成果/Result
- Analyte Regeneration Fluorescent Probes for Formaldehyde Enabled by Regiospecific Formaldehyde-Induced Intramolecularity被引量：72收藏
- 作者：Xu, Hang Xu, Huan Ma, Shengnan Chen, Xiani Huang, Lixian Chen, Junwei Gao, Feng Wang, Rui Lou, Kaiyan Wang, Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ Arizona;Univ Arizona
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2018
- 关键词：Fluorescence spectroscopy - Fluorescence - Probes - Molecules
- A PET-based fluorescent probe for monitoring labile Fe(II) pools in macrophage activations and ferroptosis被引量：30收藏
- 作者：Xing, Wanjin Xu, Hang Ma, Huijuan Abedi, Syed Ali Abbas Wang, Shanshan Zhang, Xingchen Liu, Xiaogang Xu, Huan Wang, Wei Lou, Kaiyan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Singapore Univ Technol & Design;Univ Arizona;Univ Arizona
- 来源：CHEMICAL COMMUNICATIONS 2022
- 关键词：Fluorophores - Macrophages - Fluorescence spectroscopy - Iron compounds - Chemical activation - Fluorescence quenching
- Formaldehyde reinforces pro-inflammatory responses of macrophages through induction of glycolysis被引量：28收藏
- 作者：Ma, Huijuan Lin, Jinxuan Li, Linyi Ding, Zhaoqian Huang, Ping Song, Xiaodong Lou, Kaiyan Wang, Wei Xu, Huan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Fudan Univ;Univ Arizona;Univ Arizona
- 来源：CHEMOSPHERE 2021
- 关键词：Formaldehyde Macrophage Glycolysis Pro-inflammatory responses Lipopolysaccharide stimulation HIF-1 alpha
- Fluorophore-Promoted facile Deprotonation and Exocyclic Five-Membered Ring Cyclization for Selective and Dynamic Tracking of Labile Glyoxals被引量：27收藏
- 作者：Xu, Huan Liu, Qianqian Song, Xiaodong Wang, Chao Wang, Xinru Ma, Shengnan Wang, Xiaolei Feng, Yan Meng, Xiangming Liu, Xiaogang Wang, Wei Lou, Kaiyan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Fudan Univ;Singapore Univ Technol & Design;Anhui Univ
- 来源：ANALYTICAL CHEMISTRY 2020
- 关键词：Fluorophores - Formaldehyde - Metabolism - Mass spectrometry - Mammals - Liquid chromatography - Metabolites - Amino acids - Nitric oxide - Complex networks - Modulation - Diagnosis
- A naphthalimide-aminal-based pH-sensitive fluorescent donor for lysosome-targeted formaldehyde release and fluorescence turn-on readout被引量：21收藏
- 作者：Xu, Hang Ma, Shengnan Liu, Qianqian Huang, Lixian Wu, Peimin Liu, Xiaolin Huang, Yali Wang, Xiaolei Xu, Huan Lou, Kaiyan Wang, Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ Arizona;Univ Arizona
- 来源：CHEMICAL COMMUNICATIONS 2019
- Toxicity of environmentally-relevant concentrations of arsenic on developing T lymphocyte被引量：21收藏
- 作者：Xu, Huan Wang, Xiaolei Burchiel, Scott W.
