胡凤仙 收藏
( 任职于 生物工程学院)
微生物学专业: 硕士生导师 生物工程专业：硕士生导师 湖北人，微生物学、生物工程专业硕士生导师。近十年来，一直从事微生物选育、生理生化和代谢工程相关基础研究。针对微生物代谢产物的合成与基因遗传改造进行了大量研究工作，涉及微生物生理生化、基因工程、代谢工程以及代谢组学等方面的相关工作。通过微生物细胞代谢过程的碳流向解析、营养组分对微生物细胞代谢全组分的研究等多种手段找到产抗生物放线菌进行基因工程改造的关键基因。目前正在从事放线菌高产抗癌药物的过程优化以及基因工程改造等研究工作。作为项目负责人国家自然科学青年基金、中央高校基本科研业务费-探索研究基金、上海市自然科学基... 详细>>
- Screening of Oleaginous Yeast Strains Tolerant to Lignocellulose Degradation Compounds被引量：179收藏
- 作者：Chen, Xi Li, Zihui Zhang, Xiaoxi Hu, Fengxian Ryu, Dewey D. Y. Bao, Jie
- 机构：E China Univ Sci & Technol;Univ Calif Davis
- 来源：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 2009
- 关键词：Triacylglycerol lipid Oleaginous yeasts Trichosporon cutaneum Screening Lignocellulose degradation compounds
- 质疑
- Chemical bioengineering in plant cell culture被引量：121收藏
- 作者：Hu, Fengxian Xu, Yufang Zhao, Zhenjiang
- 机构： School of Biotechnology; Shanghai Key Laboratory of New Drug Design
- 来源：RSC Green Chemistry 2015
- 质疑
- Jasmonic acid mediates gene transcription of ginsenoside biosynthesis in cell cultures of Panax notoginseng treated with chemically synthesized 2-hydroxyethyl jasmonate被引量：71收藏
- 作者：Hu, Feng-Xian Zhong, Jian-Jiang
- 机构：Shanghai Jiao Tong Univ;E China Univ Sci & Technol
- 来源：PROCESS BIOCHEMISTRY 2008
- 关键词：panax notoginseng gene transcription ginsenoside biosynthesis secondary metabolite production synthetic jasmonate derivatives plant cell suspension culture
- 质疑
- Responses of defense signals, biosynthetic gene transcription and taxoid biosynthesis to elicitation by a novel synthetic jasmonate in cell cultures of Taxus chinensis被引量：44收藏
- 作者：Hu, Fengxian Huang, Junhai Xu, Yufang Gian, Xuhong Zhong, Jian-Jiang
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2006
- 关键词：elicitation jasmonate acid H2O2 gene transcription plant cell culture taxoid biosynthesis secondary metabolite Taxus chinensis novel synthetic jasmonate derivatives
- 质疑
- Heterozygous diploid structure of Amorphotheca resinae ZN1 contributes efficient biodetoxification on solid pretreated corn stover被引量：36收藏
- 作者：Yi, Xia Gao, Qiuqiang Zhang, Lei Wang, Xia He, Yanqing Hu, Fengxian Zhang, Jian Zou, Gen Yang, Shihui Zhou, Zhihua Bao, Jie
- 机构：East China Univ Sci & Technol;Jiujiang Univ;Chinese Acad Sci;Hubei Univ
- 来源：BIOTECHNOLOGY FOR BIOFUELS 2019
- 关键词：Biodetoxification Amorphotheca resinae ZN1 Heterozygous diploid Gene pair Coordinate expression
- 质疑
- Responses of defense signals, biosynthetic gene transcription and taxoid biosynthesis to elicitation by a novel synthetic jasmonate in cell cultures of Taxus chinensis被引量：35收藏
- 作者：Hu, Fengxian Huang, Junhai Xu, Yufang Qian, Xuhong Zhong, Jian-Jiang
- 机构： State Key Laboratory of Bioreactor Engineering; Shanghai Key Laboratory of Chemical Biology
- 来源：Biotechnology and Bioengineering 2006
- 关键词：Biosynthesis - Biotechnology - Genes - Genetic engineering - Plant cell culture
- 质疑
