成果/Result
- Bioactive Indole Diketopiperazine Alkaloids from the Marine Endophytic Fungus Aspergillus sp. YJ191021被引量：29收藏
- 作者：Yang, Jin Gong, Lizhi Guo, Miaomiao Jiang, Yu Ding, Yi Wang, Zhijie Xin, Xiujuan An, Faliang
- 机构：East China Univ Sci & Technol;Beijing Technol & Business Univ
- 来源：MARINE DRUGS 2021
- 关键词：indole diketopiperazine alkaloids endophytic fungus Aspergillus sp antimicrobial
- Cloning of Thermostable Cellulase Genes of Clostridium thermocellum and Their Secretive Expression in Bacillus subtilis被引量：24收藏
- 作者：Liu, Jian-Ming Xin, Xiu-Juan Li, Chun-Xiu Xu, Jian-He Bao, Jie
- 机构：E China Univ Sci & Technol
- 来源：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 2012
- 关键词：Clostridium thermocellum Bacillus subtilis pP43JM2 Cellulase genes Synergy
- Perpyrrospirone A, an unprece dente d hirsutellone peroxide from the marine-derived Penicillium citrinum被引量：19收藏
- 作者：Ding, Yi Jiang, Yu Xu, Sunjie Xin, Xiujuan An, Faliang
- 机构：East China Univ Sci & Technol
- 来源：CHINESE CHEMICAL LETTERS 2023
- 关键词：Penicillium citrinum Hirsutellone Peroxide X-ray Cytotoxicity
- Association study of four activity SNPs of CYP3A4 with the precocious puberty in Chinese girls被引量：13收藏
- 作者：Xin, XJ Luan, XH Xiao, JH Wei, DZ Wang, JH Lu, DR Yang, SL
- 机构：E China Univ Sci & Technol;Fudan Univ;Shanghai Bioengn Res Ctr
- 来源：NEUROSCIENCE LETTERS 2005
- 关键词：precocious puberty CYP3A4 genetic variation
- Hypericin Enhances Paclitaxel-Induced B16-F10 Cell Apoptosis by Activating a Cytochrome c Release-Dependent Pathway被引量：11收藏
- 作者：Sun, Liyun Li, Zixuan Shang, Huoli Xin, Xiujuan
- 机构：East China Univ Sci & Technol
- 来源：FRONTIERS IN PHARMACOLOGY 2021
- 关键词：hypericin paclitaxel apoptosis B16-F10 cells mitochondrial dysfunction cytochrome c release
- Adsorption Characteristics and Enrichment of Emodin from Marine-Derived Aspergillus flavipes HN4-13 Extract by Macroporous Resin XAD-16被引量：11收藏
- 作者：Gong, Lizhi Wu, Yuzhen Qiu, Xiaohan Xin, Xiujuan An, Faliang Guo, Miaomiao
- 机构：Beijing Technol & Business Univ;East China Univ Sci & Technol
- 来源：MARINE DRUGS 2022
- 关键词：Aspergillus flavipes HN4-13 emodin macroporous resin XAD-16 adsorption kinetics and isotherms enrichment
- Enhancement of Emodin Production by Medium Optimization and KH2PO4 Supplementation in Submerged Fermentation of Marine-Derived Aspergillus favipes HN4-13被引量：11收藏
- 作者：Qiu, Xiaohan Gong, Lizhi Xin, Xiujuan An, Faliang
- 机构：East China Univ Sci & Technol
- 来源：MARINE DRUGS 2021
- 关键词：emodin Aspergillus favipes HN4-13 KH2PO4 submerged fermentation
- DMC triggers MDA-MB-231 cells apoptosis via inhibiting protective autophagy and PI3K/AKT/mTOR pathway by enhancing ROS level被引量：10收藏
