成果/Result
- Chemo- and Regioselective Organo-Photoredox Catalyzed Hydroformylation of Styrenes via a Radical Pathway被引量：119收藏
- 作者：Huang, He Yu, Chenguang Zhang, Yueteng Zhang, Yongqiang Mariano, Patrick S. Wang, Wei
- 机构：Univ New Mexico;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2017
- 关键词：Carboxylation - Catalysis - Regioselectivity - Hydroformylation - Free radicals - Styrene
- Direct Cα-heteroarylation of structurally diverse ethers via a mild N-hydroxysuccinimide mediated cross-dehydrogenative coupling reaction被引量：89收藏
- 作者：Liu, Shihui Liu, Aoxia Zhang, Yongqiang Wang, Wei
- 机构：East China Univ Sci & Technol;Univ New Mexico
- 来源：CHEMICAL SCIENCE 2017
- 关键词：Free radical reactions - Atoms
- Synthesis of Z-alkenes via visible light promoted photocatalytic E → Z isomerization under metal-free conditions被引量：76收藏
- 作者：Cai, Wenbin Fan, Huaqiang Ding, Dazhong Zhang, Yongqiang Wang, Wei
- 机构：East China Univ Sci & Technol;Qingdao Inst Food & Drug Control;Univ New Mexico
- 来源：CHEMICAL COMMUNICATIONS 2017
- Photocatalytic C-H silylation of heteroarenes by using trialkylhydrosilanes被引量：76收藏
- 作者：Liu, Shihui Pan, Peng Fan, Huaqiang Li, Hao Wang, Wei Zhang, Yongqiang
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ Arizona
- 来源：CHEMICAL SCIENCE 2019
- 关键词：Chemical stability
- Highly stereoselective synthesis of aryl/heteroaryl-C-nucleosides via the merger of photoredox and nickel catalysis被引量：69收藏
- 作者：Yingying Liu, Shihui Xi, Yifan Li, Hongrui Yang, Kai Cheng, Zhihao Wang, Wei Zhang, Yongqiang
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Jiaxing Univ;Univ Arizona;Univ Arizona
- 来源：CHEMICAL COMMUNICATIONS 2019
- Organophotocatalytic silyl transfer of silylboranes enabled by methanol association: a versatile strategy for C-Si bond construction被引量：63收藏
- 作者：Wan, Yi Zhao, Yumo Zhu, Jiajie Yuan, Qiyang Wang, Wei Zhang, Yongqiang
- 机构： Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism; Department of Pharmacology and Toxicology
- 来源：Green Chemistry 2022
- 关键词：Chemical bonds - Photocatalytic activity - Silicon compounds - Tin compounds
- Synthesis of β-Silyl α-Amino Acids via Visible-Light-Mediated Hydrosilylation被引量：51收藏
- 作者：Wan, Yi Zhu, Jiajie Yuan, Qiyang Wang, Wei Zhang, Yongqiang
- 机构：East China Univ Sci & Technol;Univ Arizona;Univ Arizona
- 来源：ORGANIC LETTERS 2021
- Synthesis of Aldehydes by Organocatalytic Formylation Reactions of Boronic Acids with Glyoxylic Acid被引量：49收藏
- 作者：Huang, He Yu, Chenguang Li, Xiangmin Zhang, Yongqiang Zhang, Yueteng Chen, Xiaobei Mariano, Patrick S. Xie, Hexin Wang, Wei
- 机构：Univ New Mexico;East China Univ Sci Technol;East China Univ Sci Technol
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2017
- 关键词：arenes boron formylation organocatalysis synthetic methods
- Imaging the dynamics of messenger RNA with a bright and stable green fluorescent RNA被引量：42收藏
- 作者：Zuo, Fangting Jiang, Li Su, Ni Zhang, Yaqiang Bao, Bingkun Wang, Limei Shi, Yajie Yang, Huimin Huang, Xinyi Li, Ruilong Zeng, Qingmei Chen, Zhengda Lin, Qiuning Zhuang, Yingping Zhao, Yuzheng Chen, Xianjun Zhu, Linyong Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ;East China Univ Sci & Technol;Chinese Acad Med Sci
- 来源：NATURE CHEMICAL BIOLOGY 2024
- Synthesis of 2-Quinolinones via a Hypervalent Iodine(III)-Mediated Intramolecular Decarboxylative Heck-Type Reaction at Room Temperature被引量：40收藏
- 作者：Fan, Huaqiang Pang, Peng Zhang, Yongqiang Wang, Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ Arizona
- 来源：ORGANIC LETTERS 2018
- Structure-Based Optimization of Small-Molecule Inhibitors for the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction被引量：34收藏
- 作者：Zhang, Min Wang, Zhen Zhang, Yongqiang Guo, Wenxing Ji, Haitao
- 机构：H Lee Moffitt Canc Ctr & Res Inst;Univ S Florida;Univ S Florida;East China Univ Sci & Technol;Univ Utah
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2018
- Organophotocatalytic silyl transfer of silylboranes enabled by methanol association: a versatile strategy for C-Si bond construction被引量：31收藏
- 作者：Wan, Yi Zhao, Yumo Zhu, Jiajie Yuan, Qiyang Wang, Wei Zhang, Yongqiang
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ Arizona;Univ Arizona
- 来源：GREEN CHEMISTRY 2023
