成果/Result
- A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules被引量：378收藏
- 作者：Liang, Mindong Li, Zilong Wang, Weishan Liu, Jiakun Liu, Leshi Zhu, Guoliang Karthik, Loganathan Wang, Man Wang, Ke-Feng Wang, Zhong Yu, Jing Shuai, Yuting Yu, Jiaming Zhang, Lu Yang, Zhiheng Li, Chuan Zhang, Qian Shi, Tong Zhou, Liming Xie, Feng Dai, Huanqin Liu, Xueting Zhang, Jingyu Liu, Guang Zhuo, Ying Zhang, Buchang Liu, Chenli Li, Shanshan Xia, Xuekui Tong, Yaojun Liu, Yanwen Alterovitz, Gil Tan, Gao-Yi Zhang, Li-Xin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Anhui Univ;Chinese Acad Sci;Chinese Acad Sci
- 来源：NATURE COMMUNICATIONS 2019
- Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs被引量：249收藏
- 作者：Chen, Xianjun Zhang, Dasheng Su, Ni Bao, Bingkun Xie, Xin Zuo, Fangting Yang, Lipeng Wang, Hui Jiang, Li Lin, Qiuning Fang, Mengyue Li, Ningfeng Hua, Xin Chen, Zhengda Bao, Chunyan Xu, Jinjin Du, Wenli Zhang, Lixin Zhao, Yuzheng Zhu, Linyong Loscalzo, Joseph Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：NATURE BIOTECHNOLOGY 2019
- 关键词：Cells - Enzyme kinetics - Fluorescence - Mammals - Cytology
- Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces被引量：143收藏
- 作者：Wang, Weishan Li, Shanshan Li, Zilong Zhang, Jingyu Fan, Keqiang Tan, Gaoyi Ai, Guomin Lam, Sin Man Shui, Guanghou Yang, Zhiheng Lu, Hongzhong Jin, Pinjiao Li, Yihong Chen, Xiangyin Xia, Xuekui Liu, Xueting Dannelly, H. Kathleen Yang, Chen Yang, Yi Zhang, Siliang Alterovitz, Gil Xiang, Wensheng Zhang, Lixin
- 机构：Chinese Acad Sci;East China Univ Sci & Technol;Chinese Acad Agr Sci;Chinese Acad Sci;Qilu Univ Technol
- 来源：NATURE BIOTECHNOLOGY 2020
- 关键词：Ketones - Metabolism - Biochemistry - Bacteria - Metabolites - Glycerol
- Candida albicans promotes tooth decay by inducing oral microbial dysbiosis被引量：116收藏
- 作者：Du, Qian Ren, Biao He, Jinzhi Peng, Xian Guo, Qiang Zheng, Liwei Li, Jiyao Dai, Huanqin Chen, Vivian Zhang, Lixin Zhou, Xuedong Xu, Xin
- 机构：Sichuan Univ;Sichuan Univ;Sichuan Univ;Chinese Acad Sci;Chinese Acad Sci
- 来源：ISME JOURNAL 2021
- Application of Antibiotics/Antimicrobial Agents on Dental Caries被引量：109收藏
- 作者：Qiu, Wei Zhou, Yujie Li, Zixin Huang, Tu Xiao, Yuhan Cheng, Lei Peng, Xian Zhang, Lixin Ren, Biao
- 机构：Southern Med Univ;Sichuan Univ;Sichuan Univ;Sichuan Univ;Chinese Acad Sci
- 来源：BIOMED RESEARCH INTERNATIONAL 2020
- A versatile biosensing platform coupling CRISPR-Cas12a and aptamers for detection of diverse analytes被引量：88收藏
- 作者：Zhao, Xiangxiang Li, Shanshan Liu, Guang Wang, Zhong Yang, Zhiheng Zhang, Quanwei Liang, Mindong Liu, Jiakun Li, Zilong Tong, Yaojun Zhu, Guoliang Wang, Xinye Jiang, Lan Wang, Weishan Tan, Gao-Yi Zhang, Lixin
- 机构：East China Univ Sci & Technol ECUST;East China Univ Sci & Technol ECUST;Chinese Acad Agr Sci;Chinese Acad Sci;Shanghai Jiao Tong Univ
- 来源：SCIENCE BULLETIN 2021
- 关键词：CRISPR-Cas12a Aptamer Biosensing platform Diverse analyte Alpha fetoprotein detection Cocaine detection
- Optimization of microbial cell factories for astaxanthin production: Biosynthesis and regulations, engineering strategies and fermentation optimization strategies被引量：71收藏
