成果/Result
- Catalytic asymmetric michael reactions of α,β-unsaturated ketones with sulfonyl-containing nucleophiles: Chiral synthesis of (R)-muscone and (S)-celery ketone被引量：68收藏
- 作者：Sun, Xiaomin Yu, Feng Ye, Tingting Liang, Xinmiao Ye, Jinxing
- 机构： Engineering Research Center of Pharmaceutical Process Chemistry
- 来源：Chemistry - A European Journal 2011
- 关键词：Nucleophiles - Sulfur - Stereochemistry - Addition reactions - Catalysis - Enantioselectivity
- Br?nsted acid cocatalysis in photocatalytic intramolecular coupling of tertiary amines: Efficient synthesis of 2-arylindols被引量：64收藏
- 作者：Yuan, Xiaoqian Wu, Xinxin Dong, Shupeng Wu, Guibing Ye, Jinxing
- 机构： Engineering Research Centre of Pharmaceutical Process Chemistry
- 来源：Organic and Biomolecular Chemistry 2016
- 关键词：Amines
- Copper on Charcoal: Tempo Free Cu0 Nanoparticles Catalyzed Aerobic Oxidation of Alcohols被引量：61收藏
- 作者：Wang, Zhiwei Zhao, Rong Lin, Jia Liu, Chaoyang Jia, Qiang Chu, Changhu
- 机构： Engineering Research Centre of Pharmaceutical Process Chemistry; Seasons Biotechnology Co.
- 来源：SSRN 2023
- 关键词：Catalytic oxidation - Charcoal - Copper - Ketones - Nanoparticles
- Theoretical Exploration of Mechanism and Ligand Effects of Asymmetric Hydrogenation of β-Amino Ketone Catalyzed by an Iridium-PNN Catalyst被引量：59收藏
- 作者：Xiong, Yan Liu, Chengyu Zhang, Lei Wang, Xin Yang, Jiaxin Liu, Zhen Ye, Jinxing Cheng, Ruihua
- 机构： School of Chemical Engineering; Engineering Research Centre of Pharmaceutical Process Chemistry; School of Biomedical and Pharmaceutical Sciences
- 来源：Organometallics 2023
- 关键词：Amides - Amines - Binding energy - Catalysts - Chemical bonds - Density functional theory - Enantioselectivity - Iridium - Ketones - Ligands - Phosphorus compounds - Scaffolds - Sodium compounds
- Development of a gliclazide ionic liquid and its mesoporous silica particles: An effective formulation strategy to improve oral absorption properties被引量：58收藏
- 作者：Zhou, Bijian Teng, Dan Li, Jinghui Zhang, Yanhong Qi, Minghui Hong, Minghuang Ren, Guo-Bin
- 机构： Engineering Research Centre of Pharmaceutical Process Chemistry; Shanghai Key Laboratory of New Drug Design; State Key Laboratory of Bioreactor Engineering
- 来源：RSC Advances 2022
- 关键词：Silica - Targeted drug delivery - Molecules - Controlled drug delivery - Encapsulation - Solubility - Positive ions - Mesoporous materials - Physicochemical properties - Supersaturation
- Chemically bonded maltose via click chemistry as stationary phase for HILIC被引量：52收藏
- 作者：Fu, Qing Guo, Zhimou Liang, Tu Zhang, Xiuli Xu, Qing Liang, Xinmiao
- 机构： Key Lab of Separation Science for Analytical Chemistry; Engineering Research Center of Pharmaceutical Process Chemistry
- 来源：Analytical Methods 2010
- 关键词：Hydrophilicity - Liquid chromatography - Synthesis (chemical) - Maltose - Hydrogen bonds - Silica
- Br?nsted acid-catalyzed aza-Mannich reaction of N-Boc aminals: access to multifunctional rhodanine/hydantoin derivatives被引量：51收藏
- 作者：Zou, Kaihe Wu, Xin-Yan Ye, Jinxing
- 机构： Key Laboratory for Advanced Materials and Institute of Fine Chemicals; Engineering Research Centre of Pharmaceutical Process Chemistry; Shanghai Key Laboratory of New Drug Design
- 来源：Research on Chemical Intermediates 2017
- Insight into the effect of cocrystal polymorphism / stoichiomorphism on thermodynamic and photoluminescence properties: a case study被引量：45收藏
- 作者：Han, Xianyang Yin, Yu Zhu, Fan Yao, Yichen Hong, Minghuang Qi, Minghui Zhu, Bin Ren, Guobin
- 机构： Laboratory of Pharmaceutical Crystal Engineering & Technology; State Key Laboratory of Bioreactor Engineering
- 来源：SSRN 2025
- 关键词：Crystal structure - Fluorescence - Fluorescence spectroscopy - Optical properties - Phase transitions - Photoluminescence - Polymorphism - Single crystals - Thermoanalysis - X ray diffraction
- Isostructural Levamisole Hydrochloride Ionic Cocrystal Solvates: High Z″ with a Low Melting Point被引量：40收藏
- 作者：Yao, Yi-Chen Jin, Zhe Hong, Minghuang Zhu, Bin Ren, Guo-Bin Qi, Ming-Hui
- 机构： Laboratory of Pharmaceutical Crystal Engineering & Technology
- 来源：Crystal Growth and Design 2024
- 关键词：Melting point - Single crystals - Surface analysis - Thermoanalysis
- East China University of Science and Technology被引量：37收藏
- 作者：Wang, Fei Teng, Jiangge Li, Zixu Fang, Chao Ma, Kai Ke, Yanxiong Jia, Qiang Chu, Changhu
- 机构： Engineering Research Centre of Pharmaceutical Process Chemistry; Seasons Biotechnology Co.