- Highly Stereoselective C-Glycosylation by Photocatalytic Decarboxylative Alkynylation on Anomeric Position: A Facile Access to Alkynyl C-Glycosides被引量：30收藏
- 作者：Lu, KaiLin Ma, Yingying Liu, Shihui Guo, Shixun Zhang, Yongqiang
- 机构：East China Univ Sci & Technol;Jiaxing Univ
- 来源：CHINESE JOURNAL OF CHEMISTRY 2022
- 关键词：Photocatalysis Anomeric position Decarboxylative alkynylation C-C coupling Glycosides
- A photoredox/nickel dual-catalytic strategy for benzylic C-H alkoxylation被引量：28收藏
- 作者：Dong, Min Jia, Yuqi Zhou, Wei Gao, Jinlai Lv, Xiaoqing Luo, Fan Zhang, Yongqiang Liu, Shihui
- 机构：Jiaxing Univ;East China Univ Sci & Technol
- 来源：ORGANIC CHEMISTRY FRONTIERS 2021
- 关键词：Synthesis (chemical) - Nickel compounds - Ethers
- Graphitic Carbon Nitride Polymer as a Recyclable Photoredox Catalyst for Decarboxylative Alkynylation of Carboxylic Acids被引量：27收藏
- 作者：Guo, Jiaqi Wang, Yating Li, Yuhang Lu, Kailin Liu, Shihui Wang, Wei Zhang, Yongqiang
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Univ Arizona;Univ Arizona
- 来源：ADVANCED SYNTHESIS & CATALYSIS 2020
- 关键词：graphitic carbon nitride heterogeneous photoredox catalysis decarboxylative alkynylation sustainable synthesis
- Photocatalytic C-Si Bond Formations Using Pentacoordinate Silylsilicates as Silyl Radical Precursors: Synthetic Tricks Using Old Reagents被引量：22收藏
- 作者：Zhao, Yumo Wan, Yi Yuan, Qiyang Wei, Jinlian Zhang, Yongqiang
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ORGANIC LETTERS 2023
- PIFA-Mediated Cross-Dehydrogenative Coupling of N-Heteroarenes with Cyclic Ethers: Ethanol as an Efficient Promoter被引量：20收藏
- 作者：Li, Xiang Liu, Chaoyang Guo, Shixun Wang, Wei Zhang, Yongqiang
- 机构：East China Univ Sci & Technol;Univ Arizona;Univ Arizona
- 来源：EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2021
- 关键词：Cross-dehydrogenative coupling Cyclic ethers Ethanol PIFA Visible Light
- New triazole derivatives containing substituted 1,2,3-triazole side chains: Design, synthesis and antifungal activity被引量：19收藏
- 作者：Chen, Hai-Jiang Jiang, Yan-Juan Zhang, Yong-Qiang Jing, Qi-Wei Liu, Na Wang, Yan Zhang, Wan-Nian Sheng, Chun-Quan
- 机构：Fujian Univ Tradit Chinese Med;Second Mil Med Univ;East China Univ Sci & Technol
- 来源：CHINESE CHEMICAL LETTERS 2017
- 关键词：Triazole derivatives Antifungal activities Click reaction Molecular docking CYP51
- Inhibition of mitochondrial complex III induces differentiation in acute myeloid leukemia被引量：15收藏
- 作者：Zhang, Youping Luo, Ting Ding, Xinyu Chang, YungTing Liu, Chuanxu Zhang, Yongqiang Hao, Siguo Yin, Qianqian Jiang, Biao
- 机构：Shanghai Jiao Tong Univ;East China Univ Sci & Technol;ShanghaiTech Univ;Shanghai Jiao Tong Univ;Chinese Acad Sci
- 来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2021
- 关键词：Acute myeloid leukemia Differentiation therapy Mitochondrial ETC complex III Pyrimidine biosynthesis
- A cascade approach to 3D cyclic carbamates via an ionic decarboxylative functionalization of olefinic oxamic acids被引量：14收藏
- 作者：Fan, Huaqiang Wan, Yi Pan, Peng Cai, Wenbin Liu, Shihui Liu, Chuanxu Zhang, Yongqiang
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：CHEMICAL COMMUNICATIONS 2020
- Discovery and optimization of betulinic acid derivatives as novel potent CD73 inhibitors被引量：14收藏
- 作者：Zhang, Yanming Ye, Shuang Wang, Yuan Wang, Chuanhao Zhu, Yazhao Wu, Yuelin Zhang, Yongqiang Zhang, Huojun Miao, Zhenyuan
- 机构：Second Mil Med Univ;East China Univ Sci & Technol;Ningxia Med Univ;Shanghai Inst Technol;Second Mil Med Univ
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY 2022
- 关键词：Drug discovery CD73 Betulinic acid Immuno-oncology
- Synthesis of novel azabicyclo derivatives containing a thiazole moiety and their biological activity against pine-wood nematodes被引量：10收藏
- 作者：Li, Hui Lu, Aoyun Zhang, Yanqiu Peng, Yanqing Song, Gonghua
- 机构：East China Univ Sci & Technol
- 来源：PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS 2020
- 关键词：Azabicyclo PWNs nematicidal activity novel nematicide
- 基于有机化学思维的药物化学教学模式被引量：10收藏
- 作者：邓卫平 马红梅 毛斐 张永强 李浩 李剑
- 机构：华东理工大学药学院
- 来源：《药学教育》 2018
- 关键词：有机化学 教学模式 药物化学 药物结构
- 摘要：药物化学是药学、制药工程和药剂等药学类专业学生的专业主干课,其主要内容涉及新药设计、新药研究与开发、阐明药物的化学本质和探索药物发挥药效的机制等方面,是一门应用性很强的课程。从有机化学官能团反应性质、结构简化和共性剖析、...