- 作者：Basiony, Mostafa Ouyang, Liming Wang, Danni Yu, Jiaming Zhou, Liming Zhu, Mohan Wang, Xuyuan Feng, Jie Dai, Jing Shen, Yijie Zhang, Chengguo Hua, Qiang Yang, Xiuliang Zhang, Lixin
- 机构：East China Univ Sci & Technol;Shandong Jincheng Biopharmaceut Co Ltd
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2022
- 关键词：Astaxanthin Carotenoids Metabolic engineering Microbial cell factories Lipid Fermentation Antioxidants
- Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p被引量：58收藏
- 作者：Tong, Yaojun Zhang, Jingyu Sun, Nuo Wang, Xiang-Ming Wei, Qi Zhang, Yu Huang, Ren Pu, Yingying Dai, Huanqin Ren, Biao Pei, Gang Song, Fuhang Zhu, Guoliang Wang, Xinye Xia, Xuekui Chen, Xiangyin Jiang, Lan Wang, Shenlin Ouyang, Liming Xie, Ning Zhang, Buchang Jiang, Yuanying Liu, Xueting Calderone, Richard Bai, Fan Zhang, Lixin Alterovitz, Gil
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Peking Univ;Georgetown Univ
- 来源：SCIENCE BULLETIN 2021
- 关键词：Candida albicans Berberine Multidrug-resistance Drug excretion transporter Mitochondria
- The antitumor capacity of mesothelin-CAR-T cells in targeting solid tumors in mice被引量：57收藏
- 作者：Zhang, Qian Liu, Guoping Liu, Jibin Yang, Mu Fu, Juan Liu, Guodi Li, Dehua Gu, Zhangjie Zhang, Linsong Pan, Yingjiao Cui, Xingbing Wang, Lu Zhang, Lixin Tian, Xiaoli
- 机构：Shanghai Yihao Biol Technol Co Ltd;Changhai Hosp;Nantong Tumor Hosp;Shanghai Jiao Tong Univ;Dalian Med Univ
- 来源：MOLECULAR THERAPY ONCOLYTICS 2021
- Chrysomycin A Derivatives for the Treatment of Multi-Drug-Resistant Tuberculosis被引量：54收藏
- 作者：Wu, Fan Zhang, Jing Song, Fuhang Wang, Sanshan Guo, Hui Wei, Qi Dai, Huanqin Chen, Xiangyin Xia, Xuekui Liu, Xueting Zhang, Lixin Yu, Jin-Quan Lei, Xiaoguang
- 机构：Peking Univ;Peking Univ;Chinese Acad Sci;East China Univ Sci & Technol;Qilu Univ Technol
- 来源：ACS CENTRAL SCIENCE 2020
- Activating cryptic biosynthetic gene cluster through a CRISPR-Cas12a-mediated direct cloning approach被引量：54收藏
- 作者：Liang, Mindong Liu, Leshi Xu, Fei Zeng, Xiaoqian Wang, Runjun Yang, Jinling Wang, Weishan Karthik, Loganathan Liu, Jiakun Yang, Zhiheng Zhu, Guoliang Wang, Shuliu Bai, Linquan Tong, Yaojun Liu, Xueting Wu, Min Zhang, Li-Xin Tan, Gao-Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Zhejiang Univ;Zhejiang Univ;Huzhou Univ
- 来源：NUCLEIC ACIDS RESEARCH 2022
- Characterization of cellular senescence in doxorubicin-induced aging mice被引量：54收藏
- 作者：Sun, Tianyue Zhang, Lanxin Feng, Jiali Bao, Lingyuan Wang, Jiqun Song, Zhouzhi Mao, Zhifan Li, Jian Hu, Zelan
- 机构：East China Univ Sci & Technol;Dali Univ;Tongji Univ
- 来源：EXPERIMENTAL GERONTOLOGY 2022
- 关键词：Doxorubicin Senescence Mice Metformin
- Polyketide pesticides from actinomycetes被引量：52收藏
- 作者：Li, Shanshan Yang, Bowen Tan, Gao-Yi Ouyang, Li-Ming Qiu, Shiwen Wang, Weishan Xiang, Wensheng Zhang, Lixin
- 机构：Chinese Acad Agr Sci;East China Univ Sci & Technol;Chinese Acad Sci;Northeast Agr Univ;Univ Chinese Acad Sci
- 来源：CURRENT OPINION IN BIOTECHNOLOGY 2021
- 关键词：Crop protection - Metabolites - Bacteria
- Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus被引量：48收藏