- 机构：East China Univ Sci & Technol;Univ New Mexico
- 来源：ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 2018
- 关键词：Arsenic T lymphocyte development Environmentally-relevant concentrations Genotoxicity IL-7 signaling Arsenite transporters
- Organocatalytic asymmetric [3+3] annulation of isatin N,N′-cyclic azomethine imines with enals: Efficient approach to functionalized spiro N-heterocyclic oxindoles被引量：20收藏
- 作者：Gu, Boqi Wu, Shuxiao Xu, Hui Yang, Wulin Liu, Zhixiang Deng, Weiping
- 机构：Zhejiang Chinese Med Univ;East China Univ Sci & Technol
- 来源：CHINESE CHEMICAL LETTERS 2021
- 关键词：Chiral secondary amine [3+3] Annulation Azomethine imines Spiro N-heterocyclic oxindole Asymmetric synthesis
- Accumulation of Intracellular Ferrous Iron in Inflammatory-Activated Macrophages被引量：20收藏
- 作者：Ma, Huijuan Shu, Qi Li, Dan Wang, Tingqian Li, Linyi Song, Xiaodong Lou, Kaiyan Xu, Huan
- 机构：East China Univ Sci & Technol;Fudan Univ
- 来源：BIOLOGICAL TRACE ELEMENT RESEARCH 2022
- 关键词：Ferrous iron Macrophages Inflammatory activation Polarization Ulcerative colitis Iron metabolism
- Inhibition of red blood cell development by arsenic-induced disruption of GATA-1被引量：20收藏
- 作者：Zhou, Xixi Medina, Sebastian Bolt, Alicia M. Zhang, Haikun Wan, Guanghua Xu, Huan Lauer, Fredine T. Wang, Shu Chun Burchiel, Scott W. Liu, Ke Jian
- 机构：Univ New Mexico;New Mexico Highlands Univ;East China Univ Sci & Technol;Chinese Acad Med Sci & Peking Union Med Coll
- 来源：SCIENTIFIC REPORTS 2020
- Influence of Temperature, Solvents, and Excipients on Crystal Transformation of Agomelatine被引量：16收藏
- 作者：Liu, Yan Gao, Huiru Xu, Hao Ren, Fuzheng Ren, Guobin
- 机构：East China Univ Sci & Technol
- 来源：ORGANIC PROCESS RESEARCH & DEVELOPMENT 2016
- 关键词：Temperature
- An "AND"-logic-gate-based fluorescent probe with dual reactive sites for monitoring extracellular methylglyoxal level changes of activated macrophages被引量：16收藏
- 作者：Wang, Wenli Chen, Junwei Ma, Huijuan Xing, Wanjin Lv, Nan Zhang, Baoning Xu, Huan Wang, Wei Lou, Kaiyan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ Arizona;Univ Arizona
- 来源：CHEMICAL COMMUNICATIONS 2021
- 关键词：Fluorescence - Probes - Computer circuits - Macrophages
- Formaldehyde aggravates allergic contact dermatitis by facilitating NLRP3 inflammasome activation in macrophages被引量：16收藏
- 作者：Ma, Huijuan Shu, Qi Li, Zhiming Song, Xiaodong Xu, Huan
- 机构：East China Univ Sci & Technol;Fudan Univ
- 来源：INTERNATIONAL IMMUNOPHARMACOLOGY 2023
- 关键词：NLRP3 inflammasome Formaldehyde immunotoxicity Allergic contact dermatitis Inflammatory cytokines Caspase-1 Macrophages
- Functional suppression of macrophages derived from THP-1 cells by environmentally-relevant concentrations of arsenite被引量：15收藏
- 作者：Xu, Huan Wang, Xiaolei Wang, Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ New Mexico
- 来源：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 2018
- 关键词：Arsenite Macrophage THP-1 cells Environmentally-relevant concentrations Phagocytosis Cytokine production Nitric oxide
- Mebendazole is a potent inhibitor to chemoresistant T cell acute lymphoblastic leukemia cells被引量：15收藏
- 作者：Wang, Xiaolei Lou, Kaiyan Song, Xiaodong Ma, Huijuan Zhou, Xinyi Xu, Huan Wang, Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Fudan Univ;Univ Arizona;Univ Arizona
- 来源：TOXICOLOGY AND APPLIED PHARMACOLOGY 2020
