张惠展 收藏
( 任职于 生物工程学院应用生物学系)
生物化学与分子生物学专业：博士生导师/硕士生导师 生物工程专业：博士生导师/硕士生导师 微生物学专业：硕士生导师 生物工程领域：工程硕士生导师 1958年11月出生于上海，中共党员，博士，教授，博士生导师。1982年2月毕业于华东理工大学应用化学系抗生素制造专业，1984年7月获华东理工大学应用化学系生化工程工学硕士学位，之后留校任教。1989年赴联邦德国乌泊塔尔大学深造，1993年获联邦德国微生物学理学博士学位，主要从事微生物分子生物学、基因工程和代谢途径工程方面的教学和研究。现任华东理工大学应用生物学系系主任、中国生物化学与分子生物学学会工业生物化学与分子生物学分会副理事长、... 详细>>
- 巴斯德毕赤酵母的基因表达系统研究进展被引量：130收藏
- 作者：欧阳立明 张惠展 张嗣良 刘志敏
- 机构：华东理工大学生物工程学院;军事医学科学院生物工程研究所
- 来源：《生物化学与生物物理进展》 2000
- 关键词：巴斯德毕赤酵母 基因表达系统 载体 受体
- 摘要：巴斯德毕赤酵母是一种近年来广泛使用的基因表达系统 ,它具有表达率高、遗传稳定、产物可分泌、发酵工艺成熟等许多优点 .综述了该系统在载体类型、载体元件 (包括启动子、选择标记和信号肽序列 )、受体类型。
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- Inhibitor degradation and lipid accumulation potentials of oleaginous yeast Trichosporon cutaneum using lignocellulose feedstock被引量：80收藏
- 作者：Wang, Juan Gao, Qiuqiang Zhang, Huizhan Bao, Jie
- 机构：East China Univ Sci & Technol
- 来源：BIORESOURCE TECHNOLOGY 2016
- 关键词：Trichosporon cutaneum ACCC 20271 Lipid Biodiesel Lignocellulose Inhibitor degradation
- 质疑
- Global regulator BldA regulates morphological differentiation and lincomycin production in Streptomyces lincolnensis被引量：46收藏
- 作者：Hou, Bingbing Tao, Liyuan Zhu, Xiaoyu Wu, Wei Guo, Meijin Ye, Jiang Wu, Haizhen Zhang, Huizhan
- 机构： State Key Laboratory of Bioreactor Engineering; Department of Applied Biology
- 来源：Applied Microbiology and Biotechnology 2018
- 关键词：Encoding (symbols) - Amino acids - Bacteria - Metabolism
- 质疑
- Unveiling of Swainsonine Biosynthesis via a Multibranched Pathway in Fungi被引量：46收藏
- 作者：Luo, Feifei Hong, Song Chen, Bo Yin, Ying Tang, Guirong Hu, Fenglin Zhang, Huizhan Wang, Chengshu
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Anhui Agr Univ;ShanghaiTech Univ
- 来源：ACS CHEMICAL BIOLOGY 2020
- 质疑
- The Novel Transcriptional Regulator LmbU Promotes Lincomycin Biosynthesis through Regulating Expression of Its Target Genes in Streptomyces lincolnensis被引量：40收藏
- 作者：Hou, Bingbing Lin, Yanwei Wu, Haizhen Guo, Meijin Petkovic, Hrvoje Tao, Liyuan Zhu, Xiaoyu Ye, Jiang Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ Ljubljana
- 来源：JOURNAL OF BACTERIOLOGY 2018
- 关键词：LmbU LmbU homologues Streptomyces cluster-situated regulator lincomycin regulatory protein
- 质疑
- Omics data reveal the unusual asexual-fruiting nature and secondary metabolic potentials of the medicinal fungus Cordyceps cicadae被引量：37收藏
- 作者：Lu, Yuzhen Luo, Feifei Cen, Kai Xiao, Guohua Yin, Ying Li, Chunru Li, Zengzhi Zhan, Shuai Zhang, Huizhan Wang, Chengshu