- 作者：Jiang, Yu Xu, Sunjie Guo, Miaomiao Lu, Zhi Wei, Xing An, Faliang Xin, Xiujuan
- 机构：East China Univ Sci & Technol;Beijing Technol & Business Univ;Shanghai Inoherb Cosmet Co Ltd;Marine Biomed Sci & Technol Innovat Platform Linga
- 来源：TOXICOLOGY IN VITRO 2024
- 关键词：DMC MDA-MB-231 cells Apoptosis PI3K-AKT-mTOR pathway
- Protection effect of 20(S)-ginsenoside Rg2 extracted from cultured Panax notoginseng cells on hydrogen peroxide-induced cytotoxity of human umbilical cord vein endothelial cells in vitro被引量：9收藏
- 作者：Xin, XJ Zhong, JJ Wei, DZ Liu, JW
- 机构：E China Univ Sci & Technol
- 来源：PROCESS BIOCHEMISTRY 2005
- 关键词：20(S)-ginsenoside Rg(2) VEC-304 plasmonigen activator (PA) reactive oxygen species (ROS)
- Four previously undescribed diketopiperazines from marine fungus Aspergillus puniceus FAHY0085 and their effects on liver X receptor a被引量：9收藏
- 作者：Hong, Qi Guo, Miao-Miao Yang, Jin Wei, Xing Liao, Li Xin, Xiu-Juan Zhang, Di An, Fa-Liang
- 机构：East China Univ Sci & Technol;Jiangsu Ocean Univ;Beijing Technol & Business Univ;Minist Nat Resources;Shanghai Jiao Tong Univ
- 来源：PHYTOCHEMISTRY 2023
- 关键词：Marine -derived fungus Diketopiperazines LXR & alpha
- Hypericin-mediated photodynamic therapy enhances gemcitabine induced Capan-2 cell apoptosis via inhibiting NADPH level被引量：9收藏
- 作者：Sun, Liyun Shang, Huoli Wu, Yuzhen Xin, Xiujuan
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF PHARMACY AND PHARMACOLOGY 2022
- 关键词：hypericin gemcitabine Capan-2 apoptosis reactive oxygen species
- Bioactive indole alkaloids from insect derived endophytic Aspergillus lentulus被引量：8收藏
- 作者：Wang, Zhijie Jiang, Yu Xin, Xiujuan An, Faliang
- 机构：East China Univ Sci & Technol
- 来源：FITOTERAPIA 2021
- 关键词：Endophytic fungus Aspergillus lentulus Indole alkaloids
- A Newly Authenticated Compound from Traditional Chinese Medicine Decoction Induces Melanogenesis in B16-F10 Cells by Increasing Tyrosinase Activity被引量：8收藏
- 作者：Xin, Xiu Juan Zou, Jiahong Zou, Tao Shang, Huoli Sun, Li Yun
- 机构：East China Univ Sci & Technol
- 来源：EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2018
- Association study of TAC3 and TACR3 gene polymorphisms with idiopathic precocious puberty in Chinese girls被引量：8收藏
- 作者：Xin, Xiujuan Zhang, Jing Chang, Yaning Wu, Yixin
- 机构：E China Univ Sci & Technol;Hamamatsu Univ Sch Med
- 来源：JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM 2015
- 关键词：association study genotyping idiopathic puberty TAC3 TACR3
- Substrate promiscuity of pyruvate kinase on various deoxynucleoside diphosphates for synthesis of deoxynucleoside triphosphates被引量：7收藏
- 作者：Gao, Shuhong Bao, Jie Gu, Xiaoming Xin, Xiujuan Chen, Changhua Ryu, Dewey D. Y.