- 作者：Li, Chunlei Zhu, Chengguang Ren, Biao Yin, Xin Shim, Sang Hee Gao, Yue Zhu, Jianhua Zhao, Peipei Liu, Changheng Yu, Rongmin Xia, Xuekui Zhang, Lixin
- 机构：Qilu Univ Technol;Jinan Univ;Sichuan Univ;Sichuan Univ;Duksung Womens Univ
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2019
- 关键词：Optimized antimicrobial peptide Anti-MRSA Anti-biofilm SEM qRT-PCR
- Hydrogenase as the basis for green hydrogen production and utilization被引量：46收藏
- 作者：Ji, Haishuo Wan, Lei Gao, Yanxin Du, Ping Li, Wenjin Luo, Hang Ning, Jiarui Zhao, Yingying Wang, Huangwei Zhang, Lixin Zhang, Liyun
- 机构：Nankai Univ;Max Planck Inst Chem Energy Convers;Nankai Univ;East China Univ Sci & Technol ECUST;East China Univ Sci & Technol ECUST
- 来源：JOURNAL OF ENERGY CHEMISTRY 2023
- 关键词：Hydrogenase Biological H-2 energy Oxygen tolerance Artificial photosynthesis Biofuel cells
- Identification of simple arylfluorosulfates as potent agents against resistant bacteria被引量：44收藏
- 作者：Zhang, Jiong Zhao, Xiangxiang Cappiello, John R. Yang, Yi Cheng, Yunfei Liu, Guang Fang, Wenjing Luo, Yinzhu Zhang, Yu Dong, Jiajia Zhang, Lixin Sharpless, K. Barry
- 机构：Chinese Acad Sci;East China Univ Sci & Technol;Scripps Res Inst;Guangdong Lab Anim Monitoring Inst
- 来源：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2021
- 关键词：SuFEx click chemistry antibacterial agents multidrug resistance biofilm disruption
- Harnessing a previously unidentified capability of bacterial allosteric transcription factors for sensing diverse small molecules in vitro被引量：42收藏
- 作者：Cao, Jiaqian Yao, Yongpeng Fan, Keqiang Tan, Gaoyi Xiang, Wensheng Xia, Xuekui Li, Shanshan Wang, Weishan Zhang, Lixin
- 机构：State Key Lab Microbial Resources;Chinese Acad Sci;East China Univ Sci & Technol;Chinese Acad Agr Sci;Qilu Univ Technol
- 来源：SCIENCE ADVANCES 2018
- 关键词：Biosensors - Transcription - DNA - Binding sites - Signal transduction
- Microbial Metabolite Inspired β-Peptide Polymers Displaying Potent and Selective Antifungal Activity被引量：41收藏
- 作者：Zhang, Donghui Shi, Chao Cong, Zihao Chen, Qi Bi, Yufang Zhang, Junyu Ma, Kaiqian Liu, Shiqi Gu, Jiawei Chen, Minzhang Lu, Ziyi Zhang, Haodong Xie, Jiayang Xiao, Ximian Liu, Longqiang Jiang, Weinan Shao, Ning Chen, Sheng Zhou, Min Shao, Xiaoyan Dai, Yidong Li, Maoquan Zhang, Lixin Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Ruijin Rehabil Hosp;Tongji Univ
- 来源：ADVANCED SCIENCE 2022
- 关键词：antifungal agents fungal keratitis host defense peptide mimicking poly(DL-diaminopropionic acid) beta-peptide polymers
- TetR-Type Regulator SLCG_2919 Is a Negative Regulator of Lincomycin Biosynthesis in Streptomyces lincolnensis被引量：39收藏
- 作者：Xu, Yurong Ke, Meilan Li, Jie Tang, Yaqian Wang, Nian Tan, Guoqing Wang, Yansheng Liu, Ruihua Bai, Linquan Zhang, Lixin Wu, Hang Zhang, Buchang
- 机构：Anhui Univ;Hefei Normal Univ;East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Xinyu Pharmaceut Co Ltd
- 来源：APPLIED AND ENVIRONMENTAL MICROBIOLOGY 2019
- 关键词：lincomycin SLCG_2919 Streptomyces lincolnensis TetR family transcriptional regulator
- Beauvericin counteracted multi-drug resistant Candida albicans by blocking ABC transporters被引量：39收藏
