成果/Result
- Simple Cyclohexanediamine-Derived Primary Amine Thiourea Catalyzed Highly Enantioselective Conjugate Addition of Nitroalkanes to Enones被引量：94收藏
- 作者：Mei, Kui Jin, Mei Zhang, Shilei Li, Ping Liu, Wenjing Chen, Xiaobei Xue, Fei Duan, Wenhu Wang, Wei
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Univ New Mexico
- 来源：ORGANIC LETTERS 2009
- Practical synthesis of C1 deuterated aldehydes enabled by NHC catalysis被引量：94收藏
- 作者：Geng, Huihui Chen, Xiaobei Gui, Jingjing Zhang, Yueteng Shen, Zuyuan Qian, Pengfei Chen, Junwei Zhang, Shilei Wang, Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Soochow Univ;Soochow Univ;Univ Arizona
- 来源：NATURE CATALYSIS 2019
- 关键词：Reaction intermediates - Cost effectiveness - Condensation reactions - Deuterium - Catalysis
- Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle被引量：66收藏
- 作者：Chen, Xu-bing Zhuang, Jing-jing Liu, Jun-hua Lei, Min Ma, Lei Chen, Jing Shen, Xu Hu, Li-hong
- 机构：Chinese Acad Sci;E China Univ Sci & Technol
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY 2011
- 关键词：Siraitia grosvenorii Swingle Cucurbitane triterpenoids AMPK HepG2 cell Anti-diabetic effect
- Synthesis of Aldehydes by Organocatalytic Formylation Reactions of Boronic Acids with Glyoxylic Acid被引量：49收藏
- 作者：Huang, He Yu, Chenguang Li, Xiangmin Zhang, Yongqiang Zhang, Yueteng Chen, Xiaobei Mariano, Patrick S. Xie, Hexin Wang, Wei
- 机构：Univ New Mexico;East China Univ Sci Technol;East China Univ Sci Technol
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2017
- 关键词：arenes boron formylation organocatalysis synthetic methods
- Trideuteromethylation Enabled by a Sulfoxonium Metathesis Reaction被引量：46收藏
- 作者：Shen, Zuyuan Zhang, Shilei Geng, Huihui Wang, Jiarui Zhang, Xinyu Zhou, Anqi Yao, Cheng Chen, Xiaobei Wang, Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Soochow Univ;Soochow Univ;Univ Arizona
- 来源：ORGANIC LETTERS 2019
- An Organocatalytic Approach to the Construction of Chiral Oxazolidinone Rings and Application in the Synthesis of Antibiotic Linezolid and Its Analogues被引量：31收藏
- 作者：Song, Lirong Chen, Xiaobei Zhang, Shilei Zhang, Haoyi Li, Ping Luo, Guangshun Liu, Wenjing Duan, Wenhu Wang, Wei
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Univ New Mexico
- 来源：ORGANIC LETTERS 2008
- Stereoselective organocatalytic oxidation of alcohols to enals: a homologation method to prepare polyenes被引量：26收藏
- 作者：Chen, Xiaobei Zhang, Yinan Wan, Huixin Wang, Wei Zhang, Shilei
- 机构：Soochow Univ;Soochow Univ;E China Univ Sci & Technol;Univ New Mexico;Shanghai Pharmaceut Holding Co Ltd
- 来源：CHEMICAL COMMUNICATIONS 2016
- FeCl3 AND MORPHOLINE AS EFFICIENT COCATALYSTS FOR THE ONE-STEP SYNTHESIS OF QUINOXALINES FROM α-HYDROXYKETONES AND 1,2-DIAMINES被引量：26收藏
- 作者：Song, Weibin Liu, Peng Lei, Min You, Hanyun Chen, Xubing Chen, Hu Ma, Lei Hu, Lihong
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：SYNTHETIC COMMUNICATIONS 2012