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- Photoredox/Nickel Dual-Catalytic Asymmetric Silylarylation of Alkenes被引量：8收藏
- 作者：Yuan, Qiyang Deng, Zhengrong Wan, Yi Zhang, Yongqiang
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ORGANIC LETTERS 2025
- Spatiotemporal control of RNA metabolism and CRISPR-Cas functions using engineered photoswitchable RNA-binding proteins被引量：7收藏
- 作者：Liu, Renmei Yao, Jing Zhou, Siyu Yang, Jing Zhang, Yaqiang Yang, Xiaoyan Li, Leshi Zhang, Yunbin Zhuang, Yingping Yang, Yi Chen, Xianjun
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：NATURE PROTOCOLS 2024
- 以培养新药创制人才为导向的药物化学课程教学创新与实践被引量：6收藏
- 作者：张永强 李浩 李剑 毛斐 邓卫平 马红梅
- 机构：华东理工大学药学院
- 来源：《中国医药导报》 2017
- 关键词：新药创制人才 药物化学 专题性教学 双轨教学模式 二维评价体系 教学实践
- 摘要：实现我国制药行业跨越式发展,迫切需要培养大量新药创制人才。药物化学是新药研发的源头学科,药物化学课程教学是培养新药创制人才的基本形式。本文针对目前高校药物化学教学中存在的弊端,通过拓展课外专题性教学、创新双轨教学模式和建...
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- Targeting Bcl-xL is a potential therapeutic strategy for extranodal NK/T cell lymphoma被引量：6收藏
- 作者：Liu, Chuanxu Ding, Xinyu Li, Gaoyang Zhang, Youping Shao, Yubao Liu, Linyi Zhang, Wenhao Ma, Yujie Guan, Wenbin Wang, Lifeng Xu, Zhongli Chang, YungTing Zhang, Yongqiang Jiang, Biao Yin, Qianqian Tao, Rong
- 机构：Fudan Univ;ShanghaiTech Univ;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ
- 来源：ISCIENCE 2023
- TfOH-Catalyzed Cascade Reaction: Metal-Free Access to 3,3-Disubstituted Phthalides from o-Alkynylbenzoic Acids被引量：6收藏
- 作者：Zhang, Yanqiu Zhang, Zhiliang Xia, Yunxin Wang, Jiayi Peng, Yanqing Song, Gonghua
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF ORGANIC CHEMISTRY 2023
- 关键词：Cyclization - Regioselectivity
- A novel metal-free synthesis of thiazole-substituted α-hydroxy carbonyl compounds and 2-alkenylthiazoles from thiazole N-oxides and olefins被引量：6收藏
- 作者：Li, Hui Zhang, Juan Zhang, Yanqiu Wang, Jiayi Song, Gonghua
- 机构：East China Univ Sci & Technol
- 来源：TETRAHEDRON LETTERS 2019
- 关键词：Metal-free Thiazole N-oxide 1, 3-Dipolar cycloaddition Thiazole-substituted alpha-hydroxy carbonyl
- Radical-Chain Hydrosilylation of Alkenes Enabled by Triplet Energy Transfer被引量：6收藏
- 作者：Guo, Shixun Wang, Wei Zhang, Yongqiang
- 机构：Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met;East China Univ Sci & Technol;Univ Arizona;Univ Arizona
- 来源：CHEMISTRY-A EUROPEAN JOURNAL 2024
- 关键词：Radical-chain reaction Hydrosilylation Alkenes Triplet energy transfer