- 作者：Tong, Yaojun Liu, Mei Zhang, Yu Liu, Xueting Huang, Ren Song, Fuhang Dai, Huanqin Ren, Biao Sun, Nuo Pei, Gang Bian, Jiang Jia, Xin-Ming Huang, Guanghua Zhou, Xuyu Li, Shaojie Zhang, Buchang Fukuda, Takashi Tomoda, Hiroshi Omura, Satoshi Cannon, Richard D. Calderone, Richard Zhang, Lixin
- 机构：Chinese Acad Sci;East China Univ Sci & Technol;Tech Univ Denmark;Guangdong Lab Anim Monitoring Inst;Anhui Univ
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2016
- 关键词：Candida albicans ABC transporter Beauvericin Virtual screening Multi-drug resistance Synergy
- Efficient editing DNA regions with high sequence identity in actinomycetal genomes by a CRISPR-Cas9 system被引量：36收藏
- 作者：Mo, Jingjun Wang, Shuwen Zhang, Wan Li, Chunyu Deng, Zixin Zhang, Lixin Qu, Xudong
- 机构：Wuhan Univ;East China Univ Sci & Technol
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2019
- 关键词：Biosynthesis Polyketide synthase CRISPR/Cas9 Antimycin Actinobacteria
- High-yield porphyrin production through metabolic engineering and biocatalysis被引量：34收藏
- 作者：Chen, Haihong Wang, Yaohong Wang, Weishan Cao, Ting Zhang, Lu Wang, Zhengduo Chi, Xuran Shi, Tong Wang, Huangwei He, Xinwei Liang, Mindong Yang, Mengxue Jiang, Wenyi Lv, Dongyuan Yu, Jiaming Zhu, Guoliang Xie, Yongtao Gao, Bei Wang, Xinye Liu, Xueting Li, Youyuan Ouyang, Limin Zhang, Jingyu Liu, Huimin Li, Zilong Tong, Yaojun Xia, Xuekui Tan, Gao-Yi Zhang, Lixin
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Shanghai Jiao Tong Univ;Qilu Univ Technol
- 来源：NATURE BIOTECHNOLOGY 2025
- 关键词：Catalysis - Diagnosis - Fermentation - Medical applications - Metabolic engineering
- Genome-Based Discovery of Enantiomeric Pentacyclic Sesterterpenes Catalyzed by Fungal Bifunctional Terpene Synthases被引量：33收藏
- 作者：Jiang, Lan Zhang, Xue Sato, Yuya Zhu, Guoliang Minami, Atsushi Zhang, Weiyan Ozaki, Taro Zhu, Bin Wang, Zhixin Wang, Xinye Lv, Kangjie Zhang, Jingyu Wang, Yongheng Gao, Shushan Liu, Chengwei Hsiang, Tom Zhang, Lixin Oikawa, Hideaki Liu, Xueting
- 机构：East China Univ Sci Technol;Hokkaido Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;Jinan Univ
- 来源：ORGANIC LETTERS 2021
- Transcriptional regulation of a leucine-responsive regulatory protein for directly controlling lincomycin biosynthesis in Streptomyces lincolnensis被引量：33收藏
- 作者：Xu, Yurong Tang, Yaqian Wang, Nian Liu, Jing Cai, Xinlu Cai, Hongyi Li, Jie Tan, Guoqing Liu, Ruihua Bai, Linquan Zhang, Lixin Wu, Hang Zhang, Buchang
- 机构：Anhui Univ;Hefei Normal Univ;Xinyu Pharmaceut Co Ltd;East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Leucine-responsive regulatory protein Metabolic regulation Streptomyces lincolnensis Lincomycin Transcriptional activator
- Yeast9: a consensus genome-scale metabolic model for S. cerevisiae curated by the community被引量：33收藏
- 作者：Zhang, Chengyu Sanchez, Benjamin J. Li, Feiran Eiden, Cheng Wei Quan Scott, William T. Liebal, Ulf W. Blank, Lars M. Mengers, Hendrik G. Anton, Mihail Rangel, Albert Tafur Mendoza, Sebastian N. Zhang, Lixin Nielsen, Jens Lu, Hongzhong Kerkhoven, Eduard J.