- 来源：SSRN 2024
- 关键词：Catalyst activity - Chemical reactions - Metal halides
- Preparation of Polyvinyl Pyrrolidone Stationary Phase and its Application in Separation and Analysis of Flavonoids被引量：35收藏
- 作者：Chen, Xin Li, Juntao Gu, Mengting Miao, Yiyuan Ke, Yanxiong Zheng, Xiangwei Xu, Jian
- 机构： Engineering Research Center of Pharmaceutical Process Chemistry; Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine; Hubei Provincial Key Laboratory of Quality and Safety of Traditional Chinese Medicine Health Food
- 来源：SSRN 2023
- 关键词：Acetonitrile - Hydrogen bonds - Methanol - Silica
- Selective separation of flavonoid glycosides in Dalbergia odorifera by matrix solid-phase dispersion using titania被引量：34收藏
- 作者：Xu, Lingyan Shi, Hui Liang, Tu Feng, Jiatao Jin, Yu Ke, Yanxiong Liang, Xinmiao
- 机构： Engineering Research Center of Pharmaceutical Process Chemistry; Dalian Institute of Chemical Physics; School of Pharmacy
- 来源：Journal of Separation Science 2011
- 关键词：Separation - Acetonitrile - Dispersions - Titanium dioxide - Sugars - Flavonoids
- An Improved Subtraction Model Applied in Supercritical Fluid Chromatography to Characterize Polar Stationary Phases被引量：33收藏
- 作者：Ge, Dandan Lu, Jiahao Yu, Zimo Jin, Yu Ke, Yanxiong Fu, Qing Liang, Xinmiao
- 机构： Engineering Research Center of Pharmaceutical Process Chemistry; Key Lab of Separation Science for Analytical Chemistry
- 来源：SSRN 2024
- 关键词：Effluent treatment - Hydrophobicity - Silica - Supercritical fluids
- 酒石酸亚铁-标准曲线法检测绿茶提取物中茶多酚含量被引量：31收藏
- 作者：邓祥 韩伟
- 机构：华东理工大学药学院
- 来源：《南京工业大学学报（自然科学版）》 2020
- 关键词：茶多酚 酒石酸亚铁 方法学验证 福林酚比色法 标准曲线法
- 摘要：采用酒石酸亚铁-标准曲线法检测茶叶提取物中茶多酚含量,单因素实验优化的显色条件为室温、蒸馏水4 mL、酒石酸亚铁溶液5 mL、以pH=7.5的磷酸盐缓冲液定容,该方法可即时检测。通过方法学验证实验,比较紫外分光光度法、酒...
