花强 收藏
( 任职于 生物工程学院)
生物化工专业：博士生导师/硕士生导师 生物工程专业：博士生导师/硕士生导师 生物工程领域：工程硕士导师 生物工程学院、生物反应器工程国家重点实验室教授，博士生导师。 学习经历 1996–2000 日本九州工业大学生命科学和生物信息学系，工学博士 1993–1996 浙江大学化工系生物化学工程专业，工学硕士 1989–1993 浙江... 详细>>
- Metabolic engineering of oleaginous yeast Yarrowia lipolytica for limonene overproduction被引量：134收藏
- 作者：Cao, Xuan Lv, Yu-Bei Chen, Jun Imanaka, Tadayuki Wei, Liu-Jing Hua, Qiang
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：BIOTECHNOLOGY FOR BIOFUELS 2016
- 关键词：Limonene Yarrowia lipolytica Neryl diphosphate synthase 1 Limonene synthase
- 质疑
- Heterologous production of α-farnesene in metabolically engineered strains of Yarrowia lipolytica被引量：122收藏
- 作者：Yang, Xia Nambou, Komi Wei, Liujing Hua, Qiang
- 机构：E China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：BIORESOURCE TECHNOLOGY 2016
- 关键词：Biofuels Fed-batch Metabolic engineering Terpene synthases Yarrowia lipolytica
- 质疑
- Programming the group behaviors of bacterial communities with synthetic cellular communication被引量：117收藏
- 作者：Kong, Wentao Celik, Venhar Liao, Chen Hua, Qiang Lu, Ting
- 机构： Department of Bioengineering; Institute for Genomic Biology; State Key Laboratory of Bioreactor Engineering; Department of Physics
- 来源：Bioresources and Bioprocessing 2014
- 关键词：Behavioral research - Cell engineering - Genes - Mobile telecommunication systems - Population statistics - Timing circuits
- 质疑
- Applicatons of Genome-Scale Metabolic Models in Biotechnology and Systems Medicine被引量：109收藏
- 作者：Zhang, Cheng Hua, Qiang
- 机构：E China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：FRONTIERS IN PHYSIOLOGY 2016
- 关键词：genome-scale metabolic models systems biology metabolic capability analysis in silico metabolic engineering systems medicine
- 质疑
- Enhancing linalool production by engineering oleaginous yeast Yarrowia lipolytica被引量：97收藏
- 作者：Cao, Xuan Wei, Liu-Jing Lin, Jia-Yu Hua, Qiang
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：BIORESOURCE TECHNOLOGY 2017
- 关键词：Linalool Yarrowia lipolytica Linalool synthase MVA pathway
- 质疑
- Enhanced squalene biosynthesis in Yarrowia lipolytica based on metabolically engineered acetyl-CoA metabolism被引量：82收藏
- 作者：Huang, Yu-Ying Jian, Xing-Xing Lv, Yu-Bei Nian, Ke-Qing Gao, Qi Chen, Jun Wei, Liu-Jing Hua, Qiang
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2018
- 关键词：Yarrowia lipolytica Acetyl-CoA Squalene Metabolic network model Terpenoid
- 质疑
- The cyanobacterial ornithine-ammonia cycle involves an arginine dihydrolase被引量：80收藏
- 作者：Zhang, Hao Liu, Yujie Nie, Xiaoqun Liu, Lixia Hua, Qiang Zhao, Guo-Ping Yang, Chen
- 机构：Chinese Acad Sci;Univ Chinese Acad Sci;East China Univ Sci & Technol;Fudan Univ;Fudan Univ
- 来源：NATURE CHEMICAL BIOLOGY 2018
- 质疑
- Improved squalene production through increasing lipid contents in Saccharomyces cerevisiae被引量：78收藏
- 作者：Wei, Liu-Jing Kwak, Suryang Liu, Jing-Jing Lane, Stephan Hua, Qiang Kweon, Dae-Hyuk Jin, Yong-Su
- 机构：East China Univ Sci & Technol;Univ Illinois;Univ Illinois;Sungkyunkwan Univ