- 关键词：Mebendazole T cell acute lymphoblastic leukemia Notch1 Drug repurposing Apoptosis Chemoresistance
- A new facile approach to N-alkylpyrroles from direct redox reaction of 4-hydroxy-L-proline with aldehydes被引量：15收藏
- 作者：Zou ZhiQin Deng ZeJun Yu XinHong Zhang ManMan Zhao SiHan Luo Ting Yin Xin Xu Hui Wang Wei
- 机构：E China Univ Sci & Technol;Univ New Mexico
- 来源：SCIENCE CHINA-CHEMISTRY 2012
- 关键词：aromatization decarboxylation enamines iminium redox isomerization
- Microwave-assisted three-component Knoevenagel-nucleophilic aromatic substitution reactions被引量：15收藏
- 作者：Xu, Hui Yu, Xinhong Sun, Leying Liu, Jing Fan, Wen Shen, Yongjia Wang, Wei
- 机构：E China Univ Sci & Technol;Univ New Mexico
- 来源：TETRAHEDRON LETTERS 2008
- 关键词：three-component reaction microwave-assisted reaction 4-halobenzaldehyde SNAr
- Formaldehyde exacerbates asthma in mice through the potentiation of HIF-1α-mediated pro-inflammatory responses in pulmonary macrophages被引量：15收藏
- 作者：Ma, Huijuan Shu, Qi Wang, Peiyao Qin, Ruilin Li, Sijia Xu, Huan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CHEMICO-BIOLOGICAL INTERACTIONS 2023
- 关键词：Formaldehyde Asthma Macrophage Glycolysis Pro-inflammatory responses HIF-1 alpha
- A compact fluorescence/circular dichroism dual-modality probe for detection, differentiation, and detoxification of multiple heavy metal ions via bond-cleavage cascade reactions被引量：15收藏
- 作者：Chen, Junwei Wang, Na Tong, Hongjuan Song, Chao Ma, Huijuan Zhang, Yajun Gao, Feng Xu, Huan Wang, Wei Lou, Kaiyan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shaanxi Inst Int Trade & Commerce;Univ Arizona;Univ Arizona
- 来源：CHINESE CHEMICAL LETTERS 2021
- 关键词：Fluorescent probe Circular dichroism Heavy metal ions Dual-modality Detoxification Cascade reaction Divergent responses
- A simple two-photon turn-on fluorescent probe for the selective detection of cysteine based on a dual PeT/ICT mechanism被引量：14收藏
- 作者：Chen, Xiani Xu, Hang Ma, Shengnan Tong, Hongjuan Lou, Kaiyan Wang, Wei
- 机构：East China Univ Sci & Technol;Shaanxi Inst Int Trade & Commerce;Univ New Mexico
- 来源：RSC ADVANCES 2018
- 关键词：Photons - Lanthanum compounds - Amino acids - Fluorescence - Infrared devices - Infrared lasers
- Minimal uranium accumulation in lymphoid tissues following an oral 60-day uranyl acetate exposure in male and female C57BL/6J mice被引量：12收藏
- 作者：Bolt, Alicia M. Medina, Sebastian Lauer, Fredine T. Xu, Huan Ali, Abdul-Mehdi Liu, Ke Jian Burchiel, Scott W.
- 机构：Univ New Mexico;East China Univ Sci & Technol;Univ New Mexico
- 来源：PLOS ONE 2018
- Organocatalytic Asymmetric Inverse-Electron-Demand Diels-Alder Reaction of Pyrrolidone-Dienes with Enals被引量：11收藏
- 作者：Wu, Shu-Xiao Gu, Bo-Qi Xu, Hui Zheng, Xing Luo, Xiaoyan Deng, Wei-Ping
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ADVANCED SYNTHESIS & CATALYSIS 2019
- 关键词：asymmetric catalysis pyrrolidone-diene inverse-electron-demand Diels-Alder reaction chiral secondary amines hexahydro-isoindol-1-one
- Methylglyoxal produced by tumor cells through formaldehyde-enhanced Warburg effect potentiated polarization of tumor-associated macrophages被引量：10收藏
- 作者：Ma, Huijuan Ding, Zhaoqian Xie, Ying Li, Linyi Li, Dan Lou, Kaiyan Wang, Wei Xu, Huan
- 机构：East China Univ Sci & Technol;Univ Arizona
- 来源：TOXICOLOGY AND APPLIED PHARMACOLOGY 2022
