施小新 收藏
( 任职于 药学院制药工程系)
1985年本科毕业于苏州大学化学系；1991年于中国科学院上海有机化学研究所获得理学博士学位；1991-1993年期间在中国科学院上海有机化学研究所工作，任助理研究员；1993-1996年期间在美国佛罗里达工学院（FIT,Florida Institute of Technology）健康与治疗研究中心进行博士后研究工作；1996-2000年期间，回中国科学院上海有机化学研究所工作，任副研究员，2000-2001年期间，在华东理工大学工作，任副教授；2001年至今，继续在华东理工大学工作，任教授；2003年起，为博士生导师。 研究方向 ------------------... 详细>>
- Highly optically selective and electrochemically active chemosensor for copper (II) based on triazole-linked glucosyl anthraquinone被引量：96收藏
- 作者：Zhang, Yin-Jie He, Xiao-Peng Hu, Min Li, Zhen Shi, Xiao-Xin Chen, Guo-Rong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;CNRS
- 来源：DYES AND PIGMENTS 2011
- 关键词：Copper (II) Chemosensor Triazolyl glycoside Anthraquinone Click reaction Voltammetry
- 质疑
- A Short and Practical Synthesis of Oseltamivir Phosphate (Tamiflu) from (-)-Shikimic Acid被引量：89收藏
- 作者：Nie, Liang-Deng Shi, Xiao-Xin Ko, Kwang Hyok Lu, Wei-Dong
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF ORGANIC CHEMISTRY 2009
- 质疑
- Dearomatization of tryptophols via a vanadium-catalyzed asymmetric epoxidation and ring-opening cascade被引量：86收藏
- 作者：Han, Long Liu, Chuan Zhang, Wei Shi, Xiao-Xin You, Shu-Li
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：CHEMICAL COMMUNICATIONS 2014
- 质疑
- Epimeric Monosaccharide-Quinone Hybrids on Gold Electrodes toward the Electrochemical Probing of Specific Carbohydrate-Protein Recognitions被引量：80收藏
- 作者：He, Xiao-Peng Wang, Xiu-Wen Jin, Xiao-Ping Zhou, Hao Shi, Xiao-Xin Chen, Guo-Rong Long, Yi-Tao
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2011
- 关键词：Electrochemical electrodes - Proteins - Binding energy - Cell membranes - Self assembled monolayers - Cyclic voltammetry - Glucose - Gold coatings - Probes
- 质疑
- A mild and efficient catalyst for the Beckmann rearrangement, BOP-Cl被引量：70收藏
- 作者：Zhu, Minze Cha, Chuantao Deng, Wei-Ping Shi, Xiao-Xin
- 机构：E China Univ Sci & Technol
- 来源：TETRAHEDRON LETTERS 2006
- 质疑
- An exo- and Enantioselective 1,3-Dipolar Cycloaddition of Azomethine Ylides with Alkylidene Malonates Catalyzed by a N,O-Ligand/Cu(OAc)2-Derived Chiral Complex被引量：67收藏
- 作者：Wang, Ming Wang, Zheng Shi, Yu-Hua Shi, Xiao-Xin Fossey, John S. Deng, Wei-Ping
- 机构：E China Univ Sci & Technol;Univ Birmingham
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2011
- 关键词：copper cycloaddition nitrogen heterocycles N,O ligands
- 质疑
- An exo- and enantioselective 1,3-dipolar cycloaddition of azomethine ylides with alkylidene malonates catalyzed by a N,O-ligand/Cu(OAc)2-derived chiral complex被引量：66收藏
- 作者：Wang, Ming Wang, Zheng Shi, Yu-Hua Shi, Xiao-Xin Fossey, John S. Deng, Wei-Ping
- 机构： School of Pharmacy; School of Chemistry
- 来源：Angewandte Chemie - International Edition 2011
- 关键词：Copper - Ligands - Nitrogen - Molecular sieves - Cycloaddition - Enantioselectivity
- 质疑
- Cu-catalyzed mild and efficient oxidation of THβCs using air: Application in practical total syntheses of perlolyrine and flazin被引量：63收藏