- 机构：Chinese Acad Sci;Univ Chinese Acad Sci;East China Univ Sci & Technol;Fudan Univ;Zhejiang BioAsia Inst Life Sci
- 来源：BMC GENOMICS 2017
- 关键词：Cordyceps cicadae Genomics Mating type Asexual fruiting Secondary metabolism Bioactive metabolites
- 质疑
- Cloning and characterization of the ddsA gene encoding decaprenyl diphosphate synthase from Rhodobacter capsulatus B10被引量：31收藏
- 作者：Liu, Xinyi Wu, Haizhen Ye, Jiang Yuan, Qinsheng Zhang, Huizhan
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Canadian Journal of Microbiology 2006
- 关键词：Amino acids - Bacteria - Cloning - Enzymes - Gene expression - Polypeptides
- 质疑
- Identification of BagI as a positive transcriptional regulator of bagremycin biosynthesis in engineered Streptomyces sp. Tü 4128被引量：30收藏
- 作者：Liu, Feng Xu, Dakui Zhang, Yuchen Zhu, Yunxia Ye, Jiang Zhang, Huizhan
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Microbiological Research 2015
- 关键词：Bacteria - Metabolism - Polymerase chain reaction - Fungi - Biochemistry
- 质疑
- AdpAlin, a Pleiotropic Transcriptional Regulator, Is Involved in the Cascade Regulation of Lincomycin Biosynthesis in Streptomyces lincolnensis被引量：29收藏
- 作者：Kang, Yajing Wang, Yingying Hou, Bingbing Wang, Ruida Ye, Jiang Zhu, Xiaoyu Wu, Haizhen Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：FRONTIERS IN MICROBIOLOGY 2019
- 关键词：AdpA lincomycin Streptomyces lincolnensis transcriptional regulator cascade regulation
- 质疑
- A novel high-copy plasmid, pEC, compatible with commonly used Escherichia coli cloning and expression vectors被引量：26收藏
- 作者：Zhang, Huijing Wu, Haizhen Zhang, Huizhan
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Biotechnology Letters 2007
- 关键词：Biomarkers - Cells - Cloning - Genes
- 质疑
- Global regulator BldA regulates morphological differentiation and lincomycin production in Streptomyces lincolnensis被引量：26收藏
- 作者：Hou, Bingbing Tao, Liyuan Zhu, Xiaoyu Wu, Wei Guo, Meijin Ye, Jiang Wu, Haizhen Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2018
- 关键词：S. lincolnensis bldA Leucine codon Morphological differentiation Lincomycin production Regulatory pathway
- 质疑
- 过程启发式教学在基因组学课程中的实践被引量：23收藏
- 作者：欧阳立明 肖君华 张惠展
- 机构：华东理工大学生物工程学院
- 来源：《微生物学通报》 2006
- 关键词：基因组学 过程启发式教学 讨论
- 摘要：基因组学是生物科学专业的一门高级专业课,前沿性强。总结了对基因组学课程应用过程启发式教学方针进行教学的经验,包括激发学习兴趣,实施讨论式教学,教学内容模块化和灵活化等。实践证明,这些措施能大大提高学生学习的自主性和积极性...
