-liang
- 机构：E China Univ Sci & Technol;Southwest Univ
- 来源：JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY 2008
- 关键词：Bioreactors Erythromycin Fed-batch culture Physiology Process integration Response surface methodology
- Target-site directed rational high-throughput screening system for high sophorolipids production by Candida bombicola被引量：17收藏
- 作者：Chen, Yang Tian, Xiwei Li, Qianhui Li, Ya Chu, Ju Hang, Haifeng Zhuang, Yingping
- 机构：East China Univ Sci & Technol
- 来源：BIORESOURCE TECHNOLOGY 2020
- 关键词：Candida bombicola Sophorolipids Combined mutagenesis Relaxation culture Combined pressure
- Exploring the metabolic fate of propanol in industrial erythromycin-producing strain via 13C labeling experiments and enhancement of erythromycin production by rational metabolic engineering of Saccharopolyspora erythraea被引量：16收藏
- 作者：Xu, Feng Ke, Xiang Hong, Ming Huang, Mingzhi Chen, Chongchong Tian, Xiwei Hang, Haifeng Chu, Ju
- 机构：East China Univ Sci & Technol
- 来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2021
- 关键词：Saccharopolyspora erythraea Erythromycin Metabolic flux analysis N-Propanol Succinyl-CoA synthetase
- A simple fermentation strategy for high-level production of recombinant phytase by Pichia pastoris using glucose as the growth substrate被引量：16收藏
- 作者：Hang, Haifeng Ye, Xinhao Guo, Meijin Chu, Ju Zhuang, Yingping Zhang, Ming Zhang, Siliang
- 机构：E China Univ Sci & Technol;Jiangxi Agr Univ
- 来源：ENZYME AND MICROBIAL TECHNOLOGY 2009
- 关键词：Pichia pastoris Phytase Glucose Feeding strategy
- A simple unstructured model-based control for efficient expression of recombinant porcine insulin precursor by Pichia pastoris被引量：16收藏
- 作者：Hang, Hai-feng Chen, Wen Guo, Mei-jin Chu, Ju Zhuang, Ying-ping Zhang, Siliang
- 机构：E China Univ Sci & Technol;Jiangxi Agr Univ
- 来源：KOREAN JOURNAL OF CHEMICAL ENGINEERING 2008
- 关键词：Pichia pastoris Porcine Insulin Precursor Monod Modeling Methanol Feeding Strategy
- Differentiation roadmap of embryonic Sertoli cells derived from mouse embryonic stem cells被引量：14收藏
- 作者：Xu, Chenze Mohsin, Ali Luo, Yanxia Xie, Lili Peng, Yan Wang, Qizheng Hang, Haifeng Zhuang, Yingping Guo, Meijin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：STEM CELL RESEARCH & THERAPY 2019
- 关键词：Embryonic stem cells Embryonic Sertoli cells Lentiviral transduction Molecular mechanism Gonadogenesis Male determinant factors
- Unveiling the mechanism of efficient β-phenylethyl alcohol conversion in wild-type Saccharomyces cerevisiae WY319 through multi-omics analysis被引量：13收藏
- 作者：Yang, Chenghan Ren, Yilin Ge, Lihao Xu, Wenting Hang, Haifeng Mohsin, Ali Tian, Xiwei Chu, Ju Zhuang, Yingping
- 机构：East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY JOURNAL 2024
- 关键词：high-yield mechanism high-yielding strain multi-omics respiratory metabolism Saccharomyces cerevisiae beta-phenylethanol
- Polyphenol oxidase inhibition by Saccharomyces cerevisiae extracts: A promising approach to prevent enzymatic browning被引量：12收藏
- 作者：Liu, Zebo Ding, Hui Martuscelli, Maria Sajid, Saria Hang, Haifeng Mohsin, Ali Zhu, Xiaofeng Sun, Huijie Xia, Jianye Yin, Zhongping Zhuang, Yingping Guo, Meijin Wang, Zejian
- 机构：East China Univ Sci & Technol;Univ Teramo;Riphah Int Univ;Jiangxi Agr Univ;East China Univ Sci & Technol
- 来源：LWT-FOOD SCIENCE AND TECHNOLOGY 2024
- 关键词：Polyphenol oxidase inhibitor Saccharomyces cerevisiae extracts Reduced glutathione Anti-browning Molecular docking and dynamics simulation
- Co-culture with TM4 cells enhances the proliferation and migration of rat adipose-derived mesenchymal stem cells with high stemness被引量：12收藏
- 作者：Luo, Yanxia Mohsin, Ali Xu, Chenze Wang, Qizheng Hang, Haifeng Zhuang, Yingping Chu, Ju Guo, Meijin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CYTOTECHNOLOGY 2018
- 关键词：adipose-derived mesenchymal stem cells TM4 cells Co-culture mode Cell proliferation and migration Stemness
- Transcriptional investigation of the effect of mixed feeding to identify the main cellular stresses on recombinant Pichia pastoris被引量：11收藏
- 作者：Zhu, Taicheng Hang, Haifeng Chu, Ju Zhuang, Yingping Zhang, Siliang Guo, Meijin
- 机构：Chinese Acad Sci;E China Univ Sci & Technol
- 来源：JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY 2013