- 关键词：Cocatalyst FeCl3 morpholine quinoxaline
- Facile Installation of 2-Reverse Prenyl Functionality into Indoles by a Tandem N-Alkylation-Aza-Cope Rearrangement Reaction and Its Application in Synthesis被引量：23收藏
- 作者：Chen, Xiaobei Fan, Huaqiang Zhang, Shilei Yu, Chenguang Wang, Wei
- 机构：E China Univ Sci & Technol;Univ New Mexico;Soochow Univ
- 来源：CHEMISTRY-A EUROPEAN JOURNAL 2016
- 关键词：alkaloids domino reactions natural products rearrangement synthesis design
- Direct insertion into the C-C bond of unactivated ketones with NaH-mediated aryne chemistry被引量：23收藏
- 作者：Luo, Fa Li, Chen-Long Ji, Peng Zhou, Yuxin Gui, Jingjing Chen, Lingyun Yin, Yuejia Zhang, Xinyu Hu, Yanwei Chen, Xiaobei Liu, Xuejun Chen, Xiaodong Yu, Zhi-Xiang Wang, Wei Zhang, Shi-Lei
- 机构：Soochow Univ;Soochow Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;Peking Univ
- 来源：CHEM 2023
- Scalable synthesis of methyl ent-isocopalate and its derivatives被引量：19收藏
- 作者：Hua, Si-Kai Wang, Jing Chen, Xi-Bo Xu, Zhong-Yu Zeng, Bu-Bing
- 机构：Shanghai Key Lab Chem Biol;E China Univ Sci & Technol
- 来源：TETRAHEDRON 2011
- 关键词：Methyl ent-isocopalate (-)-Sclareol Tricycle diterpene Spongiane
- Facile and practical hydrodehalogenations of organic halides enabled by calcium hydride and palladium chloride被引量：16收藏
- 作者：Gui, Jingjing Cai, Xin Chen, Lingyun Zhou, Yuxin Zhu, Wenjing Jiang, Yuanrui Hu, Min Chen, Xiaobei Hu, Yanwei Zhang, Shilei
- 机构：Soochow Univ;Soochow Univ;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ORGANIC CHEMISTRY FRONTIERS 2021
- 关键词：Aromatic compounds - Aromatization - Chlorine compounds - Hydrides - Calcium compounds
- A NaH-promoted N-detosylation reaction of diverse p-toluenesulfonamides被引量：15收藏
- 作者：Sun, Wanwan Chen, Xiaobei Hu, Ying Geng, Huihui Jiang, Yuanrui Zhou, Yuxin Zhu, Wenjing Hu, Min Hu, Haohua Wang, Xingyi Wang, Xinli Zhang, Shilei Hu, Yanwei
- 机构：Soochow Univ;Soochow Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;Suzhou Vocat Hlth Coll
- 来源：TETRAHEDRON LETTERS 2020
- 关键词：Sodium hydride Detosylation P-toluenesulfonamides Indole
- Synthesis of the Scalarane Sesterterpenoid 16-deacetoxy-12-epi-scalarafuranacetate被引量：13收藏
- 作者：Chen, Xi-Bo Yuan, Qian-Jia Wang, Jing Hua, Si-Kai Ren, Jiangmeng Zeng, Bu-Bing
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF ORGANIC CHEMISTRY 2011
- Construction of the Isocopalane Skeleton: Application of a Desulfinylative 1,7-Hydrogen Atom Transfer Strategy被引量：12收藏
- 作者：Xiao, Xiong Xu, ZhongYu Zeng, Qian-Ding Chen, Xi-Bo Ji, Wen-Hao Han, Ying Wu, PeiYing Ren, Jiangmeng Zeng, Bu-Bing
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Shanghai Univ Tradit Chinese Med;Yangzhou Univ
- 来源：CHEMISTRY-A EUROPEAN JOURNAL 2015
- 关键词：hydrogen transfer natural products persulfates synthons terpenoids
- The Reaction of Aryl Thiols or Thioureas with o-Diiodoarenes/NaH to Access o-Iodoaryl Thioethers被引量：10收藏
- 作者：Hu, Min Liu, Dianfan Liu, Yuan Luo, Fan Chen, Xiaobei Yin, Yuejia Zhang, Shilei Hu, Yanwei