- 关键词：Methylglyoxal Formaldehyde Tumor-associated macrophages Warburg effect Polarization HIF-1a
- Myricetin alleviates the formaldehyde-enhanced Warburg effect in tumor cells through inhibition of HIF-1α被引量：9收藏
- 作者：Li, Linyi Ma, Huijuan Li, Dan Shu, Qi Wang, Tingqian Song, Xiaodong Xu, Huan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Fudan Univ
- 来源：TOXICOLOGY AND APPLIED PHARMACOLOGY 2022
- 关键词：Myricetin Formaldehyde Warburg effect Glycolysis HIF-1a Tumor microenvironment
- Myricetin protects natural killer cells from arsenite induced DNA damage by attenuating oxidative stress and retaining poly(ADP-Ribose) polymerase 1 activity被引量：9收藏
- 作者：Ma, Huijuan Song, Xiaodong Huang, Ping Zhang, Weiwei Ling, Xinyue Yang, Xiaoning Wu, Wenwei Xu, Huan Wang, Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Fudan Univ;Univ Arizona;Univ Arizona
- 来源：MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 2021
- 关键词：Myricetin NK cells DNA damage Oxidative stress PARP-1 Genotoxicity
- An anthracenecarboximide-guanidine fluorescent probe for selective detection of glyoxals under weak acidic conditions被引量：8收藏
- 作者：Chen, Junwei Lin, Yuna Xing, Wanjin Zhang, Xingchen Xu, Huan Wang, Wei Lou, Kaiyan
- 机构：East China Univ Sci & Technol;Univ Arizona;Univ Arizona
- 来源：RSC ADVANCES 2022
- 关键词：Fluorescence
- Arsenite and monomethylarsonous acid disrupt erythropoiesis through combined effects on differentiation and survival pathways in early erythroid progenitors被引量：7收藏
- 作者：Medina, Sebastian Bolt, Alicia M. Zhou, Xixi Wan, Guanghua Xu, Huan Lauer, Fredine T. Liu, Ke Jian Burchiel, Scott W.
- 机构：Univ New Mexico;New Mexico Highlands Univ;East China Univ Sci & Technol
- 来源：TOXICOLOGY LETTERS 2021
- 关键词：Arsenic Erythropoiesis STAT5 GATA-1 Arsenite (As+3) Monomethylarsonous acid (MMA(+3))
- Formaldehyde promotes tumor-associated macrophage polarizations and functions through induction of HIF-1α-mediated glycolysis被引量：7收藏
- 作者：Shu, Qi Ma, Huijuan Wang, Tingqian Wang, Peiyao Xu, Huan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：TOXICOLOGY LETTERS 2023
- 关键词：Formaldehyde Tumor-associated macrophage Glycolytic metabolism HIF-1 alpha T cell suppression Tumor cell proliferation
- Investigation of a solution-mediated phase transformation of pranlukast DMF solvate to hemihydrate被引量：6收藏
- 作者：Hong, Minghuang Chen, Jingyan Zhou, Hui Xu, Hao Ren, Guobin
- 机构：East China Univ Sci & Technol
- 来源：CRYSTAL RESEARCH AND TECHNOLOGY 2017
- 关键词：Pranlukast polymorphism solution-mediated phase transformation
- Construction of 3-Azabicyclo[3.1.0]hexane Backbone by the Reaction of Allenes with Allylamines via Tandem Michael Addition and Copper-Mediated Oxidative Carbanion Cyclization被引量：6收藏
- 作者：Xu, Hui Han, Teng Luo, Xiaoyan Deng, Wei-Ping
- 机构：East China Univ Sci & Technol; East China Univ Sci & Technol
- 来源：CHINESE JOURNAL OF CHEMISTRY 2021
- 关键词：Oxidative coupling Allenes Allylamine 3-Azabicyclo[3,1,0]hexane Miachel addition
- Arsenite inhibits M2a polarization of macrophages through downregulation of peroxisome proliferator-activated receptor gamma被引量：5收藏
- 作者：Li, Dan Ma, Huijuan Shu, Qi Wang, Tingqian Li, Linyi Huang, Ping Lou, Kaiyan Xu, Huan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：TOXICOLOGY AND APPLIED PHARMACOLOGY 2022
- 关键词：Arsenite PPAR-? M2a polarization Macrophages Immunosuppression Rosiglitazone