- Role of jasmonic acid in alteration of ginsenoside heterogeneity in elicited cell cultures of Panax notoginseng被引量：34收藏
- 作者：Hu, Feng-Xian Zhong, Jian-Jiang
- 机构：Shanghai Jiao Tong Univ;E China Univ Sci & Technol
- 来源：JOURNAL OF BIOSCIENCE AND BIOENGINEERING 2007
- 关键词：Panax notoginseng enzyme activity ginsenoside heterogeneity secondary metabolite synthetic jasmonate derivative plant cell culture
- 质疑
- Photo-fermentation of Rhodobacter sphaeroides for hydrogen production using lignocellulose-derived organic acids被引量：26收藏
- 作者：Zhu, Zhinan Shi, Jiping Zhou, Zhihua Hu, Fengxian Bao, Jie
- 机构： State Key Laboratory of Bioreactor Engineering; Institute of Plant Physiology and Ecology
- 来源：Process Biochemistry 2010
- 关键词：Hydrogen production - Wastewater treatment - Effluents - Organic acids - Fermentation - Lignin
- 质疑
- Photo-fermentation of Rhodobacter sphaeroides for hydrogen production using lignocellulose-derived organic acids被引量：26收藏
- 作者：Zhu, Zhinan Shi, Jiping Zhou, Zhihua Hu, Fengxian Bao, Jie
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：PROCESS BIOCHEMISTRY 2010
- 关键词：Biohydrogen Photo-fermentation Rhodobacter sphaeroides Lignocellulose Synergism
- 质疑
- From chemical biology to its technology and engineering被引量：25收藏
- 作者：Qian, Xuhong Zhao, Zhenjiang Xu, Jian-He Xu, Yufang Zhang, Yi-Heng Percival Hu, Fengxian Zhang, Jingyan Yong, Yang-Chun
- 机构： Shanghai Key Laboratory of Chemical Biology; Shanghai Key Laboratory of New Drug Design; Laboratory of Biocatalysis and Synthetic Biotechnology; Cell Free Bioinnovations Inc.; School of Biotechnology
- 来源：RSC Green Chemistry 2015
- 质疑
- Jasmonic acid mediates gene transcription of ginsenoside biosynthesis in cell cultures of Panax notoginseng treated with chemically synthesized 2-hydroxyethyl jasmonate被引量：23收藏
- 作者：Hu, Feng-Xian Zhong, Jian-Jiang
- 机构： College of Life Science and Biotechnology; State Key Laboratory of Bioreactor Engineering
- 来源：Process Biochemistry 2008
- 关键词：Biosynthesis - DNA - Enzyme activity - Gene transfer - Metabolites - Plant cell culture
- 质疑
- Improvement of Ansamitocin P-3 Production by Actinosynnema mirum with Fructose as the Sole Carbon Source被引量：21收藏
- 作者：Li, Tinglan Fan, Yuxiang Nambou, Komi Hu, Fengxian Imanaka, Tadayuki Wei, Liujing Hua, Qiang
- 机构：E China Univ Sci & Technol
- 来源：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 2015
- 关键词：Actinosynnema mirum Ansamitocin P-3 Fructose Glucose Metabolite analysis
- 质疑
- Improved AP-3 production through combined ARTP mutagenesis, fermentation optimization, and subsequent genome shuffling被引量：19收藏
- 作者：Li, Juan Guo, Siyu Hua, Qiang Hu, Fengxian
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：BIOTECHNOLOGY LETTERS 2021
- 关键词：Actinosynnema pretiosum Ansamitocin P-3 ARTP mutation Genome shuffling
- 质疑
- Role of Jasmonic Acid in Alteration of Ginsenoside Heterogeneity in Elicited Cell Cultures of Panax notoginseng被引量：18收藏
- 作者：Hu, Feng-Xian Zhong, Jian-Jiang