- 机构：Soochow Univ;Soochow Univ;Jiaxing Univ;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ADVANCED SYNTHESIS & CATALYSIS 2024
- 关键词：o-Iodoaryl thioether Aryne o-Diiodoarene Sodium hydride Arylation
- A simple method for N-arylation of secondary amides/amines through a NaH-initiated aryne generation strategy被引量：9收藏
- 作者：Jiang, Yuanrui Zhu, Wenjing Huang, Jiawen Luo, Fan Chen, Xiaobei Fang, Chunhui Chen, Xin Liu, Shihui Hu, Yanwei Zhang, Shilei
- 机构：Soochow Univ;Soochow Univ;Jiaxing Univ;East China Univ Sci Technol;East China Univ Sci Technol
- 来源：ORGANIC CHEMISTRY FRONTIERS 2023
- 关键词：Amides - Aromatic compounds - Chemical reactions - Hydrides - Sodium compounds - Transition metals
- Simultaneous dehalogenation and hydrogenation reduction of halogen-heteroaromatic aldehydes被引量：7收藏
- 作者：Chen, Xi-Bo Hu, Qiu-Peng Yuan, Qian-Jia Ding, Wei Ren, Jiangmeng Zeng, Bu-Bing
- 机构：E China Univ Sci & Technol;Shanghai Key Lab Chem Biol;Chinese Acad Sci
- 来源：TETRAHEDRON LETTERS 2012
- 关键词：Halogen-heteroaromatic aldehydes Palladium catalysts Hydrogen Dehalogenation Hydrogenation
- Palladium-Catalyzed Transfer Hydrogenation and Acetylation of N -Heteroarenes with Sodium Hydride as the Reductant被引量：7收藏
- 作者：Luo, Fan Chen, Xiaobei Yu, Jing Yin, Yuejia Hu, Xiaoxiao Hu, Ying Liu, Xuejun Chen, Xiaodong Zhang, Shilei Hu, Yanwei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Soochow Univ;Suzhou Vocat Hlth Coll;Shanghai Neutan Pharmaceut Co Ltd
- 来源：SYNTHESIS-STUTTGART 2023
- 关键词：palladium sodium hydride transfer hydrogenation N -heteroarenes N -heterocycles
- Iron-Catalyzed Anti-Markovnikov Hydroamination of Vinylpyridines被引量：7收藏
- 作者：Peng, Yahui Qin, Cong Chen, Xiaobei Li, Jianjun Li, Hao Wang, Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ New Mexico
- 来源：ASIAN JOURNAL OF ORGANIC CHEMISTRY 2017
- 关键词：anti-Markovnikov azoles hydroamination iron vinylpyridines
- Anionic Fries Rearrangement of ortho-Iodophenyl Carboxylate Initiated by Potassium Hydride被引量：5收藏
- 作者：Zhou, Yuxin He, Mengyang Yi, Tingting Chen, Xiaobei Wang, Mengqing Liu, Xuejun Chen, Xiaodong Zhang, Shilei Hu, Yanwei
- 机构：Soochow Univ;Shanghai Neutan Pharmaceut Co Ltd;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ORGANIC LETTERS 2025
- Facile Construction of Troponoid Derivatives Incorporating Imidazolin-2-one Moieties被引量：5收藏
- 作者：Yu, Jing Chen, Xiaobei Liu, Ye Wu, Bing Li, Haiyan Hu, Yanwei Wang, Liang Zhang, Shilei
- 机构：Soochow Univ;Soochow Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;Qingdao Agr Univ
- 来源：SYNTHESIS-STUTTGART 2020
- 关键词：troponoid isocyanate imidazolin-2-one cascade reaction high temperature
- Site-selective deuteration at the α-position of enals by an amine and bis(phenylsulfonyl)methane co-catalyzed H/D exchange reaction被引量：5收藏
- 作者：Qian, Pengfei Zhang, Shilei Luo, Fan Wang, Jiarui Zhang, Xinyu Liu, Xuejun Chen, Xiaodong Wang, Wei Chen, Xiaobei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Soochow Univ;Soochow Univ;Shanghai Neutan Pharmaceut Co Ltd
