李忠 收藏
( 任职于 药学院)
博士，教授，博士生导师，教育部新世纪优秀人才，上海市优秀学科带头人。1968年7月出生。1990年获华东理工大学应用化学专业工学学士学位，1993年获华东理工大学物理化学专业理学硕士学位，1996年获华东理工大学精细化工专业工学博士学位。1995年在华东理工大学留校工作，1998年被聘为副教授，2003年被聘为教授，2004年被聘为博士生导师。期间于1999－2001年，获得日本国立AIST和ITIT博士后基金资助，在日本工业技术研究院从事博士后研究。现任华东理工大学药物化工研究所所长，国家“863”现代农业领域重大项目总体专家，中国农药学会理事，上海市农药学会秘书... 详细>>
- Divalent and Oxabridged Neonicotinoids Constructed by Dialdehydes and Nitromethylene Analogues of Imidacloprid: Design, Synthesis, Crystal Structure, and Insecticidal Activities被引量：116收藏
- 作者：Shao, Xusheng Fu, Hua Xu, Xiaoyong Xu, Xinglei Liu, Zewen Li, Zhong Qian, Xuhong
- 机构：E China Univ Sci & Technol;Nanjing Agr Univ;Qinghai Univ
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2010
- 关键词：Neonicotinoids dialdehydes imidacloprid insecticide oxabridge
- 质疑
- Overall status of neonicotinoid insecticides in China: Production, application and innovation被引量：112收藏
- 作者：Shao, Xusheng Liu, Zewen Xu, Xiaoyong Li, Zhong Qian, Xuhong
- 机构：E China Univ Sci & Technol;Nanjing Agr Univ
- 来源：JOURNAL OF PESTICIDE SCIENCE 2013
- 关键词：China neonicotinoid production application innovation
- 质疑
- Synthesis, insecticidal activity, and QSAR of novel nitromethylene neonicotinoids with tetrahydropyridine fixed cis configuration and exo-ring ether modification被引量：107收藏
- 作者：Tian, Zhongzhen Shao, Xusheng Li, Zhong Qian, Xuhong Huang, Qingchun
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2007
- 关键词：nitromethylene tetrahydropyridine cis position QSAR
- 质疑
- Novel 1,3,4-Oxadiazole-2-carbohydrazides as Prospective Agricultural Antifungal Agents Potentially Targeting Succinate Dehydrogenase被引量：105收藏
- 作者：Wu, Yuan-Yuan Shao, Wu-Bin Zhu, Jian-Jun Long, Zhou-Qing Liu, Li-Wei Wang, Pei-Yi Li, Zhong Yang, Song
- 机构：Guizhou Univ;East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2019
- 关键词：1,3,4-oxadiazole carbohydrazide bioactivity succinate dehydrogenase inhibitor
- 质疑
- Design, Synthesis, and Insecticidal Activities of Novel Analogues of Neonicotinoids: Replacement of Nitromethylene with Nitroconjugated System被引量：75收藏
- 作者：Shao, Xusheng Li, Zhong Qian, Xuhong Xu, Xiaoyong
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2009
- 关键词：Neonicotinoids nitromethylene imidacloprid insecticide
- 质疑
- Rational Optimization and Action Mechanism of Novel Imidazole (or Imidazolium)-Labeled 1,3,4-Oxadiazole Thioethers as Promising Antibacterial Agents against Plant Bacterial Diseases被引量：75收藏
- 作者：Wang, Pei-Yi Wang, Ming-Wei Zeng, Dan Xiang, Meng Rao, Jia-Rui Liu, Qing-Qing Liu, Li -Wei Wu, Zhi-Bing Li, Zhong Song, Bao-An Yang, Song
- 机构：Guizhou Univ;East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2019
- 关键词：1,3,4-oxadiazole imidazole or imidazolium antibacterial action mechanism
- 质疑
- cis-Nitromethylene neonicotinoids as new nicotinic family: Synthesis, structural diversity, and insecticidal evaluation of hexahydroimidazo[1,2-α]pyridine被引量：75收藏
- 作者：Shao, Xusheng Zhang, Wenwen Peng, Yanqing Li, Zhong Tian, Zhongzhen Qian, Xuhong
- 机构：E China Univ Sci & Technol
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2008
- 关键词：Neonicotinoid cis-Configuration Insecticide Resistance