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- Characterization of the bagremycin biosynthetic gene cluster in Streptomyces sp. Tü 4128被引量：22收藏
- 作者：Ye, Jiang Zhu, Yunxia Hou, Bingbing Wu, Haizhen Zhang, Huizhan
- 机构： Key Laboratory of Bioreactor Engineering; Department of Applied Biology
- 来源：Bioscience, Biotechnology and Biochemistry 2019
- 关键词：Antibiotics - Biochemistry - Bacteria - Genes
- 质疑
- Genetic engineering of the branched-chain fatty acid biosynthesis pathway to enhance surfactin production from Bacillus subtilis被引量：22收藏
- 作者：Jing, Ya-Fei Wei, Hao-Xun Liu, Fang-Fang Liu, Yi-Fan Zhou, Lei Liu, Jin-Feng Yang, Shi-Zhong Zhang, Hui-Zhan Mu, Bo-Zhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Minist Educ;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY 2023
- 关键词：Bacillus subtilis fatty acid gene expression metabolic engineering precursor biosynthesis surfactin
- 质疑
- Complete genome sequence of high-yield strain S. lincolnensis B48 and identification of crucial mutations contributing to lincomycin overproduction被引量：19收藏
- 作者：Wang, Ruida Kong, Fanjing Wu, Haizhen Hou, Bingbing Kang, Yajing Cao, Yuan Duan, Shiwei Ye, Jiang Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Ningbo Univ
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2020
- 关键词：Lincomycin Comparative genomics Regulation Overproduction
- 质疑
- Cloning and characterization of a novel tyrosine ammonia lyase-encoding gene involved in bagremycins biosynthesis in Streptomyces sp.被引量：19收藏
- 作者：Zhu, Yunxia Liao, Siyi Ye, Jiang Zhang, Huizhan
- 机构：E China Univ Sci & Technol
- 来源：BIOTECHNOLOGY LETTERS 2012
- 关键词：Aromatic amino acid ammonia lyase Bagremycins trans-coumaric acid Streptomyces Tyrosine ammonia lyase
- 质疑
- Discovery of 16-Demethylrifamycins by Removing the Predominant Polyketide Biosynthesis Pathway in Micromonospora sp. Strain TP-A0468被引量：17收藏
- 作者：Zhou, Qiang Luo, Guang-Cai Zhang, Huizhan Tang, Gang-Li
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：APPLIED AND ENVIRONMENTAL MICROBIOLOGY 2019
- 关键词：ansamycins cross talk genome mining metabolic flux redirection rifamycin
- 质疑
- Characterization of Edwardsiella tarda rpoN: roles in σ70 family regulation, growth, stress adaption and virulence toward fish被引量：16收藏
- 作者：Wang, Keping Liu, Enfu Song, Shanshan Wang, Xiaobo Zhu, Yunxia Ye, Jiang Zhang, Huizhan
- 机构：E China Univ Sci & Technol
- 来源：ARCHIVES OF MICROBIOLOGY 2012
- 关键词：Edwardsiella tarda rpoN Biofilm formation Virulence
- 质疑
- Developmental regulator RamRsl controls both morphological development and lincomycin biosynthesis in Streptomyces lincolnensis被引量：16收藏
- 作者：Wang, Ruida Cao, Yuan Kong, Fanjing Hou, Bingbing Zhao, Jiaqi Kang, Yajing Ye, Jiang Wu, Haizhen Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF APPLIED MICROBIOLOGY 2022
- 关键词：lincomycin biosynthesis morphology RamR Streptomyces lincolnensis transcriptional regulation
- 质疑
- ubiCA基因的强化表达及对大肠杆菌辅酶Q生物合成的影响被引量：15收藏
- 作者：叶江 马林 吴海珍 刘欣毅 张惠展
- 机构：华东理工大学生物反应器工程国家重点实验室
- 来源：《华东理工大学学报（自然科学版）》 2006
- 关键词：大肠杆菌 ubiCA 基因克隆 强化表达 辅酶Q
- 摘要：为调查大肠杆菌高产辅酶Q(CoQ)的可能性,首先研究大肠杆菌生物合成关键基因ubiCA强化表达对大肠杆菌CoQ产量的影响。本文构建了含有ubiCA基因的5个表达质粒,将其分别转入E.coli JM 83或BL 21(DE...
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- 弱氧化葡糖杆菌ddsA基因在大肠杆菌不同宿主菌中的表达被引量：15收藏
- 作者：范怡 刘欣毅 陈国豪 张惠展
- 机构：华东理工大学生物反应器工程国家重点实验室
- 来源：《工业微生物》 2002
- 关键词：弱氧化葡糖杆菌 ddsA基因 大肠杆菌 宿主菌 表达 聚十异戊烯焦磷酸合成酶 辅酶Q10
- 摘要：泛醌 (辅酶Q)在生物体氧化呼吸链中作为重要的质子和电子传递物质。聚十异戊烯焦磷酸合成酶催化辅酶Q10 的侧链的生物合成。为了获得高产辅酶Q10 的菌株 ,将选择了 10种不同大肠杆菌宿主菌用于弱氧化葡糖杆菌的聚十异戊烯...
