郭美锦 收藏
( 任职于 生物工程学院)
工学博士，华东理工大学生物工程学院教授，博士生导师。主要从事工业微生物发酵与过程控制技术研究，以及动物细胞（干细胞）大规模培养与抗体、疫苗的表达技术研究与开发。主讲研究生《发酵调控技术学》、《微生物遗传学》和本科生《发酵工程原理》课程。 工作经历 2015.01--今，华东理工大学，生物工程学院，教授 2014.11-2014.12，比利时根特（Ghent）大学，理学院生物医学分子生物学系，高级访问教授 2010/09-2014.10，华东理工大学，生物工程学院，教授 2005/12-2010/08，华东理工大学，生物工程学院，副教授 2004/10-2005/1... 详细>>
- Zoonotic Cryptosporidium Species and Enterocytozoon bieneusi Genotypes in HIV-Positive Patients on Antiretroviral Therapy被引量：218收藏
- 作者：Wang, Lin Zhang, Hongwei Zhao, Xudong Zhang, Longxian Zhang, Guoqing Guo, Meijin Liu, Lili Feng, Yaoyu Xiao, Lihua
- 机构：E China Univ Sci & Technol;Henan Ctr Dis Control & Prevent;Henan Agr Univ;Ctr Dis Control & Prevent
- 来源：JOURNAL OF CLINICAL MICROBIOLOGY 2013
- 质疑
- Concurrent Infections of Giardia duodenalis, Enterocytozoon bieneusi, and Clostridium difficile in Children during a Cryptosporidiosis Outbreak in a Pediatric Hospital in China被引量：174收藏
- 作者：Wang, Lin Xiao, Lihua Duan, Liping Ye, Jianbin Guo, Yaqiong Guo, Meijin Liu, Lili Feng, Yaoyu
- 机构：E China Univ Sci & Technol;Ctr Dis Control & Prevent
- 来源：PLOS NEGLECTED TROPICAL DISEASES 2013
- 质疑
- Molecular Surveillance of Cryptosporidium spp., Giardia duodenalis, and Enterocytozoon bieneusi by Genotyping and Subtyping Parasites in Wastewater被引量：171收藏
- 作者：Li, Na Xiao, Lihua Wang, Lin Zhao, Shuming Zhao, Xukun Duan, Liping Guo, Meijin Liu, Lili Feng, Yaoyu
- 机构：E China Univ Sci & Technol;Ctr Dis Control & Prevent;Third Mil Med Univ
- 来源：PLOS NEGLECTED TROPICAL DISEASES 2012
- 质疑
- Eco-toxicological effect of Carbamazepine on Scenedesmus obliquus and Chlorella pyrenoidosa被引量：104收藏
- 作者：Zhang, Wei Zhang, Meng Lin, Kuangfei Sun, Wenfang Xiong, Bang Guo, Meijin Cui, Xinhong Fu, Rongbing
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Inst Landscape Gardening;Shanghai Acad Environm Sci
- 来源：ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 2012
- 关键词：Carbamazepine Algae Acute toxicity Chronic toxicity
- 质疑
- Salt stress induced lipid accumulation in heterotrophic culture cells of Chlorella protothecoides: Mechanisms based on the multi-level analysis of oxidative response, key enzyme activity and biochemical alteration被引量：100收藏
- 作者：Wang, Tao Ge, Haiyan Liu, Tingting Tian, Xiwei Wang, Zejian Guo, Meijin Chu, Ju Zhuang, Yingping
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2016
- 关键词：Chlorella protothecoides Heterotrophic culture Lipid Microalgae ROS Salt stress
- 质疑
- Optimized biosynthesis of xanthan via effective valorization of orange peels using response surface methodology: A kinetic model approach被引量：73收藏
- 作者：Mohsin, Ali Zhang, Kuipu Hu, Junlang Salim-ur-Rehman Tariq, Muhammad Zaman, Waqas Qamar Khan, Imran Mahmood Zhuang, Yingping Guo, Meijin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ Agr Faisalabad
- 来源：CARBOHYDRATE POLYMERS 2018
- 关键词：Xanthan gum Orange peel Fermentation Response surface methodology and kinetic analysis
- 质疑
- Toxicity assessment of zebrafish following exposure to CdTe QDs被引量：67收藏
- 作者：Zhang, Wei Lin, Kuangfei Miao, Youna Dong, Qiaoxiang Huang, Changjiang Wang, Huili Guo, Meijin Cui, Xinhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;Wenzhou Med Coll;E China Univ Sci & Technol
- 来源：JOURNAL OF HAZARDOUS MATERIALS 2012