- 质疑
- Designing Tetrahydroimidazo[1,2-a]pyridine Derivatives via Catalyst-free Aza-Diels-Alder Reaction (ADAR) and Their Insecticidal Evaluation被引量：70收藏
- 作者：Zhang, Wenwen Chen, Yinbo Chen, Weidong Liu, Zewen Li, Zhong
- 机构：E China Univ Sci & Technol;Nanjing Agr Univ
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2010
- 关键词：Aza-Diels-Alder catalyst-free insecticide biological activities
- 质疑
- cis-Configuration: A New Tactic/Rationale for Neonicotinoid Molecular Design被引量：70收藏
- 作者：Shao, Xusheng Lee, Philip W. Liu, Zewen Xu, Xiaoyong Li, Zhong Qian, Xuhong
- 机构：E China Univ Sci & Technol;Nanjing Agr Univ
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2011
- 关键词：neonicotinoids cis-configuration insecticide selectivity
- 质疑
- 害虫对新烟碱类杀虫剂的抗药性及其治理策略被引量：69收藏
- 作者：唐振华 陶黎明 李忠
- 机构：华东理工大学药学院;上海农药研究所
- 来源：《农药学学报》 2006
- 关键词：新烟碱类杀虫剂 抗性机理 P450单加氧酶 靶标部位抗性 抗性治理
- 摘要：烟碱和新烟碱类杀虫剂都是作为后突触烟碱乙酰胆碱受体(nAChRs)的激动剂作用于昆虫中枢神经系统,但这两类杀虫剂存在明显不同的选择毒性:烟碱类对哺乳动物毒性较高,而杀虫活性低;新烟碱类具有高杀虫活性,而对哺乳动物低毒。由...
- 下载全文在线阅读质疑
- Antibacterial Functions and Proposed Modes of Action of Novel 1,2,3,4-Tetrahydro-β-carboline Derivatives that Possess an Attractive 1,3-Diaminopropan-2-ol Pattern against Rice Bacterial Blight, Kiwifruit Bacterial Canker, and Citrus Bacterial Canker被引量：68收藏
- 作者：Liu, Hong-Wu Ji, Qing-Tian Ren, Gang-Gang Wang, Fang Su, Fen Wang, Pei-Yi Zhou, Xiang Wu, Zhi-Bing Li, Zhong Yang, Song
- 机构：Guizhou Univ;East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2020
- 关键词：tetrahydro-beta-carboline derivatives antiphytopathogen in vitro and in vivo bioassays ROS apoptosis hypersensitive response
- 质疑
- Pyrrole- and Dihydropyrrole-Fused Neonicotinoids: Design, Synthesis, and Insecticidal Evaluation被引量：64收藏
- 作者：Ye, Zhenjun Shi, Lina Shao, Xusheng Xu, Xiaoyong Xu, Zhiping Li, Zhong
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2013
- 关键词：Pyrrole dihydropyrrole neonicotinoid nAChR
- 质疑
- Synthesis and In Vitro and In Vivo Biological Activity Evaluation and Quantitative Proteome Profiling of Oxadiazoles Bearing Flexible Heterocyclic Patterns被引量：63收藏
- 作者：Tao, Qing-Qing Liu, Li-Wei Wang, Pei-Yi Long, Qing-Su Zhao, Yong-Liang Jin, Lin-Hong Xu, Wei-Ming Chen, Yang Li, Zhong Yang, Song
- 机构：Guizhou Univ;East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2019
- 关键词：oxadiazoles heterocyclic patterns biological activity quantitative proteomics
- 质疑
- Identification of Racemic and Chiral Carbazole Derivatives Containing an Isopropanolamine Linker as Prospective Surrogates against Plant Pathogenic Bacteria: In Vitro and In Vivo Assays and Quantitative Proteomics被引量：62收藏
- 作者：Zhao, Yong-Lian Huang, Xing Liu, Li-Wei Wang, Pei-Yi Long, Qing-Su Tao, Qing-Qing Li, Zhong Yang, Song
- 机构：Guizhou Univ;East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2019
- 关键词：carbazole isopropanolamine antibacterial proteomics action mechanism
- 质疑
- Selenium-containing naphthalimides as anticancer agents: Design, synthesis and bioactivity被引量：60收藏
- 作者：Zhao, Liwei Li, Jianfeng Li, Yiquan Liu, Jianwen Wirth, Thomas Li, Zhong
- 机构：E China Univ Sci & Technol;Cardiff Univ