- 来源：CHEMICAL COMMUNICATIONS 2022
- 关键词：Catalysis - Methane
- Divergent synthesis of 1,3,5-trisubstituted benzenes from 2,3,5-triiodobenzoic acid被引量：4收藏
- 作者：Lin, Huiling Qi, Jiayi Luo, Fan Zhu, Zimei Zhu, Haojie Ge, Yan Hu, Yiou Wang, Wei Zhang, Shilei Chen, Xiaobei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Jiaxing Univ;Soochow Univ;Univ Arizona
- 来源：ORGANIC & BIOMOLECULAR CHEMISTRY 2025
- 关键词：Medicinal chemistry - Titanium compounds
- Synthesis of α-Aryl Primary Amides from α-Silyl Nitriles and Aryl Sulfoxides through [3,3]-Sigmatropic Rearrangement被引量：3收藏
- 作者：Luo, Fan Zhou, Hui Chen, Xiao-Bei Liu, Xue-Jun Chen, Xiao-Dong Qian, Peng-Fei Wu, Xin-Ping Wang, Wei Zhang, Shi-Lei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ORGANIC LETTERS 2022
- Aldehydes Switch Regioselectivity: a Prins Cyclization Strategy for the Synthesis of Indoline-fused THFs and Indole-fused Oxepanes被引量：3收藏
- 作者：Chen Xiaobei Jiang Yuanrui Geng Huihui Liu Xingyu Huang Yizhuo Lu Jingwei Gao Chenjing Zhang Shilei Zhang Jian Wang Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Soochow Univ;Soochow Univ;Shanghai Jiao Tong Univ
- 来源：ADVANCED SYNTHESIS & CATALYSIS 2020
- 关键词：Prins cyclization tetrahydrofuran oxepane aldehyde rearrangement
- Synthesis of polysubstituted naphthalenes from cyclopentadienones using o-diiodobenzene/NaH as a benzyne system被引量：3收藏
- 作者：Zhu, Haojie Hu, Ying Hu, Yiou Ge, Yan Wang, Wei Zhang, Shilei Chen, Xiaobei
- 机构：East China Univ Sci & Technol;Suzhou Vocat Hlth Coll;Soochow Univ;Univ Arizona;Univ Arizona
- 来源：TETRAHEDRON LETTERS 2025
- 关键词：Cyclopentadienone Polysubstituted naphthalene Diels-Alder reaction Benzyne Sodium hydride
- 一种N-杂环卡宾催化合成氘代苯偶姻的方法被引量：1收藏
- 作者：张心予 耿慧慧 张士磊 王卫 陈晓蓓
- 机构：华东理工大学药学院、上海市细胞代谢光遗传学技术前沿科学研究基地、上海市新药设计重点实验室生物反应器工程国家重点实验室
- 来源：《有机化学》 2023
- 关键词：氘代 重水 苯偶姻缩合 N-杂环卡宾 有机催化
- 摘要：利用D2O作为氘源,在N-杂环卡宾的催化下,两分子醛发生苯偶姻缩合反应(benzoin condensation)得到酮基α-位氘代的苯偶姻产物.反应条件温和、操作简单,多种芳香醛底物都可以给出高氘代率的产物.
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- Design and synthesis of indol-2-one derivatives as potential RET inhibitors被引量：1收藏
- 作者：Li, Zhenzhu Sun, Kai Xu, Yuanhong Zhu, Fuli Mao, Zhenyu Wang, Yang Yuan, Yaxia Qiu, Ting Chen, Xiabin Ma, Lei
- 机构：East China Univ Sci & Technol;Hangzhou Normal Univ;Hangzhou Normal Univ;Univ Texas Hlth Sci Ctr San Antonio
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2024
- 关键词：RET kinase inhibitors Indol-2-one Structure-based optimization Cell proliferation Structure-activity relationship
- 一类特殊的分子内类Aldol反应产物他达拉非有关物质E的合成研究被引量：1收藏
- 作者：钱彭飞 万惠新 蒋静 胡延维 陈晓蓓 张士磊
- 机构：苏州大学药学院;上海医药集团股份有限公司中央研究院;华东理工大学药学院
- 来源：《有机化学》 2016
- 关键词：aldol反应 酰胺 硅胶催化 胺基半缩酮 他达拉非有关物质
- 摘要：在合成他达拉非有关物质D、E、G、H的过程中,发现了一类特殊的分子内类aldol反应.在这个反应中,酮的α位碳进攻酰胺的羰基,形成一个稳定的胺基半缩酮结构.这个反应需要用硅胶催化来实现,其它酸碱性反应条件均难以得到所需的...
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