- 机构：E China Univ Sci & Technol;Univ Calif Davis
- 来源：ENZYME AND MICROBIAL TECHNOLOGY 2008
- 关键词：Promiscuity Pyruvate kinase (PK) Deoxynucleoside triphosphate (dNTP) Bacillus sp PK Zymomonas mobilis PK
- Curdepsidone A Induces Intrinsic Apoptosis and Inhibits Protective Autophagy via the ROS/PI3K/AKT Signaling Pathway in HeLa Cells被引量：7收藏
- 作者：Xu, Sunjie Li, Zhimin Xin, Xiujuan An, Faliang
- 机构：East China Univ Sci & Technol;Marine Biomed Sci & Technol Innovat Platform Lin G
- 来源：MARINE DRUGS 2024
- 关键词：curdepsidone A HeLa cells anti-tumor activity ROS PI3K/AKT signaling pathway
- Development of a High-Titer Culture Medium for the Production of Cholesterol by Engineered Saccharomyces cerevisiae and Its Fed-Batch Cultivation Strategy被引量：6收藏
- 作者：Wang, Ling-Xu Zheng, Gao-Fan Xin, Xiu-Juan An, Fa-Liang
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY 2022
- 关键词：Cholesterol S cerevisiae fermentation optimization fed -batch culture citric acid
- Regulation of the HMOX1 gene by the transcription factor AP-2δ with unique DNA binding site被引量：6收藏
- 作者：Sun, Liyun Zhao, Yuxia Gu, Shaohua Mao, Yumin Ji, Chaoneng Xin, Xiujuan
- 机构：E China Univ Sci & Technol;Fudan Univ
- 来源：MOLECULAR MEDICINE REPORTS 2014
- 关键词：AP-2 delta heme oxygenase-1 luciferase assay electromobility shift assays
- Efficient ilamycins production utilizing Enteromorpha prolifera by metabolically engineered Streptomyces atratus被引量：5收藏
- 作者：Jiang, Yu-Xi Zheng, Gao-Fan Chen, Long-Chao Yang, Na Xin, Xiu-Juan Ma, Jun-Ying Ju, Jian-Hua Wu, Hui Zhao, Ming Wang, Ruida An, Fa-Liang
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Marine Biomed Sci & Technol Innovat Platform Lin;Anhui Polytech Univ
- 来源：BIOTECHNOLOGY FOR BIOFUELS AND BIOPRODUCTS 2023
- 关键词：Ilamycins Anti-tuberculosis Streptomyces atratus SCSIO ZH16 Entromorpha prolifera BldD
- Octahydroindolizine alkaloid Homocrepidine A from Dendrobium crepidatum attenuate P. acnes-induced inflammatory in vitro and in vivo被引量：5收藏
- 作者：Gong, Lizhi Xu, Jiayao Guo, Miaomiao Zhao, Jian Xin, Xiujuan Zhang, Chaofeng Ni, Xiaoming Hu, Yang An, Faliang
- 机构：East China Univ Sci & Technol;Nanjing Univ Chinese Med;Marine Biomed Sci & Technol Innovat Platform Lin g;Beijing Technol & Business Univ;China Pharmaceut Univ
- 来源：JOURNAL OF ETHNOPHARMACOLOGY 2024
- 关键词：Dendrobium crepidatum Anti-inflammatory TLR2 NLRP3 P. acnes
- Combinatorial strategies for production improvement of anti-tuberculosis antibiotics ilamycins E1/E2 from deep sea-derived Streptomyces atratus SCSIO ZH16 ΔilaR被引量：4收藏
- 作者：Zhu, Yunfei Zheng, Gaofan Xin, Xiujuan Ma, Junying Ju, Jianhua An, Faliang
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：BIORESOURCES AND BIOPROCESSING 2022
- 关键词：Ilamycins Streptomyces atratus Fermentation optimization Exogenous adding strategy
- Improving the bioactivity of rHirudin with boronophenylalanine site-specific modification被引量：3收藏
- 作者：Xin, Xiujuan Liu, Wenshe Sun, Liyun
- 机构：E China Univ Sci & Technol;Texas A&M Univ
- 来源：MOLECULAR MEDICINE REPORTS 2015
- 关键词：antithrombin activity boronophenylalanine proliferation inhibition recombinant Hirudin site-specific modification
- Palmitoyl copper peptide and acetyl tyrosine complex enhances melanin production in both A375 and B16 cell lines被引量：3收藏
- 作者：Hong, Minhua Gui, Yingyue Xu, Jiayao Zhao, Xianglong Jiang, Chunyang Zhao, Jian Xin, Xiujuan Liu, Dan Tang, Xiaolin Tang, Rong An, Faliang
- 机构：East China Univ Sci & Technol;Shanghai Peptide Biotechnol Co Ltd;Marine Biomed Sci & Technol Innovat Platform Lin G