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- Preparation of a stationary phase with s-triazine ring embedded group for reversed phase high-performance LC被引量：26收藏
- 作者：Li, Yingyu Dai, Peichun Ke, Yanxiong Jin, Yu Liang, Xinmiao
- 机构： Engineering Research Center of Pharmaceutical Process Chemistry
- 来源：Journal of Separation Science 2010
- Cocrystals of Oxymatrine: Reducing Hygroscopicity and Affecting the Dissolution Rate被引量：25收藏
- 作者：Qi, Ming-Hui Li, Heng Zhu, Bin Hong, Minghuang Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2021
- 关键词：Dissolution - Hydrogen bonds - Metabolism
- Resurrecting the 'Disappearing Polymorph' of Rotigotine via Conformational Landscape Engineering被引量：25收藏
- 作者：Yi, Dongxu Qi, Minghui Xu, Shaohong Qi, Yonghua Xia, Ran Wu, Hao Ren, Guobin
- 机构： School of Pharmacy; School of Pharmacy; Children's Hospital Affiliated to Zhengzhou University; Henan Children’ s Hospital Zhengzhou Children’s Hospital; Engineering Research Centre of Pharmaceutical Process Chemistry
- 来源：SSRN 2025
- 关键词：Boltzmann equation - Conformations - Crystallization kinetics - Drug products - Engineering research - Molecular biology - Molecular physics - Polymorphism - Potential energy
- Preparation of "click" binaphthyl stationary phase and its application for separation of anthraquinones from Rheum palmatum L.被引量：24收藏
- 作者：Yu, Danhua Yu, Hui Wang, Xinliang Jin, Yu Ke, Yanxiong Liang, Xinmiao
- 机构： Engineering Research Center of Pharmaceutical Process Chemistry
- 来源：Journal of Separation Science 2011
- 关键词：Separation - Ketones - Polycyclic aromatic hydrocarbons - Silica - Medicine
- Pvp-I Catalyzed Oxidation of Benzylamines to Aryl Formamides被引量：23收藏
- 作者：Lu, Guangying Yuan, Xinxin Wang, Jian Sun, Xue-Qin Cao, Fu-Rong Ren, Jiangmeng Ke, Yanxiong Mu, Xin Bu-Bing, Zeng
- 机构： Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism; Engineering Research Centre of Pharmaceutical Process Chemistry
- 来源：SSRN 2023
- 关键词：Amides
- Carbonyl-Bridged Trifluoromethyl Pyridine Derivatives for Pest Control and Mechanistic Investigations被引量：22收藏
- 作者：Sheng, Zhubo Deng, Jie Yuan, Qinglong Fu, Wen Xu, Zhiping Li, Xiaoyan Li, Zhong Shao, Xusheng
- 机构： Shanghai Key Laboratory of Chemical Biology; State Key Laboratory of Bioreactor Engineering; Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism; Engineering Research Center of Pharmaceutical Process Chemistry; National Key Laboratory of Green Pesticide
- 来源：SSRN 2025
- 关键词：Synthesis (chemical)
- Combination of off-line two-dimensional hydrophilic interaction liquid chromatography for polar fraction and two-dimensional hydrophilic interaction liquid chromatography×reversed-phase liquid chromatography for medium-polar fraction in a traditional Chinese medicine被引量：20收藏
- 作者：Liang, Zheng Li, Kuiyong Wang, Xinliang Ke, Yanxiong Jin, Yu Liang, Xinmiao
- 机构： Engineering Research Center of Pharmaceutical Process Chemistry
- 来源：Journal of Chromatography A 2012
- 关键词：Liquid chromatography - Medicine - Phase separation - Liquids
- Synthesis and evaluation of a maltose-bonded silica gel stationary phase for hydrophilic interaction chromatography and its application in Ginkgo Biloba extract separation in two-dimensional systems被引量：18收藏
- 作者：Sheng, Qianying Yang, Kaiya Ke, Yanxiong Liang, Xinmiao Lan, Minbo
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF SEPARATION SCIENCE 2016
- 关键词：Ginkgo Biloba extract Hydrophilic interaction liquid chromatography Saccharide-modified stationary phases Separation selectivity Two-dimensional chromatography
- 华东地区某水源水中13种磺胺类抗生素的分布特征及人体健康风险评价被引量：17收藏
- 作者：金磊 姜蕾 韩琪 薛佳怡 叶辉 曹国民 林匡飞 崔长征
- 机构：华东理工大学资源与环境工程学院;上海城市水资源开发利用国家工程中心有限公司;华东理工大学药学院
- 来源：《环境科学》 2016
- 关键词：磺胺类抗生素 饮用水源水 分布特征 风险熵 健康风险评价
- 摘要：饮用水源水中残留微量抗生素对人体健康的潜在威胁日益引起广泛关注.采用固相萃取、高效液相串联质谱方法分析了13种磺胺类抗生素在华东地区某水源水中的分布特征.结果表明,13种磺胺类抗生素在水源水中均有不同程度检出,总浓度为1...