- 作者：Zheng, Bo Trieu, Tien Ha Meng, Tian-Zhuo Lu, Xia Dong, Jing Zhang, Qiang Shi, Xiao-Xin
- 机构： Shanghai Key Laboratory of Chemical Biology
- 来源：RSC Advances 2018
- 关键词：Catalysis - Copper compounds - Pyridine
- 质疑
- Creation of 3,4-bis-triazolocoumarin-sugar conjugates via flourogenic dual click chemistry and their quenching specificity with silver(I) in aqueous media被引量：61收藏
- 作者：He, Xiao-Peng Song, Zhuo Wang, Zhi-Zhou Shi, Xiao-Xin Chen, Kaixian Chen, Guo-Rong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Acad Sci
- 来源：TETRAHEDRON 2011
- 关键词：Fluorogenic Click chemistry Glycosyl coumarin Silver(I) Quenching
- 质疑
- A novel asymmetric synthesis of oseltamivir phosphate (Tamiflu) from (-)-shikimic acid被引量：61收藏
- 作者：Nie, Liang-Deng Shi, Xiao-Xin
- 机构：E China Univ Sci & Technol
- 来源：TETRAHEDRON-ASYMMETRY 2009
- 质疑
- Highly stereoselective Pictet-Spengler reaction of D-tryptophan methyl ester with piperonal:: convenient syntheses of Cialis (Tadalafil), 12a-epi-Cialis, and their deuterated analogues被引量：46收藏
- 作者：Shi, Xiao-Xin Liu, Shi-Ling Xu, Wei Xu, Yu-Lan
- 机构：E China Univ Sci & Technol
- 来源：TETRAHEDRON-ASYMMETRY 2008
- 质疑
- Novel N,O-Cu(OAc)2 complex catalysed diastereo- and enantioselective 1,4-addition of glycine derivatives to alkylidene malonates被引量：43收藏
- 作者：Wang, Ming Shi, Yu-Hua Luo, Jun-Fei Du, Wenting Shi, Xiao-Xin Fossey, John S. Deng, Wei-Ping
- 机构： School of Pharmacy; School of Chemistry
- 来源：Catalysis Science and Technology 2011
- 关键词：Enantioselectivity
- 质疑
- Efficient and Practical One-Pot Conversions of N-Tosyltetrahydroisoquinolines into Isoquinolines and of N-Tosyltetrahydro-β-carbolines into β-Carbolines through Tandem β-Elimination and Aromatization被引量：41收藏
- 作者：Dong, Jing Shi, Xiao-Xin Yan, Jing-Jing Xing, Jing Zhang, Qiang Xiao, Sen
- 机构：E China Univ Sci & Technol
- 来源：EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2010
- 关键词：Synthetic methods Heterocycles Nitrogen heterocycles Dehydrogenation
- 质疑
- Mild and efficient syntheses of 1-aryl-3,4-dihydroisoquinolines and 1-aryl-3,4-dihydro-β-carbolines via regiospecific β-eliminations of the corresponding N-tosyl-1,2,3,4-tetrahydroisoquinolines and N-tosyl-1,2,3,4-tetrahydro-β-carbolines被引量：39收藏
- 作者：Dong, Jing Shi, Xiao-Xin Xing, Jing Yan, Jing-Jing
- 机构： Department of Pharmaceutical Engineering
- 来源：Synthetic Communications 2012
- 关键词：Potassium hydroxide - Solvents
- 质疑
- Dearomatization of Indoles via a Phenol-Directed Vanadium-Catalyzed Asymmetric Epoxidation and Ring-Opening Cascade被引量：35收藏
- 作者：Han, Long Zhang, Wei Shi, Xiao-Xin You, Shu-Li
- 机构：Chinese Acad Sci;E China Univ Sci & Technol
- 来源：ADVANCED SYNTHESIS & CATALYSIS 2015
- 关键词：asymmetric catalysis dearomatization epoxidation indoles vanadium
- 质疑
- Microwave-assisted construction of triazole-linked amino acid-glucoside conjugates as novel PTP1B inhibitors被引量：34收藏