- 来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2025
- 关键词：Tyrosinase enzyme activity Melanin Copper peptide Melanogenic agent
- Association study of six activity SNPS in adrenal steroid hormone metabolism and IBM related genes with precocious puberty in Chinese girls被引量：2收藏
- 作者：Xin, Xiujuan Xiao, Junhua Luan, Xiaohui Zhou, Yuxun Lu, Daru Wei, Dongzhi Yang, Shengli
- 机构：E China Univ Sci & Technol;Donghua Univ;Fudan Univ;Acad Sci China
- 来源：NEUROENDOCRINOLOGY LETTERS 2006
- 关键词：precocious puberty association study activity SNP adrenal steroid hormone Body Mass Index (BMI)
- Phragmalin-Type Limonoids from the Fruits of Chukrasia tabularis and Their Anti-Inflammatory Activity被引量：2收藏
- 作者：Dai, Shujun Wu, Yuzhen Xin, Xiujuan An, Faliang
- 机构：East China Univ Sci & Technol;Marine Biomed Sci & Technol Innovat Platform Lin G
- 来源：MOLECULES 2023
- 关键词：Chukrasia tabularis meliaceae limonoid anti-inflammatory
- Rational High-Throughput System for Screening Emodin High-Yielding Mutant from Marine Strains of Aspergillus flavipes HN4-13被引量：1收藏
- 作者：Gong, Lizhi Li, Zixuan Xu, Meina Zhou, Yushan Zhang, Wenqing Zhao, Jian Xin, Xiujuan An, Faliang
- 机构：East China Univ Sci & Technol;Jinan Univ;Marine Biomed Sci & Technol Innovat Platform Lin g
- 来源：MARINE DRUGS 2025
- 关键词：marine strain
Aspergillus flavipes HN4-13 emodin ARTP high-throughput screening medium optimize
- Diketopiperazines with anti-skin inflammation from marine-derived endophytic fungus Aspergillus sp. and configurational reassignment of aspertryptanthrins被引量：1收藏
- 作者：Yang, Jin Xiong, Xianmei Gong, Lizhi Gan, Fengyu Shi, Hanling Bin Zhu Wu, Haizhen Xin, Xiujuan Kong, Lingyi An, Faliang
- 机构：East China Univ Sci & Technol;China Pharmaceut Univ;China Pharmaceut Univ;Marine Biomed Sci & Technol Innovat Platform Lin
- 来源：CHINESE JOURNAL OF NATURAL MEDICINES 2025
- 关键词：Diketopiperazines Aspergillus sp. Configurational reassignment Anti-skin inflammation
- Marine-derived curdepsidone A inhibits HeLa cell proliferation by modulating ER stress and PERK/ATF4/CHOP pathway被引量：0收藏
- 作者：Xu, Sunjie Gong, Lizhi Wang, Wei Ma, Wenxu Xin, Xiujuan Liu, Xigao An, Faliang
- 机构：East China Univ Sci & Technol;Shandong Univ;Shandong Univ;Marine Biomed Sci & Technol Innovat Platform Linga
- 来源：EUROPEAN JOURNAL OF PHARMACOLOGY 2026
- 关键词：Curdepsidone A HeLa cells ER stress PERK/ATF4/CHOP signaling pathway IRE1 alpha
- Balancing nitrogen metabolism to efficiently drive anti-tuberculosis ilamycins biosynthesis in Streptomyces atratus被引量：0收藏
- 作者：Zheng, Gaofan Zhou, Weiyan Gui, Yingyue Jiang, Yuxi Zhu, Yunfei Ma, Junying Ju, Jianhua Xin, Xiujuan Li, Baoli Wang, Ruida Zhao, Ming An, Faliang
- 机构：East China Univ Sci & Technol;Anhui Polytech Univ;East China Univ Sci & Technol;Marine Biomed Sci & Technol Innovat Platform Lin G;Chinese Acad Sci
- 来源：BIORESOURCE TECHNOLOGY 2025
- 关键词：Ilamycins Anti-tuberculosis Nitrogen metabolism balance RNA sequencing S. atratus SCSIO ZH16
- Computational fluid dynamics (CFD) modeling of Ilamycin E production in Streptomyces atratus SCSIO ZH16 submerged fermentation被引量：0收藏
- 作者：Zhou, Weiyan Zheng, Gaofan Wang, Jialuo Xin, Xiujuan Zhuang, Liwei An, Faliang
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Marine Biomed Sci & Technol Innovat Platform Lin G;East China Univ Sci & Technol
- 来源：CHEMICAL ENGINEERING SCIENCE 2027
- 关键词：Computational fluid dynamics Bioprocess optimization Viscosity S.atratus SCSIO ZH16