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2018
- 关键词：beta-oxidation diacylglycerol acyltransferase HMG-CoA reductase lipid bodies Saccharomyces cerevisiae squalene
- 质疑
- Metabolic engineering of β-carotene biosynthesis in Yarrowia lipolytica被引量：72收藏
- 作者：Zhang, Xin-Kai Wang, Dan-Ni Chen, Jun Liu, Zhi-Jie Wei, Liu-Jing Hua, Qiang
- 机构：East China Univ Sci & Technol;Hubei Univ Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：BIOTECHNOLOGY LETTERS 2020
- 关键词：Yarrowia lipolytica beta-carotene CRISPR Cas9 system Metabolic engineering Fermenter cultivation
- 质疑
- Optimization of microbial cell factories for astaxanthin production: Biosynthesis and regulations, engineering strategies and fermentation optimization strategies被引量：71收藏
- 作者：Basiony, Mostafa Ouyang, Liming Wang, Danni Yu, Jiaming Zhou, Liming Zhu, Mohan Wang, Xuyuan Feng, Jie Dai, Jing Shen, Yijie Zhang, Chengguo Hua, Qiang Yang, Xiuliang Zhang, Lixin
- 机构：East China Univ Sci & Technol;Shandong Jincheng Biopharmaceut Co Ltd
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2022
- 关键词：Astaxanthin Carotenoids Metabolic engineering Microbial cell factories Lipid Fermentation Antioxidants
- 质疑
- Biosynthesis of α-Pinene by Genetically Engineered Yarrowia lipolytica from Low-Cost Renewable Feedstocks被引量：63收藏
- 作者：Wei, Liu-Jing Zhong, Yu-Tao Nie, Ming-Yue Liu, Shun-Cheng Hua, Qiang
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2021
- 关键词：Yarrowia lipolytica alpha-pinene waste cooking oil lignocellulosic hydrolysate
- 质疑
- Phosphoketolase Pathway for Xylose Catabolism in Clostridium acetobutylicum Revealed by 13C Metabolic Flux Analysis被引量：60收藏
- 作者：Liu, Lixia Zhang, Lei Tang, Wei Gu, Yang Hua, Qiang Yang, Sheng Jiang, Weihong Yang, Chen
- 机构：Chinese Acad Sci;E China Univ Sci & Technol
- 来源：JOURNAL OF BACTERIOLOGY 2012
- 质疑
- Elevating Limonene Production in Oleaginous Yeast Yarrowia lipolytica via Genetic Engineering of Limonene Biosynthesis Pathway and Optimization of Medium Composition被引量：59收藏
- 作者：Cheng, Bo-Qian Wei, Liu-Jing Lv, Yu-Bei Chen, Jun Hua, Qiang
- 机构：East China Univ Sci & Technol;SCICBT
- 来源：BIOTECHNOLOGY AND BIOPROCESS ENGINEERING 2019
- 关键词：limonene Yarrowia lipolytica carbon source fed-batch fermentation
- 质疑
- Multicopy integrants of crt genes and co-expression of AMP deaminase improve lycopene production in Yarrowia lipolytica被引量：58收藏
- 作者：Zhang, Xin-Kai Nie, Ming-Yue Chen, Jun Wei, Liu-Jing Hua, Qiang
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2019
- 关键词：Lycopene Yarrowia lipolytica Multicopy integration AMP deaminase overexpression Fermenter cultivation
- 质疑
- CRISPR/Cas9-mediated targeted mutagenesis of bZIP2 in Salvia miltiorrhiza leads to promoted phenolic acid biosynthesis被引量：57收藏
- 作者：Shi, Min Du, Zhiyan Hua, Qiang Kai, Guoyin
- 机构：East China Univ Sci & Technol;Zhejiang Chinese Med Univ;Univ Hawaii Manoa
- 来源：INDUSTRIAL CROPS AND PRODUCTS 2021
- 关键词：Salvia miltiorrhiza bZIP2 Phenolic acids Abscisic acid Transcriptional regulation