- 作者：He, Xiao-Peng Li, Cui Jin, Xiao-Ping Song, Zhuo Zhang, Hai-Lin Zhu, Cheng-Jiang Shen, Qiang Zhang, Wei Sheng, Li Shi, Xiao-Xin Tang, Yun Li, Jia Chen, Guo-Rong Xie, Juan
- 机构：Chinese Acad Sci;CNRS;E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：NEW JOURNAL OF CHEMISTRY 2011
- 质疑
- A unique and rapid approach toward the efficient development of novel protein tyrosine phosphatase (PTP) inhibitors based on 'clicked' pseudo-glycopeptides被引量：33收藏
- 作者：Yang, Jin-Wei He, Xiao-Peng Li, Cui Gao, Li-Xin Sheng, Li Xie, Juan Shi, Xiao-Xin Tang, Yun Li, Jia Chen, Guo-Rong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Acad Sci;E China Univ Sci & Technol;CNRS
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2011
- 关键词：Glycopeptides Click reaction Protein tyrosine phosphatase inhibitor Microwave irradiation Docking simulation
- 质疑
- Microwave-accelerated click chemistry: Expeditious synthesis of novel triazole-linked salicylic β-D-O-glycosides with PTP1B inhibitory activity被引量：32收藏
- 作者：Yang, Jin-Wei Li, Cui He, Xiao-Peng Zhao, Hong Gao, Li-Xin Zhang, Wei Shi, Xiao-Xin Tang, Yun Li, Jia Chen, Guo-Rong
- 机构： Key Laboratory for Advanced Materials and Institute of Fine Chemicals; National Center for Drug Screening; School of Pharmacy; PPSM
- 来源：Bulletin of the Korean Chemical Society 2010
- 关键词：Amino acids - Binding energy - Irradiation - Synthesis (chemical) - Phosphatases - Sugars
- 质疑
- Inversion of secondary chiral alcohols in toluene with the tunable complex of R3N-R′COOH被引量：32收藏
- 作者：Shi, Xiao-Xin Shen, Chun-Li Yao, Jian-Zhong Nie, Liang-Deng Quan, Na
- 机构：E China Univ Sci & Technol
- 来源：TETRAHEDRON-ASYMMETRY 2010
- 质疑
- Chiral counteranion-directed silver-catalyzed asymmetric synthesis of 1,2-dihydroisoquinolines by Friedel-Crafts alkylation reactions被引量：32收藏
- 作者：Zhang, Jun-Wei Xu, Zhe Gu, Qing Shi, Xiao-Xin Leng, Xue-Bing You, Shu-Li
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：TETRAHEDRON 2012
- 关键词：Chiral counteranion 1,2-Dihydroisoquinoline Friedel-Crafts alkylation Chiral sliver phosphate Asymmetric synthesis
- 质疑
- Syntheses of chiral 1,3-disubstituted tetrahydro-β-carbolines via CIAT process: highly stereoselective Pictet-Spengler reaction of D-tryptophan ester hydrochlorides with various aldehydes被引量：30收藏
- 作者：Xiao, Sen Lu, Xia Shi, Xiao-Xin Sun, Yu Liang, Li-Li Yu, Xin-Hong Dong, Jing
- 机构：E China Univ Sci & Technol
- 来源：TETRAHEDRON-ASYMMETRY 2009
- 质疑
- Facile fabrication of promising protein tyrosine phosphatase (PTP) inhibitor entities based on 'clicked' serine/threonine-monosaccharide hybrids被引量：28收藏
- 作者：He, Xiao-Peng Deng, Qiong Gao, Li-Xin Li, Cui Zhang, Wei Zhou, Yu-Bo Tang, Yun Shi, Xiao-Xin Xie, Juan Li, Jia Chen, Guo-Rong Chen, Kaixian
- 机构：CNRS;E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Acad Sci
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY 2011
- 关键词：Sugar template Click chemistry Amino acid PTP inhibitor MTT assay