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- AflQ1-Q2 represses lincomycin biosynthesis via multiple cascades in Streptomyces lincolnensis被引量：15收藏
- 作者：Wang, Ruida Zhou, Tianyu Kong, Fanjing Hou, Bingbing Ye, Jiang Wu, Haizhen Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2023
- 关键词：AflQ1-Q2 Streptomyces lincolnensis Two-component system Lincomycin biosynthesis Transcriptional regulation Aspartate metabolism
- 质疑
- Converting Chemical Oxygen Demand (COD) of Cellulosic Ethanol Fermentation Wastewater into Microbial Lipid by Oleaginous Yeast Trichosporon cutaneum被引量：14收藏
- 作者：Wang, Juan Hu, Mingshan Zhang, Huizhan Bao, Jie
- 机构：East China Univ Sci & Technol
- 来源：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 2017
- 关键词：Trichosporon cutaneum Cellulosic ethanol fermentation wastewater Chemical oxygen demand (COD) Microbial lipid
- 质疑
- An alternative s factor sLsl regulates lincomycin production in Streptomyces lincolnensis被引量：13收藏
- 作者：Tu, Bingbing Mao, Yue Wang, Ruida Kang, Yajing Ye, Jiang Zhang, Huizhan Wu, Haizhen
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF BASIC MICROBIOLOGY 2023
- 关键词：alternative sigma factor lincomycin Streptomyces lincolnensis sigma(L)(sl)
- 质疑
- A putative redox-sensing regulator Rex regulates lincomycin biosynthesis in Streptomyces lincolnensis被引量：13收藏
- 作者：Hou, Bingbing Wang, Ruida Zou, Jingyun Zhang, Feixue Wu, Haizhen Ye, Jiang Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF BASIC MICROBIOLOGY 2021
- 关键词：Streptomyces lincolnensis lincomycin Rex transcriptional regulation
- 质疑
- Molecular cloning of an insertion sequence-like element from Vibrio anguillarum and its functional identification in E. coli被引量：13收藏
- 作者：Liang, Na Wu, Haizhen Ye, Jiang Xu, Peng Zhang, Yuanxing Zhang, Huizhan
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Biotechnology Letters 2007
- 关键词：Cloning - Enzymes - Escherichia coli - Gene expression
- 质疑
- Characterization of a TetR-type positive regulator AtrA for lincomycin production in Streptomyces lincolnensis被引量：12收藏
- 作者：Wu, Wei Kang, Yajing Hou, Bingbing Ye, Jiang Wang, Ruida Wu, Haizhen Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 2023
- 关键词：Streptomyces lincolnensis AtrA lincomycin production regulatory pathway
- 质疑
- LmbU, a Cluster-Situated Regulator for Lincomycin, Consists of a DNA-Binding Domain, an Auto-Inhibitory Domain, and Forms Homodimer被引量：12收藏
- 作者：Hou, Bingbing Zhu, Xiaoyu Kang, Yajing Wang, Ruida Wu, Haizhen Ye, Jiang Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：FRONTIERS IN MICROBIOLOGY 2019
- 关键词：LmbU CSR functional domain HTH homodimer regulatory mechanism
- 质疑
- 基因组学课程体系与教学实践被引量：12收藏
- 作者：欧阳立明 张惠展
- 机构：华东理工大学生物工程学院
- 来源：《遗传》 2011
- 关键词：基因组学 生物科学 课程体系 教学 创新实验
- 摘要：基因组学是现代生命科学"组学"理论体系和研究方法中的核心,其教学存在内容多、难点多、进展快、对英文基础和前修课程知识要求高等特点。作者根据自身教学实践提出了适于生物科学本科专业教学的课程体系和经验体会,强调通过启发式思考...
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- LcbR1, a newly identified GntR family regulator, represses lincomycin biosynthesis in Streptomyces lincolnensis被引量：10收藏
- 作者：Wang, Ruida Zhao, Jiaqi Chen, Lei Ye, Jiang Wu, Haizhen Zhang, Huizhan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2023
- 关键词：Streptomyces lincolnensis LcbR1 GntR family Lincomycin biosynthesis Transcriptional regulation
- 质疑