- 质疑
- Overproduction of Fatty Acid Ethyl Esters by the Oleaginous Yeast Yarrowia lipolytica through Metabolic Engineering and Process Optimization被引量：56收藏
- 作者：Gao, Qi Cao, Xuan Huang, Yu-Ying Yang, Jing-Lin Chen, Jun Wei, Liu-Jing Hua, Qiang
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：ACS SYNTHETIC BIOLOGY 2018
- 关键词：Yarrowia lipolytica fatty acid ethyl esters (FAEEs) promoter beta-oxidation ethanol
- 质疑
- Combining adaptive laboratory evolution and metabolic engineering for efficient erythritol production from crude glycerol by Yarrowia lipolytica被引量：55收藏
- 作者：Zhao, Ling-Xuan Li, Jiawei Wang, Ya-Ting Zhu, Qin-Yi Chen, Jun Liu, Zhi-Jie Liu, Feng Hua, Qiang
- 机构： State Key Laboratory of Bioreactor Engineering; State Key Laboratory of Microbial Metabolism; Key Laboratory of Fermentation Engineering
- 来源：Journal of Biotechnology 2026
- 关键词：Biochemistry - Fermentation - Food additives - Glycerol - Metabolic engineering
- 质疑
- Interaction variability shapes succession of synthetic microbial ecosystems被引量：55收藏
- 作者：Liu, Feng Mao, Junwen Kong, Wentao Hua, Qiang Feng, Youjun Bashir, Rashid Lu, Ting
- 机构：Univ Illinois;Univ Illinois;East China Univ Sci & Technol;East China Univ Sci & Technol;Huzhou Univ
- 来源：NATURE COMMUNICATIONS 2020
- 质疑
- Analysis of metabolic fluxes for better understanding of mechanisms related to lipid accumulation in oleaginous yeast Trichosporon cutaneum被引量：53收藏
- 作者：Liu, Zhijie Gao, Yang Chen, Jun Imanaka, Tadayuki Bao, Jie Hua, Qiang
- 机构：E China Univ Sci & Technol;Ritsumeikan Univ
- 来源：BIORESOURCE TECHNOLOGY 2013
- 关键词：Metabolic flux analysis Trichosporon cutaneum Biodiesel Malic enzyme Citrate pyruvate cycle
- 质疑
- A novel WRKY34-bZIP3 module regulates phenolic acid and tanshinone biosynthesis in Salvia miltiorrhiza被引量：53收藏
- 作者：Shi, Min Zhu, Ruiyan Zhang, Yi Zhang, Siwei Liu, Tingyao Li, Kunlun Liu, Shucan Wang, Leran Wang, Yao Zhou, Wei Hua, Qiang Kai, Guoyin
- 机构：Zhejiang Chinese Med Univ;East China Univ Sci & Technol;Shanghai Normal Univ
- 来源：METABOLIC ENGINEERING 2022
- 关键词：Salvia miltiorrhiza Hairy root SmWRKY34 SmbZIP3 Phenolic acids Tanshinones
- 质疑
- Antibacterial activity and mechanism of the sesquiterpene δ-cadinene against Listeria monocytogenes被引量：47收藏
- 作者：Qin, Rong Yang, Shengping Fu, Bin Chen, Yang Zhou, Mengzhou Qi, Yonggang Xu, Ning Wu, Qian Hua, Qiang Wu, Yongkang Liu, Zhijie
- 机构： Key Laboratory of Fermentation Engineering ; State Key Laboratory of Bioreactor Engineering; Hubei Juhui Agriculture Co.
- 来源：LWT 2024
- 关键词：Biofilms - Cytology - Diseases - Gene expression - Gene Ontology - Listeria - Morphology
- 质疑
- Antibacterial Activity and Mechanism of the Sesquiterpene Δ-Cadinene Against Listeria Monocytogenes and its Application in Milk被引量：46收藏
- 作者：Qin, Rong Yang, Shengping Fu, Bin Chen, Yang Qi, Yonggang Xu, Ning Wu, Qian Hua, Qiang Wu, Yongkang Liu, Zhijie
- 机构： Key Laboratory of Fermentation Engineering ; State Key Laboratory of Bioreactor Engineering; Hubei Juhui Agriculture Co.