- 关键词：TGA-CdTe QDs Zebrafish Developmental toxicity Behavioral toxicity
- 质疑
- Advances in engineered Bacillus subtilis biofilms and spores, and their applications in bioremediation, biocatalysis, and biomaterials被引量：64收藏
- 作者：Mohsin, Muhammad Zubair Omer, Rabia Huang, Jiaofang Mohsin, Ali Guo, Meijin Qian, Jiangchao Zhuang, Yingping
- 机构：East China Univ Sci & Technol
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2021
- 关键词：Bacillus subtilis Biofilms Spores Biocatalysis Bioremediation Biomaterials Synthetic biology
- 质疑
- Enhanced Biosynthesis of Chlorogenic Acid and Its Derivatives in Methyl-Jasmonate-Treated Gardenia jasminoides Cells: A Study on Metabolic and Transcriptional Responses of Cells被引量：63收藏
- 作者：Liu, Zebo Mohsin, Ali Wang, Zejian Zhu, Xiaofeng Zhuang, Yingping Cao, Liming Guo, Meijin Yin, Zhongping
- 机构： State Key Laboratory of Bioreactor Engineering; Jiangxi Key Laboratory of Natural Products and Functional Foods; Crop Breeding and Cultivation Research Institute
- 来源：Frontiers in Bioengineering and Biotechnology 2020
- 关键词：Biosynthesis - Plants (botany) - Signal transduction - Bacteriophages - Transcription
- 质疑
- Xanthan-Curdlan nexus for synthesizing edible food packaging films被引量：61收藏
- 作者：Mohsin, Ali Zaman, Waqas Qamar Guo, Meijin Ahmed, Waheed Khan, Imran Mahmood Niazi, Sobia Rehman, Abdur Hang, Haifeng Zhuang, Yingping
- 机构：East China Univ Sci & Technol;Natl Univ Sci & Technol NUST;Jiangnan Univ
- 来源：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2020
- 关键词：Xanthangum Curdlan Blendfilms
- 质疑
- Advances in sustainable approaches utilizing orange peel waste to produce highly value-added bioproducts被引量：55收藏
- 作者：Mohsin, Ali Hussain, Muhammad Hammad Zaman, Waqas Qamar Mohsin, Muhammad Zubair Zhang, Junhong Liu, Zebo Tian, Xiwei Salim-Ur-Rehman Khan, Imran Mehmood Niazi, Sobia Zhuang, Yingping Guo, Meijin
- 机构：East China Univ Sci & Technol;Natl Univ Sci & Technol;Univ Agr Faisalabad;Jiangnan Univ
- 来源：CRITICAL REVIEWS IN BIOTECHNOLOGY 2022
- 关键词：Orange peel waste valorization extraction technologies fermentation approaches biorefineries bioproducts
- 质疑
- Engineered Bacteria-Based Living Materials for Biotherapeutic Applications被引量：51收藏
- 作者：Omer, Rabia Mohsin, Muhammad Zubair Mohsin, Ali Mushtaq, Bilal Sajid Huang, Xumeng Guo, Meijin Zhuang, Yingping Huang, Jiaofang
- 机构：East China Univ Sci & Technol;Jiangnan Univ
- 来源：FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 2022
- 关键词：engineered living materials synthetic live therapy synthetic biology biodiagnostic biotherapeutics multiplex diseases
- 质疑
- Production of polymalic acid and malic acid from xylose and corncob hydrolysate by a novel Aureobasidium pullulans YJ 6-11 strain被引量：51收藏
- 作者：Zou, Xiang Yang, Jing Tian, Xu Guo, Meijing Li, Zhenghua Li, Yunzheng
- 机构：Southwest Univ;Chongqing Univ;E China Univ Sci & Technol;Anhui Sealong Biotechnol Co Ltd
- 来源：PROCESS BIOCHEMISTRY 2016
- 关键词：Aureobasidium pullulans Corncob hydrolysate Fermentation Malic acid Polymalic acid Xlyose
- 质疑
- 重组巴氏毕赤酵母高密度发酵表达rHSA被引量：49收藏
- 作者：郭美锦 庄英萍 储炬 张嗣良 刘志敏
- 机构：华东理工大学生物反应器工程国家重点实验室;军事医学科学院生物工程研究所
- 来源：《微生物学报》 2002
- 关键词：重组巴斯德毕赤酵母 高密度发酵 重组人血清白蛋白 rHSA 表达
- 摘要：对基因工程菌Pichiapastoris的摇瓶发酵条件进行了试验 ,并根据摇瓶发酵的优化结果进行了补料分批高密度发酵。在摇瓶发酵时 ,甲醇诱导基因工程菌P .pastoris表达重组人血清白蛋白的发酵周期为 96h ;甲...