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY 2012
- 关键词：Anticancer Naphthalimides Selenium K562 DNA
- 质疑
- Characterization of hepatotoxic effects induced by pyraclostrobin in human HepG2 cells and zebrafish larvae被引量：60收藏
- 作者：Wu, Mengqi Bian, Jinhao Han, Shuang Zhang, Cheng Xu, Wenping Tao, Liming Li, Zhong Zhang, Yang
- 机构： Shanghai Key Laboratory of Chemical Biology; Department of Pathology; State Key Laboratory of Bioreactor Engineering
- 来源：Chemosphere 2023
- 关键词：Activation analysis - Disease control - Mitochondria
- 质疑
- Synthesis of Thiazolium-Labeled 1,3,4-Oxadiazole Thioethers as Prospective Antimicrobials: In Vitro and in Vivo Bioactivity and Mechanism of Action被引量：59收藏
- 作者：Wang, Ming-Wei Zhu, Huai-He Wang, Pei-Yi Zeng, Dan Wu, Yuan-Yuan Liu, Li-Wei Wu, Zhi-Bing Li, Zhong Yang, Song
- 机构：Guizhou Univ;East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2019
- 关键词：1,3,4-oxadiazole thiazolium antimicrobial 3D-QSAR proteomics action mechanism
- 质疑
- Developmental toxicity and estrogenicity of glyphosate in zebrafish in vivo and in silico studies被引量：58收藏
- 作者：Lu, Jian Zhang, Cheng Xu, Wenping Chen, Weidong Tao, Liming Li, Zhong Cheng, Jiagao Zhang, Yang
- 机构： Shanghai Key Laboratory of Chemical Biology; Department of Pathology
- 来源：Chemosphere 2023
- 关键词：Animals - Deep learning - Endocrine disrupters - Herbicides
- 质疑
- Surface Morphology and the Action Mechanism of Macrophage Immuno-Stimulating Activity of Rosa Setate X Rosa Rugosa Polysaccharide Wsrp-1b被引量：57收藏
- 作者：Wu, Mengqi Xu, Jingying Li, Wei Han, Qifeng Xia, Wei Li, Zhong Zhang, Yang Zhang, Wenqing
- 机构： Shanghai Key Laboratory of Chemical Biology; Shanghai Key Laboratory of Functional Materials Chemistry; State Key Laboratory of Dairy Biotechnology
- 来源：SSRN 2023
- 关键词：Antigen-antibody reactions - Azo dyes - Disease control - Electrophoresis - Morphology - Nitric oxide - Scanning electron microscopy - Surface morphology
- 质疑
- Synthesis and Nematicidal Activities of 1,2,3-Benzotriazin-4-one Derivatives against Meloidogyne incognita被引量：57收藏
- 作者：Wang, Gaolei Chen, Xiulei Deng, Yayun Li, Zhong Xu, Xiaoyong
- 机构：E China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2015
- 关键词：1,2,3-benzotriazin-4-one 2-cyanoiminothiazolidin-4-one nematicide Meloidogyne incognita in vivo
- 质疑
- The thiazoylmethoxy modification on pyrazole oximes: Synthesis and insecticidal biological evaluation beyond acaricidal activity被引量：56收藏
- 作者：Dai, Hong Xiao, Yan-Shuang Li, Zhong Xu, Xiao-Yong Qian, Xu-Hong
- 机构：E China Univ Sci & Technol;Nantong Univ
- 来源：CHINESE CHEMICAL LETTERS 2014
- 关键词：Pyrazole oxime Substituted thiazole Acaricidal activity Insecticidal activity
- 质疑
- Characterization of glyphosate-induced cardiovascular toxicity and apoptosis in zebrafish被引量：55收藏
- 作者：Lu, Jian Wang, Weiguo Zhang, Cheng Xu, Wenping Chen, Weidong Tao, Liming Li, Zhong Cheng, Jiagao Zhang, Yang
- 机构：East China Univ Sci & Technol;UT southwestern Med Ctr
- 来源：SCIENCE OF THE TOTAL ENVIRONMENT 2022
- 关键词：Glyphosate Developmental toxicity Heart Vascular Apoptosis Zebra fish
- 质疑