- 关键词：Mixed feeding Pichia pastoris Porcine insulin precursor Physiological stress mRNA quantitative analysis
- Computational Fluid Dynamics Modeling of an Inverted Frusto-conical Shaking Bioreactor for Mammalian Cell Suspension Culture被引量：11收藏
- 作者：Hang, Haifeng Guo, Yuanxin Liu, Jian Bai, Li Xia, Jianye Guo, Meijin Hui, Matthew
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：BIOTECHNOLOGY AND BIOPROCESS ENGINEERING 2011
- 关键词：inverted frusto-conical shaking bioreactor mammalian cell suspension culture mixing time volumetric oxygen transfer coefficient computational fluid dynamics simulation
- Oxygen-enriched fermentation of sodium gluconate by Aspergillus niger and its impact on intracellular metabolic flux distributions被引量：10收藏
- 作者：Shen, Yuting Tian, Xiwei Zhao, Wei Hang, Haifeng Chu, Ju
- 机构：East China Univ Sci & Technol;Shan Dong Fuyang Biol Technol Co Ltd
- 来源：BIOPROCESS AND BIOSYSTEMS ENGINEERING 2018
- 关键词：Gluconic acid Aspergillus niger Oxygen Metabolic flux distribution
- Promoter screening and identification for metabolic regulation in Acremonium chrysogenum被引量：10收藏
- 作者：Liu, Ling Li, Runge Zhang, Xinrun Chen, Zhen Mohsin, Ali Hang, Haifeng Tian, Xiwei Chu, Ju
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;POB 329
- 来源：BIOTECHNOLOGY JOURNAL 2024
- 关键词：Acremonium chrysogenum bidirectional promoter cephalosporin C Golden Gate assembly promoter library
- Combined available nitrogen resources enhanced erythromycin production and preliminary exploration of metabolic flux analysis under nitrogen perturbations被引量：9收藏
- 作者：Zhang, Qi Hang, Haifeng Tian, Xiwei Zeng, Wei Yu, Zhenhua Wang, Xiaojian Tang, Yin Zhuang, Yingping Chu, Ju
- 机构：East China Univ Sci & Technol;Yidu HEC Biochem Co Ltd
- 来源：BIOPROCESS AND BIOSYSTEMS ENGINEERING 2019
- 关键词：Erythromycin Available nitrogen sources Corn steep liquor Yeast powder Metabolic flux
- Application of 8-parallel micro-bioreactor system with non-invasive optical pH and DO biosensor in high-throughput screening of L-lactic acid producing strain被引量：8收藏
- 作者：Tian, Xiwei Zhou, Gang Wang, Weifei Zhang, Ming Hang, Haifeng Mohsin, Ali Chu, Ju Zhuang, Yingping Zhang, Siliang
- 机构：East China Univ Sci & Technol
- 来源：BIORESOURCES AND BIOPROCESSING 2018
- 关键词：High-throughput screening Lactic acid Lactobacillus paracasei Micro-bioreactor Optical biosensor
- The "Coexistence" of Ehrlich pathway and de novo pathway improves 2-PE synthesis in Saccharomyces cerevisiae被引量：6收藏
- 作者：Yang, Chenghan Lv, Qingqing Zhang, Li Jia, Huining Chen, Hailong Yang, Sainan Qiu, Yuxin Hang, Haifeng Mohsin, Ali Chu, Ju Zhuang, Yingping Tian, Xiwei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CHEMICAL ENGINEERING JOURNAL 2025
- 关键词：beta-Phenylethanol Saccharomyces cerevisiae Coexisting metabolism Specific growth rate Chemostat culture
- Response Surface Methodology for Optimization of the Erythromycin Production by Fed-Batch Fermentation Using an Inexpensive Biological Nitrogen Source被引量：5收藏
- 作者：Zou, X. Chen, C. -F. Hang, H. -F. Chu, J. Zhuang, Y. -P. Zhang, S. -L.
- 机构：E China Univ Sci & Technol;Southwest Univ
- 来源：CHEMICAL AND BIOCHEMICAL ENGINEERING QUARTERLY 2010
- 关键词：Biological nitrogen erythromycin production fed-batch strategy medium optimization response surface methodology Saccharopolyspora etythraea
- Variable selection in partial least squares with the weighted variable contribution to the first singular value of the covariance matrix被引量：5收藏
- 作者：Lin, Weilu Hang, Haifeng Zhuang, Yingping Zhang, Siliang
- 机构：East China Univ Sci & Technol
- 来源：CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS 2018
- 关键词：Informative variables Interval variable selection Partial least squares Variable contribution Maximal singular value Spectroscopy
- Evaluation of a Virus-like Nanoparticle Porcine Circovirus Type-2 (PCV2) Capsid Protein Fused with the Pig Immunoglobulin Fc Fragment as a Novel Vaccine Candidate against PCV2 in Mice被引量：5收藏
- 作者：Luo, Qingping Ahmed, Waqas Dai, Yichen Mohsin, Ali Hang, Haifeng Zhuang, Yingping Guo, Meijin
- 机构：East China Univ Sci & Technol
- 来源：VACCINES 2021
- 关键词：PCV2 capsid ( increment 1-41aa)-pFc fusion protein virus-like nanoparticles