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- Mechanistic insight for improving butenyl-spinosyn production through combined ARTP/UV mutagenesis and ribosome engineering in Saccharopolyspora pogona被引量：49收藏
- 作者：Zhao, Xueli Hussain, Muhammad Hammad Mohsin, Ali Liu, Zebo Xu, Zhixian Li, Zhanxia Guo, Weiqun Guo, Meijin
- 机构： State Key Laboratory of Bioreactor Engineering; Department of Respiratory Medicine; Academy of National Food and Strategic Reserves Administration
- 来源：Frontiers in Bioengineering and Biotechnology 2023
- 关键词：Biochemistry - Macromolecules - Mutagenesis
- 质疑
- Toxicological effect of MPA-CdSe QDs exposure on zebrafish embryo and larvae被引量：48收藏
- 作者：Zhang, Wei Lin, Kuangfei Sun, Xue Dong, Qiaoxiang Huang, Changjiang Wang, Huili Guo, Meijin Cui, Xinhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;Wenzhou Med Coll;E China Univ Sci & Technol
- 来源：CHEMOSPHERE 2012
- 关键词：MPA-CdSe QDs Zebrafish embryo Zebrafish larvae Developmental toxicity Behavioral toxicity
- 质疑
- Sustainable biosynthesis of curdlan from orange waste by using Alcaligenes faecalis: A systematically modeled approach被引量：48收藏
- 作者：Mohsin, Ali Sun, Jingyun Khan, Imran Mahmood Hang, Haifeng Tariq, Muhammad Tian, Xiwei Ahmed, Waqas Niazi, Sobia Zhuang, Yingping Chu, Ju Mohsin, Muhammad Zubair Salim-ur-Rehman Guo, Meijin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Jiangnan Univ;Univ Agr Faisalabad;Univ Agr Faisalabad
- 来源：CARBOHYDRATE POLYMERS 2019
- 关键词：Sustainable biosynthesis Orange peels Kinetics Curdlan Batch culture fermentation
- 质疑
- Acute and chronic toxic effects of bisphenol a on Chlorella pyrenoidosa and Scenedesmus obliquus被引量：48收藏
- 作者：Zhang, Wei Xiong, Bang Sun, Wen-Fang An, Shuai Lin, Kuang-Fei Guo, Mei-Jin Cui, Xin-Hong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Inst Landscape Gardening
- 来源：ENVIRONMENTAL TOXICOLOGY 2014
- 关键词：acute toxicity Scenedesmus obliquus BPA Chlorella pyrenoidosa chronic toxicity
- 质疑
- Understanding the effect of foreign gene dosage on the physiology of Pichia pastoris by transcriptional analysis of key genes被引量：47收藏
- 作者：Zhu, Taicheng Guo, Meijin Zhuang, Yingping Chu, Ju Zhang, Siliang
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2011
- 关键词：Gene dosage Pichia pastoris Methanol metabolism Cell physiology mRNA quantitative analysis
- 质疑
- Global regulator BldA regulates morphological differentiation and lincomycin production in Streptomyces lincolnensis被引量：46收藏
- 作者：Hou, Bingbing Tao, Liyuan Zhu, Xiaoyu Wu, Wei Guo, Meijin Ye, Jiang Wu, Haizhen Zhang, Huizhan
- 机构： State Key Laboratory of Bioreactor Engineering; Department of Applied Biology
- 来源：Applied Microbiology and Biotechnology 2018
- 关键词：Encoding (symbols) - Amino acids - Bacteria - Metabolism
- 质疑
- A two-stage fed-batch heterotrophic culture of Chlorella protothecoides that combined nitrogen depletion with hyperosmotic stress strategy enhanced lipid yield and productivity被引量：45收藏
- 作者：Wang, Tao Tian, Xiwei Liu, Tingting Wang, Zejian Guan, Wenyan Guo, Meijin Chu, Ju Zhuang, Yingping
- 机构：East China Univ Sci & Technol
- 来源：PROCESS BIOCHEMISTRY 2017
- 关键词：Microalgae Lipid Glucose inhibition Hyperosmotic stress Two-stage fed-batch culture
- 质疑
- Effect of glycosylation on biochemical characterization of recombinant phytase expressed in Pichia pastoris被引量：44收藏
- 作者：Guo, Meijin Hang, Haifeng Zhu, Taicheng Zhuang, Yingping Chu, Ju Zhang, Siliang
- 机构：E China Univ Sci & Technol;Jiangxi Agr Univ
- 来源：ENZYME AND MICROBIAL TECHNOLOGY 2008
- 关键词：phytase glycosylation biochemical characterization thermostability micro-heterogeneity