- 机构： College of Life Science and Biotechnology; State Key Laboratory of Bioreactor Engineering
- 来源：Journal of Bioscience and Bioengineering 2007
- 关键词：Enzyme activity - Hormones - Organic acids - Plant cell culture
- 质疑
- Effects of the Methylmalonyl-CoA Metabolic Pathway on Ansamitocin Production in Actinosynnema pretiosum被引量：18收藏
- 作者：Zhao, Mengjiang Fan, Yuxiang Wei, Liujing Hu, Fengxian Hua, Qiang
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 2017
- 关键词：Actinosynnema pretiosum Ansamitocins Methylmalonyl-CoA mutase Propionyl-CoA carboxylase
- 质疑
- Enhancement of UDPG synthetic pathway improves ansamitocin production in Actinosynnem pretiosum被引量：17收藏
- 作者：Fan, Yuxiang Zhao, Mengjiang Wei, Liujing Hu, Fengxian Imanaka, Tadayuki Bai, Linquan Hua, Qiang
- 机构：E China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;SCICBT
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2016
- 关键词：Actinosynnema pretiosum Ansamitocins UDPG synthetic pathway Metabolic engineering
- 质疑
- Combination of atmospheric and room temperature plasma (ARTP) mutagenesis, genome shuffling and dimethyl sulfoxide (DMSO) feeding to improve FK506 production in Streptomyces tsukubaensis被引量：17收藏
- 作者：Ye, Liting Ye, Ruifang Hu, Fengxian Wang, Guozhu
- 机构：East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY LETTERS 2021
- 关键词：Streptomyces tsukubaensis ARTP mutation Genome shuffling DMSO
- 质疑
- Consolidated Bioprocessing of Highly Concentrated Jerusalem Artichoke Tubers for Simultaneous Saccharification and Ethanol Fermentation被引量：17收藏
- 作者：Guo, Lihao Zhang, Jian Hu, Fengxian Ryu, Dewey Dy Bao, Jie
- 机构：E China Univ Sci & Technol;Univ Calif Davis
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2013
- 关键词：consolidated bioprocessing (CBP) Jerusalem artichoke tuber (Jat) Saccharomyces cerevisiae DQ1 inulin inulinase high titer ethanol
- 质疑
- Effects of modulation of pentose-phosphate pathway on biosynthesisof ansamitocins in Actinosynnema pretiosum被引量：14收藏
- 作者：Fan, Yuxiang Hu, Fengxian Wei, Liujing Bai, Linquan Hua, Qiang
- 机构：E China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2016
- 关键词：Actinosynnema pretiosum Ansamitocins Pentose phosphate pathway Phosphoglucomutase Metabolic engineering
- 质疑
- Simultaneous improvement of lincomycin A production and reduction of lincomycin B levels in Streptomyces lincolnensis using a combined medium optimization approach被引量：9收藏
- 作者：Zheng, Xiu-hong Ye, Rui-fang Ding, Qi-hang Hu, Feng-xian Zhang, Hong-zhou Lai, Shen
- 机构：East China Univ Sci & Technol;Topfond Pharmaceut Co Ltd
- 来源：ANNALS OF MICROBIOLOGY 2022
- 关键词：Streptomyces lincolnensis Lincomycin Medium optimization Osmotic stress qRT-PCR
- 质疑
- “微生物学”全英文课程的建设改革与思考被引量：5收藏
- 作者：罗远婵 张晓彦 王启要 黄娇芳 胡凤仙 高淑红 叶蕊芳 左鹏 庄英萍 吴辉
- 机构：华东理工大学生物工程学院
- 来源：《生物工程学报》 2022
- 关键词：全英文授课 微生物学 教学改革 专业英语 科研能力
- 摘要：“微生物学”是高等院校生物类、生物工程类及相关专业的专业基础课程。目前我国高等院校的“微生物学”以中文授课为主,但随着“双一流”建设等教改政策的推进及学生求学多元化需求的增加,全英文“微生物学”课程建设已势在必行。华东理...