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- 灵芝三萜的提取工艺及其抗氧化研究进展被引量：15收藏
- 作者：赵佳敏 陈泓鑫 林宇冲 金喆 韩伟
- 机构：华东理工大学药学院制药工程与过程化学教育部工程研究中心
- 来源：《安徽化工》 2021
- 关键词：灵芝三萜 提取 抗氧化
- 摘要：灵芝三萜为灵芝中的重要成分,药理作用突出,提高其提取率是一大研究热点。综述了灵芝三萜的提取方法及体外抗氧化研究进展,为实验研究及工业生产提供参考。
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- Iodine-Catalysed Conversion of Decahydrophenothiazines into Phenothiazines被引量：15收藏
- 作者：Zhao, Yinglin Luo, Jiayue Wang, Ruitong Yuan, Yuqin Chu, Changhu Liu, Renhua
- 机构： Engineering Research Centre of Pharmaceutical Process Chemistry
- 来源：SSRN 2024
- 关键词：Insecticides - Iodine - Sulfur
- 本芴醇的合成工艺改进被引量：14收藏
- 作者：Yang, Kang Zheng, Qun Wu, Weiting Chen, Xuxiang Zhao, Jianhong
- 机构： Engineering Research Center of Pharmaceutical Process Chemistry
- 来源：[1] Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China 2024
- 当归藤总黄酮超声提取工艺优化被引量：14收藏
- 作者：姜鹏程 陆晔晗 常芮宁 宋艺 王艾雯 王春丽 郭美珠 张春芳
- 机构：华东理工大学药学院;上海市宝山区中西医结合医院;厦门大学附属翔安医院
- 来源：《中成药》 2023
- 关键词：当归藤总黄酮 超声提取工艺 Plackett-Burman法 Box-Behnken响应面法
- 摘要：目的优化当归藤总黄酮超声提取工艺。方法在单因素试验基础上,以乙醇体积分数、料液比、超声功率、超声温度、超声时间为影响因素,总黄酮得率为评价指标,Plackett?Burman法结合Box?Behnken响应面法优化超声提...
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- 木瓜皮多酚和黄酮提取工艺优化及酪氨酸酶与胰脂肪酶抑制活性研究被引量：14收藏
- 作者：裴文清 吕泸楠 王靖宇 浦思琦 雷霜 王春丽
- 机构：华东理工大学药学院
- 来源：《食品工业科技》 2022
- 关键词：木瓜皮 多酚 黄酮 抑制酪氨酸酶 抑制胰脂肪酶
- 摘要：以木瓜皮为原料,研究了木瓜皮多酚和黄酮的提取工艺及抗氧化、酪氨酸酶和胰脂肪酶抑制活性。在单因素实验基础上采用正交试验研究超声温度、超声时间、乙醇浓度、料液比对木瓜皮多酚和黄酮含量的影响,并测定木瓜皮对DPPH自由基和AB...
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- 郁金香总多酚提取工艺优化及其抗氧化活性研究被引量：13收藏
- 作者：崔巧玉 沈雯娟 孙小璐 王梓嫣 毛振宇 王春丽
- 机构：华东理工大学药学院
- 来源：《中成药》 2022
- 关键词：郁金香 总多酚 提取工艺 抗氧化活性 Plackett-Burman设计 Box-Behnken响应面试验
- 摘要：目的 优化郁金香总多酚提取工艺,并考察其抗氧化活性。方法 在单因素试验基础上,以料液比、乙醇体积分数、提取时间为影响因素,总多酚含量为评价指标,Plackett-Burman设计结合Box-Behnken响应面试验优化提...
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- 基于UPLC-MS/MS定量检测法优化灵芝三萜热回流提取工艺的研究被引量：12收藏
- 作者：彭小芳 程池露 唐庆九 张劲松 唐传红 王晨光 冯娜 韩伟
- 机构：华东理工大学药学院制药工程与过程化学教育部工程研究中心上海市新药设计重点实验室;上海市农业科学院食用菌研究所国家食用菌工程技术研究中心国家食用菌加工技术研发分中心农业部南方食用菌资源利用重点实验室上海市农业遗传育种重点开放实验室;上海百信生物科技有限公司;上海海洋大学食品学院
- 来源：《菌物学报》 2021
- 关键词：三萜类化合物 液质联用分析 中试提取 响应面优化
- 摘要：基于超高效液相-三重四级杆质谱联用(UPLC-MS/MS)定量检测法优化出一种灵芝三萜热回流提取的工艺。通过本实验建立的灵芝三萜UPLC-MS/MS精确方法检测不同来源的7个栽培品种灵芝子实体中19个三萜化合物的含量,筛...
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