- Insights into pesticide toxicity against aquatic organism: QSTR models on Daphnia Magna被引量：53收藏
- 作者：He, Lujue Xiao, Keya Zhou, Cong Li, Guanglong Yang, Hongbin Li, Zhong Cheng, Jiagao
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 2019
- 关键词：Pesticide Aquatic toxicity Daphnia magna Quantitative structure toxicity relationship (QSTR) Machine learning
- 质疑
- Specific Synergist for Neonicotinoid Insecticides: IPPA08, a cis-Neonicotinoid Compound with a Unique Oxabridged Substructure被引量：53收藏
- 作者：Bao, Haibo Shao, Xusheng Zhang, Yixi Deng, Yayun Xu, Xiaoyong Liu, Zewen Li, Zhong
- 机构：Nanjing Agr Univ;E China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2016
- 关键词：neonicotinoid insecticide synergist detoxification enzyme nicotinic acetylcholine receptors
- 质疑
- Cis-configuration: A new tactic/rationale for neonicotinoid molecular design被引量：52收藏
- 作者：Shao, Xusheng Lee, Philip W. Liu, Zewen Xu, Xiaoyong Li, Zhong Qian, Xuhong
- 机构： Shanghai Key Laboratory of Chemical Biology; Key Laboratory of Monitoring and Management of Plant Disease and Insect
- 来源：Journal of Agricultural and Food Chemistry 2011
- 关键词：Organic compounds
- 质疑
- Simultaneous Quantification of Hg2+ and MeHg+ in Aqueous Media with a Single Fluorescent Probe by Multiplexing in the Time Domain被引量：51收藏
- 作者：Zhang, Ziqian Zhang, Baoyan Qian, Xuhong Li, Zhong Xu, Zhiping Yang, Youjun
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：ANALYTICAL CHEMISTRY 2014
- 关键词：Cost effectiveness - Time domain analysis
- 质疑
- An unusual synthesis of Troger's bases using DMSO/HCl as formaldehyde equivalent被引量：50收藏
- 作者：Li, Z Xu, XY Peng, YQ Jiang, ZX Ding, CY Qian, XH
- 机构：E China Univ Sci & Technol;Dalian Univ Technol
- 来源：SYNTHESIS-STUTTGART 2005
- 关键词：Troger's bases DMSO/HCl formaldehyde equivalent
- 质疑
- Synthesis and Docking Study of N-(Cinnamoyl)-N′-(substituted)acryloyl Hydrazide Derivatives Containing Pyridinium Moieties as a Novel Class of Filamentous Temperature-Sensitive Protein Z Inhibitors against the Intractable Xanthomonas oryzae pv. oryzae Infections in Rice被引量：50收藏
- 作者：Zhou, Xiang Feng, Yu-Mei Qi, Pu-Ying Shao, Wu-Bin Wu, Zhi-Bing Liu, Li-Wei Wang, Yi Ma, Hao-Dong Wang, Pei-Yi Li, Zhong Yang, Song
- 机构：Guizhou Univ;East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2020
- 关键词：rice bacterial blight diacylhydrazine derivatives FtsZ inhibitor antibacterial assay
- 质疑
- Actions between neonicotinoids and key residues of insect nAChR based on an ab initio quantum chemistry study:: Hydrogen bonding and cooperative π-π interaction被引量：50收藏
- 作者：Wang, Yanli Cheng, Jiagao Qian, Xuhong Li, Zhong
- 机构：E China Univ Sci & Technol
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY 2007
- 关键词：neonicotinoids nicotinic acetylcholine receptor binding model
- 质疑
- Characterization of Glyphosate-Induced Cardiovascular Toxicity and Apoptosis in Zebrafish Embryos被引量：49收藏
- 作者：Lu, Jian Wang, Weiguo Zhang, Cheng Xu, Wenping Tao, Liming Li, Zhong Cheng, Jiagao Zhang, Yang
- 机构： Shanghai Key Laboratory of Chemical Biology; Department of Pathology
- 来源：SSRN 2022
- 关键词：Cell death - Health hazards - Herbicides
- 质疑