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- Two strategies to improve the supply of PKS extender units for ansamitocin P-3 biosynthesis by CRISPR-Cas9被引量：5收藏
- 作者：Guo, Siyu Sun, Xueyuan Li, Ruihua Zhang, Tianyao Hu, Fengxian Liu, Feng Hua, Qiang
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：BIORESOURCES AND BIOPROCESSING 2022
- 关键词：Actinosynnema pretiosum CRISPR-Cas9 Bidirectional promoters Ansamitocin P-3 (AP-3) Extender unit
- 质疑
- Metabolomic change and pathway profiling reveal enhanced ansamitocin P-3 production in Actinosynnema pretiosum with low organic nitrogen availability in culture medium被引量：5收藏
- 作者：Liu, Ting Yang, Linbing Chen, Jun Hu, Fengxian Wei, Liu-Jing Hua, Qiang
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Actinosynnema pretiosum Ansamitocins Metabolomics Pathway profiling Organic nitrogen availability
- 质疑
- Global Regulator AdpA_1075 Regulates Morphological Differentiation and Ansamitocin Production in Actinosynnema pretiosum subsp. auranticum被引量：4收藏
- 作者：Guo, Siyu Leng, Tingting Sun, Xueyuan Zheng, Jiawei Li, Ruihua Chen, Jun Hu, Fengxian Liu, Feng Hua, Qiang
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：BIOENGINEERING-BASEL 2022
- 关键词：Actinosynnema pretiosum ansamitocin P-3 ssgA AdpA morphological differentiation
- 质疑
- Simultaneous Saccharification of Inulin and Starch Using Commercial Glucoamylase and the Subsequent Bioconversion to High Titer Sorbitol and Gluconic Acid被引量：4收藏
- 作者：An, Kehong Hu, Fengxian Bao, Jie
- 机构：E China Univ Sci & Technol
- 来源：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 2013
- 关键词：Inulin Starch Glucoamylase Sorbitol Immobilized Zymomonas mobilis
- 质疑
- Learning from Competition: An Outcome-Based Introductory Activity for First-Year Biotechnology Undergraduates被引量：4收藏
- 作者：Zhang, Xiaoyan Ye, Ruifang Hu, Fengxian Zheng, Yitao Gao, Shuhong Zhuang, Yingping Wang, Qiyao Bai, Yunpeng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：AMERICAN BIOLOGY TEACHER 2019
- 关键词：First-year undergraduate interdisciplinary discovery learning biotechnology
- 质疑
- 基因组重排提高珍贵橙色束丝放线菌中安丝菌素P-3被引量：2收藏
- 作者：李瑞华 李娟 胡凤仙
- 机构：华东理工大学生物工程学院
- 来源：《基因组学与应用生物学》 2021
- 关键词：基因组重排 安丝菌素P-3 原生质体 珍贵橙色束丝放线菌
- 摘要：安丝菌素P-3(ansamitocin P-3,AP-3)是一种具有高抗肿瘤活性的安莎类抗生素,为了进一步提高AP-3高产菌的产量,开展了利用基因组重排技术提高AP-3发酵水平的研究。首先对AP-3生产菌珍贵橙色束丝放线...
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- Influence of Al3+ on the titer of spiramycin and effective components in fermentor被引量：1收藏
- 作者：Li, Zhen Hu, Fengxian Ye, Ruifang Lv, Heping Zeng, Jun
- 机构：East China Univ Sci & Technol;Topfond Pharmaceut Co Ltd
- 来源：PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY 2017
- 关键词：Al3+ Streptomyces spiramyceticus 16-10-2 Spiramycin
- 质疑