- 质疑
- Novel N,O-Cu(OAc)2 complex catalysed diastereo- and enantioselective 1,4-addition of glycine derivatives to alkylidene malonates被引量：28收藏
- 作者：Wang, Ming Shi, Yu-Hua Luo, Jun-Fei Du, Wenting Shi, Xiao-Xin Fossey, John S. Deng, Wei-Ping
- 机构：E China Univ Sci & Technol;Univ Birmingham
- 来源：CATALYSIS SCIENCE & TECHNOLOGY 2011
- 质疑
- A novel and high-yielding asymmetric synthesis of oseltamivir phosphate (Tamiflu) starting from (-)-shikimic acid被引量：26收藏
- 作者：Nie, Liang-Deng Ding, Wei Shi, Xiao-Xin Quan, Na Lu, Xia
- 机构：E China Univ Sci & Technol
- 来源：TETRAHEDRON-ASYMMETRY 2012
- 质疑
- Efficient and Practical Syntheses of Enantiomerically Pure (S)-(-)-Norcryptostyline I, (S)-(-)-Norcryptostyline II, (R)-(+)-Salsolidine and (S)-(-)-Norlaudanosine via a Resolution-Racemization Method被引量：25收藏
- 作者：Zhu, Ruiheng Xu, Zhangli Ding, Wei Liu, Shiling Shi, Xiaoxin Lu, Xia
- 机构：E China Univ Sci & Technol
- 来源：CHINESE JOURNAL OF CHEMISTRY 2014
- 关键词：tetrahydroisoquinolines norcryptostyline salsolidine norlaudanosine resolution racemization
- 质疑
- Click to a focused library of benzyl 6-triazolo(hydroxy)benzoic glucosides: Novel construction of PTP1B inhibitors on a sugar scaffold被引量：24收藏
- 作者：Li, Cui He, Xiao-Peng Zhang, Yin-Jie Li, Zhen Gao, Li-Xin Shi, Xiao-Xin Xie, Juan Li, Jia Chen, Guo-Rong Tang, Yun
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Acad Sci;CNRS
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2011
- 关键词：Click chemistry PTP1B inhibitor Sugar scaffold (Hydroxy)benzoate Molecular docking
- 质疑
- Total Syntheses of Eudistomins Y1-Y7 by an Efficient One-Pot Process of Tandem Benzylic Oxidation and Aromatization of 1-Benzyl-3,4-dihydro-β-Carbolines被引量：24收藏
- 作者：Trieu, Tien Ha Dong, Jing Zhang, Qiang Zheng, Bo Meng, Tian-Zhuo Lu, Xia Shi, Xiao-Xin
- 机构：E China Univ Sci & Technol
- 来源：EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2013
- 关键词：Natural products Alkaloids Total synthesis Nitrogen heterocycles Aromatization
- 质疑
- Enantioselective synthesis of 4,5,6,7-tetrahydroindoles via olefin cross-metathesis/intramolecular Friedel-Crafts alkylation reaction of pyrroles被引量：23收藏
- 作者：Zhang, Jun-Wei Liu, Xiao-Wei Gu, Qing Shi, Xiao-Xin You, Shu-Li
- 机构：Chinese Acad Sci;E China Univ Sci & Technol
- 来源：ORGANIC CHEMISTRY FRONTIERS 2015
- 关键词：Alkylation - Olefins
- 质疑
- Cu-catalyzed mild and efficient oxidation of THbCs using air: application in practical total syntheses of perlolyrine and flazin被引量：22收藏
- 作者：Zheng, Bo Trieu, Tien Ha Meng, Tian-Zhuo Lu, Xia Dong, Jing Zhang, Qiang Shi, Xiao-Xin
- 机构：East China Univ Sci & Technol
- 来源：RSC ADVANCES 2018
- 质疑
- Enantioselective synthesis of benzofurans and benzoxazines via an olefin cross-metathesis-intramolecular oxo-Michael reaction被引量：22收藏
- 作者：Zhang, Jun-Wei Cai, Quan Gu, Qing Shi, Xiao-Xin You, Shu-Li
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：CHEMICAL COMMUNICATIONS 2013
- 质疑