- 质疑
- Toxicity assessment of Chlorella vulgaris and Chlorella protothecoides following exposure to Pb(II)被引量：42收藏
- 作者：Zhang, Wei Xiong, Bang Chen, Lin Lin, Kuangfei Cui, Xinhong Bi, Huasong Guo, Meijin Wang, Weiliang
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Inst Landscape Gardening;E China Univ Sci & Technol
- 来源：ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 2013
- 关键词：Pb(II) Chlorella vulgaris Chlorella protothecoides Short-term toxicity Long-term toxicity
- 质疑
- A systematical investigation on the genetic stability of multi-copy Pichia pastoris strains被引量：41收藏
- 作者：Zhu, Taicheng Guo, Meijin Sun, Chen Qian, Jiangchao Zhuang, Yingping Chu, Ju Zhang, Siliang
- 机构：E China Univ Sci & Technol;Jiangxi Agr Univ
- 来源：BIOTECHNOLOGY LETTERS 2009
- 关键词：Copy number Genetic stability Multi-copy Pichia pastoris Porcine insulin precursor
- 质疑
- The Novel Transcriptional Regulator LmbU Promotes Lincomycin Biosynthesis through Regulating Expression of Its Target Genes in Streptomyces lincolnensis被引量：40收藏
- 作者：Hou, Bingbing Lin, Yanwei Wu, Haizhen Guo, Meijin Petkovic, Hrvoje Tao, Liyuan Zhu, Xiaoyu Ye, Jiang Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ Ljubljana
- 来源：JOURNAL OF BACTERIOLOGY 2018
- 关键词：LmbU LmbU homologues Streptomyces cluster-situated regulator lincomycin regulatory protein
- 质疑
- Effects of Pb(II) exposure on Chlorella protothecoides and Chlorella vulgaris growth, malondialdehyde, and photosynthesis-related gene transcription被引量：38收藏
- 作者：Xiong, Bang Zhang, Wei Chen, Lin Lin, Kuang-Fei Guo, Mei-Jin Wang, Wei-Liang Cui, Xin-Hong Bi, Hua-Song Wang, Bin
- 机构： State Env. Protection Key Lab. of Env. Risk Ass. and Control on Chemical Process; School of Resource and Environmental Engineering; The State Key Laboratory of Bioreactor Engineering; Shanghai Institute of Landscape Gardening
- 来源：Environmental Toxicology 2020
- 关键词：Polymerase chain reaction - Aldehydes - Aquatic organisms - Plants (botany) - Transcription - Lead compounds
- 质疑
- Dynamic Metabolism Mechanism of Halomonas Elongata Dsm 2581t Response to Nacl Shock Stress: An Effective Technology for Enhancing Ectoine Biosynthesis被引量：36收藏
- 作者：Yu, Junxiong Zhang, Yue Wang, Jing Liu, Yuxuan Mohisn, Ali Liu, Hao Zheng, Yanning Xing, Jianmin Zhuang, Yingping Guo, Meijin Wang, Zejian
- 机构： State Key Laboratory of Bioreactor Engineering; Department of Chemical Engineering for Energy Resources; State Key Laboratory of Microbial Resources; College of Chemical Engineering
- 来源：SSRN 2023
- 关键词：Biochemistry - Biosynthesis - Industrial research - Industrial water treatment - Metabolism - Metabolites - Wastewater treatment
- 质疑
- Real-time viable-cell mass monitoring in high-cell-density fed-batch glutathione fermentation by Saccharomyces cerevisiae T65 in industrial complex medium被引量：35收藏
- 作者：Xiong, Zhi-Qiang Guo, Mei-Jin Guo, Yuan-Xin Chu, Ju Zhuang, Ying-Ping Zhang, Si-Liang
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF BIOSCIENCE AND BIOENGINEERING 2008
- 关键词：on-line viable-cell mass monitoring capacitance complex medium glutathione production high-cell-density culture Saccharomyces cerevisiae
- 质疑
- Molecular cloning and functional characterization of an ATP-binding cassette transporter OtrC from Streptomyces rimosus被引量：34收藏
- 作者：Yu, Lan Yan, Xiangyun Wang, Long Chu, Ju Zhuang, Yingping Zhang, Siliang Guo, Meijin
- 机构： State Key Laboratory of Bioreactor Engineering; School of Life and Science
- 来源：BMC Biotechnology 2012
- 关键词：Clone cells - Cloning - Escherichia coli
- 质疑