- 机构：Shanghai Jiao Tong Univ;East China Univ Sci & Technol ECUST;Tech Univ Denmark;Tech Univ Denmark;Tsinghua Univ
- 来源：MOLECULAR SYSTEMS BIOLOGY 2024
- 关键词：Saccharomyces cerevisiae Genome-scale Metabolic Models Machine Learning Multi-omics Integration
- Genome-based mining of new antimicrobial meroterpenoids from the phytopathogenic fungus Bipolaris sorokiniana strain 11134被引量：32收藏
- 作者：Han, Jianying Zhang, Jingyu Song, Zhijun Zhu, Guoliang Liu, Miaomiao Dai, Huanqin Hsiang, Tom Liu, Xueting Zhang, Lixin Quinn, Ronald J. Feng, Yunjiang
- 机构：Griffith Univ;Chinese Acad Sci;East China Univ Sci & Technol;Univ Guelph
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Meroterpenoids Phytopathogenic fungus Bipolaris sorokiniana Genome-based mining Antimicrobial activity
- Learn from microbial intelligence for avermectins overproduction被引量：32收藏
- 作者：Gao, Qiang Tan, Gao-Yi Xia, Xuekui Zhang, Lixin
- 机构：East China Univ Sci & Technol;Tianjin Univ Sci & Technol;Shandong Acad Sci;Qingdao Natl Lab Marine Sci & Technol
- 来源：CURRENT OPINION IN BIOTECHNOLOGY 2017
- New Diketopiperazines from a Marine-Derived Fungus Strain Aspergillus versicolor MF180151被引量：31收藏
- 作者：Hu, Jiansen Li, Zheng Gao, Jieyu He, Hongtao Dai, Huanqin Xia, Xuekui Liu, Cuihua Zhang, Lixin Song, Fuhang
- 机构：Chinese Acad Sci;Univ Chinese Acad Sci;Hefei Univ Technol;Qilu Univ Technol;East China Univ Sci Technol
- 来源：MARINE DRUGS 2019
- 关键词：marine-derived fungus Aspergillus versicolor diketopiperazine antibacterial
- Genome-Inspired Chemical Exploration of Marine FungusAspergillus fumigatusMF071被引量：31收藏
- 作者：Han, Jianying Liu, Miaomiao Jenkins, Ian D. Liu, Xueting Zhang, Lixin Quinn, Ronald J. Feng, Yunjiang
- 机构：Griffith Univ;Chinese Acad Sci;East China Univ Sci & Technol
- 来源：MARINE DRUGS 2020
- 关键词：Aspergillus fumigatus genome mining chemical diversity antimicrobial activity biosynthetic gene cluster prenyltransferase
- Anti-mycobacterial natural products and mechanisms of action被引量：28收藏
- 作者：Han, Jianying Liu, Xueting Zhang, Lixin Quinn, Ronald J. Feng, Yunjiang
- 机构：Griffith Univ;East China Univ Sci & Technol
- 来源：NATURAL PRODUCT REPORTS 2022