- 来源：SSRN 2023
- 关键词：Biofilms - Cytology - Diseases - Gene expression - Gene Ontology - Listeria - Nucleic acids
- 质疑
- Reconstruction and analysis of the genome-scale metabolic network of Candida glabrata被引量：42收藏
- 作者：Xu, Nan Liu, Liming Zou, Wei Liu, Jie Hua, Qiang Chen, Jian
- 机构：Jiangnan Univ;Jiangnan Univ;E China Univ Sci & Technol
- 来源：MOLECULAR BIOSYSTEMS 2013
- 质疑
- Lycopene production in recombinant strains of Escherichia coli is improved by knockout of the central carbon metabolism gene coding for glucose-6-phosphate dehydrogenase被引量：41收藏
- 作者：Zhou, Yan Nambou, Komi Wei, Liujing Cao, Jingjing Imanaka, Tadayuki Hua, Qiang
- 机构：E China Univ Sci & Technol
- 来源：BIOTECHNOLOGY LETTERS 2013
- 关键词：Escherichia coli Glucose-6-phosphate dehydrogenase Lycopene MEP pathway
- 质疑
- Metabolome analysis and pathway abundance profiling of Yarrowia lipolytica cultivated on different carbon sources被引量：40收藏
- 作者：Zhao, Chen Gu, Deqing Nambou, Komi Wei, Liujing Chen, Jun Imanaka, Tadayuki Hua, Qiang
- 机构：E China Univ Sci & Technol;SCICBT
- 来源：JOURNAL OF BIOTECHNOLOGY 2015
- 关键词：Yarrowia lipolytica Metabolomics Pathway abundance Carbon sources Lipid production
- 质疑
- Engineering oleaginous yeast Yarrowia lipolytica for enhanced limonene production from xylose and lignocellulosic hydrolysate被引量：40收藏
- 作者：Yao, Feng Liu, Shun-Cheng Wang, Dan-Ni Liu, Zhi-Jie Hua, Qiang Wei, Liu-Jing
- 机构：East China Univ Sci & Technol;Hubei Univ Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：FEMS YEAST RESEARCH 2020
- 关键词：limonene xylose Yarrowia lipolytica lignocellulosic hydrolysate
- 质疑
- In silico profiling of cell growth and succinate production in Escherichia coli NZN111被引量：40收藏
- 作者：Jian, Xingxing Li, Ningchuan Zhang, Cheng Hua, Qiang
- 机构： State Key Laboratory of Bioreactor Engineering; Science for Life Laboratory; Shanghai Collaborative Innovation Center for Biomanufacturing Technology
- 来源：Bioresources and Bioprocessing 2016
- 关键词：Cell growth - Glucose - Growth kinetics - Metabolism - Metabolites
- 质疑
- Reconstruction and analysis of a genome-scale metabolic model of the vitamin C producing industrial strain Ketogulonicigenium vulgare WSH-001被引量：40收藏
- 作者：Zou, Wei Liu, Liming Zhang, Jing Yang, Haoru Zhou, Maoda Hua, Qiang Chen, Jian
- 机构： State Key Laboratory of Food Science and Technology; State Key Laboratory of Bioreactor Engineering; The Key Laboratory of Industrial Biotechnology; College of Bioengineering
- 来源：Journal of Biotechnology 2012
- 关键词：Physiological models - Genes - Sulfur compounds - Physiology - Amino acids - Production efficiency
- 质疑
- Designing of a "cheap to run'' fermentation platform for an enhanced production of single cell oil from Yarrowia lipolytica DSM3286 as a potential feedstock for biodiesel被引量：39收藏
- 作者：Nambou, Komi Zhao, Chen Wei, Liujing Chen, Jun Imanaka, Tadayuki Hua, Qiang
- 机构：E China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：BIORESOURCE TECHNOLOGY 2014
- 关键词：Biodiesel Fermentation Lipids Phosphate limitation Yarrowia lipolytica
- 质疑
- In silico analysis and experimental improvement of taxadiene heterologous biosynthesis in Escherichia coli被引量：37收藏
- 作者：Meng, Hailin Wang, Yong Hua, Qiang Zhang, Siliang Wang, Xiaoning
- 机构： School of Bioscience and Bioengineering; Key Laboratory of Synthetic Biology; State Key Laboratory of Bioreactor Engineering
- 来源：Biotechnology and Bioprocess Engineering 2011
- 关键词：Thermodynamic properties - Chromosomes - Lipids - Escherichia coli - Biochemistry
- 质疑
